Detailed information for compound 1214336

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 313.818 | Formula: C15H17ClFNOS
  • H donors: 0 H acceptors: 1 LogP: 4.24 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1CCC1N1C(=O)CSC1c1c(F)cccc1Cl
  • InChi: 1S/C15H17ClFNOS/c1-2-9-6-7-12(9)18-13(19)8-20-15(18)14-10(16)4-3-5-11(14)17/h3-5,9,12,15H,2,6-8H2,1H3
  • InChiKey: RNLSNLFZBURDLT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0018 0.0156 0.0327
Entamoeba histolytica cysteine proteinase 1, putative 0.0009 0.0044 0.0284
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0156 0.0326
Toxoplasma gondii cathepsin CPL 0.0018 0.0156 0.0306
Echinococcus granulosus cathepsin l1 0.0012 0.008 0.0144
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0177 0.22 0.4653
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0022 0.021 0.0421
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0044 0.0735
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0804 0.1683
Echinococcus multilocularis cysteine protease 0.0018 0.0156 0.0144
Loa Loa (eye worm) hypothetical protein 0.0017 0.0146 0.0305
Schistosoma mansoni hypothetical protein 0.0035 0.0373 0.0787
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.0044 0.009
Onchocerca volvulus 0.0018 0.0156 0.0756
Loa Loa (eye worm) hypothetical protein 0.0053 0.0606 0.1283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0156 0.3284
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0156 0.0327
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.0218 0.0458
Mycobacterium ulcerans hypothetical protein 0.0023 0.022 0.0442
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0156 0.0327
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0012 0.0025
Onchocerca volvulus 0.0018 0.0156 0.0756
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0804 0.1683
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0022 0.021 0.0442
Entamoeba histolytica hypothetical protein 0.0035 0.0373 0.3171
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0727 0.154
Echinococcus granulosus p2X purinoceptor 4 0.0122 0.1493 0.315
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0373 0.0767
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0804 0.1683
Schistosoma mansoni P2X receptor subunit 0.0122 0.1493 0.3165
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.1149 0.2434
Schistosoma mansoni P2X receptor subunit 0.0122 0.1493 0.3165
Leishmania major chloride channel protein, putative 0.0022 0.021 0.0421
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0156 0.0306
Schistosoma mansoni patched 1 0.0041 0.045 0.0952
Trypanosoma cruzi chloride channel protein, putative 0.0022 0.021 0.0442
Loa Loa (eye worm) cysteine protease 0.0018 0.0156 0.0327
Onchocerca volvulus 0.0018 0.0156 0.0756
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0156 0.0306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0044 0.0735
Schistosoma mansoni hypothetical protein 0.0039 0.0432 0.0912
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0284
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0022 0.021 1
Mycobacterium ulcerans hypothetical protein 0.0022 0.021 0.0421
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.1149 0.1138
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0155 0.1916 0.4061
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0372 0.4715 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0804 0.1683
Echinococcus granulosus cpg binding protein 0.0024 0.0234 0.0473
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0156 0.1267
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0022 0.021 0.0442
Brugia malayi AMP-binding enzyme family protein 0.0023 0.022 0.0463
Echinococcus multilocularis p2X purinoceptor 4 0.0122 0.1493 0.1483
Loa Loa (eye worm) oxidoreductase 0.0007 0.0012 0.0022
Brugia malayi ancient conserved domain protein 2 0.0022 0.021 0.0442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0156 0.3284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0156 0.3284
Onchocerca volvulus 0.0023 0.0218 0.1081
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.022 0.0442
Onchocerca volvulus 0.0018 0.0156 0.0756
Echinococcus granulosus H:Cl exchange transporter 4 0.0022 0.021 0.0421
Leishmania major CBS domain protein, conserved 0.0022 0.021 0.0421
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0156 0.0326
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0616 0.1303
Trypanosoma brucei GMP reductase 0.0372 0.4715 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.045 0.0952
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0156 0.3284
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0012 0.0025
Trypanosoma cruzi cysteine protease, putative 0.0009 0.0044 0.009
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0372 0.4715 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0009 0.0044 0.0069
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0022 0.021 0.0198
Leishmania major cathepsin L-like protease 0.0018 0.0156 0.0306
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0022 0.021 0.0445
Loa Loa (eye worm) hypothetical protein 0.0023 0.022 0.0463
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0156 0.3284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0156 0.3284
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0156 0.0144
Loa Loa (eye worm) loechrig isoform VII 0.0022 0.021 0.0442
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0022 0.021 0.0445
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0012 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.022 0.0442
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0022 0.021 0.0198
Mycobacterium ulcerans transcriptional regulator 0.0022 0.021 0.0421
Brugia malayi Voltage gated chloride channel family protein 0.0022 0.021 0.0442
Leishmania major guanosine monophosphate reductase 0.0372 0.4715 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0048 0.0545 0.1154
Echinococcus granulosus expressed conserved protein 0.0089 0.1075 0.2259
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0012 0.0025
Brugia malayi Cathepsin L-like precursor 0.0018 0.0156 0.0327
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0196 0.244 0.5175
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.008 0.0166
Plasmodium falciparum protein MAM3, putative 0.0022 0.021 0.0448
Trypanosoma cruzi cysteine peptidase, putative 0.0009 0.0044 0.009
Schistosoma mansoni chloride channel protein 0.0022 0.021 0.0442
Onchocerca volvulus 0.0018 0.0156 0.0756
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1168 0.2474
Echinococcus granulosus H:Cl exchange transporter 3 0.0022 0.021 0.0421
Loa Loa (eye worm) hypothetical protein 0.0041 0.045 0.0952
Trypanosoma cruzi GMP reductase 0.0372 0.4715 1
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0022 0.021 0.0445
Echinococcus multilocularis protein dispatched 1 0.0047 0.0525 0.0513
Echinococcus granulosus tumor protein p63 0.0362 0.4576 0.9705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0156 0.3284
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0156 0.0756
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0804 0.1683
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0156 0.3284
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0044 0.0284
Schistosoma mansoni cpg binding protein 0.0024 0.0234 0.0494
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0012 0.0025
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0022 0.021 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0146 0.0305
Loa Loa (eye worm) hypothetical protein 0.0018 0.0156 0.0327
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0012 0.0022
Schistosoma mansoni cpg binding protein 0.0024 0.0234 0.0494
Onchocerca volvulus 0.0023 0.022 0.1093
Entamoeba histolytica cysteine protease, putative 0.0018 0.0156 0.1267
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0012 0.0022
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0146 0.0309
Leishmania major cathepsin L-like protease 0.0068 0.0804 0.1683
Toxoplasma gondii CBS domain-containing protein 0.0022 0.021 0.0421
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.022 0.0442
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0156 0.3284
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0156 0.0327
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0022 0.021 0.0421
Loa Loa (eye worm) hypothetical protein 0.0022 0.021 0.0442
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0372 0.4715 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.022 0.0442
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0804 0.1683
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0016 0.0004
Mycobacterium leprae conserved hypothetical protein 0.0022 0.021 0.0421
Onchocerca volvulus Putative GMP reductase 0.0155 0.1916 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0155 0.1916 0.4061
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0156 0.0327
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0372 0.4715 1
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0156 0.1267
Toxoplasma gondii histone lysine methyltransferase SET1 0.0043 0.0479 0.0993
Echinococcus granulosus p2X purinoceptor 4 0.0122 0.1493 0.315
Schistosoma mansoni hypothetical protein 0.0039 0.0432 0.0912
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0804 0.1701
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0156 0.3284
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0022 0.021 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0044 0.0284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0156 0.3284
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0022 0.021 0.0442
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0373 0.0361
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0156 0.3284
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0044 0.009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0146 0.0305
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.022 0.183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0804 0.1683
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0012 0.0022
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0022 0.021 0.0198
Echinococcus multilocularis cysteine protease 0.0018 0.0156 0.0144
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.035 0.443 0.9395
Brugia malayi AMP-binding enzyme family protein 0.0023 0.022 0.0463
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0804 0.1701
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0022 0.021 0.0198
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0156 0.3284
Toxoplasma gondii IMP dehydrogenas 0.0372 0.4715 1
Loa Loa (eye worm) chloride channel protein 7 0.0022 0.021 0.0442
Loa Loa (eye worm) hypothetical protein 0.0012 0.008 0.0166
Entamoeba histolytica hypothetical protein 0.0035 0.0373 0.3171
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0372 0.4715 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.022 0.0442
Treponema pallidum Mg2+ transport protein (mgtE) 0.0022 0.021 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0156 0.3284
Plasmodium vivax vivapain-1 0.0009 0.0044 0.0096
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0134 0.0283
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0044 0.009
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0804 0.1701
Brugia malayi Cathepsin L-like precursor 0.0018 0.0156 0.0327
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0156 0.3284
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0372 0.4715 1
Leishmania major chloride channel protein, putative 0.0022 0.021 0.0421
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0022 0.021 0.0421
Mycobacterium ulcerans cystathionine beta-synthase 0.0022 0.021 0.0421
Plasmodium vivax vivapain-3 0.0009 0.0044 0.0096
Leishmania major cathepsin L-like protease 0.0018 0.0156 0.0306
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0012 0.0022
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0012 0.0022
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0022 0.021 0.0421
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0156 0.0756
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0156 0.3284
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0134 0.0283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0804 0.1683
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0022 0.021 0.0442
Leishmania major inosine-5-monophosphate dehydrogenase 0.0372 0.4715 1
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0022 0.021 0.0445
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0156 0.3284
Loa Loa (eye worm) hypothetical protein 0.005 0.0569 0.1203
Leishmania major cathepsin L-like protease 0.0068 0.0804 0.1683
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0156 0.0144
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.1149 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0016 0.0008
Loa Loa (eye worm) chloride channel 3 0.0022 0.021 0.0442
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0196 0.244 0.5163
Mycobacterium ulcerans hypothetical protein 0.0022 0.021 0.0421
Toxoplasma gondii CBS domain-containing protein 0.0022 0.021 0.0421
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0284
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0044 0.009
Schistosoma mansoni hypothetical protein 0.0039 0.0432 0.0912
Echinococcus multilocularis expressed conserved protein 0.0089 0.1075 0.1064
Plasmodium vivax unspecified product 0.0009 0.0044 0.0096
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0009 0.0044 0.009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0156 0.3284
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0372 0.4715 0.4708
Entamoeba histolytica cysteine proteinase 2 0.0009 0.0044 0.0284
Onchocerca volvulus 0.0053 0.0606 0.3121
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0012 0.0025
Brugia malayi hypothetical protein 0.0035 0.0373 0.0787
Brugia malayi Cathepsin L-like precursor 0.0012 0.008 0.0166
Mycobacterium tuberculosis Conserved protein 0.0022 0.021 0.0445
Brugia malayi F/Y-rich N-terminus family protein 0.0007 0.0015 0.0028
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.022 0.0442
Schistosoma mansoni hypothetical protein 0.0324 0.4088 0.867
Brugia malayi GMP reductase 0.0155 0.1916 0.4061
Echinococcus granulosus cysteine protease 0.0009 0.0044 0.0069
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0022
Onchocerca volvulus 0.0018 0.0156 0.0756
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0156 0.0327
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0044 0.0284
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0156 0.0327
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0022 0.021 0.0445
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.022 0.0442
Loa Loa (eye worm) hypothetical protein 0.0022 0.021 0.0442
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0012 0.0022
Entamoeba histolytica hypothetical protein 0.0035 0.0373 0.3171
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.008 0.0166
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0284
Loa Loa (eye worm) hypothetical protein 0.0023 0.022 0.0463
Onchocerca volvulus 0.0012 0.008 0.0356
Brugia malayi Cathepsin L-like precursor 0.0018 0.0156 0.0327
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.1149 0.2417
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0372 0.4715 1
Brugia malayi CBS domain containing protein 0.0022 0.021 0.0442
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0012 0.0022
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0284
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0156 0.0144
Chlamydia trachomatis Mg++ transporter 0.0022 0.021 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0022
Brugia malayi CLC chloride channel protein 0.0022 0.021 0.0442
Leishmania major hypothetical protein, conserved 0.0022 0.021 0.0421
Echinococcus granulosus cathepsin L 0.0009 0.0044 0.0069
Echinococcus granulosus Protein patched homolog 1 0.0041 0.045 0.0932
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0156 0.0144
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0177 0.22 0.4653
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0804 0.1683
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0156 0.3284
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0146 0.0302
Loa Loa (eye worm) hypothetical protein 0.0022 0.021 0.0442
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0804 0.1701
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0284
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0372 0.4715 1
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0284
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0022 0.021 0.0421
Loa Loa (eye worm) hypothetical protein 0.0023 0.022 0.0463
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0156 0.3284
Brugia malayi chloride channel protein 7 0.0022 0.021 0.0442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0156 0.3284
Onchocerca volvulus 0.0022 0.021 0.104
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.035 0.443 1
Brugia malayi loechrig isoform VII 0.0022 0.021 0.0442
Trypanosoma cruzi GMP reductase 0.0372 0.4715 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.022 0.0467
Loa Loa (eye worm) ctsf protein 0.0018 0.0156 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.008 0.1546
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0372 0.4715 1
Schistosoma mansoni hypothetical protein 0.0039 0.0432 0.0912
Echinococcus granulosus cathepsin l1 0.0018 0.0156 0.0306
Echinococcus multilocularis dnaJ subfamily B 0.0324 0.4088 0.4081
Schistosoma mansoni P2X receptor subunit 0.0122 0.1493 0.3165
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.1674 0.1664
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0022 0.021 0.0421
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.022 0.183
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0146 0.0325
Echinococcus multilocularis tumor protein p63 0.0362 0.4576 0.4569
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0012 0.0022
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0373 0.0787
Brugia malayi cathepsin L-like precursor 0.0012 0.008 0.0166
Plasmodium falciparum cysteine proteinase falcipain 1 0.0009 0.0044 0.0073
Plasmodium vivax vivapain-2 0.0018 0.0156 0.0348
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.045 0.0932
Schistosoma mansoni P2X receptor subunit 0.0122 0.1493 0.3165
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0022 0.021 0.0445
Leishmania major cathepsin L-like protease 0.0068 0.0804 0.1683
Mycobacterium tuberculosis Conserved protein 0.0022 0.021 0.0445
Brugia malayi CHE-14 protein 0.0041 0.045 0.0952
Mycobacterium ulcerans hypothetical protein 0.0022 0.021 0.0421
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.022 0.0442
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.008 0.1546
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.022 0.183
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0146 0.0284
Loa Loa (eye worm) fibroinase 0.0018 0.0156 0.0327
Echinococcus multilocularis protein patched 0.0041 0.045 0.0439
Treponema pallidum hemolysin (tlyC) 0.0022 0.021 0.5
Chlamydia trachomatis CBS domain-containing protein 0.0022 0.021 1
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0284
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.1674 0.3533
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0156 0.0306
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0022 0.021 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.008 0.0166
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0022 0.021 0.0198
Loa Loa (eye worm) hypothetical protein 0.0022 0.021 0.0442
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0156 0.3284
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0044 0.009
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.022 0.0442
Giardia lamblia Hypothetical protein 0.0022 0.021 0.5
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0012 0.0025
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0022 0.021 0.0421
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0156 0.3284
Mycobacterium tuberculosis Conserved protein 0.0022 0.021 0.0445
Trypanosoma cruzi chloride channel protein, putative 0.0022 0.021 0.0442
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0012 0.0025
Trypanosoma cruzi chloride channel protein, putative 0.0022 0.021 0.0442
Loa Loa (eye worm) hypothetical protein 0.0012 0.008 0.0166
Brugia malayi CXXC zinc finger family protein 0.0023 0.0218 0.0458
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0372 0.4715 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0009 0.0044 0.0069
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0606 0.1283
Schistosoma mansoni cpg binding protein 0.0023 0.0218 0.0458
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.022 0.0442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0156 0.3284
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.045 0.0439
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0012 0.0022
Loa Loa (eye worm) IMP dehydrogenase 1 0.0372 0.4715 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.022 0.0442
Plasmodium vivax vivapain-2 0.0018 0.0156 0.0348
Echinococcus granulosus dnaJ subfamily B 0.0324 0.4088 0.8667
Onchocerca volvulus 0.0018 0.0156 0.0756
Echinococcus granulosus p2X purinoceptor 4 0.0122 0.1493 0.315
Brugia malayi AMP-binding enzyme family protein 0.0023 0.022 0.0463
Loa Loa (eye worm) hypothetical protein 0.0095 0.1149 0.2434
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0284
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.035 0.443 1
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0284
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0146 0.0305
Leishmania major cathepsin L-like protease 0.0018 0.0156 0.0306
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0284
Schistosoma mansoni chloride channel protein 0.0022 0.021 0.0442
Schistosoma mansoni chloride channel protein 0.0022 0.021 0.0442
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0012 0.0025
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0022 0.021 0.0421
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0012 0.0025
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0012 0.0022
Toxoplasma gondii CBS family protein 0.0022 0.021 0.0421
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.0044 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.045 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0012 0.0025
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0044 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0804 0.1683
Schistosoma mansoni protein kinase subunit gamma 0.0022 0.021 0.0442
Brugia malayi Cathepsin L-like precursor 0.0012 0.008 0.0166
Leishmania major cathepsin L-like protease 0.0018 0.0156 0.0306
Loa Loa (eye worm) GMP reductase 0.0155 0.1916 0.4061
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0012 0.0025
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0372 0.4715 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0012 0.0023
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0284
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.0044 0.0069
Echinococcus granulosus H:Cl exchange transporter 7 0.0022 0.021 0.0421
Echinococcus multilocularis cathepsin L 0.0009 0.0044 0.0032
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0044 0.0284
Entamoeba histolytica hypothetical protein 0.0035 0.0373 0.3171
Trypanosoma cruzi chloride channel protein, putative 0.0022 0.021 0.0442
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0804 0.1683
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.022 0.0442
Echinococcus multilocularis cpg binding protein 0.0024 0.0234 0.0223
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0134 0.0283
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0012 0.0022
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0284
Echinococcus multilocularis p2X purinoceptor 4 0.0122 0.1493 0.1483
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.022 0.0467
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0156 0.0326
Loa Loa (eye worm) hypothetical protein 0.0017 0.0146 0.0305
Brugia malayi Cathepsin L-like precursor 0.0018 0.0156 0.0327
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0134 0.0283
Echinococcus multilocularis p2X purinoceptor 4 0.0122 0.1493 0.1483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0156 0.3284
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0022 0.021 0.0442
Brugia malayi ancient conserved domain protein 4 0.0022 0.021 0.0442
Leishmania major cathepsin L-like protease 0.0018 0.0156 0.0306
Brugia malayi Cathepsin L-like precursor 0.0018 0.0156 0.0327
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.008 0.0596
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0022 0.021 0.0442
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0156 0.0756
Loa Loa (eye worm) histone methyltransferase 0.0007 0.0016 0.003

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.