Detailed information for compound 1241188

Basic information

Technical information
  • TDR Targets ID: 1241188
  • Name: 3-(2,3-dihydroindol-1-ylsulfonyl)-N-(4,6-dime thyl-1,3-benzothiazol-2-yl)benzamide; ethanol
  • MW: 509.64 | Formula: C26H27N3O4S2
  • H donors: 2 H acceptors: 5 LogP: 4.93 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cc1cc(C)c2c(c1)sc(n2)NC(=O)c1cccc(c1)S(=O)(=O)N1CCc2c1cccc2.CCO
  • InChi: 1S/C24H21N3O3S2.C2H6O/c1-15-12-16(2)22-21(13-15)31-24(25-22)26-23(28)18-7-5-8-19(14-18)32(29,30)27-11-10-17-6-3-4-9-20(17)27;1-2-3/h3-9,12-14H,10-11H2,1-2H3,(H,25,26,28);3H,2H2,1H3
  • InChiKey: PMPQJWWOOVNMAY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4,6-dimethyl-1,3-benzothiazol-2-yl)-3-indolin-1-ylsulfonyl-benzamide; ethanol
  • N-(4,6-dimethyl-1,3-benzothiazol-2-yl)-3-(1-indolinylsulfonyl)benzamide; ethanol
  • SMR000247488
  • T0509-4442
  • MLS000418637

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 0.0016 0.0019 0.0019
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0048 0.0048
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0051 0.0032
Loa Loa (eye worm) hypothetical protein 0.0225 0.1604 0.1604
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0089 0.0577 0.0577
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.133 1 1
Echinococcus granulosus para nitrobenzyl esterase 0.0225 0.1604 0.1604
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0394 0.2891 0.2891
Schistosoma mansoni neuroligin 3 (S09 family) 0.0225 0.1604 0.1604
Echinococcus multilocularis cysteine protease 0.002 0.0051 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0483 1
Schistosoma mansoni ap endonuclease 0.002 0.0048 0.0048
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0225 0.1604 1
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0259 0.1614
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0483 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0051 0.0051
Echinococcus multilocularis para nitrobenzyl esterase 0.0225 0.1604 0.1588
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0094 0.1627
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0051 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0051 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0051 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0051 0.0032
Brugia malayi Cathepsin L-like precursor 0.002 0.0051 0.0051
Brugia malayi Cathepsin L-like precursor 0.002 0.0051 0.0051
Echinococcus granulosus BC026374 protein S09 family 0.0225 0.1604 0.1604
Brugia malayi Carboxylesterase family protein 0.0225 0.1604 0.1604
Mycobacterium leprae putative cytochrome p450 0.0016 0.0019 0.5
Echinococcus multilocularis acetylcholinesterase 0.133 1 1
Plasmodium vivax vivapain-2 0.002 0.0051 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0051 0.0317
Leishmania major cytochrome p450-like protein 0.0026 0.0094 0.1627
Loa Loa (eye worm) hypothetical protein 0.0139 0.0952 0.0952
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0051 0.0317
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0051 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0483 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0048 0.5
Brugia malayi MH2 domain containing protein 0.0135 0.0925 0.0925
Onchocerca volvulus Huntingtin homolog 0.0139 0.0952 0.5934
Loa Loa (eye worm) hypothetical protein 0.0225 0.1604 0.1604
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0048 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0051 0.0317
Schistosoma mansoni hypothetical protein 0.0394 0.2891 0.2891
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0051 1
Echinococcus multilocularis cysteine protease 0.002 0.0051 0.0032
Leishmania major cathepsin L-like protease 0.002 0.0051 0.0685
Loa Loa (eye worm) acetylcholinesterase 1 0.133 1 1
Onchocerca volvulus 0.0225 0.1604 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0357 0.7297
Schistosoma mansoni hypothetical protein 0.0018 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0051 0.0317
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0432 0.8904
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.0019
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0497 0.3098
Leishmania major cathepsin L-like protease 0.002 0.0051 0.0685
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0191 0.0191
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0048 0.0631
Loa Loa (eye worm) hypothetical protein 0.0225 0.1604 0.1604
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.0925 0.0925
Echinococcus multilocularis potassium voltage gated channel protein 0.0089 0.0577 0.0559
Loa Loa (eye worm) hypothetical protein 0.133 1 1
Onchocerca volvulus 0.002 0.0051 0.0317
Schistosoma mansoni hypothetical protein 0.0018 0.0033 0.0033
Onchocerca volvulus Cathepsin F homolog 0.002 0.0051 0.0317
Echinococcus granulosus neuropeptide receptor A26 0.0529 0.392 0.392
Schistosoma mansoni ap endonuclease 0.002 0.0048 0.0048
Toxoplasma gondii cathepsin CPL 0.002 0.0051 1
Onchocerca volvulus 0.002 0.0051 0.0317
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0048 0.5
Echinococcus multilocularis geminin 0.0394 0.2891 0.2877
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0497 0.3098
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0094 0.0094
Loa Loa (eye worm) ctsf protein 0.002 0.0051 0.0051
Leishmania major cathepsin L-like protease 0.0077 0.0483 1
Brugia malayi Carboxylesterase family protein 0.0225 0.1604 0.1604
Echinococcus multilocularis chromobox protein 1 0.0079 0.0497 0.0479
Brugia malayi Cytochrome P450 family protein 0.0059 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0089 0.0577 0.0577
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0051 0.0317
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0483 1
Loa Loa (eye worm) hypothetical protein 0.0225 0.1604 0.1604
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0225 0.1604 1
Echinococcus granulosus neuropeptide s receptor 0.0529 0.392 0.392
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0225 0.1604 0.1588
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0233 0.1455
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0051 0.0032
Brugia malayi chromobox protein homolog 3 0.0044 0.0233 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0483 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0191 0.0191
Brugia malayi Carboxylesterase family protein 0.133 1 1
Echinococcus granulosus geminin 0.0394 0.2891 0.2891
Onchocerca volvulus 0.002 0.0051 0.0317
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0225 0.1604 0.1604
Loa Loa (eye worm) hypothetical protein 0.0225 0.1604 0.1604
Echinococcus granulosus cathepsin l1 0.002 0.0051 0.0051
Loa Loa (eye worm) carboxylesterase 0.133 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0035 0.0161 0.0161
Brugia malayi hypothetical protein 0.0139 0.0952 0.0952
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0135 0.0843
Onchocerca volvulus 0.0225 0.1604 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0033 0.0033
Mycobacterium tuberculosis Carboxylesterase LipT 0.0225 0.1604 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0952 0.0952
Leishmania major cathepsin L-like protease 0.0077 0.0483 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0033 0.0014
Brugia malayi Cytochrome P450 family protein 0.0026 0.0094 0.0094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0051 0.0317
Schistosoma mansoni cytochrome P450 0.0016 0.0019 0.0019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0048 0.0631
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0048 0.0048
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0225 0.1604 0.1604
Brugia malayi cytochrome P450 0.0016 0.0019 0.0019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0326 0.0326
Echinococcus multilocularis neuropeptide receptor A26 0.0529 0.392 0.3909
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0051 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0051 0.0317
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0051 0.0317
Brugia malayi Cathepsin L-like precursor 0.002 0.0051 0.0051
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0048 0.0029
Onchocerca volvulus 0.0225 0.1604 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0094 0.0094
Leishmania major cysteine peptidase A (CPA) 0.002 0.0051 0.0685
Brugia malayi Heterochromatin protein 1 0.0079 0.0497 0.0497
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.0925 0.0925
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0483 1
Onchocerca volvulus 0.0225 0.1604 1
Echinococcus granulosus acetylcholinesterase 0.133 1 1
Echinococcus granulosus acetylcholinesterase 0.133 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0051 0.0317
Leishmania major cathepsin L-like protease 0.002 0.0051 0.0685
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0044 0.0233 0.0233
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0051 0.0317
Brugia malayi hypothetical protein 0.0225 0.1604 0.1604
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0048 0.0184
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0225 0.1604 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0051 0.0317
Mycobacterium leprae Conserved hypothetical protein 0.0016 0.0019 0.5
Onchocerca volvulus 0.002 0.0051 0.0317
Leishmania major cathepsin L-like protease 0.002 0.0051 0.0685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0051 0.0317
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0033 0.0033
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0259 0.1614
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0348 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0135 0.0843
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0051 0.0317
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0051 0.0317
Echinococcus granulosus GPCR family 2 0.0018 0.0033 0.0033
Echinococcus multilocularis neuroligin 0.0225 0.1604 0.1588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0483 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0225 0.1604 0.1604
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0048 0.0048
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0094 0.1627
Onchocerca volvulus 0.002 0.0051 0.0317
Leishmania major cathepsin L-like protease 0.0077 0.0483 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0326 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0233 0.1455
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0326 0.0326
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0033 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0483 1
Echinococcus multilocularis carboxylesterase 5A 0.133 1 1
Echinococcus multilocularis acetylcholinesterase 0.133 1 1
Loa Loa (eye worm) hypothetical protein 0.0225 0.1604 0.1604
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0089 0.0577 0.0577
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0048 0.0301
Trichomonas vaginalis spcc417.12 protein, putative 0.0225 0.1604 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0033
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0051 1
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0051 0.0317
Toxoplasma gondii exonuclease III APE 0.002 0.0048 0.9203
Echinococcus granulosus chromobox protein 1 0.0079 0.0497 0.0497
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0051 0.0051
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0033 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0483 1
Loa Loa (eye worm) carboxylesterase 0.0225 0.1604 0.1604
Loa Loa (eye worm) hypothetical protein 0.133 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0051
Echinococcus multilocularis chromobox protein 1 0.0079 0.0497 0.0479
Onchocerca volvulus 0.0035 0.0161 0.1002
Loa Loa (eye worm) cysteine protease 0.002 0.0051 0.0051
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0225 0.1604 0.1604
Schistosoma mansoni chromobox protein 0.0079 0.0497 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0051 0.0317
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0051 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0051 0.0317
Plasmodium vivax vivapain-2 0.002 0.0051 1
Onchocerca volvulus 0.002 0.0051 0.0317
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0051 0.0317
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0051 0.0317
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0048 0.0631
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0051 0.0317
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0483 1
Loa Loa (eye worm) carboxylesterase 0.0225 0.1604 0.1604
Mycobacterium ulcerans carboxylesterase, LipT 0.0225 0.1604 1
Schistosoma mansoni hypothetical protein 0.0039 0.0191 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0051 0.0317
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0483 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0048 0.9502
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0051 0.0051
Brugia malayi Carboxylesterase family protein 0.0225 0.1604 0.1604
Loa Loa (eye worm) fibroinase 0.002 0.0051 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0483 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0051 0.0051
Schistosoma mansoni acetylcholinesterase 0.0225 0.1604 0.1604
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0229 0.1634 0.1634
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0483 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0051 0.0051
Brugia malayi Cathepsin L-like precursor 0.002 0.0051 0.0051
Echinococcus granulosus carboxylesterase 5A 0.133 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0051 0.0051
Leishmania major cathepsin L-like protease 0.002 0.0051 0.0685
Brugia malayi Cytochrome P450 family protein 0.0016 0.0019 0.0019
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0094 0.1627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0051 0.0317
Echinococcus multilocularis GPCR, family 2 0.0018 0.0033 0.0014
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0048 0.0184
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0051 0.0317
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0048 0.5
Echinococcus granulosus neuroligin 0.0225 0.1604 0.1604
Echinococcus granulosus potassium voltage gated channel protein 0.0089 0.0577 0.0577
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0094 0.0094
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0051 0.0685
Schistosoma mansoni hypothetical protein 0.0018 0.0033 0.0033
Schistosoma mansoni gliotactin 0.0225 0.1604 0.1604
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0259 0.1614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0051 0.0317
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0048 0.0631
Brugia malayi Carboxylesterase family protein 0.0225 0.1604 0.1604
Brugia malayi Cytochrome P450 family protein 0.0026 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0225 0.1604 0.1604
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0051 0.0317
Onchocerca volvulus 0.002 0.0051 0.0317
Schistosoma mansoni voltage-gated potassium channel 0.0089 0.0577 0.0577
Echinococcus multilocularis neuropeptide s receptor 0.0529 0.392 0.3909
Schistosoma mansoni voltage-gated potassium channel 0.0089 0.0577 0.0577
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0051 0.0317
Schistosoma mansoni chromobox protein 0.0079 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0056 0.0326 0.0326
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0483 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0225 0.1604 0.1588
Schistosoma mansoni hypothetical protein 0.0018 0.0033 0.0033
Echinococcus granulosus chromobox protein 1 0.0079 0.0497 0.0497
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0094 0.0476
Onchocerca volvulus Huntingtin homolog 0.0139 0.0952 0.5934
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0233 0.1455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0051 0.0317
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0086 0.0547 0.0529
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0483 1
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0497 0.0497
Onchocerca volvulus 0.0225 0.1604 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 37.6505 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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