Detailed information for compound 1245448

Basic information

Technical information
  • TDR Targets ID: 1245448
  • Name: Maybridge4_000929
  • MW: 367.23 | Formula: C16H16Cl2N4O2
  • H donors: 1 H acceptors: 2 LogP: 3.67 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=NC(=O)c1c(C)onc1c1c(Cl)cccc1Cl)N1CCCC1
  • InChi: 1S/C16H16Cl2N4O2/c1-9-12(15(23)20-16(19)22-7-2-3-8-22)14(21-24-9)13-10(17)5-4-6-11(13)18/h4-6H,2-3,7-8H2,1H3,(H2,19,20,23)
  • InChiKey: NIYGHLFZKWUHJC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(2,6-dichlorophenyl)-N-[imino(1-pyrrolidinyl)methyl]-5-methyl-4-isoxazolecarboxamide
  • MLS000851320
  • SMR000457663
  • IDI1_031511

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0204 0.0606
Echinococcus granulosus cpg binding protein 0.0032 0.0892 0.2653
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.046 0.0364
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0011 0.01 0.0298
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0044 0.0044
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.01 0.0009
Trichomonas vaginalis hypothetical protein 0.0014 0.0204 0.0104
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0011 0.01 0.0298
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.01 0.01
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.01 0.0009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0204
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0204 0.0104
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0011 0.01 0.01
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.01 0.01
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0323 0.0224
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0131
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0011 0.01 0.0298
Echinococcus multilocularis chromobox protein 1 0.0084 0.281 0.8362
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Mycobacterium ulcerans lipase LipD 0.0037 0.1051 0.0966
Brugia malayi beta-lactamase family protein 0.0037 0.1051 0.1051
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0402 0.0373
Trichomonas vaginalis glutaminase, putative 0.0278 1 1
Brugia malayi Heterochromatin protein 1 0.0084 0.281 0.281
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.3361 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1441 0.1354
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0402 0.1197
Echinococcus granulosus chromobox protein 1 0.0084 0.281 0.8362
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.01 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1441 0.1354
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.2563 0.2563
Schistosoma mansoni glutaminase 0.0278 1 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.1051 0.1157
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0341 0.0243
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0113 0.3892 0.3892
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.01 0.0009
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.01 0.01
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0424 0.0425
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0011 0.01 0.0298
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Schistosoma mansoni hypothetical protein 0.0036 0.1022 0.1022
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0221 0.7871 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0204 0.0204
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0011 0.01 0.0298
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0221 0.7871 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Loa Loa (eye worm) glutaminase 0.0278 1 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.1051 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Mycobacterium ulcerans glutaminase 0.0278 1 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.281 0.8362
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.01 0.0298
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.1022 0.304
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.01 0.01
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0204 0.0104
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.1051 0.1157
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0204
Trichomonas vaginalis chromobox protein, putative 0.0084 0.281 0.2738
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0204 0.0104
Loa Loa (eye worm) hypothetical protein 0.0009 0.0024 0.0024
Schistosoma mansoni chromobox protein 0.0014 0.0204 0.0204
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.2098 0.2098
Leishmania major cAMP-specific phosphodiesterase, putative 0.0011 0.01 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1051 0.096
Loa Loa (eye worm) CYP4Cod1 0.002 0.0424 0.0424
Brugia malayi M-phase phosphoprotein, mpp8 0.0014 0.0204 0.0204
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1573 0.1488
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.3361 1
Onchocerca volvulus 0.0037 0.1063 0.6276
Schistosoma mansoni cytochrome P450 0.0011 0.0094 0.0094
Brugia malayi chromobox protein homolog 3 0.0047 0.1441 0.1441
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0268 0.0268
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0011 0.01 0.01
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.3361 0.3361
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0402 0.0397
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0204 0.0104
Mycobacterium ulcerans beta-lactamase 0.0037 0.1051 0.0966
Onchocerca volvulus 0.0037 0.1051 0.6185
Plasmodium vivax hypothetical protein, conserved 0.0037 0.1051 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.1051 0.3127
Brugia malayi Cytochrome P450 family protein 0.003 0.0813 0.0813
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Leishmania major cytochrome p450-like protein 0.002 0.0424 0.0425
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.01 0.0009
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.01 0.0009
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.8366 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.1051 0.1051
Loa Loa (eye worm) hypothetical protein 0.0037 0.1051 0.1051
Loa Loa (eye worm) hypothetical protein 0.0011 0.01 0.01
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0011 0.01 0.0009
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0011 0.01 0.0009
Schistosoma mansoni chromobox protein 0.0084 0.281 0.281
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0011 0.01 0.0009
Brugia malayi Cytochrome P450 family protein 0.002 0.0424 0.0424
Schistosoma mansoni hypothetical protein 0.0036 0.1022 0.1022
Echinococcus granulosus Chromobox protein 3 0.0014 0.0204 0.0606
Onchocerca volvulus 0.0014 0.0228 0.0181
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.1051 0.1157
Trichomonas vaginalis Heterochromatin protein, putative 0.0014 0.0204 0.0104
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.3361 0.3361
Brugia malayi Valyl-tRNA synthetase 0.0014 0.0204 0.0204
Schistosoma mansoni chromobox protein 0.0014 0.0204 0.0204
Leishmania major hypothetical protein, conserved 0.0221 0.7871 1
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.1051 0.0966
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.01 0.01
Schistosoma mansoni hypothetical protein 0.0036 0.1022 0.1022
Brugia malayi beta-lactamase 0.0037 0.1051 0.1051
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0402 0.0305
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0094 0.0278
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.1841 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Brugia malayi Cytochrome P450 family protein 0.002 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0204
Trichomonas vaginalis esterase, putative 0.0037 0.1051 0.096
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.046 0.0364
Schistosoma mansoni hypothetical protein 0.0077 0.2563 0.2563
Leishmania major hypothetical protein, conserved 0.0037 0.1051 0.1231
Loa Loa (eye worm) helicase 0.0014 0.0204 0.0204
Brugia malayi cytochrome P450 0.0011 0.0094 0.0094
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0424 0.0424
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0113 0.3892 0.3892
Schistosoma mansoni ap endonuclease 0.0019 0.0402 0.0402
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.01 0.0009
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.1051 0.1051
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Mycobacterium tuberculosis Conserved protein 0.0037 0.1051 0.1157
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.1051 0.1231
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.046 0.0364
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0204 0.1086
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0402 0.0397
Loa Loa (eye worm) PDE1B protein 0.0011 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0037 0.1063 0.1063
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.01 0.0298
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0011 0.01 0.0009
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0014 0.0204 0.3416
Loa Loa (eye worm) hypothetical protein 0.0011 0.01 0.01
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0402 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0204 0.0204
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0014 0.0228 0.0228
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.1051 0.1231
Mycobacterium ulcerans hypothetical protein 0.0037 0.1051 0.0966
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1051 0.096
Schistosoma mansoni chromobox protein 0.0084 0.281 0.281
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0402 0.0397
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0402 0.5
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0011 0.01 0.0009
Schistosoma mansoni hypothetical protein 0.0036 0.1022 0.1022
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0827 0.0827
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0204 0.0104
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.1051 0.1157
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0011 0.01 0.01
Loa Loa (eye worm) beta-lactamase 0.0037 0.1051 0.1051
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.0204 0.0606
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0204 0.0204
Echinococcus multilocularis chromobox protein 2 0.0014 0.0204 0.0606
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.01 0.0009
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.1051 0.1157
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0014 0.0204 0.0629
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.1051 0.1051
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0402 0.0402
Toxoplasma gondii exonuclease III APE 0.0019 0.0402 0.1767
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.3361 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0204
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.3361 0.3361
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0424 0.0424
Schistosoma mansoni hypothetical protein 0.0014 0.0204 0.0204
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.01 0.01
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.4195 0.4195
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.1051 0.1157
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0131
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.046 0.0364
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0011 0.01 0.0298
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.3361 0.3361
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.1051 0.1231
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Mycobacterium leprae conserved hypothetical protein 0.0037 0.1051 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0268 0.0268
Mycobacterium tuberculosis Conserved protein 0.0037 0.1051 0.1157
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0204
Echinococcus granulosus GPCR family 2 0.0036 0.1022 0.304
Toxoplasma gondii ABC1 family protein 0.0037 0.1051 0.5477
Brugia malayi Protein cec-1. 0.0014 0.0204 0.0204
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0011 0.01 0.0009
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0011 0.01 0.0298
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0011 0.01 0.0298
Onchocerca volvulus 0.0031 0.0827 0.4552
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0402 0.3178
Echinococcus multilocularis cpg binding protein 0.0032 0.0892 0.2653
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.01 0.0298
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0268 0.0798
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0014 0.0204 0.3416
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.01 0.0009
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.01 0.0298
Brugia malayi CXXC zinc finger family protein 0.0031 0.0827 0.0827
Plasmodium vivax heterochromatin protein 1, putative 0.0014 0.0204 0.1086
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.0204 0.0204
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.046 0.0364
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0011 0.01 0.0298
Loa Loa (eye worm) hypothetical protein 0.0037 0.1051 0.1051
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.1051 0.3127
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.01 0.01
Schistosoma mansoni cpg binding protein 0.0031 0.0827 0.0827
Schistosoma mansoni ap endonuclease 0.0019 0.0402 0.0402
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.01 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.1051 0.1051
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0204 0.0104
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.004 0.004
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.01 0.01
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.1573 1
Schistosoma mansoni cpg binding protein 0.0032 0.0892 0.0892
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1051 0.096
Schistosoma mansoni cpg binding protein 0.0032 0.0892 0.0892
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0011 0.01 0.01
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0014 0.0204 0.0629
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.3361 0.3361
Loa Loa (eye worm) hypothetical protein 0.0011 0.01 0.01
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0011 0.01 0.0298
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0402 1
Loa Loa (eye worm) glutaminase 2 0.0278 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.1441 0.1441
Loa Loa (eye worm) hypothetical protein 0.0037 0.1051 0.1051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.3361 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0011 0.01 0.01
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.01 0.01
Brugia malayi hypothetical protein 0.0014 0.0204 0.0204
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.1051 0.096
Schistosoma mansoni hypothetical protein 0.0011 0.0094 0.0094
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0402 0.1197
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0204 0.0104
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.01 0.01
Brugia malayi Cytochrome P450 family protein 0.0011 0.0094 0.0094
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0424 0.0333
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.046 0.0364
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.1441 0.9031
Echinococcus multilocularis Chromo domain 0.0014 0.0204 0.0606
Echinococcus granulosus Chromo domain 0.0014 0.0204 0.0606
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0402 0.0305
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0204 0.1086
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.1051 0.096
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.0204 0.0204
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0402 1
Echinococcus multilocularis 0.0011 0.0094 0.0278
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.1022 0.304
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.1022 0.304
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0011 0.01 0.01
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0402 0.0312
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0424 0.0425
Loa Loa (eye worm) hypothetical protein 0.0037 0.1051 0.1051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0204
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0204 0.0104
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.1051 0.0966
Echinococcus multilocularis GPCR, family 2 0.0036 0.1022 0.304
Trypanosoma brucei cytochrome P450, putative 0.002 0.0424 0.0425
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0402 0.0402
Brugia malayi SET domain containing protein 0.0014 0.0228 0.0228
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.1022 0.1022
Trichomonas vaginalis chromobox protein, putative 0.0084 0.281 0.2738
Echinococcus granulosus chromobox protein 2 0.0014 0.0204 0.0606
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0011 0.01 0.01
Brugia malayi CHD4 protein 0.0016 0.0268 0.0268
Onchocerca volvulus 0.0037 0.1051 0.6185
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.093 0.0839
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0204 0.0104
Loa Loa (eye worm) hypothetical protein 0.0037 0.1051 0.1051
Mycobacterium tuberculosis Conserved protein 0.0037 0.1051 0.1157
Onchocerca volvulus 0.0037 0.1051 0.6185
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0011 0.01 0.0298
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.0204 0.0606
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0204 0.0104
Brugia malayi MH2 domain containing protein 0.0121 0.4195 0.4195
Loa Loa (eye worm) hypothetical protein 0.0011 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0113 0.3892 0.3892
Brugia malayi beta-lactamase family protein 0.0037 0.1051 0.1051
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.281 0.281
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.1051 0.1051
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0011 0.01 0.0009
Echinococcus granulosus chromobox protein 1 0.0084 0.281 0.8362
Brugia malayi Latrophilin receptor protein 2 0.0036 0.1022 0.1022
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0014 0.0204 0.0629
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0204 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0204 0.0104
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.1051 0.1157
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0011 0.01 0.0298
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.01 0.0009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0011 0.01 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.1022 0.1022
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0204 0.0104
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0341 0.0243
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0402 0.5
Loa Loa (eye worm) cytochrome P450 0.0011 0.0094 0.0094
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0813 0.0813
Loa Loa (eye worm) hypothetical protein 0.0077 0.2563 0.2563
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.1022 0.1022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.046 0.0364
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.4195 0.4195
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.01 0.0038
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.01 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0402 0.0397
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.093 0.0839
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0204
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0268 0.0798
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1573 0.1488
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0204 0.0104
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.046 0.0364
Brugia malayi Calcitonin receptor-like protein seb-1 0.0113 0.3892 0.3892
Leishmania major hypothetical protein, conserved 0.0011 0.01 0.0009
Plasmodium falciparum heterochromatin protein 1 0.0014 0.0204 0.3416
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.1022 0.304
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0011 0.01 0.01

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3162 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 22.3342 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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