Detailed information for compound 1247672

Basic information

Technical information
  • TDR Targets ID: 1247672
  • Name: 3-(2-methoxyethyl)-6-methyl-2-(2-oxo-2-phenyl ethyl)sulfanyl-6,7-dihydrothieno[2,3-e]pyrimi din-4-one
  • MW: 376.493 | Formula: C18H20N2O3S2
  • H donors: 0 H acceptors: 2 LogP: 2.86 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1c(SCC(=O)c2ccccc2)nc2c(c1=O)SC(C2)C
  • InChi: 1S/C18H20N2O3S2/c1-12-10-14-16(25-12)17(22)20(8-9-23-2)18(19-14)24-11-15(21)13-6-4-3-5-7-13/h3-7,12H,8-11H2,1-2H3
  • InChiKey: XLYQFJASWDCIAH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(2-methoxyethyl)-6-methyl-2-(2-oxo-2-phenyl-ethyl)sulfanyl-6,7-dihydrothieno[2,3-e]pyrimidin-4-one
  • 3-(2-methoxyethyl)-6-methyl-2-[(2-oxo-2-phenylethyl)thio]-6,7-dihydrothieno[2,3-e]pyrimidin-4-one
  • 2-[(2-keto-2-phenyl-ethyl)thio]-3-(2-methoxyethyl)-6-methyl-6,7-dihydrothieno[2,3-e]pyrimidin-4-one
  • MLS000091063
  • MLS000101661
  • SMR000016253
  • EU-0091638

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glucose transport protein 0.0312 0.3428 1
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0019 0.0119 0.0462
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0012 0.0038 0.0044
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0019 0.0119 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0997 0.1161
Loa Loa (eye worm) hypothetical protein 0.0032 0.0266 0.031
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0396 0.0927
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0633 0.1496
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0019 0.0119 0.0263
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0633 0.0736
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0024 0.0017
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0768 0.8592 1
Brugia malayi DNA polymerase alpha catalytic subunit 0.0019 0.0119 0.0127
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0768 0.8592 1
Mycobacterium ulcerans integral membrane transport protein 0.0044 0.04 0.044
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0038 0.0058
Echinococcus granulosus lamin 0.0033 0.0273 0.0631
Echinococcus granulosus lamin dm0 0.0033 0.0273 0.0631
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0019 0.0119 0.018
Schistosoma mansoni coup transcription factor 0.0011 0.0024 0.0042
Brugia malayi Major Facilitator Superfamily protein 0.0044 0.04 0.0454
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0024 0.0028
Loa Loa (eye worm) calpain 0.002 0.0132 0.0154
Trichomonas vaginalis sugar transporter, putative 0.0097 0.0997 0.1161
Loa Loa (eye worm) hypothetical protein 0.0033 0.0273 0.0317
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0038 0.0044
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0071 0.0708 0.2044
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0044 0.04 0.1141
Trypanosoma brucei glucose transporter 1E 0.0097 0.0997 0.3807
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0119 0.0462
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0633 0.0956
Plasmodium falciparum mitogen-activated protein kinase 2 0.034 0.3748 0.3748
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0312 0.3428 0.399
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0448 0.1051
Trypanosoma cruzi hexose transporter 0.0097 0.0997 0.3861
Schistosoma mansoni glucose transport protein 0.0312 0.3428 1
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Onchocerca volvulus 0.0044 0.04 0.0454
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0024 0.0042
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0618 0.1779
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0038 0.0148
Echinococcus granulosus calpain 7 C02 family 0.002 0.0132 0.0293
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0024 0.0042
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0465
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0012 0.0038 0.0044
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0024 0.0042
Plasmodium falciparum protein kinase 7 0.0594 0.6625 0.6625
Entamoeba histolytica hypothetical protein 0.0043 0.0396 0.0461
Giardia lamblia Hexose transporter 0.0044 0.04 0.0465
Giardia lamblia Glycyl-tRNA synthetase 0.0012 0.0038 0.0044
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0618 0.0719
Onchocerca volvulus 0.0044 0.04 0.0454
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0092 0.0197
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0119 0.0462
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0074 0.0736 0.1111
Trypanosoma brucei antigen, putative 0.002 0.0132 0.0427
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0496 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.04 0.0465
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0465
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0024 0.0035
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0312 0.3428 0.8211
Loa Loa (eye worm) hypothetical protein 0.019 0.2048 0.2384
Loa Loa (eye worm) calpain 5 0.002 0.0132 0.0154
Schistosoma mansoni hypothetical protein 0.0017 0.0092 0.0239
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0019 0.0119 0.0139
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0024 0.0017
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0633 0.0597
Echinococcus granulosus synaptic vesicle 2 protein 0.0044 0.04 0.0937
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0132 0.0511
Trypanosoma cruzi hypothetical protein, conserved 0.0237 0.2582 1
Schistosoma mansoni hypothetical protein 0.0089 0.0907 0.2625
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0083 0.0843 0.2437
Loa Loa (eye worm) hypothetical protein 0.0063 0.0618 0.0719
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0448 0.1051
Trichomonas vaginalis DNA polymerase II, putative 0.0019 0.0119 0.0139
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0633 0.0633
Schistosoma mansoni sugar transporter 0.0044 0.04 0.1141
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0273 0.0317
Trypanosoma brucei glucose transporter, putative 0.0097 0.0997 0.3807
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0465
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0768 0.8592 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0273 0.0306
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0312 0.3428 0.8211
Leishmania major glucose transporter, lmgt2 0.0097 0.0997 0.3861
Trypanosoma brucei glucose transporter, putative 0.0097 0.0997 0.3807
Schistosoma mansoni sugar transporter 0.0044 0.04 0.1141
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0633 0.1822
Toxoplasma gondii sugar transporter ST1 0.0044 0.04 0.0603
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0044 0.04 0.04
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0633 0.0633
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0024 0.0035
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0465
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.0023 0.0088
Brugia malayi calpain family protein 1 0.0068 0.0669 0.0768
Loa Loa (eye worm) hypothetical protein 0.0048 0.0442 0.0514
Leishmania major glucose transporter, lmgt3 0.0097 0.0997 0.3861
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0496 0.0567
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0435 0.0435
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0024 0.0017
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0435 0.1686
Echinococcus granulosus solute carrier family 22 0.0044 0.04 0.0937
Onchocerca volvulus 0.0044 0.04 0.0454
Onchocerca volvulus 0.0044 0.04 0.0454
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0028
Onchocerca volvulus 0.0011 0.0024 0.0017
Loa Loa (eye worm) hypothetical protein 0.0064 0.0633 0.0736
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0768 0.8592 1
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0038 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0023 0.0088
Brugia malayi calpain 7 0.002 0.0132 0.0142
Toxoplasma gondii DNA polymerase 0.0019 0.0119 0.018
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0132 0.0511
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0465
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0024 0.0035
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0092 0.0095
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0768 0.8592 1
Leishmania major glucose transporter, lmgt1 0.0097 0.0997 0.3861
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0019 0.0119 0.0263
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Schistosoma mansoni sugar transporter 0.0044 0.04 0.1141
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0024 0.0035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0496 0.0578
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0024 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0448 0.1281
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0011 0.0024 0.0024
Brugia malayi calpain 5 0.002 0.0132 0.0142
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0156 1
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0019 0.0119 0.0139
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0024 0.0042
Onchocerca volvulus 0.0048 0.0442 0.0503
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0019 0.0119 0.0263
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0024 0.0017
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0618 0.1461
Trichomonas vaginalis glucose transporter, putative 0.0097 0.0997 0.1161
Trypanosoma brucei glucose transporter, putative 0.0097 0.0997 0.3807
Trichomonas vaginalis sugar transport protein, putative 0.0044 0.04 0.0465
Trichomonas vaginalis glucose transporter, putative 0.0044 0.04 0.0465
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0633 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0023 0.0026
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0312 0.3428 0.8211
Giardia lamblia Threonyl-tRNA synthetase 0.0012 0.0038 0.0044
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0618 0.0719
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0132 0.0511
Echinococcus multilocularis solute carrier family 22 0.0044 0.04 0.0937
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0132 0.0511
Trypanosoma cruzi sugar transporter, putative 0.0044 0.04 0.1548
Trypanosoma brucei calpain-like protein, putative 0.002 0.0132 0.0427
Plasmodium vivax CDK-related protein kinase 6, putative 0.0893 1 1
Brugia malayi nuclear hormone receptor 0.0011 0.0024 0.0017
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0038 0.0061
Trypanosoma brucei THT1 - hexose transporter, putative 0.0097 0.0997 0.3807
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0019 0.0119 0.0127
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0435 0.6932
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0237 0.2582 0.3006
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0156 0.2978
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0024 0.0017
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0768 0.8592 1
Onchocerca volvulus 0.0044 0.04 0.0454
Onchocerca volvulus Putative transporter 0.0044 0.04 0.0454
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0024 0.0017
Plasmodium vivax hexose transporter 0.0312 0.3428 0.3403
Brugia malayi hypothetical protein 0.0044 0.04 0.0454
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0024 0.0042
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0019 0.0119 0.0139
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0633 0.0633
Echinococcus granulosus solute carrier family 22 0.0044 0.04 0.0937
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0024 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.04 0.0465
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0038 0.0148
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0435 0.1245
Echinococcus granulosus General substrate transporter 0.0268 0.2932 0.7021
Trypanosoma cruzi hexose transporter, putative 0.0097 0.0997 0.3861
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0618 0.1461
Trypanosoma cruzi glucose transporter, putative 0.0044 0.04 0.1548
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0997 0.1161
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0465
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0448 0.1051
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0197 0.023
Loa Loa (eye worm) hypothetical protein 0.0017 0.0092 0.0107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0633 0.1496
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0435 0.1245
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0024 0.0035
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0633 0.1496
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0028
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0312 0.3428 0.8211
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0044 0.04 0.044
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0044 0.04 1
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0435 0.0496
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0465
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0038 0.0044
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0312 0.3428 0.8211
Loa Loa (eye worm) hypothetical protein 0.0068 0.0669 0.0779
Trypanosoma cruzi kinesin, putative 0.002 0.0132 0.0511
Entamoeba histolytica protein kinase, putative 0.0064 0.0633 0.0736
Brugia malayi hypothetical protein 0.0043 0.0396 0.045
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0019 0.0119 0.0127
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0736 0.2851
Brugia malayi Cache domain containing protein 0.0076 0.0764 0.0878
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0768 0.8592 1
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0531 0.5914 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0097 0.0997 0.3861
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0024 0.0042
Loa Loa (eye worm) calpain family protein 1 0.0048 0.0442 0.0514
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0019 0.0119 0.0378
Schistosoma mansoni intermediate filament proteins 0.0033 0.0273 0.0769
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0435 1
Echinococcus multilocularis solute carrier family 22 0.0044 0.04 0.0937
Loa Loa (eye worm) sugar transporter 0.0044 0.04 0.0465
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0768 0.8592 1
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0019 0.0119 0.0127
Leishmania major myo-inositol/proton symporter (MIT) 0.0044 0.04 0.1548
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0024 0.0042
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Brugia malayi N-terminal motif family protein 0.019 0.2048 0.2375
Plasmodium vivax calpain, putative 0.002 0.0132 0.0094
Onchocerca volvulus 0.0768 0.8592 1
Trypanosoma cruzi hexose transporter, putative 0.0097 0.0997 0.3861
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0038 0.0018
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0019 0.0119 0.0378
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0028
Loa Loa (eye worm) calpain family protein 1 0.0068 0.0669 0.0779
Schistosoma mansoni protein kinase 0.0064 0.0633 0.1822
Schistosoma mansoni hypothetical protein 0.0036 0.0309 0.0875
Trypanosoma cruzi kinesin, putative 0.002 0.0132 0.0511
Echinococcus granulosus solute carrier family 22 0.0044 0.04 0.0937
Trypanosoma cruzi hexose transporter, putative 0.0044 0.04 0.1548
Onchocerca volvulus 0.0044 0.04 0.0454
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0038 0.0033
Echinococcus granulosus voltage dependent calcium channel subunit 0.0377 0.4172 1
Brugia malayi Cam kinase protein 1 0.0064 0.0633 0.0726
Leishmania major hypothetical protein, conserved 0.0237 0.2582 1
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0019 0.0119 0.0139
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0024 0.0042
Toxoplasma gondii protein kinase, putative 0.0594 0.6625 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0024 0.0035
Echinococcus granulosus calpain 0.002 0.0132 0.0293
Echinococcus multilocularis hypothetical protein 0.002 0.0132 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.04 0.0465
Onchocerca volvulus 0.0044 0.04 0.0454
Echinococcus multilocularis calpain 5 0.002 0.0132 0.0293
Echinococcus multilocularis lamin 0.0033 0.0273 0.0631
Loa Loa (eye worm) hypothetical protein 0.0036 0.0309 0.036
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0024 0.0017
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0028
Brugia malayi nuclear receptor NHR-88 0.0011 0.0024 0.0017
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0024 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0024 0.0017
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0024 0.0042
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0044 0.04 0.044
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0024 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0465
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0132 0.0511
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0132 0.0293
Trypanosoma brucei glucose transporter, putative 0.0097 0.0997 0.3807
Trypanosoma brucei kinesin, putative 0.002 0.0132 0.0427
Toxoplasma gondii hypothetical protein 0.0009 0.001 0.0015
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0024 0.0017
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.001 0.0012
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0633 0.0726
Plasmodium vivax proline--tRNA ligase, putative 0.0074 0.0736 0.0701
Leishmania major protein kinase, putative 0.0064 0.0633 0.245
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0736 0.2788
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0019 0.0119 0.0263
Toxoplasma gondii facilitative glucose transporter GT1 0.0312 0.3428 0.5174
Trypanosoma cruzi hypothetical protein, conserved 0.0237 0.2582 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0024 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0396 0.1129
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0038 0.0083
Echinococcus granulosus Sugar transporter ERD6 protein 0.0044 0.04 0.0937
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0038 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0024 0.0017
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0019 0.0119 0.0139
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0618 0.0709
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0465
Echinococcus multilocularis calpain 0.002 0.0132 0.0293
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0024 0.0042
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0019 0.0119 0.032
Echinococcus multilocularis musashi 0.0033 0.0273 0.0631
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0355 0.0565
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0633 0.1496
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0012
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0768 0.8592 1
Brugia malayi steroid hormone receptor 0.0011 0.0024 0.0017
Brugia malayi Major Facilitator Superfamily protein 0.0044 0.04 0.0454
Onchocerca volvulus 0.0044 0.04 0.0454
Trypanosoma brucei calpain-like protein, putative 0.002 0.0132 0.0427
Echinococcus multilocularis lamin dm0 0.0033 0.0273 0.0631
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0024 0.0035
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0019 0.0119 0.0139
Loa Loa (eye worm) hypothetical protein 0.0047 0.0435 0.0507
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0588 0.1388
Brugia malayi intermediate filament protein 0.0033 0.0273 0.0306
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Brugia malayi Sugar transporter family protein 0.0044 0.04 0.0454
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0132 0.0357
Onchocerca volvulus 0.0033 0.0273 0.0306
Plasmodium falciparum hexose transporter 0.0312 0.3428 0.3428
Brugia malayi hypothetical protein 0.0044 0.04 0.0454
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0024 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0377 0.4172 1
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.0023 0.0088
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0011 0.0024 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0024 0.0028
Loa Loa (eye worm) major facilitator superfamily transporter 0.0044 0.04 0.0465
Brugia malayi calpain family protein 1 0.0068 0.0669 0.0768
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0465
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0092 0.0197
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0633 0.0736
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Loa Loa (eye worm) major facilitator superfamily transporter 0.0044 0.04 0.0465
Brugia malayi Sugar transporter family protein 0.0312 0.3428 0.3983
Trypanosoma brucei glucose transporter 2A 0.0097 0.0997 0.3807
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0119 0.0462
Schistosoma mansoni protein kinase 0.0064 0.0633 0.1822
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0024 0.0017
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0019 0.0119 0.0263
Trypanosoma brucei THT1 - hexose transporter, putative 0.0097 0.0997 0.3807
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Trypanosoma cruzi hexose transporter, putative 0.0053 0.0502 0.1943
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0038 0.0044
Trypanosoma brucei THT1 - hexose transporter, putative 0.0097 0.0997 0.3807
Entamoeba histolytica protein kinase, putative 0.0024 0.0178 0.0207
Mycobacterium ulcerans sugar transporter 0.0044 0.04 0.044
Onchocerca volvulus 0.0044 0.04 0.0454
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.001 0.0023 0.0034
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0618 0.0709
Plasmodium vivax DNA polymerase alpha, putative 0.0019 0.0119 0.0081
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0237 0.2582 1
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0019 0.0119 0.0462
Plasmodium vivax sugar transporter, putative 0.0044 0.04 0.0363
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0618 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0024 0.0035
Loa Loa (eye worm) hypothetical protein 0.0063 0.0618 0.0719
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Trypanosoma brucei glucose transporter, putative 0.0097 0.0997 0.3807
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0019 0.0119 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0132 0.0427
Trypanosoma brucei calpain-like protein, putative 0.002 0.0132 0.0427
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0132 0.0357
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0088
Schistosoma mansoni serine-rich repeat protein 0.0089 0.0907 0.2625
Brugia malayi hypothetical protein 0.0044 0.04 0.0454
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Brugia malayi major facilitator superfamily protein 0.0044 0.04 0.0454
Leishmania major hypothetical protein, conserved 0.0044 0.04 0.1548
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0028
Brugia malayi major facilitator superfamily protein 0.0044 0.04 0.0454
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0102 0.0118
Echinococcus granulosus voltage dependent calcium channel subunit 0.0172 0.1846 0.441
Trypanosoma cruzi hexose transporter, putative 0.0097 0.0997 0.3861
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0465
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0633 0.1496
Leishmania major kinesin, putative 0.002 0.0132 0.0511
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0172 0.1846 0.441
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0312 0.3428 0.8211
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0633 0.1496
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0071 0.0708 0.2044
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0024 0.0017
Schistosoma mansoni hypothetical protein 0.0312 0.3428 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0633 0.0633
Onchocerca volvulus 0.0044 0.04 0.0454
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0019 0.0119 0.0139
Schistosoma mansoni hypothetical protein 0.0043 0.0396 0.1129
Giardia lamblia Sugar-proton symporter 0.0044 0.04 0.0465
Trypanosoma brucei sugar transporter, putative 0.0044 0.04 0.1473
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0119 0.0378
Loa Loa (eye worm) hypothetical protein 0.0051 0.0484 0.0564
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0092 0.0107
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0435 0.1612
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0023 0.0026
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0019 0.0119 0.0462
Echinococcus granulosus intermediate filament protein 0.0033 0.0273 0.0631
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0019 0.0119 0.0081
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0082 0.0174
Schistosoma mansoni Mername-AA248 (C02 family) 0.002 0.0132 0.0357
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0038 0.0068
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0132 0.0511
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0024 0.0035
Schistosoma mansoni sugar transporter 0.0044 0.04 0.1141
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0396 0.0927
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0019 0.0119 0.0378
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0024 0.0017
Brugia malayi Sugar transporter family protein 0.0044 0.04 0.0454
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0019 0.0119 0.0263
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0312 0.3428 0.8211
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0092 0.0095
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0448 0.1051
Echinococcus multilocularis calpain family protein 1, d 0.0048 0.0442 0.1037
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0435 0.0482
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0011 0.0024 0.0028
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0355 0.5587
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0024 0.0035
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0435 0.0482
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0028
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0309 0.0349
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0633 0.0597
Echinococcus granulosus calpain 5 0.002 0.0132 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.04 0.0465
Echinococcus granulosus calpain A 0.0071 0.0708 0.1678
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0465
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0019 0.0119 0.0462
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0633 0.1496
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0139
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.037 0.0431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0448 0.1281
Leishmania major hypothetical protein, conserved 0.001 0.0023 0.0088
Onchocerca volvulus 0.0044 0.04 0.0454
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0028
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0019 0.0119 0.0081
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0588 0.1388
Loa Loa (eye worm) sugar transporter 0.0312 0.3428 0.399
Schistosoma mansoni calpain C (C02 family) 0.002 0.0132 0.0357
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0044 0.04 0.064
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.002 0.0132 0.0427
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0132 0.0511
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0273 0.0317
Brugia malayi DNA polymerase delta catalytic subunit 0.0019 0.0119 0.0127
Echinococcus multilocularis calpain A 0.0071 0.0708 0.1678
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0068 0.0669 0.193
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0633 0.0597
Echinococcus multilocularis solute carrier family 22 0.0044 0.04 0.0937
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0024 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Echinococcus multilocularis solute carrier family 22 0.0044 0.04 0.0937
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0038 0.0068
Schistosoma mansoni protein kinase 0.0064 0.0633 0.1822
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0012
Onchocerca volvulus 0.0044 0.04 0.0454
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0237 0.2582 0.3006
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0023 0.0088
Loa Loa (eye worm) hypothetical protein 0.0052 0.0496 0.0578
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0044 0.04 0.0937
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0633 0.1496
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0024 0.0035
Entamoeba histolytica calpain large subunit domain III containing protein 0.002 0.0132 0.0154
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0633 0.0956
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0435 0.1022
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0132 0.0511
Echinococcus granulosus solute carrier family 22 0.0044 0.04 0.0937
Leishmania major hypothetical protein, conserved 0.001 0.0023 0.0088
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0024 0.0017
Echinococcus multilocularis General substrate transporter 0.0268 0.2932 0.7021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.0076 0.0764 0.0889
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0355 0.0565
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0019 0.0119 0.0081
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Entamoeba histolytica protein kinase, putative 0.0064 0.0633 0.0736
Schistosoma mansoni glucose transporter 0.0044 0.04 0.1141
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0038 0.0033
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.001 0.0012
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0024 0.0042
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0038 0.0018
Schistosoma mansoni lamin 0.0033 0.0273 0.0769
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0044 0.04 0.064
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0435 0.1022
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Loa Loa (eye worm) hypothetical protein 0.0068 0.0669 0.0779
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0618 0.1779
Schistosoma mansoni hypothetical protein 0.0017 0.0092 0.0239
Trichomonas vaginalis sugar transporter, putative 0.0097 0.0997 0.1161
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Trichomonas vaginalis myo-inositol transporter, putative 0.0044 0.04 0.0465
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0465
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Entamoeba histolytica hypothetical protein 0.0043 0.0396 0.0461
Plasmodium falciparum proline--tRNA ligase 0.0074 0.0736 0.0736
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0156 0.0156
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.034 0.3748 0.5658
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0102 0.0107
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0448 0.051
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0435 0.0507
Toxoplasma gondii DNA polymerase family B protein 0.0019 0.0119 0.018
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0024 0.0035
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0028
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0448 0.0521
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0019 0.0119 0.0263
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0012
Schistosoma mansoni hypothetical protein 0.0017 0.0092 0.0239
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0088
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0038 0.0058
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0435 0.1686
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0435 0.0657
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0023 0.0026
Brugia malayi Major Facilitator Superfamily protein 0.0044 0.04 0.0454
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0019 0.0119 0.032
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.034 0.3748 0.3724
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0038 0.0068
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0132 0.0511
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0132 0.0511
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0019 0.0119 0.0119
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0071 0.0708 0.1678
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0435 0.0507
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0038 0.0026
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0019 0.0119 0.0263
Onchocerca volvulus 0.0044 0.04 0.0454
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0024 0.0028
Schistosoma mansoni calpain (C02 family) 0.002 0.0132 0.0357
Echinococcus granulosus calpain A 0.002 0.0132 0.0293
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0736 0.2851
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0465
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0024 0.0028
Brugia malayi DNA polymerase family B containing protein 0.0019 0.0119 0.0127
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0768 0.8592 1
Schistosoma mansoni lamin 0.0033 0.0273 0.0769
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0028
Toxoplasma gondii transporter, major facilitator family protein 0.0044 0.04 0.0603
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Loa Loa (eye worm) hypothetical protein 0.0048 0.0442 0.0514
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0024 0.0017
Trypanosoma brucei glucose transporter, putative 0.0097 0.0997 0.3807
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0044
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0435 0.0399
Echinococcus multilocularis synaptic vesicle 2 protein 0.0044 0.04 0.0937
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0019 0.0119 0.032
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0024 0.0035
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0633 0.2384
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0024 0.0017
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0038 0.0148
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0448 0.1281
Trypanosoma brucei glucose transporter, putative 0.0097 0.0997 0.3807
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0132 0.0511
Trichomonas vaginalis glucose transporter, putative 0.0097 0.0997 0.1161
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0165 0.1766 0.5139
Entamoeba histolytica hypothetical protein 0.0047 0.0435 0.0507
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0633 0.0633
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0068 0.0672 0.0636
Toxoplasma gondii sugar transporter ST3 0.0044 0.04 0.0603
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0038 0.0262
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0633 0.0736
Onchocerca volvulus 0.0044 0.04 0.0454
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0044 0.04 0.1473
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.04 0.0465
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0312 0.3428 0.8211
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.019 0.2048 0.2375
Trichomonas vaginalis sugar transporter, putative 0.0097 0.0997 0.1161
Trichomonas vaginalis sugar transporter, putative 0.0044 0.04 0.0465
Onchocerca volvulus 0.0044 0.04 0.0454
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0768 0.8592 1
Schistosoma mansoni glucose transport protein 0.0312 0.3428 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0082 0.0096
Plasmodium falciparum threonine--tRNA ligase 0.0012 0.0038 0.0038
Brugia malayi ecdysteroid receptor 0.0011 0.0024 0.0017
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0092 0.0197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0024 0.0028
Onchocerca volvulus DNA polymerase homolog 0.0019 0.0119 0.0127
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0736 0.2851
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0024 0.0035
Trypanosoma brucei calpain-like protein, putative 0.002 0.0132 0.0427
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0736 0.2851
Onchocerca volvulus 0.0044 0.04 0.0454
Onchocerca volvulus 0.0033 0.0273 0.0306
Toxoplasma gondii sugar transporter ST2 0.0044 0.04 0.0603
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0071 0.0708 0.1678
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0465
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0092 0.0197
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0132 0.0511
Schistosoma mansoni hypothetical protein 0.0017 0.0092 0.0239
Echinococcus multilocularis GPCR, family 2 0.0017 0.0092 0.0197
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0132 0.0511
Echinococcus granulosus GPCR family 2 0.0017 0.0092 0.0197
Entamoeba histolytica hypothetical protein 0.0043 0.0396 0.0461
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0024 0.0035
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0038 0.0068
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0618 0.0719
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0768 0.8592 1
Entamoeba histolytica hypothetical protein 0.0043 0.0396 0.0461
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0019 0.0119 0.0127
Trypanosoma brucei glucose transporter, putative 0.0097 0.0997 0.3807

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.1735 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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