TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 332.359 | Formula: C18H16N6O
H donors: 3 H acceptors: 3 LogP: 0.99 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Nc1nccc(n1)c1[nH]c(c(c1)C(=O)N)c1cc2c(n1C)cccc2
InChi: 1S/C18H16N6O/c1-24-14-5-3-2-4-10(14)8-15(24)16-11(17(19)25)9-13(22-16)12-6-7-21-18(20)23-12/h2-9,22H,1H3,(H2,19,25)(H2,20,21,23)
InChiKey: IYFKRIWGRGFLBL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cell division cycle 7	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_129189	All targets in OG5_129189
Echinococcus multilocularis	CDC7 cell division cycle 7	Get druggable targets OG5_129189	All targets in OG5_129189
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_129189	All targets in OG5_129189
Loa Loa (eye worm)	CDC7 protein kinase	Get druggable targets OG5_129189	All targets in OG5_129189
Giardia lamblia	Kinase, CDC7	Get druggable targets OG5_129189	All targets in OG5_129189
Echinococcus granulosus	CDC7 cell division cycle 7	Get druggable targets OG5_129189	All targets in OG5_129189
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129189	All targets in OG5_129189
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_129189	All targets in OG5_129189
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_129189	All targets in OG5_129189
Schistosoma japonicum	ko:K02214 cell division control protein CDC7, putative	Get druggable targets OG5_129189	All targets in OG5_129189
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129189	All targets in OG5_129189
Onchocerca volvulus		Get druggable targets OG5_129189	All targets in OG5_129189
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_129189	All targets in OG5_129189
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_129189	All targets in OG5_129189

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0048	0.1637	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0675	0.077
Brugia malayi	MH2 domain containing protein	0.0009	0.0156	0.0178
Echinococcus granulosus	Glycosyl transferase family 8	0.0082	0.2891	0.4919
Loa Loa (eye worm)	glycosyl transferase family 8 protein	0.0082	0.2891	0.3298
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.0675	0.1085
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0011	0.0216	0.0247
Loa Loa (eye worm)	nuclear hormone receptor	0.0011	0.0216	0.0247
Loa Loa (eye worm)	MH2 domain-containing protein	0.0136	0.4932	0.5626
Echinococcus multilocularis	smad	0.0009	0.0156	0.0221
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0027	0.0811	0.5
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0048	0.1637	0.1586
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0216	0.0335
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.0675	0.077
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.0675	0.1117
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0265	0.0303
Echinococcus granulosus	glycosyltransferase protein LARGE2	0.0079	0.2793	0.4751
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0484	0.079
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0011	0.0216	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0265	0.0303
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.0675	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0675	0.077
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.0675	0.1097
Schistosoma mansoni	nuclear receptor	0.0011	0.0216	0.0335
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0216	0.0247
Loa Loa (eye worm)	Smad1	0.0009	0.0156	0.0178
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0156	0.0178
Brugia malayi	Bromodomain containing protein	0.0006	0.0023	0.0026
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.0675	0.077
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0265	0.0303
Brugia malayi	steroid hormone receptor	0.0023	0.0675	0.077
Entamoeba histolytica	hypothetical protein	0.0041	0.1351	0.8027
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0027	0.0811	0.5
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0201	0.0229
Brugia malayi	hypothetical protein	0.0041	0.1351	0.1542
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0603	0.0687
Onchocerca volvulus		0.003	0.0927	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0675	0.077
Schistosoma mansoni	cpg binding protein	0.0031	0.0991	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0675	0.077
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0011	0.0216	0.0331
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.1113	0.1869
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0012	0.0265	0.0415
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.1947	0.2221
Brugia malayi	orphan nuclear receptor NR2E1	0.0011	0.0216	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0216	0.0247
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0675	0.077
Onchocerca volvulus		0.0035	0.1113	0.0916
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1113	0.127
Echinococcus granulosus	thyroid hormone receptor alpha	0.0011	0.0216	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0216	0.0247
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.0675	0.077
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.0675	0.077
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0156	0.0221
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.0675	0.077
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0675	0.077
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0023	0.0026
Brugia malayi	PHD-finger family protein	0.0006	0.0023	0.0026
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0484	0.0552
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0675	0.1097
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.0675	0.077
Brugia malayi	Nuclear hormone receptor E75	0.0011	0.0216	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0039	0.127	0.1449
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0048	0.1637	0.2767
Echinococcus multilocularis	glycosyltransferase protein LARGE2	0.0079	0.2793	0.4613
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.1113	0.1826
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0216	0.0247
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0132	0.0182
Brugia malayi	hypothetical protein	0.0011	0.0216	0.0247
Schistosoma mansoni	Smad4	0.0009	0.0156	0.0235
Echinococcus multilocularis	Glycosyl transferase, family 8	0.0082	0.2891	0.4776
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0201	0.0304
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0675	0.077
Trichomonas vaginalis	set domain proteins, putative	0.027	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.0675	0.1117
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.1113	0.1826
Brugia malayi	hypothetical protein	0.0012	0.0265	0.0303
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.0675	0.1097
Onchocerca volvulus	Bile acid receptor homolog	0.0023	0.0675	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0675	0.077
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0216	0.0247
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0675	0.077
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0156	0.0235
Brugia malayi	nuclear receptor RXR	0.0012	0.0265	0.0303
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0048	0.1637	0.6266
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0216	0.0247
Onchocerca volvulus		0.0023	0.0675	0.0469
Schistosoma mansoni	cpg binding protein	0.0031	0.0991	0.1623
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0216	0.0321
Brugia malayi	nuclear hormone receptor family member odr-7	0.0011	0.0216	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0216	0.0247
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0484	0.0767
Plasmodium vivax	SET domain protein, putative	0.0035	0.1113	0.6738
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.1351	0.2278
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0675	0.077
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0216	0.0335
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0484	0.0767
Echinococcus granulosus	CDC7 cell division cycle 7	0.0069	0.2402	0.4079
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0048	0.1637	0.6266
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.0675	0.1117
Echinococcus granulosus	smad	0.0009	0.0156	0.0228
Schistosoma mansoni	coup transcription factor	0.0023	0.0675	0.1097
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0484	0.0767
Loa Loa (eye worm)	DR-78	0.0011	0.0216	0.0247
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.1113	0.1826
Brugia malayi	nuclear receptor NHR-67	0.0011	0.0216	0.0247
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.0675	0.1117
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.0675	0.1085
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0675	0.077
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0012	0.0265	0.0403
Brugia malayi	hypothetical protein	0.0011	0.0216	0.0247
Schistosoma mansoni	hypothetical protein	0.0018	0.0484	0.078
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0484	0.079
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.1351	0.2222
Schistosoma mansoni	bromodomain containing protein	0.0006	0.0023	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0216	0.0247
Mycobacterium leprae	conserved hypothetical protein	0.0027	0.0811	0.5
Onchocerca volvulus		0.0095	0.3376	0.323
Echinococcus multilocularis	glycosyltransferase protein LARGE2	0.0079	0.2793	0.4613
Brugia malayi	nuclear hormone receptor	0.0023	0.0675	0.077
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.0675	0.077
Trichomonas vaginalis	CMGC family protein kinase	0.0069	0.2402	0.2355
Entamoeba histolytica	hypothetical protein	0.0041	0.1351	0.8027
Echinococcus granulosus	Smad4	0.0009	0.0156	0.0228
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0484	0.0552
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0012	0.0265	0.0417
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0095	0.3376	0.3851
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.0675	0.077
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0156	0.0235
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.0675	0.1097
Echinococcus multilocularis	conserved hypothetical protein	0.0061	0.2096	0.3451
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0265	0.0303
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.0675	0.077
Echinococcus granulosus	L aminoadipate semialdehyde	0.0095	0.3376	0.575
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0484	0.0552
Brugia malayi	MH2 domain containing protein	0.0136	0.4932	0.5626
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.0675	0.077
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0132	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0216	0.0247
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.0675	0.077
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.0675	0.077
Schistosoma mansoni	hypothetical protein	0.0018	0.0484	0.078
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0675	0.1097
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.0675	0.1085
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0675	0.1117
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.223	0.3684
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.0675	0.1117
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0156	0.0228
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.1041	0.1746
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0675	0.1097
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0027	0.0811	0.4856
Brugia malayi	conserved hypotetical protein	0.0011	0.0216	0.0247
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0675	0.1085
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0132	0.0187
Giardia lamblia	Kinase, CDC7	0.0069	0.2402	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0216	0.0247
Echinococcus multilocularis	Smad4	0.0009	0.0156	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0265	0.0303
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0265	0.0417
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0011	0.0216	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0675	0.077
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0484	0.0552
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.0675	0.077
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0011	0.0216	0.0321
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0156	0.0228
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0156	0.0221
Schistosoma mansoni	bromodomain containing protein	0.0006	0.0023	0.0014
Brugia malayi	tailless protein	0.0011	0.0216	0.0247
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0156	0.0235
Echinococcus granulosus	histone acetyltransferase KAT2B	0.016	0.5854	1
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0196	0.0224
Brugia malayi	Pre-SET motif family protein	0.0237	0.8766	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0165	0.6029	1
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0156	0.0235
Entamoeba histolytica	hypothetical protein	0.0041	0.1351	0.8027
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0095	0.3376	0.5589
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.0675	0.077
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.0675	0.1097
Echinococcus granulosus	nuclear receptor nhr 48	0.0011	0.0216	0.0331
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.0675	0.077
Loa Loa (eye worm)	transcription factor SMAD2	0.0136	0.4932	0.5626
Brugia malayi	ecdysone receptor	0.0011	0.0216	0.0247
Brugia malayi	Nuclear hormone receptor E75	0.0011	0.0216	0.0247
Loa Loa (eye worm)	acetyltransferase	0.0165	0.6029	0.6878
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.1947	0.2221
Onchocerca volvulus		0.0069	0.2402	0.2234
Brugia malayi	CXXC zinc finger family protein	0.003	0.0927	0.1058
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0237	0.8766	1
Echinococcus multilocularis	glycosyltransferase protein LARGE2	0.0079	0.2793	0.4613
Loa Loa (eye worm)	CDC7 protein kinase	0.0069	0.2402	0.274
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1947	0.2221
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.0675	0.1097
Trichomonas vaginalis	CMGC family protein kinase	0.0069	0.2402	0.2355
Echinococcus granulosus	GPCR family 2	0.0018	0.0484	0.079
Trichomonas vaginalis	CMGC family protein kinase	0.0069	0.2402	0.2355
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0216	0.0331
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0027	0.0811	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0265	0.0303
Brugia malayi	nuclear hormone receptor	0.0011	0.0216	0.0247
Schistosoma mansoni	nuclear receptor nhr-48	0.0011	0.0216	0.0335
Onchocerca volvulus		0.0069	0.2402	0.2234
Brugia malayi	Smad1	0.0009	0.0156	0.0178
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.0675	0.1117
Schistosoma mansoni	smad	0.0009	0.0156	0.0235
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0011	0.0216	0.0247
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.0675	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0023	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0216	0.0247
Brugia malayi	acetyltransferase, GNAT family protein	0.0165	0.6029	0.6878
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.127	0.1449
Entamoeba histolytica	hypothetical protein	0.0041	0.1351	0.8027
Schistosoma mansoni	hypothetical protein	0.0041	0.1351	0.2222
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0675	0.077
Brugia malayi	AT16019p	0.0021	0.0603	0.0687
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.1947	0.2221
Brugia malayi	MH1 domain containing protein	0.0009	0.0156	0.0178
Schistosoma mansoni	glycosyltransferase-related	0.0082	0.2891	0.4783
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0675	0.1097
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0011	0.0216	0.0335
Schistosoma mansoni	hypothetical protein	0.0039	0.127	0.2087
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0062	0.2129	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.1113	0.1814
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.0675	0.1097
Brugia malayi	Glycosyl transferase family 8 protein	0.0082	0.2891	0.3298
Echinococcus multilocularis	Glycosyltransferase protein LARGE1	0.0061	0.2096	0.3451
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0011	0.0216	0.0321
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0156	0.0178
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.1351	0.2211
Schistosoma mansoni	zinc finger protein	0.0006	0.0023	0.0014
Brugia malayi	MH1 domain containing protein	0.0009	0.0156	0.0178
Echinococcus granulosus	Glycosyltransferase protein LARGE1	0.0061	0.2096	0.3554
Echinococcus multilocularis	cpg binding protein	0.0031	0.0991	0.1611
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0675	0.1117
Leishmania major	phosphopantetheinyl transferase-like protein	0.0027	0.0811	0.5
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0023	0.0675	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0216	0.0247
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0048	0.1637	0.1586
Schistosoma mansoni	hypothetical protein	0.0018	0.0484	0.078
Echinococcus multilocularis	nuclear receptor nhr 48	0.0011	0.0216	0.0321
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0095	0.3376	0.5583
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0216	0.0247
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0011	0.0216	0.0321
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0165	0.6029	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.0044	0.1484	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.1113	0.1826
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0011	0.0216	0.0247
Echinococcus multilocularis	CDC7 cell division cycle 7	0.0069	0.2402	0.396
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0011	0.0216	0.0331
Brugia malayi	MH2 domain containing protein	0.0009	0.0156	0.0178
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0675	0.077
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.0675	0.1085
Onchocerca volvulus	Protein ultraspiracle homolog	0.0023	0.0675	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0265	0.0303
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0132	0.0187
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.0675	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3376	0.3851
Brugia malayi	Protein kinase domain containing protein	0.0069	0.2402	0.274
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0027	0.0811	0.5
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0201	0.0295
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0012	0.0265	0.0303
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0675	0.1085
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.1113	0.1814
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0675	0.077
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0132	0.0182
Brugia malayi	nuclear receptor RXR	0.0011	0.0216	0.0247
Schistosoma mansoni	hypothetical protein	0.0018	0.0484	0.078
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.0675	0.077
Schistosoma mansoni	zinc finger protein	0.0011	0.0216	0.0335
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.0675	0.1097
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.1113	0.2292
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0675	0.077
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0011	0.0216	0.0321
Echinococcus granulosus	cpg binding protein	0.0031	0.0991	0.166
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0027	0.0811	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0216	0.0247
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0027	0.0811	0.5
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0927	0.1058
Trypanosoma brucei	hypothetical protein, conserved	0.0027	0.0811	0.5
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0011	0.0216	0.0247
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.0675	0.1117
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.0675	0.077
Brugia malayi	hypothetical protein	0.0012	0.0265	0.0303
Schistosoma mansoni	cpg binding protein	0.003	0.0927	0.1517
Schistosoma mansoni	nuclear receptor	0.0011	0.0216	0.0335
Entamoeba histolytica	acetyltransferase, GNAT family	0.0044	0.1484	1
Brugia malayi	Pre-SET motif family protein	0.0035	0.1113	0.127
Schistosoma mansoni	serine/threonine protein kinase	0.0069	0.2402	0.3969
Brugia malayi	ecdysteroid receptor	0.0023	0.0675	0.077
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.0675	0.1097

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.09 uM	Inhibition of Cdc7	ChEMBL.	20873740
IC50 (functional)	= 0.1 uM	Antiproliferative activity against human A2780 cells expressing p53 after 72 hrs by celltiter-glo assay	ChEMBL.	20873740

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	20873740

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1270618

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1250388