Detailed information for compound 1255362

Basic information

Technical information
  • TDR Targets ID: 1255362
  • Name: 2-(3-oxo-4H-1,4-benzothiazin-2-yl)-N-(1-pheny lethyl)acetamide
  • MW: 326.413 | Formula: C18H18N2O2S
  • H donors: 2 H acceptors: 2 LogP: 2.59 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(c1ccccc1)C)CC1Sc2ccccc2NC1=O
  • InChi: 1S/C18H18N2O2S/c1-12(13-7-3-2-4-8-13)19-17(21)11-16-18(22)20-14-9-5-6-10-15(14)23-16/h2-10,12,16H,11H2,1H3,(H,19,21)(H,20,22)
  • InChiKey: LOUOZKOTGFFHFW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3-keto-4H-1,4-benzothiazin-2-yl)-N-(1-phenylethyl)acetamide
  • 2-(3-oxo-4H-1,4-benzothiazin-2-yl)-N-(1-phenylethyl)ethanamide
  • MLS000672167
  • SMR000293333
  • IFLab1_006334
  • T5675454
  • 2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)-N-(1-phenylethyl)acetamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.025 0.4008
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2261
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3394 0.67
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.024 0.0523
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0575 0.982
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3208 0.6322
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0096 0.0012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.069 0.1374
Schistosoma mansoni pyruvate kinase 0.004 0.0583 0.057
Schistosoma mansoni ferritin 0.0017 0.009 0.0076
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0155 0.2963 0.5826
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2261
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0152 0.0315
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0176 0.1295
Echinococcus multilocularis Aminotransferase class III 0.0022 0.0204 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0169 0.0159
Toxoplasma gondii histone lysine methyltransferase SET1 0.017 0.3274 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0509 0.0422
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0509 0.0925
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0022 0.0204 0.2355
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.024 0.0523
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2261
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0114 0.0015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.1364 0.1285
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0152 0.0139
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.024 0.2709
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.024 0.1019
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0575 0.9848
Echinococcus multilocularis pyruvate kinase 0.0032 0.0407 0.032
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2261
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.024 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0169 0.0159
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0575 0.0983
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0113 0.1552
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0169 0.0159
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0403 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.024 0.0523
Mycobacterium ulcerans beta-lactamase 0.0037 0.0509 0.1457
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0113 0.1552
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0316 0.0628
Schistosoma mansoni hypothetical protein 0.0205 0.3995 0.3986
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0583 0.1716
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0583 0.1
Loa Loa (eye worm) pyruvate kinase 0.004 0.0583 0.0958
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0509 0.0925
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0583 0.109
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0583 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2261
Brugia malayi CXXC zinc finger family protein 0.009 0.1609 0.3203
Echinococcus granulosus geminin 0.0205 0.3995 0.394
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5022 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.024 0.026
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0114 0.0015
Schistosoma mansoni pyruvate kinase 0.0021 0.0176 0.0162
Mycobacterium ulcerans acetylornithine aminotransferase 0.0022 0.0204 0.0397
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5022 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0575 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0152 0.0138
Onchocerca volvulus 0.0037 0.0509 0.0904
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.069 0.0677
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.1364 0.1351
Echinococcus granulosus tar DNA binding protein 0.0126 0.2372 0.2302
Schistosoma mansoni apoferritin-2 0.0017 0.009 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0509 0.0849
Plasmodium falciparum pyruvate kinase 0.004 0.0583 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0179 0.141
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3208 0.6322
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0169 0.0159
Echinococcus multilocularis pyruvate kinase 0.004 0.0583 0.0498
Echinococcus multilocularis pyruvate kinase 0.004 0.0583 0.0498
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0169 0.0159
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0113 0.0225
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0022 0.0204 0.0397
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.024 0.0332
Brugia malayi AMP-binding enzyme family protein 0.0024 0.024 0.0479
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0113 0.1552
Toxoplasma gondii exonuclease III APE 0.004 0.0575 0.1461
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3208 0.6322
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0152 0.0138
Mycobacterium ulcerans hypothetical protein 0.0024 0.024 0.0523
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0113 0.1552
Mycobacterium leprae Probable lipase LipE 0.0037 0.0509 0.1457
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0169 0.0159
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0113 0.1552
Entamoeba histolytica hypothetical protein 0.0078 0.1364 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.024 0.0479
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0113 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0509 0.8417
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.024 0.0332
Loa Loa (eye worm) TAR-binding protein 0.0126 0.2372 0.4601
Toxoplasma gondii FATC domain-containing protein 0.0024 0.025 0.0432
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0152 0.0839
Trichomonas vaginalis esterase, putative 0.0037 0.0509 0.0849
Entamoeba histolytica hypothetical protein 0.0078 0.1364 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0403 0.0316
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0509 0.8417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0005
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0583 0.1488
Mycobacterium ulcerans L-lysine aminotransferase 0.0022 0.0204 0.0397
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.2372 0.4601
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0155 0.2963 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0152 0.0217
Schistosoma mansoni hypothetical protein 0.0032 0.0403 0.0389
Leishmania major pyruvate kinase 0.004 0.0583 1
Echinococcus granulosus dna polymerase eta 0.002 0.0152 0.0063
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0204 0.0115
Echinococcus granulosus pyruvate kinase 0.0021 0.0176 0.0087
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0152 0.008
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3208 0.6322
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0152 0.0063
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.182 0.3624
Brugia malayi beta-lactamase family protein 0.0037 0.0509 0.1013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.025 0.0324
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.1364 0.1285
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0323 0.0235
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0575 0.982
Schistosoma mansoni cpg binding protein 0.0095 0.1715 0.1703
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.069 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0323 0.0235
Plasmodium falciparum ornithine aminotransferase 0.0022 0.0204 0.1895
Entamoeba histolytica hypothetical protein 0.0024 0.025 0.1093
Loa Loa (eye worm) hypothetical protein 0.0028 0.033 0.0442
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0509 0.0849
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.5022 1
Trichomonas vaginalis helicase, putative 0.002 0.0169 0.0159
Brugia malayi AMP-binding enzyme family protein 0.0024 0.024 0.0479
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0155 0.2963 0.6351
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5022 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0575 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.024 0.0523
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0509 0.1457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3208 0.6322
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0113 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0005
Schistosoma mansoni ferritin 0.0017 0.009 0.0076
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0169 0.0159
Entamoeba histolytica hypothetical protein 0.0078 0.1364 1
Schistosoma mansoni cpg binding protein 0.0095 0.1715 0.1703
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.3208 1
Schistosoma mansoni ap endonuclease 0.004 0.0575 0.0562
Echinococcus granulosus pyruvate kinase 0.0021 0.0176 0.0087
Loa Loa (eye worm) hypothetical protein 0.0037 0.0509 0.0806
Echinococcus multilocularis dna polymerase eta 0.002 0.0152 0.0063
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0403 0.0316
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0583 1
Echinococcus granulosus serine protein kinase ATM 0.0024 0.025 0.0161
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.5022 1
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0509 0.0925
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.024 0.0523
Giardia lamblia DINP protein human, muc B family 0.002 0.0152 0.0839
Mycobacterium tuberculosis Probable aminotransferase 0.0155 0.2963 0.6351
Leishmania major DNA polymerase kappa, putative 0.002 0.0152 0.0839
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0022 0.0204 0.0252
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.025 0.0161
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3208 0.6322
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.024 0.1019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.069 0.0605
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0155 0.2963 1
Schistosoma mansoni hypothetical protein 0.0205 0.3995 0.3986
Schistosoma mansoni cpg binding protein 0.009 0.1609 0.1597
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0169 0.0159
Onchocerca volvulus 0.0037 0.0509 0.0904
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0575 0.0983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0169 0.0159
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0022 0.0204 0.0289
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0152 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2261
Schistosoma mansoni tar DNA-binding protein 0.0126 0.2372 0.2361
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2261
Trypanosoma brucei unspecified product 0.002 0.0152 0.2261
Brugia malayi beta-lactamase family protein 0.0037 0.0509 0.1013
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0575 0.1071
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0022 0.0204 0.0252
Plasmodium vivax pyruvate kinase, putative 0.004 0.0583 1
Schistosoma mansoni hypothetical protein 0.0032 0.0403 0.0389
Schistosoma mansoni ferritin light chain 0.0017 0.009 0.0076
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0575 0.9819
Echinococcus multilocularis geminin 0.0205 0.3995 0.394
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0169 0.0159
Loa Loa (eye worm) pyruvate kinase 0.004 0.0583 0.0958
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0113 0.0099
Echinococcus granulosus dna polymerase kappa 0.002 0.0152 0.0063
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0509 0.0925
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5022 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0209 0.012
Schistosoma mansoni hypothetical protein 0.0078 0.1364 0.1351
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.069 0.0605
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.069 0.0605
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0113 0.0023
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Trypanosoma brucei pyruvate kinase 1 0.004 0.0583 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0113 0.0099
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0575 0.3692
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0583 1
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0509 0.0925
Mycobacterium ulcerans hypothetical protein 0.0037 0.0509 0.1457
Leishmania major DNA polymerase eta, putative 0.002 0.0152 0.0839
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0169 0.0159
Echinococcus multilocularis pyruvate kinase 0.0021 0.0176 0.0087
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0509 0.1013
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.033 0.0442
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0575 0.0489
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0152 0.0839
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0152 0.0126
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0583 0.1
Giardia lamblia Pyruvate kinase 0.004 0.0583 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0509 0.0925
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0583 0.1161
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0096 0.0012
Schistosoma mansoni ap endonuclease 0.004 0.0575 0.0562
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0116 0.0056
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0169 0.0159
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.182 0.3477
Schistosoma mansoni ferritin light chain 0.0017 0.009 0.0076
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0152 0.0304
Echinococcus granulosus cpg binding protein 0.0095 0.1715 0.1639
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0583 0.1155
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0152 0.0839
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0176 0.02
Brugia malayi TAR-binding protein 0.0126 0.2372 0.4723
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0209 0.012
Echinococcus granulosus ornithine aminotransferase 0.0022 0.0204 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0169 0.0159
Schistosoma mansoni mixed-lineage leukemia protein mll 0.019 0.3696 0.3687
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0152 0.0126
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0022 0.0204 0.0191
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.024 0.0523
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.069 0.0677
Brugia malayi RNA binding protein 0.0126 0.2372 0.4723
Loa Loa (eye worm) hypothetical protein 0.004 0.0583 0.0958
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0403 0.0802
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0575 0.9819
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0509 0.0925
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0323 0.0428
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.182 0.3624
Onchocerca volvulus 0.009 0.1609 0.4611
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.025 0.0497
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2261
Mycobacterium ulcerans hypothetical protein 0.0155 0.2963 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0509 0.0806
Schistosoma mansoni pyruvate kinase 0.004 0.0583 0.057
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0169 0.0159
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0509 0.0495
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Mycobacterium tuberculosis Conserved protein 0.0037 0.0509 0.0925
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0022 0.0204 0.1895
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0152 0.2261
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0209 0.0196
Echinococcus granulosus pyruvate kinase 0.004 0.0583 0.0498
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0209 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2261
Echinococcus granulosus pyruvate kinase 0.0021 0.0176 0.0087
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0509 0.8663
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0204 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0179 0.0135
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0509 0.0422
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0169 0.0159
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0005
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0575 0.0489
Echinococcus multilocularis GPCR, family 2 0.0032 0.0403 0.0316
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0113 0.0225
Loa Loa (eye worm) hypothetical protein 0.0032 0.0403 0.0591
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.024 0.2709
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.069 0.0677
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.2372 0.4723
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0403 0.0802
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0022 0.0204 0.0397
Echinococcus granulosus Aminotransferase class III 0.0022 0.0204 0.0115
Echinococcus multilocularis pyruvate kinase 0.0021 0.0176 0.0087
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0096 0.0012
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0509 0.0806
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0509 0.1457
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0152 0.0839
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0005
Loa Loa (eye worm) pyruvate kinase 0.004 0.0583 0.0958
Loa Loa (eye worm) hypothetical protein 0.0037 0.0509 0.0806
Echinococcus multilocularis tar DNA binding protein 0.0126 0.2372 0.2302
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0169 0.0159
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0575 0.0941
Mycobacterium ulcerans lipase LipD 0.0037 0.0509 0.1457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.024 0.0523
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0113 0.0023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0096 0.0012
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0022 0.0204 0.0397
Loa Loa (eye worm) hypothetical protein 0.0037 0.0509 0.0806
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Entamoeba histolytica hypothetical protein 0.0078 0.1364 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.024 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Loa Loa (eye worm) CXXC zinc finger family protein 0.009 0.1609 0.3047
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0575 0.1687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Schistosoma mansoni hypothetical protein 0.0032 0.0403 0.0389
Brugia malayi hypothetical protein 0.0078 0.1364 0.2715
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0583 0.1155
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0575 0.1144
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3394 0.67
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3208 0.6322
Echinococcus multilocularis dna polymerase kappa 0.002 0.0152 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.069 0.1175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0022 0.0204 0.0397
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2261
Loa Loa (eye worm) RNA binding protein 0.0126 0.2372 0.4601
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0022 0.0204 0.0252
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0152 0.2261
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0403 0.0591
Chlamydia trachomatis pyruvate kinase 0.004 0.0583 1
Echinococcus multilocularis pyruvate kinase 0.0021 0.0176 0.0087
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.1164 0.2318
Schistosoma mansoni DNA polymerase eta 0.002 0.0152 0.0139
Schistosoma mansoni hypothetical protein 0.0494 1 1
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0022 0.0204 0.0407
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0152 0.2261
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0575 0.982
Brugia malayi beta-lactamase 0.0037 0.0509 0.1013
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0152 0.0063
Schistosoma mansoni ferritin 0.0017 0.009 0.0076
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.025 0.0236
Loa Loa (eye worm) hypothetical protein 0.01 0.182 0.3477
Plasmodium vivax ornithine aminotransferase, putative 0.0022 0.0204 0.1895
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0152 0.0839
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.024 0.1019
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0509 0.8408
Schistosoma mansoni apoferritin-2 0.0017 0.009 0.0076
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0152 0.0139
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0022 0.0204 0.0397
Giardia lamblia Pyruvate kinase 0.0021 0.0176 0.1344
Plasmodium falciparum pyruvate kinase 2 0.0021 0.0176 0.1295
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.4614 1
Mycobacterium ulcerans pyruvate kinase 0.004 0.0583 0.1716
Echinococcus granulosus GPCR family 2 0.0032 0.0403 0.0316
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0583 0.1161
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0509 0.0849
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0509 0.0849
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.008
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0583 0.1155
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0509 0.1457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Loa Loa (eye worm) beta-lactamase 0.0037 0.0509 0.0806
Mycobacterium tuberculosis Conserved protein 0.0037 0.0509 0.0925
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0152 0.0839
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0152 0.0304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.033 0.1737
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.024 0.2709
Loa Loa (eye worm) hypothetical protein 0.0037 0.0509 0.0806
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0169 0.0159
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0509 0.0495
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0022 0.0204 0.0397
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0209 0.012
Schistosoma mansoni tar DNA-binding protein 0.0126 0.2372 0.2361
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0022 0.0204 0.0252
Schistosoma mansoni tar DNA-binding protein 0.0126 0.2372 0.2361
Echinococcus granulosus pyruvate kinase 0.004 0.0583 0.0498
Loa Loa (eye worm) hypothetical protein 0.0024 0.024 0.026
Mycobacterium tuberculosis Conserved protein 0.0037 0.0509 0.0925
Schistosoma mansoni hypothetical protein 0.0068 0.1164 0.1152
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0116 0.0089
Loa Loa (eye worm) hypothetical protein 0.0037 0.0509 0.0806
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5022 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0575 0.982
Echinococcus multilocularis cpg binding protein 0.0095 0.1715 0.1639
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.024 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0022 0.0204 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5022 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0126 0.2372 0.2361
Schistosoma mansoni tar DNA-binding protein 0.0126 0.2372 0.2361
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0403 0.0316
Onchocerca volvulus 0.0037 0.0509 0.0904
Loa Loa (eye worm) hypothetical protein 0.0068 0.1164 0.2141
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.025 0.2907
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0005
Toxoplasma gondii ABC1 family protein 0.0037 0.0509 0.1252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0113 0.0046
Leishmania major pyruvate kinase 0.004 0.0583 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0509 0.0849
Leishmania major hypothetical protein, conserved 0.0037 0.0509 0.8417
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0152 0.2261
Schistosoma mansoni hypothetical protein 0.0032 0.0403 0.0389
Schistosoma mansoni ferritin 0.0017 0.009 0.0076

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.6513 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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