TDR Targets

Basic information

Technical information

TDR Targets ID: 1256880
Name: Oprea1_142650
MW: 367.398 | Formula: C20H21N3O4
H donors: 2 H acceptors: 3 LogP: 1.31 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)NC(=O)CC1C(=O)NCCN1C(=O)c1ccccc1
InChi: 1S/C20H21N3O4/c1-27-16-9-7-15(8-10-16)22-18(24)13-17-19(25)21-11-12-23(17)20(26)14-5-3-2-4-6-14/h2-10,17H,11-13H2,1H3,(H,21,25)(H,22,24)
InChiKey: LJIDJCREAALYBO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-benzoyl-N-(4-methoxyphenyl)-3-oxo-2-piperazinecarboxamide
MLS000834754
SMR000458372

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0195	0.029
Brugia malayi	Animal haem peroxidase family protein	0.0195	0.6723	0.6723
Echinococcus granulosus	neurogenic locus notch protein 4	0.0025	0.0722	0.1074
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0195	0.029
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0021	0.0021
Onchocerca volvulus	Slit protein homolog	0.0025	0.0722	0.1074
Onchocerca volvulus	Peroxidase homolog	0.0195	0.6723	1
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0206	0.0206
Trichomonas vaginalis	glucosylceramidase, putative	0.0287	1	1
Schistosoma mansoni	hypothetical protein	0.0025	0.0722	0.1074
Schistosoma mansoni	notch	0.0025	0.0722	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0195	0.6723	0.6723
Loa Loa (eye worm)	hypothetical protein	0.0195	0.6723	0.6723
Echinococcus granulosus	neurogenic locus notch protein	0.0025	0.0722	0.1074
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0287	1	1
Schistosoma mansoni	hypothetical protein	0.0025	0.0722	0.1074
Trichomonas vaginalis	glucosylceramidase, putative	0.0188	0.6501	0.6465
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0195	0.029
Onchocerca volvulus	Chorion peroxidase homolog	0.0195	0.6723	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0195	0.0195
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0195	0.029
Onchocerca volvulus		0.0025	0.0722	0.1074
Schistosoma mansoni	serine/threonine protein kinase	0.0147	0.5037	0.7491
Loa Loa (eye worm)	hypothetical protein	0.0195	0.6723	0.6723
Brugia malayi	nuclear receptor NHR-88	0.001	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0195	0.6723	0.6723
Brugia malayi	Cadherin domain containing protein	0.0025	0.0722	0.0722
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0147	0.5037	0.5037
Echinococcus multilocularis	neurogenic locus notch protein	0.0025	0.0722	0.1074
Onchocerca volvulus	Neurogenic locus notch homolog	0.0025	0.0722	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Schistosoma mansoni	hypothetical protein	0.0025	0.0722	0.1074
Brugia malayi	Animal haem peroxidase family protein	0.0195	0.6723	0.6723
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0195	0.029
Loa Loa (eye worm)	hypothetical protein	0.0195	0.6723	0.6723
Brugia malayi	Muscle positioning protein 4	0.0025	0.0722	0.0722
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0195	0.029
Loa Loa (eye worm)	hypothetical protein	0.001	0.0195	0.0195
Brugia malayi	phosphoinositide-dependent protein kinase I	0.0147	0.5037	0.5037
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0195	0.0195
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0195	0.029
Echinococcus granulosus	neurogenic locus notch protein	0.0025	0.0722	0.1074
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0025	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Brugia malayi	hypothetical protein	0.0006	0.0021	0.0021
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0131	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Brugia malayi	CXXC zinc finger family protein	0.0035	0.1055	0.1055
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0195	0.029
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0201	0.0201
Onchocerca volvulus	Peroxidasin homolog	0.0195	0.6723	1
Loa Loa (eye worm)	notch protein	0.0025	0.0722	0.0722
Trichomonas vaginalis	glucosylceramidase, putative	0.0188	0.6501	0.6465
Echinococcus granulosus	protein jagged 2	0.0025	0.0722	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Echinococcus granulosus	notch	0.0025	0.0722	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Schistosoma mansoni	cpg binding protein	0.0037	0.1125	0.1673
Schistosoma mansoni	slit	0.0025	0.0722	0.1074
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0147	0.5037	0.5037
Trichomonas vaginalis	glucosylceramidase, putative	0.0287	1	1
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0195	0.0195
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0131	0.0195
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.2432	0.3617
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0195	0.029
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0195	0.029
Onchocerca volvulus		0.001	0.0195	0.029
Schistosoma mansoni	peroxidasin	0.0195	0.6723	1
Brugia malayi	EGF-like domain containing protein	0.0025	0.0722	0.0722
Echinococcus granulosus	delta-like protein 1	0.0025	0.0722	0.1074
Schistosoma mansoni	hypothetical protein	0.0025	0.0722	0.1074
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0021	0.0021
Onchocerca volvulus		0.0035	0.1055	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0195	0.6723	0.6723
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0021	0.0031
Schistosoma mansoni	hypothetical protein	0.0025	0.0722	0.1074
Onchocerca volvulus		0.0195	0.6723	1
Schistosoma mansoni	cpg binding protein	0.0035	0.1055	0.1568
Brugia malayi	nuclear hormone receptor	0.001	0.0195	0.0195
Trichomonas vaginalis	AGC family protein kinase	0.0147	0.5037	0.4984
Loa Loa (eye worm)	hypothetical protein	0.001	0.0195	0.0195
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0195	0.0195
Brugia malayi	Animal haem peroxidase family protein	0.0195	0.6723	0.6723
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0025	0.0722	0.1074
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0195	0.0195
Echinococcus granulosus	cpg binding protein	0.0037	0.1125	0.1673
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0021	0.0031
Onchocerca volvulus		0.0195	0.6723	1
Brugia malayi	ecdysteroid receptor	0.001	0.0195	0.0195
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0195	0.0195
Loa Loa (eye worm)	animal heme peroxidase	0.0195	0.6723	0.6723
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0021	0.0031
Brugia malayi	GCC2 and GCC3 family protein	0.0025	0.0722	0.0722
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0195	0.0195
Loa Loa (eye worm)	animal heme peroxidase	0.0195	0.6723	0.6723
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.001	0.0195	0.0195
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0195	0.029
Echinococcus granulosus	fibropellin Ia	0.0025	0.0722	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0195	0.6723	0.6723
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0195	0.0195
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0206	0.0306
Brugia malayi	nuclear receptor RXR	0.0006	0.0021	0.0021
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0131	0.0195
Brugia malayi	Delta serrate ligand family protein	0.0025	0.0722	0.0722
Echinococcus multilocularis	fibropellin Ia	0.0025	0.0722	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Brugia malayi	notch-like transmembrane receptor	0.0025	0.0722	0.0722
Schistosoma mansoni	notch	0.0025	0.0722	0.1074
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0005	0.0002	0.0003
Loa Loa (eye worm)	hypothetical protein	0.001	0.0195	0.0195
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0025	0.0722	0.1074
Onchocerca volvulus		0.0025	0.0722	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0195	0.6723	0.6723
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0195	0.029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Schistosoma mansoni	notch	0.0025	0.0722	0.1074
Schistosoma mansoni	hypothetical protein	0.0025	0.0722	0.1074
Brugia malayi	Calcium binding EGF domain containing protein	0.0025	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0021
Entamoeba histolytica	protein kinase, putative	0.0147	0.5037	0.5
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0025	0.0722	0.1074
Echinococcus multilocularis	notch	0.0025	0.0722	0.1074
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0195	0.029
Echinococcus multilocularis	neurogenic locus notch protein	0.0025	0.0722	0.1074
Trichomonas vaginalis	glucosylceramidase, putative	0.0287	1	1
Echinococcus multilocularis	peroxidasin	0.0195	0.6723	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0188	0.6501	0.6465
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0195	0.029
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0195	0.029
Loa Loa (eye worm)	hypothetical protein	0.0195	0.6723	0.6723
Echinococcus multilocularis	neural cadherin	0.0025	0.0722	0.1074
Schistosoma mansoni	notch	0.0025	0.0722	0.1074
Onchocerca volvulus		0.0025	0.0722	0.1074
Trichomonas vaginalis	glucosylceramidase, putative	0.0287	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0188	0.6501	0.6465
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0195	0.029
Brugia malayi	hypothetical protein	0.0006	0.0021	0.0021
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0195	0.029
Brugia malayi	EGF-like domain containing protein	0.0025	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0021
Brugia malayi	Cadherin domain containing protein	0.0025	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0195	0.6723	0.6723
Trichomonas vaginalis	glucosylceramidase, putative	0.0188	0.6501	0.6465
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0195	0.029
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0195	0.029
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0195	0.029
Brugia malayi	hypothetical protein	0.0195	0.6723	0.6723
Loa Loa (eye worm)	hypothetical protein	0.001	0.0195	0.0195
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0021	0.0021
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0021	0.0031
Trichomonas vaginalis	glucosylceramidase, putative	0.0188	0.6501	0.6465
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0131	0.0195
Brugia malayi	EGF-like domain containing protein	0.0025	0.0722	0.0722
Echinococcus granulosus	neural cadherin	0.0025	0.0722	0.1074
Trichomonas vaginalis	glucosylceramidase, putative	0.0188	0.6501	0.6465
Schistosoma mansoni	coup transcription factor	0.001	0.0195	0.029
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0195	0.0195
Echinococcus multilocularis	neurogenic locus protein delta	0.0025	0.0722	0.1074
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0195	0.0195
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0195	0.029
Schistosoma mansoni	cell polarity protein	0.0025	0.0722	0.1074
Onchocerca volvulus	Dual oxidase homolog	0.0195	0.6723	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Onchocerca volvulus	Peroxidase homolog	0.0195	0.6723	1
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0025	0.0722	0.1074
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0195	0.029
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0195	0.0195
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0195	0.0195
Schistosoma mansoni	notch	0.0025	0.0722	0.1074
Echinococcus multilocularis	protein jagged 1	0.0025	0.0722	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0195	0.6723	0.6723
Echinococcus granulosus	protein jagged 1	0.0025	0.0722	0.1074
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0195	0.0195
Echinococcus granulosus	slit 2 protein	0.0025	0.0722	0.1074
Echinococcus granulosus	peroxidasin	0.0195	0.6723	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0021
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0195	0.029
Echinococcus granulosus	protein jagged 1	0.0025	0.0722	0.1074
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0195	0.029
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0195	0.029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Onchocerca volvulus	Glucosylceramidase homolog	0.0188	0.6501	0.967
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0195	0.029
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0195	0.0195
Giardia lamblia	High cysteine protein	0.0025	0.0722	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0195	0.0195
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0195	0.029
Schistosoma mansoni	cpg binding protein	0.0037	0.1125	0.1673
Onchocerca volvulus		0.0195	0.6723	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.6723	0.6723
Trichomonas vaginalis	glucosylceramidase, putative	0.0287	1	1
Echinococcus granulosus	neurogenic locus protein delta	0.0025	0.0722	0.1074
Schistosoma mansoni	notch	0.0025	0.0722	0.1074
Echinococcus multilocularis	protein jagged 2	0.0025	0.0722	0.1074
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0195	0.029
Brugia malayi	Peroxidasin	0.0195	0.6723	0.6723
Onchocerca volvulus	Putative cubilin	0.0025	0.0722	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Schistosoma mansoni	peroxidasin	0.0195	0.6723	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Onchocerca volvulus	Peroxidasin homolog	0.0195	0.6723	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0025	0.0722	0.0722
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0195	0.029
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.0147	0.5037	0.7491
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Echinococcus granulosus	protein jagged 2	0.0025	0.0722	0.1074
Trichomonas vaginalis	glucosylceramidase, putative	0.0199	0.6861	0.6828
Trichomonas vaginalis	AGC family protein kinase	0.0147	0.5037	0.4984
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0195	0.0195
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0206	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0195	0.6723	0.6723
Brugia malayi	Protein kinase domain containing protein	0.0147	0.5037	0.5037
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.0147	0.5037	0.7491
Brugia malayi	EGF-like domain containing protein	0.0025	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Brugia malayi	steroid hormone receptor	0.001	0.0195	0.0195
Schistosoma mansoni	hypothetical protein	0.0025	0.0722	0.1074
Trichomonas vaginalis	glucosylceramidase, putative	0.0199	0.6861	0.6828
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Echinococcus multilocularis	cpg binding protein	0.0037	0.1125	0.1673
Brugia malayi	EGF-like domain containing protein	0.0025	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0021
Brugia malayi	Blistered cuticle protein 3	0.0195	0.6723	0.6723
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.2154	1
Echinococcus multilocularis	protein jagged 1	0.0025	0.0722	0.1074
Loa Loa (eye worm)	animal heme peroxidase	0.0195	0.6723	0.6723
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0195	0.029
Echinococcus multilocularis	neurogenic locus protein delta	0.0025	0.0722	0.1074
Trichomonas vaginalis	AGC family protein kinase	0.0147	0.5037	0.4984
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0195	0.029
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Onchocerca volvulus		0.0025	0.0722	0.1074
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0195	0.0195
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0131	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Trichomonas vaginalis	glucosylceramidase, putative	0.0287	1	1
Brugia malayi	EGF-like domain containing protein	0.0025	0.0722	0.0722
Loa Loa (eye worm)	Notch2	0.0025	0.0722	0.0722
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.001	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0021
Schistosoma mansoni	laminin gamma-3 chain	0.0025	0.0722	0.1074
Loa Loa (eye worm)	blistered cuticle protein 3	0.0195	0.6723	0.6723
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.1055	0.1055
Brugia malayi	Animal haem peroxidase family protein	0.0195	0.6723	0.6723
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0195	0.029
Echinococcus multilocularis	slit 2 protein	0.0025	0.0722	0.1074
Brugia malayi	Animal haem peroxidase family protein	0.0195	0.6723	0.6723
Loa Loa (eye worm)	hypothetical protein	0.0195	0.6723	0.6723
Schistosoma mansoni	septate junction protein	0.0025	0.0722	0.1074
Loa Loa (eye worm)	animal heme peroxidase	0.0195	0.6723	0.6723
Brugia malayi	EGF-like domain containing protein	0.0025	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.001	0.0195	0.0195
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0195	0.0195
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0195	0.0195
Onchocerca volvulus		0.0025	0.0722	0.1074
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0195	0.029
Brugia malayi	Calcium binding EGF domain containing protein	0.0025	0.0722	0.0722

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 1.4125 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1339224

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1256880