Detailed information for compound 1264786

Basic information

Technical information
  • TDR Targets ID: 1264786
  • Name: N-(2-furan-2-yl-2-morpholin-4-ylethyl)-2,4,6- trimethylbenzenesulfonamide
  • MW: 378.486 | Formula: C19H26N2O4S
  • H donors: 1 H acceptors: 2 LogP: 2.27 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)c(c(c1)C)S(=O)(=O)NCC(c1ccco1)N1CCOCC1
  • InChi: 1S/C19H26N2O4S/c1-14-11-15(2)19(16(3)12-14)26(22,23)20-13-17(18-5-4-8-25-18)21-6-9-24-10-7-21/h4-5,8,11-12,17,20H,6-7,9-10,13H2,1-3H3
  • InChiKey: DTHXLTDKPABXME-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(2-furyl)-2-morpholino-ethyl]-2,4,6-trimethyl-benzenesulfonamide
  • N-[2-(2-furyl)-2-morpholinoethyl]-2,4,6-trimethylbenzenesulfonamide
  • N-(2-furan-2-yl-2-morpholin-4-yl-ethyl)-2,4,6-trimethyl-benzenesulfonamide
  • G856-4920
  • NCGC00136415-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0078 0.0126 0.0126
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0189 0.0592
Loa Loa (eye worm) glutathione reductase 0.0046 0.0031 0.0031
Entamoeba histolytica protein kinase, putative 0.0195 0.0472 0.3973
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0031 0.0228
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0139 0.0306 0.2621
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0014 0.0043
Echinococcus multilocularis dual specificity mitogen activated protein 0.0093 0.0172 0.0539
Schistosoma mansoni tyrosine kinase 0.0518 0.1427 0.4481
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0054 0.0055 0.0283
Giardia lamblia Kinase, AGC PKA 0.0099 0.0189 0.1289
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0061 0.0075 0.0236
Entamoeba histolytica protein kinase, putative 0.0123 0.0259 0.2092
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0099 0.0189 0.1464
Schistosoma mansoni tyrosine kinase 0.0991 0.2828 0.8877
Echinococcus granulosus tyrosine protein kinase shark 0.0055 0.0059 0.0187
Schistosoma mansoni cell adhesion molecule 0.0081 0.0134 0.042
Loa Loa (eye worm) gastrulation defective protein 1 0.0128 0.0273 0.0273
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0099 0.0189 0.1464
Trichomonas vaginalis STE family protein kinase 0.0123 0.0259 0.2092
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0195 0.0472 0.3973
Echinococcus granulosus casein kinase I alpha 0.0058 0.0067 0.0211
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0058 0.0067 0.0067
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0102 0.0197 0.0618
Loa Loa (eye worm) hypothetical protein 0.0042 0.0019 0.0019
Schistosoma mansoni nephrin 0.0076 0.0121 0.038
Echinococcus multilocularis dual specificity 0.0195 0.0472 0.1482
Trichomonas vaginalis STE family protein kinase 0.0093 0.0172 0.1315
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0099 0.0189 0.1464
Trichomonas vaginalis AGC family protein kinase 0.0099 0.0189 0.1464
Plasmodium falciparum casein kinase 1 0.0058 0.0067 0.0389
Schistosoma mansoni protein kinase 0.0044 0.0025 0.0079
Brugia malayi serine/threonine kinase 12 0.0386 0.1039 0.1039
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0055 0.0059 0.0187
Echinococcus granulosus casein kinase I delta 0.0058 0.0067 0.0211
Entamoeba histolytica protein kinase domain containing protein 0.0425 0.1153 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0056 0.0063 0.0063
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0099 0.0189 0.0189
Trypanosoma cruzi cdc2-related kinase 1 0.0063 0.0082 0.0672
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.0059 0.0187
Leishmania major protein kinase, putative 0.0139 0.0306 0.2499
Schistosoma mansoni tyrosine kinase 0.054 0.1495 0.4691
Brugia malayi Protein kinase domain containing protein 0.0055 0.0059 0.0059
Echinococcus granulosus casein kinase I alpha 0.0058 0.0067 0.0211
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0078 0.0127 0.04
Echinococcus granulosus rho-associated protein kinase 1 0.1112 0.3186 1
Schistosoma mansoni protein kinase 0.0386 0.1039 0.3262
Echinococcus multilocularis casein kinase I delta 0.0058 0.0067 0.0211
Plasmodium falciparum protein kinase 5 0.0063 0.0082 0.0518
Giardia lamblia Kinase, CMGC CLK 0.0139 0.0306 0.2345
Trichomonas vaginalis CK1 family protein kinase 0.0058 0.0067 0.0389
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0386 0.1039 0.8991
Echinococcus multilocularis neuroglian 0.0076 0.0121 0.038
Entamoeba histolytica protein kinase, putative 0.0195 0.0472 0.3973
Echinococcus granulosus cyclin dependent kinase 5 0.0063 0.0082 0.0256
Entamoeba histolytica PH domain containing protein kinase, putative 0.0099 0.0189 0.1464
Schistosoma mansoni serine/threonine protein kinase 0.1112 0.3186 1
Echinococcus multilocularis cyclin dependent kinase 19 0.0149 0.0336 0.1053
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0137 0.0301 0.0301
Echinococcus granulosus cyclin dependent kinase 1 0.0063 0.0082 0.0256
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0065 0.0088 0.0088
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.111 0.3182 0.9987
Loa Loa (eye worm) CAMK protein kinase 0.0037 0.0004 0.0004
Onchocerca volvulus 0.0055 0.0059 0.0187
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0123 0.0259 0.0814
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0102 0.0197 0.0618
Schistosoma mansoni protein kinase 0.0123 0.0259 0.0814
Entamoeba histolytica protein kinase, putative 0.0123 0.0259 0.2092
Trypanosoma cruzi cdc2-related kinase 3 0.0063 0.0082 0.0672
Loa Loa (eye worm) hypothetical protein 0.0061 0.0075 0.0075
Loa Loa (eye worm) AGC/PKA protein kinase 0.0099 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0096 0.018 0.018
Echinococcus multilocularis PAK box P21 Rho binding 0.0102 0.0197 0.0618
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0102 0.0197 0.0618
Schistosoma mansoni tyrosine kinase 0.0328 0.0867 0.2721
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0134 0.0291 0.0291
Schistosoma mansoni tyrosine kinase 0.0055 0.0059 0.0187
Echinococcus granulosus dual specificity 0.0195 0.0472 0.1482
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0023
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0051 0.0046 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.1059 0.3029 0.9507
Echinococcus multilocularis epidermal growth factor receptor 0.054 0.1495 0.4691
Loa Loa (eye worm) hypothetical protein 0.0102 0.0197 0.0197
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0055 0.0059 0.0187
Echinococcus multilocularis geminin 0.0192 0.0463 0.1454
Brugia malayi Protein kinase domain containing protein 0.0149 0.0336 0.0336
Echinococcus granulosus roundabout 2 0.0096 0.018 0.0564
Brugia malayi casein kinase 1, delta 0.0058 0.0067 0.0067
Brugia malayi Fibronectin type III domain containing protein 0.0061 0.0075 0.0075
Echinococcus multilocularis cyclin dependent kinase 9 0.0073 0.0111 0.0348
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0023 0.0072
Toxoplasma gondii aurora kinase 0.0386 0.1039 0.8991
Schistosoma mansoni protein kinase 0.0102 0.0197 0.0618
Echinococcus multilocularis Immunoglobulin 0.0061 0.0075 0.0236
Echinococcus granulosus cyclin dependent kinase 7 0.0096 0.018 0.0564
Giardia lamblia Kinase, STE STE20 0.0093 0.0172 0.1136
Schistosoma mansoni hypothetical protein 0.0192 0.0463 0.1454
Giardia lamblia Kinase, CK1 Casein kinase 0.0058 0.0067 0.0191
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.0059 0.0187
Brugia malayi intracellular kinase 0.0425 0.1153 0.1153
Loa Loa (eye worm) TK/ALK protein kinase 0.0293 0.0762 0.0762
Plasmodium falciparum serine/threonine protein kinase, putative 0.0386 0.1039 0.8991
Entamoeba histolytica protein kinase , putative 0.0386 0.1039 0.8991
Brugia malayi Stress-activated protein kinase jnk-1 0.0246 0.0624 0.0624
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0425 0.1153 0.1153
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0096 0.018 0.018
Trichomonas vaginalis STE family protein kinase 0.0123 0.0259 0.2092
Loa Loa (eye worm) hypothetical protein 0.0174 0.041 0.041
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0023 0.0072
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1004 0.2868 0.2868
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0139 0.0306 0.0306
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0102 0.0197 0.0618
Trypanosoma brucei trypanothione reductase 0.0046 0.0031 0.0067
Entamoeba histolytica cell division protein kinase 2, putative 0.0063 0.0082 0.0518
Echinococcus multilocularis death associated protein kinase 1 0.0814 0.2306 0.7237
Echinococcus multilocularis PAK box P21 Rho binding 0.0123 0.0259 0.0814
Brugia malayi Protein kinase domain containing protein 0.0055 0.0059 0.0059
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0099 0.0189 0.1464
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0043 0.0023 0.0162
Trypanosoma cruzi cdc2-related kinase 1 0.0063 0.0082 0.0672
Brugia malayi serine/threonine-protein kinase PAK 7 0.1212 0.3483 0.3483
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0078 0.0126 0.0395
Brugia malayi P21-Rho-binding domain containing protein 0.0102 0.0197 0.0197
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.3414 1 1
Echinococcus granulosus dual specificity protein kinase clk2 0.0139 0.0306 0.0959
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0099 0.0189 0.0592
Trypanosoma brucei cdc2-related kinase 1 0.0063 0.0082 0.0518
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0099 0.0189 0.0592
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0139 0.0306 0.2621
Brugia malayi Thioredoxin reductase 0.0046 0.0031 0.0031
Onchocerca volvulus 0.0055 0.0059 0.0187
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0425 0.1153 0.362
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0195 0.0472 0.0472
Echinococcus granulosus c src tyrosine kinase 0.0055 0.0059 0.0187
Leishmania major protein kinase, putative 0.0386 0.1039 0.8991
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1059 0.3029 0.3029
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0099 0.0189 0.1603
Schistosoma mansoni hypothetical protein 0.0192 0.0463 0.1454
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0093 0.0172 0.0172
Schistosoma mansoni hypothetical protein 0.0102 0.0197 0.0618
Loa Loa (eye worm) hypothetical protein 0.0061 0.0075 0.0075
Brugia malayi Protein kinase domain containing protein 0.0063 0.0082 0.0082
Brugia malayi Furin-like cysteine rich region family protein 0.0991 0.2828 0.2828
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0306 0.0959
Echinococcus granulosus casein kinase I alpha 0.0058 0.0067 0.0211
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0037 0.0004 0.0004
Leishmania major casein kinase, putative 0.0058 0.0067 0.0389
Entamoeba histolytica protein kinase, putative 0.0386 0.1039 0.8991
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0055 0.0059 0.0187
Onchocerca volvulus 0.0058 0.0067 0.0211
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0058 0.0067 0.0067
Trypanosoma brucei cdc2-related kinase 3 0.0063 0.0082 0.0518
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0134 0.0291 0.0914
Brugia malayi protein unc-22 0.0037 0.0004 0.0004
Plasmodium falciparum protein serine/threonine kinase-1 0.0139 0.0306 0.2499
Entamoeba histolytica p21-activated kinase 0.0123 0.0259 0.2092
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0063 0.0082 0.0518
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0059 0.0187
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0238 1
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.018 0.0564
Brugia malayi glutathione reductase 0.0046 0.0031 0.0031
Echinococcus multilocularis casein kinase I delta 0.0058 0.0067 0.0211
Onchocerca volvulus 0.0055 0.0059 0.0187
Onchocerca volvulus 0.0037 0.0004 0.0013
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0123 0.0259 0.0814
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0063 0.0082 0.0082
Schistosoma mansoni tyrosine kinase 0.0055 0.0059 0.0187
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0055 0.0059 0.0322
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0099 0.0189 0.0592
Echinococcus granulosus cyclin dependent kinase 19 0.0149 0.0336 0.1053
Loa Loa (eye worm) TK protein kinase 0.0055 0.0059 0.0059
Brugia malayi Protein kinase domain containing protein 0.0139 0.0306 0.0306
Schistosoma mansoni protein kinase 0.0195 0.0473 0.1484
Loa Loa (eye worm) SRC-1 0.0055 0.0059 0.0059
Leishmania major protein kinase A catalytic subunit 0.0099 0.0189 0.1464
Onchocerca volvulus 0.0425 0.1153 0.362
Trichomonas vaginalis STE family protein kinase 0.0093 0.0172 0.1315
Brugia malayi SH2 domain containing protein 0.0055 0.0059 0.0059
Echinococcus granulosus tyrosine protein kinase Lyn 0.0077 0.0122 0.0383
Echinococcus multilocularis cyclin dependent kinase 7 0.0096 0.018 0.0564
Giardia lamblia Kinase, CMGC CDK 0.0063 0.0082 0.0323
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0189 0.0592
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0099 0.0189 0.1603
Loa Loa (eye worm) hypothetical protein 0.0055 0.0059 0.0059
Schistosoma mansoni tyrosine kinase 0.0058 0.0067 0.021
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0055 0.0059 0.0187
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0204 0.8342
Schistosoma mansoni tyrosine kinase 0.0518 0.1427 0.4481
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0059 0.0059
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0043 0.0023 0.0162
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0023 0.0072
Echinococcus granulosus defective proboscis extension response 0.0061 0.0075 0.0236
Brugia malayi hypothetical protein 0.0055 0.0059 0.0059
Echinococcus granulosus titin 0.0037 0.0004 0.0013
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0061 0.0075 0.0236
Echinococcus multilocularis tyrosine protein kinase Abl 0.0055 0.0059 0.0187
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0139 0.0306 0.2499
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0063 0.0082 0.0518
Echinococcus multilocularis cyclin dependent kinase 1 0.0063 0.0082 0.0256
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.1059 0.3029 0.9507
Schistosoma mansoni protein kinase 0.0123 0.0259 0.0814
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0238 1
Schistosoma mansoni serine/threonine protein kinase 0.0137 0.0301 0.0944
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0004 0.0013
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0055 0.0059 0.0187
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0082 0.0256
Loa Loa (eye worm) hypothetical protein 0.0096 0.018 0.018
Echinococcus granulosus Immunoglobulin 0.0061 0.0075 0.0236
Trichomonas vaginalis STE family protein kinase 0.0123 0.0259 0.2092
Leishmania major protein kinase A catalytic subunit isoform 1 0.0099 0.0189 0.1464
Echinococcus multilocularis activin receptor type 0.0044 0.0025 0.0079
Plasmodium falciparum thioredoxin reductase 0.0046 0.0031 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0067 0.0211
Echinococcus multilocularis cyclin dependent kinase 1 0.0063 0.0082 0.0256
Loa Loa (eye worm) hypothetical protein 0.0061 0.0075 0.0075
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0081 0.0134 0.042
Brugia malayi SRC-1 0.0055 0.0059 0.0059
Plasmodium vivax protein kinase Crk2 0.0063 0.0082 0.0454
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0099 0.0189 0.1407
Echinococcus multilocularis 0.0301 0.0787 0.2472
Schistosoma mansoni protein kinase 0.0058 0.0067 0.0211
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0061 0.0075 0.0075
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0044 0.0025 0.018
Brugia malayi Tyrosine-protein kinase abl-1 0.0055 0.0059 0.0059
Entamoeba histolytica protein kinase, putative 0.0054 0.0055 0.0283
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0055 0.0059 0.0187
Entamoeba histolytica protein kinase domain containing protein 0.0065 0.0088 0.0574
Brugia malayi Protein kinase domain 0.0123 0.0259 0.0259
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0031 0.0098
Loa Loa (eye worm) TK/INSR protein kinase 0.0328 0.0867 0.0867
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0093 0.0172 0.1315
Brugia malayi cell division control protein 2 homolog 0.0063 0.0082 0.0082
Echinococcus multilocularis twitchin 0.0037 0.0004 0.0013
Plasmodium falciparum glutathione reductase 0.0046 0.0031 0.0067
Entamoeba histolytica protein kinase domain containing protein 0.0044 0.0025 0.0018
Giardia lamblia Kinase, CMGC GSK 0.0425 0.1153 1
Schistosoma mansoni protein kinase 0.0195 0.0473 0.1484
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0139 0.0306 0.2499
Echinococcus granulosus neuroglian 0.0076 0.0121 0.038
Leishmania major protein kinase, putative 0.0044 0.0025 0.0018
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0059 0.0059
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0031 0.0031
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0195 0.0472 0.4071
Brugia malayi hypothetical protein 0.0061 0.0075 0.0075
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0134 0.0291 0.0914
Echinococcus granulosus tyrosine kinase 0.0055 0.0059 0.0187
Schistosoma mansoni vesicular amine transporter 0.0061 0.0075 0.0236
Toxoplasma gondii AGC kinase 0.0099 0.0189 0.1464
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0093 0.0172 0.1456
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0306 0.0959
Echinococcus granulosus hypothetical protein 0.0117 0.0243 0.0762
Brugia malayi Protein kinase domain containing protein 0.0055 0.0059 0.0059
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0055 0.0059 0.0187
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.1212 0.3483 0.3483
Plasmodium vivax casein kinase 1, putative 0.0058 0.0067 0.0324
Echinococcus granulosus c-Jun N-terminal kinases 0.0246 0.0624 0.1959
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0425 0.1153 1
Onchocerca volvulus Tyrosine kinase homolog 0.0939 0.2675 0.8397
Echinococcus multilocularis insulin receptor 0.0328 0.0867 0.2721
Echinococcus multilocularis cyclin dependent kinase 9 0.0065 0.0088 0.0276
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0023 0.0072
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0137 0.0301 0.0301
Entamoeba histolytica hypothetical protein 0.0102 0.0197 0.1537
Brugia malayi Serine/threonine-protein kinase Pim-3 0.1059 0.3029 0.3029
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0043 0.0023 0.0072
Echinococcus multilocularis casein kinase i 0.0058 0.0067 0.0211
Loa Loa (eye worm) hypothetical protein 0.0174 0.041 0.041
Entamoeba histolytica protein kinase domain containing protein 0.0386 0.1039 0.8991
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0055 0.0059 0.0187
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.111 0.3182 0.9987
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0014 0.0043
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0055 0.0059 0.0187
Schistosoma mansoni tyrosine kinase 0.0518 0.1427 0.4481
Brugia malayi Protein kinase domain containing protein 0.0078 0.0126 0.0126
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0102 0.0197 0.0618
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0044 0.0025 0.018
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0246 0.0624 0.1959
Trypanosoma brucei aurora B kinase 0.0386 0.1039 0.8991
Schistosoma mansoni tyrosine kinase 0.0328 0.0867 0.2721
Entamoeba histolytica protein kinase, putative 0.0123 0.0259 0.2092
Loa Loa (eye worm) AUR protein kinase 0.0386 0.1039 0.1039
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.018 0.0564
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0055 0.0059 0.0187
Giardia lamblia Kinase, CMGC GSK 0.0425 0.1153 1
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0014 0.0043
Trichomonas vaginalis CMGC family protein kinase 0.0425 0.1153 1
Loa Loa (eye worm) AUR protein kinase 0.0386 0.1039 0.1039
Brugia malayi P21-Rho-binding domain containing protein 0.0102 0.0197 0.0197
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1059 0.3029 0.3029
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0328 0.0867 0.2721
Entamoeba histolytica cell division protein kinase 2, putative 0.0071 0.0104 0.072
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0099 0.0189 0.0592
Schistosoma mansoni serine/threonine protein kinase 0.0386 0.1039 0.3262
Schistosoma mansoni hypothetical protein 0.0102 0.0197 0.0618
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0082 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0386 0.1039 0.8991
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0055 0.0059 0.0187
Echinococcus granulosus casein kinase I delta 0.0058 0.0067 0.0211
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0146 0.0328 0.0328
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0043 0.0023 0.0023
Brugia malayi Protein kinase domain containing protein 0.1059 0.3029 0.3029
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0204 0.8342
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0099 0.0189 0.1603
Brugia malayi protein-tyrosine kinase 0.0055 0.0059 0.0059
Trichomonas vaginalis STE family protein kinase 0.0123 0.0259 0.2092
Leishmania major protein kinase, putative 0.0139 0.0306 0.2499
Brugia malayi cyclin-dependent kinase 9 0.0065 0.0088 0.0088
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0134 0.0291 0.0291
Echinococcus multilocularis peroxidasin 0.0035 0 0.0001
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0386 0.1039 0.3262
Trichomonas vaginalis AGC family protein kinase 0.0386 0.1039 0.8991
Brugia malayi WH1 domain containing protein 0.0102 0.0197 0.0197
Brugia malayi Protein kinase domain containing protein 0.0328 0.0867 0.0867
Loa Loa (eye worm) hypothetical protein 0.0061 0.0075 0.0075
Echinococcus granulosus tyrosine protein kinase Src64B 0.0055 0.0059 0.0187
Schistosoma mansoni serine/threonine protein kinase 0.0246 0.0624 0.1959
Schistosoma mansoni tyrosine kinase 0.0055 0.0059 0.0187
Echinococcus granulosus tyrosine protein kinase ABL1 0.0055 0.0059 0.0187
Trypanosoma cruzi cdc2-related kinase 3 0.0063 0.0082 0.0672
Plasmodium falciparum glycogen synthase kinase 3 0.0425 0.1153 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0099 0.0189 0.1603
Echinococcus multilocularis epidermal growth factor receptor 0.0991 0.2828 0.8877
Brugia malayi jmjC domain containing protein 0.004 0.0014 0.0014
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0099 0.0189 0.0592
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0014 0.0043
Schistosoma mansoni protein kinase 0.0123 0.0259 0.0814
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0038 0.0008 0.0026
Entamoeba histolytica protein kinase, putative 0.0386 0.1039 0.8991
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0139 0.0306 0.2621
Echinococcus granulosus dual specificity mitogen activated protein 0.0093 0.0172 0.0539
Echinococcus multilocularis cyclin dependent kinase 5 0.0063 0.0082 0.0256
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.0328 0.103
Brugia malayi Protein kinase domain containing protein 0.0293 0.0762 0.0762
Onchocerca volvulus 0.1091 0.3123 0.9803
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0004 0.0013
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0044 0.0025 0.0018
Echinococcus multilocularis casein kinase I alpha 0.0058 0.0067 0.0211
Echinococcus granulosus titin 0.0037 0.0004 0.0013
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0099 0.0189 0.0592
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0425 0.1153 0.362
Echinococcus granulosus tyrosine protein kinase Src42A 0.0055 0.0059 0.0187
Echinococcus granulosus cyclin dependent kinase 0.0063 0.0082 0.0256
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0032 0.0102
Schistosoma mansoni tyrosine kinase 0.0124 0.0264 0.0828
Trypanosoma cruzi casein kinase, putative 0.0058 0.0067 0.0545
Loa Loa (eye worm) AUR protein kinase 0.0386 0.1039 0.1039
Echinococcus granulosus tyrosine kinase 0.0055 0.0059 0.0187
Echinococcus granulosus serine:threonine kinase SAD 1 0.0043 0.0023 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0425 0.1153 1
Brugia malayi putative serine/threonine kinase SADA gamma 0.0043 0.0023 0.0023
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0123 0.0259 0.0814
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0008 0.0008
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0078 0.0126 0.0395
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0108 0.0215 0.0676
Loa Loa (eye worm) hypothetical protein 0.0057 0.0063 0.0063
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0195 0.0472 0.4071
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0425 0.1153 0.1153
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0004 0.0004
Leishmania major protein kinase A catalytic subunit isoform 2 0.0099 0.0189 0.1464
Schistosoma mansoni tyrosine kinase 0.0055 0.0059 0.0187
Echinococcus granulosus epidermal growth factor receptor 0.054 0.1495 0.4691
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0123 0.0259 0.0814
Echinococcus granulosus cyclin dependent kinase 9 0.0065 0.0088 0.0276
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0059 0.0187
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0195 0.0472 0.3973
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0078 0.0126 0.0396
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0102 0.0197 0.0197
Echinococcus multilocularis casein kinase I alpha 0.0058 0.0067 0.0211
Echinococcus multilocularis Immunoglobulin 0.0061 0.0075 0.0236
Loa Loa (eye worm) hypothetical protein 0.027 0.0695 0.0695
Toxoplasma gondii AGC kinase 0.0099 0.0189 0.1464
Trichomonas vaginalis AGC family protein kinase 0.0386 0.1039 0.8991
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0099 0.0189 0.1464
Echinococcus granulosus PAK box P21 Rho binding 0.0102 0.0197 0.0618
Trichomonas vaginalis STE family protein kinase 0.0093 0.0172 0.1315
Trichomonas vaginalis AGC family protein kinase 0.0386 0.1039 0.8991
Brugia malayi jmjC domain containing protein 0.0108 0.0215 0.0215
Echinococcus granulosus insulin receptor 0.0328 0.0867 0.2721
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0425 0.1153 1
Echinococcus granulosus protein kinase shaggy 0.0425 0.1153 0.362
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0055 0.0059 0.0187
Loa Loa (eye worm) TK/ABL protein kinase 0.0055 0.0059 0.0059
Echinococcus multilocularis dual specificity protein kinase clk2 0.0139 0.0306 0.0959
Echinococcus multilocularis 0.0117 0.0243 0.0762
Entamoeba histolytica casein kinase, putative 0.0058 0.0067 0.0389
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0386 0.1039 0.8985
Echinococcus multilocularis tyrosine protein kinase Srms 0.0055 0.0059 0.0187
Entamoeba histolytica protein kinase domain containing protein 0.0425 0.1153 1
Schistosoma mansoni titin 0.0037 0.0004 0.0013
Onchocerca volvulus 0.0037 0.0004 0.0014
Brugia malayi cyclin-dependent kinase 7 homolog 0.0104 0.0202 0.0202
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0082 0.0518
Schistosoma mansoni tyrosine kinase 0.0055 0.0059 0.0187
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0123 0.0259 0.0814
Entamoeba histolytica casein kinase 1, putative 0.0058 0.0067 0.0389
Trypanosoma cruzi aurora B kinase, putative 0.0386 0.1039 0.9008
Giardia lamblia Aurora kinase 0.0386 0.1039 0.8971
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0059 0.0059
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0044 0.0025 0.0018
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0093 0.0172 0.1315
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0058 0.0067 0.0545
Toxoplasma gondii thioredoxin reductase 0.0046 0.0031 0.0067
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0134 0.0291 0.0291
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0336 0.1053
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0139 0.0306 0.2499
Schistosoma mansoni jumonji domain containing protein 0.0086 0.015 0.047
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0059 0.0187
Entamoeba histolytica protein kinase, putative 0.0425 0.1153 1
Echinococcus multilocularis c src tyrosine kinase 0.0055 0.0059 0.0187
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0058 0.0067 0.0067
Loa Loa (eye worm) TK/EGFR protein kinase 0.0991 0.2828 0.2828
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0306 0.2499
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0061 0.0075 0.0236
Echinococcus granulosus twitchin 0.0097 0.0184 0.0577
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0059 0.0059
Echinococcus multilocularis casein kinase I alpha 0.0058 0.0067 0.0211
Echinococcus multilocularis tyrosine kinase 0.0055 0.0059 0.0187
Trypanosoma brucei casein kinase I, isoform 2 0.0058 0.0067 0.0389
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0097 0.0097
Trypanosoma cruzi casein kinase, putative 0.0058 0.0067 0.0545
Plasmodium vivax serine/threonine kinase-1, putative 0.0139 0.0306 0.2448
Brugia malayi Protein kinase domain containing protein 0.0055 0.0059 0.0059
Mycobacterium tuberculosis Probable reductase 0.0104 0.0204 0.8342
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0386 0.1039 0.3262
Brugia malayi Protein kinase domain containing protein 0.0195 0.0472 0.0472
Loa Loa (eye worm) hypothetical protein 0.0081 0.0134 0.0134
Trichomonas vaginalis STE family protein kinase 0.0123 0.0259 0.2092
Leishmania major trypanothione reductase 0.0046 0.0031 0.0067
Entamoeba histolytica protein kinase, putative 0.0123 0.0259 0.2092
Brugia malayi Protein kinase domain containing protein 0.0055 0.0059 0.0059
Brugia malayi SH2 domain containing protein 0.0055 0.0059 0.0059
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0031 0.0098
Trypanosoma cruzi casein kinase, putative 0.0058 0.0067 0.0545
Entamoeba histolytica protein kinase domain containing protein 0.0195 0.0472 0.3973
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0386 0.1039 0.8991
Loa Loa (eye worm) hypothetical protein 0.0061 0.0075 0.0075
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.1059 0.3029 0.9507
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0063 0.0082 0.0256
Plasmodium vivax glycogen synthase kinase 3, putative 0.0425 0.1153 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0139 0.0306 0.2621
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0055 0.0059 0.0187
Onchocerca volvulus 0.0055 0.0059 0.0187
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0386 0.1039 0.8991
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0108 0.0215 0.0676
Trichomonas vaginalis CK1 family protein kinase 0.0058 0.0067 0.0389
Schistosoma mansoni kinase 0.0065 0.0088 0.0276
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0195 0.0473 0.1484
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0093 0.0172 0.0172
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0059 0.0059
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0238 1
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0088 0.0276
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0038 0.0008 0.0026
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0238 1
Trypanosoma brucei protein kinase, putative 0.0044 0.0025 0.0018
Loa Loa (eye worm) AGC/PKA protein kinase 0.0099 0.0189 0.0189
Loa Loa (eye worm) TK/ROR protein kinase 0.0038 0.0008 0.0008
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0063 0.0082 0.0082
Loa Loa (eye worm) TK protein kinase 0.0038 0.0008 0.0008
Trypanosoma cruzi casein kinase, putative 0.0058 0.0067 0.0545
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0014 0.0014
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0063 0.0082 0.0518
Onchocerca volvulus 0.1112 0.3186 1
Toxoplasma gondii casein kinase I 0.0058 0.0067 0.0389
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0246 0.0624 0.0624
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0059 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0197 0.1537
Entamoeba histolytica hypothetical protein 0.0195 0.0472 0.3973
Loa Loa (eye worm) hypothetical protein 0.0117 0.0243 0.0243
Trypanosoma brucei protein kinase, putative 0.0425 0.1153 1
Brugia malayi casein kinase I 0.0058 0.0067 0.0067
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0032 0.0102
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0055 0.0059 0.0187
Loa Loa (eye worm) hypothetical protein 0.0099 0.0189 0.0189
Brugia malayi Immunoglobulin I-set domain containing protein 0.0061 0.0075 0.0075
Trypanosoma cruzi casein kinase, putative 0.0058 0.0067 0.0545
Plasmodium falciparum protein kinase, putative 0.0044 0.0025 0.0018
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.054 0.1495 0.4691
Echinococcus granulosus aurora kinase A 0.0386 0.1039 0.3262
Schistosoma mansoni tyrosine kinase 0.0055 0.0059 0.0187
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0328 0.0867 0.2721
Echinococcus granulosus tyrosine protein kinase Blk 0.0055 0.0059 0.0187
Onchocerca volvulus 0.0055 0.0059 0.0187
Echinococcus granulosus cyclin dependent kinase 9 0.0073 0.0111 0.0348
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0425 0.1153 1
Onchocerca volvulus 0.0901 0.2562 0.8043
Echinococcus granulosus geminin 0.0192 0.0463 0.1454
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0059 0.0059
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0204 0.8342
Onchocerca volvulus 0.0055 0.0059 0.0187
Entamoeba histolytica PH domain containing protein kinase, putative 0.0099 0.0189 0.1464
Schistosoma mansoni tyrosine kinase 0.054 0.1495 0.4691
Echinococcus granulosus casein kinase i 0.0058 0.0067 0.0211
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0137 0.0301 0.0944
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0204 0.8342
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0149 0.0336 0.0336
Trichomonas vaginalis CK1 family protein kinase 0.0058 0.0067 0.0389
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0123 0.0259 0.0814
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0059 0.0059
Brugia malayi serine/threonine-protein kinase 6 0.0386 0.1039 0.1039
Giardia lamblia Kinase, CMGC CDK 0.0063 0.0082 0.0323
Echinococcus granulosus activin receptor type 0.0044 0.0025 0.0079
Echinococcus multilocularis cyclin dependent kinase 0.0063 0.0082 0.0256
Echinococcus multilocularis aurora kinase A 0.0386 0.1039 0.3262
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0059 0.0059
Brugia malayi serine/threonine protein kinase 6 0.0386 0.1039 0.1039
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0099 0.0189 0.0592
Echinococcus multilocularis roundabout 2 0.0096 0.018 0.0564
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0425 0.1153 0.362
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0063 0.0082 0.0082
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0055 0.0059 0.0187
Echinococcus multilocularis tyrosine protein kinase shark 0.0055 0.0059 0.0187
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0137 0.0301 0.0944
Echinococcus multilocularis titin 0.0037 0.0004 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.0264 0.0828
Entamoeba histolytica hypothetical protein 0.0102 0.0197 0.1537
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.0472 0.1482
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.1059 0.3029 0.9507
Echinococcus granulosus epidermal growth factor receptor 0.0991 0.2828 0.8877
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0204 0.8342
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.0059 0.0187
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0082 0.0518
Echinococcus multilocularis rho associated protein kinase 0.1112 0.3186 1
Echinococcus granulosus peroxidasin 0.0035 0 0.0001
Echinococcus multilocularis tyrosine protein kinase Blk 0.0055 0.0059 0.0187
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0146 0.0328 0.0328
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0189 0.0592
Brugia malayi Immunoglobulin I-set domain containing protein 0.1004 0.2868 0.2868
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0082 0.0518
Echinococcus granulosus tyrosine protein kinase Srms 0.0055 0.0059 0.0187
Echinococcus multilocularis protein kinase shaggy 0.0425 0.1153 0.362
Schistosoma mansoni protein kinase 0.0093 0.0172 0.0539
Giardia lamblia Kinase, STE STE20 0.0123 0.0259 0.1929
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0195 0.0473 0.1484

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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