Detailed information for compound 1270229

Basic information

Technical information
  • TDR Targets ID: 1270229
  • Name: N-[(2,5-dimethoxyphenyl)methyl]-3-methyl-[1,2 ]oxazolo[4,5-e]pyrimidin-4-amine
  • MW: 300.313 | Formula: C15H16N4O3
  • H donors: 1 H acceptors: 3 LogP: 2.48 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1CNc1ncnc2c1c(C)no2)OC
  • InChi: 1S/C15H16N4O3/c1-9-13-14(17-8-18-15(13)22-19-9)16-7-10-6-11(20-2)4-5-12(10)21-3/h4-6,8H,7H2,1-3H3,(H,16,17,18)
  • InChiKey: HPHWWCGTFRXFSX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(2,5-dimethoxyphenyl)methyl]-3-methyl-isoxazolo[4,5-e]pyrimidin-4-amine
  • N-[(2,5-dimethoxyphenyl)methyl]-3-methyl-4-isoxazolo[4,5-e]pyrimidinamine
  • (2,5-dimethoxybenzyl)-(3-methylisoxazolo[4,5-e]pyrimidin-4-yl)amine
  • E944-0197
  • NCGC00126589-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Onchocerca volvulus 0.0037 0.0198 0.0483
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0198 0.0198
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0198 0.0198
Onchocerca volvulus 0.0037 0.0198 0.0483
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0465 0.4532
Onchocerca volvulus 0.0234 0.2003 0.565
Onchocerca volvulus 0.0234 0.2003 0.565
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0401 0.3524 0.6814
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0465 0.0437
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0198 0.0193
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Echinococcus granulosus Rhodanese 0.0018 0.0029 0.0024
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0198 0.0193
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.1186 0.116
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0234 0.2003 0.198
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0135 0.0129
Loa Loa (eye worm) hypothetical protein 0.0032 0.0154 0.0154
Brugia malayi Thiosulfate sulfurtransferase D2023.5 0.0018 0.0029 0.0008
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Trichomonas vaginalis cdc25c, putative 0.0234 0.2003 0.385
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0198 0.0169
Loa Loa (eye worm) protein-tyrosine phosphatase 0.111 1 1
Onchocerca volvulus 0.003 0.0135 0.0302
Brugia malayi Pre-SET motif family protein 0.003 0.0135 0.0114
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0135 0.0129
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0465 0.0445
Onchocerca volvulus 0.0037 0.0198 0.0483
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0401 0.3524 1
Onchocerca volvulus 0.0037 0.0198 0.0483
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0037 0.0198 0.0169
Leishmania major hypothetical protein, conserved 0.0124 0.0991 1
Trypanosoma cruzi hypothetical protein, conserved 0.0124 0.0991 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0159 0.0159
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0037 0.0198 0.0193
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0401 0.3524 0.351
Echinococcus multilocularis tRNA 2 selenouridine synthase 0.0018 0.0029 0.0024
Loa Loa (eye worm) protein tyrosine phosphatase 0.0037 0.0198 0.0198
Brugia malayi intermediate filament protein 0.0033 0.0159 0.0138
Loa Loa (eye worm) hypothetical protein 0.0216 0.1836 0.1836
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0198 0.0193
Onchocerca volvulus 0.0037 0.0198 0.0483
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0465 0.4532
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0198 0.0193
Echinococcus multilocularis centrosomal protein of 41 kDa 0.0018 0.0029 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0029
Onchocerca volvulus 0.0033 0.0159 0.0373
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0251 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0135 0.0135
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0037 0.0198 0.0169
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0251 0.0433
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.111 1 1
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.1186 0.1167
Onchocerca volvulus 0.0401 0.3524 1
Giardia lamblia Protein tyrosine phosphatase 0.0037 0.0198 0.0483
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0198 0.0198
Chlamydia trachomatis hypothetical protein 0.0018 0.0029 0.5
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0401 0.3524 0.6814
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0037 0.0198 0.0329
Brugia malayi MoeZ/MoeB domain containing protein 0.0018 0.0029 0.0008
Brugia malayi hypothetical protein 0.0037 0.0198 0.0177
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Brugia malayi hypothetical protein 0.0037 0.0198 0.0177
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0401 0.3524 0.6814
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0401 0.3524 0.6814
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0198 0.0198
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0198 0.0198
Brugia malayi Protein-tyrosine phosphatase 0.0037 0.0198 0.0177
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0198 0.0169
Echinococcus multilocularis hypothetical protein 0.0037 0.0198 0.0193
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0219 0.037
Mycobacterium leprae Probable thiosulfate sulfurtransferase SseA (RHODANESE) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE) 0.0018 0.0029 0.5
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0037 0.0198 0.0193
Brugia malayi hypothetical protein 0.0037 0.0198 0.0177
Brugia malayi Rhodanese-like domain containing protein 0.0234 0.2003 0.1986
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0198 0.0193
Echinococcus granulosus centrosomal protein of 41 kDa 0.0018 0.0029 0.0024
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0037 0.0198 0.0169
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Onchocerca volvulus 0.0037 0.0198 0.0483
Onchocerca volvulus 0.0037 0.0198 0.0483
Onchocerca volvulus 0.0037 0.0198 0.0483
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0277 0.2395 1
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0234 0.2003 0.385
Brugia malayi hypothetical protein 0.0037 0.0198 0.0177
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0198 0.0193
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0198 0.0193
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0037 0.0198 0.0169
Onchocerca volvulus 0.0037 0.0198 0.0483
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0198 0.0193
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0251 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0198 0.0198
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0234 0.2003 0.1999
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0465 0.0465
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0037 0.0198 0.0169
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0198 0.0193
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0037 0.0198 0.0169
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Trichomonas vaginalis set domain proteins, putative 0.0237 0.2026 0.3893
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0465 0.4532
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0198 0.0198
Echinococcus multilocularis Rhodanese 0.0018 0.0029 0.0024
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Echinococcus granulosus protein tyrosine phosphatase n9 0.0037 0.0198 0.0193
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0198 0.0193
Brugia malayi Protein-tyrosine phosphatase 1 0.0037 0.0198 0.0177
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0037 0.0198 0.1756
Onchocerca volvulus 0.0037 0.0198 0.0483
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0198 0.0169
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0198 0.0198
Schistosoma mansoni dual specificity protein phosphatase 0.0021 0.0055 0.0026
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0037 0.0198 0.0177
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0198 0.0169
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0135 0.0106
Echinococcus granulosus lamin 0.0033 0.0159 0.0154
Echinococcus multilocularis lamin dm0 0.0033 0.0159 0.0154
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0198 0.0193
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0234 0.2003 0.2003
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0401 0.3524 0.6814
Onchocerca volvulus 0.0037 0.0198 0.0483
Loa Loa (eye worm) hypothetical protein 0.0234 0.2003 0.2003
Mycobacterium leprae PROBABLE THIOSULFATE SULFURTRANSFERASE CYSA2 (RHODANESE-LIKE PROTEIN) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRAN 0.0018 0.0029 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Onchocerca volvulus 0.0037 0.0198 0.0483
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0198 0.0169
Onchocerca volvulus 0.0037 0.0198 0.0483
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0219 0.0543
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0198 0.0193
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0198 0.0193
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.111 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.1763 0.1763
Trypanosoma brucei protein tyrosine phosphatase 1 0.0037 0.0198 0.1756
Brugia malayi Pre-SET motif family protein 0.0208 0.1763 0.1746
Echinococcus granulosus lamin dm0 0.0033 0.0159 0.0154
Onchocerca volvulus 0.0037 0.0198 0.0483
Entamoeba histolytica rodhanase-like domain containing protein 0.0234 0.2003 0.385
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0135 0.4747
Onchocerca volvulus 0.0037 0.0198 0.0483
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0198 0.0193
Brugia malayi Protein-tyrosine phosphatase 0.0037 0.0198 0.0177
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0005
Onchocerca volvulus 4.1 G protein, putative homolog 0.0037 0.0198 0.0483
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0198 0.0193
Echinococcus multilocularis lamin 0.0033 0.0159 0.0154
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0198 0.0193
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0037 0.0198 0.0198
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0465 0.4532
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0124 0.0991 0.1875
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0198 0.0193
Onchocerca volvulus 0.0037 0.0198 0.0483
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Trichomonas vaginalis cdc25b, putative 0.0234 0.2003 0.385
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0037 0.0198 0.0198
Wolbachia endosymbiont of Brugia malayi sulfurtransferase 0.0018 0.0029 0.5
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0037 0.0198 0.0193
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0037 0.0198 0.0193
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0037 0.0198 0.0193
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0198 0.0193
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0037 0.0198 0.0329
Entamoeba histolytica rodhanase-like domain containing protein 0.0234 0.2003 0.385
Echinococcus multilocularis musashi 0.0033 0.0159 0.0154
Schistosoma mansoni lamin 0.0033 0.0159 0.0131
Echinococcus multilocularis 0.0037 0.0198 0.0193
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0211 0.0206
Entamoeba histolytica dual specificity protein phosphatase, putative 0.058 0.5158 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0198 0.0169
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0029
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0401 0.3524 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0029
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0037 0.0198 0.0169
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0037 0.0198 0.0169
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0198 0.0193
Loa Loa (eye worm) thiosulfate sulfurtransferase 0.0018 0.0029 0.0029
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Leishmania major tyrosine specific protein phosphatase, putative 0.0037 0.0198 0.1756
Onchocerca volvulus 0.0037 0.0198 0.0483
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0021 0.0021
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0198 0.0193
Schistosoma mansoni lamin 0.0033 0.0159 0.0131
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0037 0.0198 0.0198
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0037 0.0198 0.0193
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Schistosoma mansoni intermediate filament proteins 0.0033 0.0159 0.0131
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0198 0.0193
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.1149 0.1144
Onchocerca volvulus 0.0234 0.2003 0.565
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0401 0.3524 0.3524
Onchocerca volvulus 0.0037 0.0198 0.0483
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0135 0.0129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0135 0.0106
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0251 0.0433
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0219 1
Brugia malayi Rhodanese-like domain containing protein 0.0018 0.0029 0.0008
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0198 0.0193
Trichomonas vaginalis pten, drome, putative 0.0037 0.0198 0.0329
Trichomonas vaginalis cdc25b, putative 0.0234 0.2003 0.385
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0251 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0037 0.0198 0.0198
Onchocerca volvulus 0.0234 0.2003 0.565
Onchocerca volvulus 0.0037 0.0198 0.0483
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0037 0.0198 0.0193
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0029
Echinococcus granulosus 5'partial|tRNA 2 selenouridine synthase 0.0018 0.0029 0.0024
Brugia malayi RIKEN cDNA 4930451A13 0.0018 0.0029 0.0008
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0198 0.0198
Brugia malayi Rhodanese-like domain containing protein 0.0234 0.2003 0.1986
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0037 0.0198 0.0177
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0037 0.0198 0.0193
Brugia malayi Rhodanese-like domain containing protein 0.0018 0.0029 0.0008
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.1186 0.1181
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0198 0.0193
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0198 0.0193
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0198 0.0169
Brugia malayi hypothetical protein 0.0037 0.0198 0.0177
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0198 0.0198
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0124 0.0991 1
Echinococcus granulosus intermediate filament protein 0.0033 0.0159 0.0154
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0198 0.0198
Loa Loa (eye worm) acetyltransferase 0.0145 0.1186 0.1186
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0234 0.2003 0.385
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0159 0.0138
Loa Loa (eye worm) hypothetical protein 0.0216 0.1836 0.1836
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0037 0.0198 0.1756
Loa Loa (eye worm) hypothetical protein 0.0033 0.0159 0.0159
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0159 0.0159
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0037 0.0198 0.1756
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0465 0.085
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0198 0.0193
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0211 0.0206
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0401 0.3524 0.6814
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0198 0.0193
Plasmodium vivax SET domain protein, putative 0.003 0.0135 0.4747
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0234 0.2003 0.1999
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0135 0.0106
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0037 0.0198 0.0193
Entamoeba histolytica rodhanase-like domain containing protein 0.0234 0.2003 0.385
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0251 0.0246
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0198 0.0198
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0037 0.0198 0.0193
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0465 0.046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0029
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0401 0.3524 0.6814
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Trypanosoma cruzi hypothetical protein, conserved 0.0124 0.0991 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0037 0.0198 0.0193
Schistosoma mansoni pcd6 interacting protein-related 0.0037 0.0198 0.0169
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0234 0.2003 0.385
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0198 0.0177
Onchocerca volvulus 0.0037 0.0198 0.0483
Onchocerca volvulus 0.0037 0.0198 0.0483
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0125 0.0119
Onchocerca volvulus 0.0237 0.2026 0.5714
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0198 0.0169
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0465 0.046
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0029 0.5
Onchocerca volvulus 0.0033 0.0159 0.0373
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0198 0.0198
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0037 0.0198 0.0169
Mycobacterium leprae PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE) 0.0018 0.0029 0.5
Echinococcus granulosus heat shock protein 67b2 0.0018 0.0029 0.0024
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0234 0.2003 0.385
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0401 0.3524 0.6814
Onchocerca volvulus 0.0037 0.0198 0.0483
Onchocerca volvulus 0.0037 0.0198 0.0483
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.111 1 1
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0037 0.0198 0.1756
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.058 0.5158 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0037 0.0198 0.0329
Echinococcus multilocularis heat shock protein 67b2 0.0018 0.0029 0.0024
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0234 0.2003 0.385
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0135 0.0106
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0198
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0198 0.0193
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0124 0.0991 0.1875

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0079 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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