Detailed information for compound 1272536

Basic information

Technical information
  • TDR Targets ID: 1272536
  • Name: 3-[3-[(4-bromophenyl)sulfamoyl]phenyl]-1-(2-m orpholin-4-ylethyl)thiourea
  • MW: 499.445 | Formula: C19H23BrN4O3S2
  • H donors: 3 H acceptors: 2 LogP: 2.41 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(Nc1cccc(c1)S(=O)(=O)Nc1ccc(cc1)Br)NCCN1CCOCC1
  • InChi: 1S/C19H23BrN4O3S2/c20-15-4-6-16(7-5-15)23-29(25,26)18-3-1-2-17(14-18)22-19(28)21-8-9-24-10-12-27-13-11-24/h1-7,14,23H,8-13H2,(H2,21,22,28)
  • InChiKey: QUMWLIWTPWCOOQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[3-[(4-bromophenyl)sulfamoyl]phenyl]-1-(2-morpholinoethyl)thiourea
  • T5348895

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.006 0.1764 0.202
Schistosoma mansoni cpg binding protein 0.0035 0.0831 0.1455
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0043 0.112 0.4205
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0392 0.069
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3747 0.3492
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0007
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0392 0.5
Schistosoma mansoni cpg binding protein 0.0039 0.0988 0.1731
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0027 0.0547 0.0964
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0392 0.5
Schistosoma mansoni bromodomain containing protein 0.0078 0.2412 0.4241
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.1137 0.2003
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0043 0.112 0.1972
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0392 0.069
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0006 0.001
Echinococcus multilocularis GPCR, family 2 0.0019 0.0257 0.0453
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0392 0.0459
Brugia malayi Sodium:solute symporter family protein 0.0043 0.112 0.1276
Loa Loa (eye worm) hypothetical protein 0.0053 0.1505 0.1723
Loa Loa (eye worm) hypothetical protein 0.0046 0.1245 0.1425
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.1648 0.2901
Schistosoma mansoni hypothetical protein 0.0019 0.0257 0.0443
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0307 0.0541
Echinococcus granulosus sodium:glucose cotransporter 0.0167 0.568 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0006 0.001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0006 0.0007
Schistosoma mansoni hypothetical protein 0.0019 0.0257 0.0443
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.1648 0.2894
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0006 0.001
Trichomonas vaginalis set domain proteins, putative 0.0284 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1769 0.2025
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0043 0.112 0.1972
Trypanosoma brucei polo-like protein kinase 0.0114 0.3747 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3747 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0257 0.0294
Plasmodium falciparum ataxin-2 like protein, putative 0.006 0.1764 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.112 0.1282
Giardia lamblia Kinase, PLK 0.0114 0.3747 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.112 0.1282
Trypanosoma cruzi PAB1-binding protein , putative 0.006 0.1764 0.4362
Leishmania major hypothetical protein, conserved 0.006 0.1764 0.4362
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0006 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0006 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3747 0.3492
Loa Loa (eye worm) hypothetical protein 0.0019 0.0257 0.0294
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0167 0.568 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.3747 0.6598
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3747 0.3492
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0006 0.0007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0006 0.001
Brugia malayi Pre-SET motif family protein 0.0036 0.0898 0.1022
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.3747 0.4286
Loa Loa (eye worm) hypothetical protein 0.0041 0.1069 0.1224
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1769 0.2019
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0257 0.0453
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0006 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0392 0.0459
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0334 0.0383
Brugia malayi hypothetical protein 0.006 0.1764 0.2014
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0006 0.001
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0006 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3747 0.3492
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0831 0.0952
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0257 0.0453
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0392 0.0459
Echinococcus granulosus sodium:myo inositol cotransporter 0.0167 0.568 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0621 0.1085
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.3747 0.429
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0007
Schistosoma mansoni inositol transporter 0.0167 0.568 1
Brugia malayi Pre-SET motif family protein 0.025 0.8736 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0007
Echinococcus granulosus solute carrier family 5 0.0167 0.568 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.1349 0.1544
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0392 0.5
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0006 0.001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0006 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1632 0.129
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.3747 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0006 0.0007
Brugia malayi hypothetical protein 0.0039 0.0982 0.1118
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.025 0.8736 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0898 0.1572
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.2308 0.4057
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.3747 0.3744
Toxoplasma gondii LsmAD domain-containing protein 0.006 0.1764 0.7926
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0167 0.568 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.2255 0.397
Plasmodium vivax ataxin-2 like protein, putative 0.006 0.1764 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0898 0.1581
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0621 0.1094
Brugia malayi Bromodomain containing protein 0.0046 0.1241 0.1415
Brugia malayi GH02984p 0.0043 0.112 0.1276
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0006 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.1648 0.2894
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0465 0.0532
Schistosoma mansoni hypothetical protein 0.0018 0.023 0.0395
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0007
Schistosoma mansoni hypothetical protein 0.0041 0.1069 0.1874
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0898 0.2923
Echinococcus granulosus sodium:glucose cotransporter 2 0.0167 0.568 1
Plasmodium vivax SET domain protein, putative 0.0036 0.0898 0.3688
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1632 0.129
Brugia malayi Bromodomain containing protein 0.0092 0.2928 0.3347
Schistosoma mansoni ap endonuclease 0.0023 0.0392 0.068
Brugia malayi CXXC zinc finger family protein 0.0035 0.0831 0.0946
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.3747 0.6598
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3747 0.3492
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0822 0.1447
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0307 0.0531
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3747 0.3492
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0307 0.0531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0006 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0006 0.0007
Onchocerca volvulus 0.0035 0.0831 0.0826
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1769 0.2025
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0392 0.0442
Echinococcus granulosus cpg binding protein 0.0039 0.0988 0.174
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0006 0.001
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0392 0.5
Echinococcus granulosus GPCR family 2 0.0019 0.0257 0.0453
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.2123 1
Echinococcus granulosus zinc finger protein 0.0025 0.0491 0.0864
Echinococcus multilocularis cpg binding protein 0.0039 0.0988 0.174
Schistosoma mansoni kinase 0.0058 0.1687 0.2963
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0007
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3747 1
Echinococcus multilocularis high affinity choline transporter 1 0.0043 0.112 0.1972
Schistosoma mansoni ap endonuclease 0.0023 0.0392 0.068
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0257 0.0288
Echinococcus multilocularis solute carrier family 5 0.0167 0.568 1
Schistosoma mansoni hypothetical protein 0.0027 0.0547 0.0954
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0392 0.0459
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0006 0.001
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1069 0.1218
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0027 0.0547 0.0964
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0898 0.1572
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0006 0.001
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0006 0.001
Schistosoma mansoni sodium/solute symporter 0.0043 0.112 0.1963
Plasmodium falciparum ataxin-2 like protein, putative 0.006 0.1764 1
Schistosoma mansoni hypothetical protein 0.0019 0.0257 0.0443
Loa Loa (eye worm) hypothetical protein 0.0085 0.2667 0.3053
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0006 0.001
Schistosoma mansoni cpg binding protein 0.0039 0.0988 0.1731
Schistosoma mansoni hypothetical protein 0.0019 0.0257 0.0443
Echinococcus multilocularis zinc finger protein 0.0025 0.0491 0.0864
Loa Loa (eye worm) hypothetical protein 0.0057 0.1648 0.1886
Echinococcus granulosus high affinity choline transporter 1 0.0043 0.112 0.1972
Trypanosoma cruzi PAB1-binding protein , putative 0.006 0.1764 0.4362
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.3747 1
Brugia malayi PHD-finger family protein 0.0032 0.0725 0.0824
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0621 0.1094
Schistosoma mansoni inositol transporter 0.0167 0.568 1
Trypanosoma brucei PAB1-binding protein , putative 0.006 0.1764 0.4362
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0007
Schistosoma mansoni zinc finger protein 0.0018 0.023 0.0395
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1769 0.2019
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0392 0.0448
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.3747 0.6594
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0257 0.0453
Schistosoma mansoni zinc finger protein 0.0025 0.0491 0.0855
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3747 0.3492
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0006 0.0007
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0079 0.0084
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.1648 0.2901
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0006 0.001
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.1137 0.2003
Schistosoma mansoni high-affinity choline transporter 0.0043 0.112 0.1963
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0257 0.0288
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0307 0.0541
Onchocerca volvulus 0.0043 0.112 0.1115
Schistosoma mansoni hypothetical protein 0.0025 0.0465 0.0809
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0257 0.0453
Onchocerca volvulus 0.0036 0.0898 0.0893
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0006 0.001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.2255 0.397

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3769 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.8876 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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