Detailed information for compound 1276544

Basic information

Technical information
  • TDR Targets ID: 1276544
  • Name: 1-[4-(4-fluorophenyl)piperazin-1-yl]-3-(1H-in dol-3-yl)propan-1-one
  • MW: 351.417 | Formula: C21H22FN3O
  • H donors: 1 H acceptors: 1 LogP: 3.43 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)N1CCN(CC1)C(=O)CCc1c[nH]c2c1cccc2
  • InChi: 1S/C21H22FN3O/c22-17-6-8-18(9-7-17)24-11-13-25(14-12-24)21(26)10-5-16-15-23-20-4-2-1-3-19(16)20/h1-4,6-9,15,23H,5,10-14H2
  • InChiKey: WRMUAGLPXKOFDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[4-(4-fluorophenyl)-1-piperazinyl]-3-(1H-indol-3-yl)propan-1-one
  • SMR000343242
  • STOCK6S-21922
  • MLS000517055
  • ZINC03333446

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CCG1-interacting factor B 0.0046 0.0487 0.0487
Mycobacterium tuberculosis Unknown protein 0.0046 0.0487 0.101
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0447 0.0409
Mycobacterium leprae PROBABLE LIPASE/ESTERASE LIPG 0.0046 0.0487 1
Echinococcus multilocularis protein phosphatase methylesterase 1 0.0554 0.9213 0.921
Giardia lamblia Protein phosphatase methylesterase-1 0.06 1 1
Mycobacterium ulcerans oxidoreductase 0.0046 0.0487 1
Mycobacterium ulcerans hypothetical protein 0.0046 0.0487 1
Mycobacterium tuberculosis Conserved protein 0.0046 0.0487 0.101
Schistosoma mansoni intermediate filament proteins 0.0033 0.026 0.0221
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.026 0.026
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0046 0.0487 0.0449
Schistosoma mansoni protein phosphatase methylesterase 1 (S33 family) 0.06 1 1
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0046 0.0487 0.101
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0447 0.0919
Mycobacterium tuberculosis Probable epoxide hydrolase EphC (epoxide hydratase) 0.0046 0.0487 0.101
Echinococcus granulosus abhydrolase domain containing protein 8 0.0046 0.0487 0.0449
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0447 0.0919
Echinococcus granulosus lamin 0.0033 0.026 0.0221
Mycobacterium ulcerans hydrolase 0.0046 0.0487 1
Echinococcus multilocularis lamin dm0 0.0033 0.026 0.0221
Loa Loa (eye worm) intermediate filament protein 0.0033 0.026 0.026
Brugia malayi beta-lactamase family protein 0.0043 0.0447 0.0447
Mycobacterium ulcerans hydrolase 0.0046 0.0487 1
Brugia malayi intermediate filament protein 0.0033 0.026 0.026
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0447 0.0919
Brugia malayi beta-lactamase 0.0043 0.0447 0.0447
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0046 0.0487 1
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0046 0.0487 0.0449
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0447 0.0409
Onchocerca volvulus Putative protein phosphatase methylesterase 1 0.06 1 1
Giardia lamblia ENC6 protein 0.0046 0.0487 0.0449
Mycobacterium ulcerans hypothetical protein 0.0046 0.0487 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0447 0.0409
Onchocerca volvulus 0.0046 0.0487 0.0234
Mycobacterium ulcerans lipase LipV 0.0046 0.0487 1
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0046 0.0487 0.0449
Mycobacterium ulcerans hypothetical protein 0.0046 0.0487 1
Trypanosoma brucei Ankyrin repeats (many copies)/Alpha/beta hydrolase family, putative 0.0046 0.0487 0.0449
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0447 0.0919
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0487 0.0449
Mycobacterium ulcerans hydrolase 0.0046 0.0487 1
Echinococcus multilocularis protein phosphatase methylesterase 1 0.06 1 1
Mycobacterium leprae conserved hypothetical protein 0.0046 0.0487 1
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0046 0.0487 0.101
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0447 0.9102
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.004 0.5
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.004 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.4469 1
Onchocerca volvulus 0.0043 0.0447 0.0192
Mycobacterium tuberculosis Possible hydrolase 0.0046 0.0487 0.101
Toxoplasma gondii hypothetical protein 0.0046 0.0487 0.0449
Echinococcus multilocularis maspardin 0.0046 0.0487 0.0449
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0046 0.0487 0.0449
Mycobacterium tuberculosis Conserved protein 0.0043 0.0447 0.0919
Mycobacterium tuberculosis Conserved hypothetical protein 0.0046 0.0487 0.101
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0046 0.0487 0.0449
Echinococcus granulosus protein phosphatase methylesterase 1 0.0554 0.9213 0.921
Mycobacterium tuberculosis Possible lipase LipV 0.0046 0.0487 0.101
Mycobacterium tuberculosis Conserved protein 0.0043 0.0447 0.0919
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1014 0.0978
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.06 1 1
Leishmania major hypothetical protein, conserved 0.0046 0.0487 0.0449
Mycobacterium tuberculosis Probable epoxide hydrolase MesT (epoxide hydratase) (arene-oxide hydratase) 0.0046 0.0487 0.101
Onchocerca volvulus Alpha\/beta hydrolase2 homolog 0.0046 0.0487 0.0234
Echinococcus granulosus maspardin 0.0046 0.0487 0.0449
Mycobacterium leprae Possible membrane protein 0.0046 0.0487 1
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0447 0.0919
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0447 0.0409
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0046 0.0487 0.0449
Onchocerca volvulus 0.0043 0.0447 0.0192
Loa Loa (eye worm) beta-lactamase 0.0043 0.0447 0.0447
Mycobacterium tuberculosis Conserved protein 0.0043 0.0447 0.0919
Schistosoma mansoni lamin 0.0033 0.026 0.0221
Mycobacterium tuberculosis Possible lysophospholipase 0.0046 0.0487 0.101
Mycobacterium leprae POSSIBLE HYDROLASE 0.0046 0.0487 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.004 0.004
Echinococcus granulosus intermediate filament protein 0.0033 0.026 0.0221
Mycobacterium ulcerans hydrolase 0.0046 0.0487 1
Onchocerca volvulus 0.0046 0.0487 0.0234
Mycobacterium tuberculosis Possible hydrolase 0.0046 0.0487 0.101
Schistosoma mansoni lamin 0.0033 0.026 0.0221
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0447 0.0409
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1014 0.1014
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0447 0.0409
Mycobacterium tuberculosis Conserved hypothetical protein 0.0046 0.0487 0.101
Mycobacterium tuberculosis Probable oxidoreductase 0.0046 0.0487 0.101
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1014 0.0978
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0447 0.0409
Echinococcus multilocularis abhydrolase domain containing protein 8 0.0046 0.0487 0.0449
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0447 0.0409
Mycobacterium ulcerans lysophospholipase 0.0046 0.0487 1
Giardia lamblia Hypothetical protein 0.0046 0.0487 0.0449
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1014 0.0978
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1014 0.0978
Echinococcus multilocularis abhydrolase domain containing protein 13 0.0046 0.0487 0.0449
Mycobacterium ulcerans hypothetical protein 0.0046 0.0487 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0447 0.0447
Mycobacterium tuberculosis Unknown protein 0.0046 0.0487 0.101
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0447 0.0409
Brugia malayi beta-lactamase family protein 0.0043 0.0447 0.0447
Loa Loa (eye worm) RNA binding protein 0.0076 0.1014 0.1014
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.004 0.004
Mycobacterium ulcerans epoxide hydrolase EphC 0.0046 0.0487 1
Echinococcus multilocularis musashi 0.0033 0.026 0.0221
Leishmania major hypothetical protein, conserved 0.0046 0.0487 0.0449
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0447 0.0919
Brugia malayi RNA binding protein 0.0076 0.1014 0.1014
Loa Loa (eye worm) hypothetical protein 0.0033 0.026 0.026
Toxoplasma gondii ABC1 family protein 0.0043 0.0447 0.0409
Mycobacterium ulcerans hypothetical protein 0.0046 0.0487 1
Onchocerca volvulus Valacyclovir hydrolase homolog 0.0046 0.0487 0.0234
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0447 0.0409
Treponema pallidum carboxylesterase (est) 0.0046 0.0487 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0447 0.0447
Toxoplasma gondii hypothetical protein 0.0046 0.0487 0.0449
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1014 0.1014
Leishmania major hypothetical protein, conserved 0.0046 0.0487 0.0449
Loa Loa (eye worm) hypothetical protein 0.0043 0.0447 0.0447
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.026 0.026
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0046 0.0487 0.0449
Mycobacterium tuberculosis Probable proline iminopeptidase Pip (prolyl aminopeptidase) (pap) 0.0046 0.0487 0.101
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0447 1
Mycobacterium ulcerans thioesterase 0.0046 0.0487 1
Mycobacterium tuberculosis Probable lignin peroxidase LipJ 0.0046 0.0487 0.101
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0046 0.0487 0.0449
Mycobacterium ulcerans lipase LipD 0.0043 0.0447 0.9102
Mycobacterium tuberculosis Conserved hypothetical alanine rich protein 0.0046 0.0487 0.101
Mycobacterium tuberculosis Conserved protein 0.0046 0.0487 0.101
Brugia malayi TAR-binding protein 0.0076 0.1014 0.1014
Toxoplasma gondii chain a, pp2a-specific methylesterase apo form (pme), putative 0.06 1 1
Mycobacterium leprae Possible hydrolase 0.0046 0.0487 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0249 0.0249
Giardia lamblia Hypothetical protein 0.0046 0.0487 0.0449
Leishmania major hypothetical protein, conserved 0.0043 0.0447 0.0409
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0487 0.0449
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1014 0.0978
Loa Loa (eye worm) hypothetical protein 0.0043 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0043 0.0447 0.0447
Mycobacterium tuberculosis Unknown protein 0.0046 0.0487 0.101
Onchocerca volvulus 0.0043 0.0447 0.0192
Trichomonas vaginalis esterase, putative 0.0043 0.0447 0.0409
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0447 0.9102
Mycobacterium tuberculosis Conserved hypothetical protein 0.0046 0.0487 0.101
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.06 1 1
Echinococcus granulosus lamin dm0 0.0033 0.026 0.0221
Mycobacterium ulcerans beta-lactamase 0.0043 0.0447 0.9102
Brugia malayi hydrolase, alpha/beta fold family protein 0.0046 0.0487 0.0487
Loa Loa (eye worm) hypothetical protein 0.0043 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0043 0.0447 0.0447
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0447 0.0919
Echinococcus granulosus protein phosphatase methylesterase 1 0.06 1 1
Mycobacterium tuberculosis Probable epoxide hydrolase EphB (epoxide hydratase) 0.0046 0.0487 0.101
Leishmania major hypothetical protein, conserved 0.06 1 1
Loa Loa (eye worm) protein phosphatase methylesterase 1 0.06 1 1
Mycobacterium tuberculosis Probable hydrolase 0.0046 0.0487 0.101
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.06 1 1
Echinococcus multilocularis lamin 0.0033 0.026 0.0221
Mycobacterium tuberculosis Possible hydrolase 0.0046 0.0487 0.101
Giardia lamblia Hypothetical protein 0.0046 0.0487 0.0449
Mycobacterium ulcerans hydrolase 0.0046 0.0487 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0447 0.0447
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0447 0.0409
Mycobacterium tuberculosis Probable lipase/esterase LipG 0.0046 0.0487 0.101
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1014 0.1014
Brugia malayi CCG1-interacting factor B 0.0046 0.0487 0.0487
Mycobacterium ulcerans hydrolase 0.0046 0.0487 1
Mycobacterium ulcerans hypothetical protein 0.0043 0.0447 0.9102
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1014 0.0978
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0046 0.0487 0.0449
Toxoplasma gondii hypothetical protein 0.0046 0.0487 0.0449
Echinococcus granulosus tar DNA binding protein 0.0076 0.1014 0.0978
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0447 0.0409
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.004 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.