Detailed information for compound 1279390

Basic information

Technical information
  • TDR Targets ID: 1279390
  • Name: ethyl 2-[4-chloro-2-methoxy-6-(4-oxo-3-phenyl -1,2-dihydroquinazolin-2-yl)phenoxy]acetate
  • MW: 466.914 | Formula: C25H23ClN2O5
  • H donors: 1 H acceptors: 2 LogP: 5.18 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)COc1c(OC)cc(cc1C1Nc2ccccc2C(=O)N1c1ccccc1)Cl
  • InChi: 1S/C25H23ClN2O5/c1-3-32-22(29)15-33-23-19(13-16(26)14-21(23)31-2)24-27-20-12-8-7-11-18(20)25(30)28(24)17-9-5-4-6-10-17/h4-14,24,27H,3,15H2,1-2H3
  • InChiKey: CVKVEIXLKAHZSW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[4-chloro-2-methoxy-6-(4-oxo-3-phenyl-1,2-dihydroquinazolin-2-yl)phenoxy]acetic acid ethyl ester
  • 2-[4-chloro-2-(4-keto-3-phenyl-1,2-dihydroquinazolin-2-yl)-6-methoxy-phenoxy]acetic acid ethyl ester
  • ethyl 2-[4-chloro-2-methoxy-6-(4-oxo-3-phenyl-1,2-dihydroquinazolin-2-yl)phenoxy]ethanoate
  • SMR000160727
  • ethyl [4-chloro-2-methoxy-6-(4-oxo-3-phenyl-1,2,3,4-tetrahydro-2-quinazolinyl)phenoxy]acetate
  • AN-465/42244602
  • MLS000539224

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.004 0.004
Loa Loa (eye worm) cyclin domain-containing protein 0.0478 0.1613 0.6877
Echinococcus granulosus cyclin dependent kinase 1 0.0085 0.0187 0.0187
Entamoeba histolytica cyclin, putative 0.0069 0.013 0.0521
Trypanosoma cruzi cdc2-related kinase 1 0.0085 0.0187 0.0387
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0109 0.0274 0.0274
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.032 0.104 0.2702
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0473 0.1596 0.4086
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.101 0.4207
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0095 0.0222 0.0946
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0247 0.0776 0.0776
Trypanosoma brucei cdc2-related kinase 1 0.0085 0.0187 0.0798
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0109 0.0274 0.0274
Schistosoma mansoni hypothetical protein 0.0042 0.003 0.0079
Entamoeba histolytica cyclin family protein 0.0069 0.013 0.0521
Trypanosoma brucei cdc2-related kinase 3 0.0085 0.0187 0.0798
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0473 0.1596 0.4147
Brugia malayi Protein kinase domain containing protein 0.0085 0.0187 0.0486
Loa Loa (eye worm) hypothetical protein 0.0083 0.0181 0.077
Leishmania major hypothetical protein, unknown function 0.0109 0.0274 0.0636
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0078 0.0204
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0096 0.025
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0109 0.0274 0.1279
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0568 0.1938 0.4985
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1094 0.3848 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0109 0.0274 0.1279
Entamoeba histolytica hypothetical protein 0.0109 0.0274 0.1279
Onchocerca volvulus 0.0109 0.0274 0.2945
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0109 0.0274 1
Echinococcus granulosus cyclins 0.0069 0.013 0.013
Loa Loa (eye worm) phosphatidylinositol 3 0.0109 0.0274 0.1169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0109 0.0274 1
Echinococcus multilocularis cyclin B3 1 0.0069 0.013 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.0274 0.1016
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0262 0.083 0.2075
Echinococcus multilocularis cyclins 0.0069 0.013 0.013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0473 0.1596 0.4147
Trichomonas vaginalis PIKK family atypical protein kinase 0.032 0.104 0.4337
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0568 0.1938 0.5037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Trichomonas vaginalis cyclins, putative 0.0069 0.013 0.0389
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0109 0.0274 0.0615
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.004 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.0274 0.1016
Trichomonas vaginalis PIKK family atypical protein kinase 0.032 0.104 0.4337
Echinococcus granulosus cyclin b3 0.0069 0.013 0.013
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0109 0.0274 0.0274
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0109 0.0274 0.0615
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0109 0.0274 0.0615
Plasmodium falciparum protein kinase 5 0.0085 0.0187 0.6825
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.101 0.4207
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0095 0.0222 0.1145
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0621 0.2519
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.101 0.4306
Giardia lamblia GTOR 0.0568 0.1938 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0357 0.1173 0.605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Giardia lamblia Kinase, CMGC GSK 0.0095 0.0222 0.0959
Brugia malayi Cyclin, N-terminal domain containing protein 0.0069 0.013 0.0337
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0109 0.0274 0.0713
Echinococcus granulosus cyclins 0.0069 0.013 0.013
Leishmania major phosphatidylinositol 4-kinase, putative 0.0109 0.0274 0.0636
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.0274 0.1016
Loa Loa (eye worm) hypothetical protein 0.0112 0.0285 0.1216
Loa Loa (eye worm) phosphatidylinositol 3 0.0109 0.0274 0.1169
Schistosoma mansoni hypothetical protein 0.0247 0.0776 0.2017
Trichomonas vaginalis PIKK family atypical protein kinase 0.032 0.104 0.4337
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0109 0.0274 0.0615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.003 0.003
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0109 0.0274 0.1016
Loa Loa (eye worm) hypothetical protein 0.032 0.104 0.4433
Trichomonas vaginalis PIKK family atypical protein kinase 0.032 0.104 0.4337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.004 0.0104
Loa Loa (eye worm) hypothetical protein 0.0045 0.004 0.017
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.101 0.2624
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0187 0.0486
Giardia lamblia Hypothetical protein 0.0069 0.013 0.0472
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0109 0.0274 0.1016
Loa Loa (eye worm) phosphatidylinositol 3 0.0109 0.0274 0.1169
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0621 0.2519
Echinococcus multilocularis cyclin dependent kinase 5 0.0085 0.0187 0.0187
Plasmodium falciparum glycogen synthase kinase 3 0.0095 0.0222 0.8094
Brugia malayi RNA, U transporter 1 0.0096 0.0225 0.0585
Entamoeba histolytica hypothetical protein 0.0473 0.1596 0.8206
Echinococcus multilocularis cyclins 0.0069 0.013 0.013
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.003 0.003
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0085 0.0187 0.0798
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0096 0.0411
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0568 0.1938 0.8263
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0568 0.1938 0.8263
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0109 0.0274 0.0713
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0364 0.1199 0.3045
Entamoeba histolytica protein kinase, putative 0.0095 0.0222 0.1005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0432 0.1447 0.6104
Loa Loa (eye worm) phosphatidylinositol 3 0.0109 0.0274 0.1169
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0078 0.0078
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1094 0.3848 1
Echinococcus granulosus snurportin 1 0.0359 0.1182 0.1182
Trypanosoma brucei mitotic cyclin 6 0.0069 0.013 0.0553
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0109 0.0274 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0568 0.1938 0.4985
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0109 0.0274 0.1016
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0085 0.0187 0.04
Schistosoma mansoni cyclin B3 0.0069 0.013 0.0337
Loa Loa (eye worm) hypothetical protein 0.0041 0.0027 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.032 0.104 0.4337
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.004 0.004
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.004 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Entamoeba histolytica hypothetical protein 0.0109 0.0274 0.1279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Echinococcus granulosus cyclins 0.0069 0.013 0.013
Trypanosoma cruzi cyclin, putative 0.0069 0.013 0.0235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0109 0.0274 0.1279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0357 0.1173 0.4912
Trypanosoma cruzi cyclin, putative 0.0069 0.013 0.0235
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0109 0.0274 0.1234
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0109 0.0274 0.1279
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0568 0.1938 0.1938
Trichomonas vaginalis cyclin B, putative 0.0069 0.013 0.0389
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0473 0.1596 0.6803
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.032 0.104 0.104
Trichomonas vaginalis cyclin D, putative 0.0069 0.013 0.0389
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0109 0.0274 0.1169
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0095 0.0222 0.0478
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0109 0.0274 0.1169
Trypanosoma cruzi CYC2-like cyclin, putative 0.0069 0.013 0.0235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Trypanosoma cruzi cyclin 6, putative 0.0069 0.013 0.0235
Trypanosoma cruzi hypothetical protein, conserved 0.095 0.3326 0.8628
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0109 0.0274 0.0274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0078 0.0204
Trichomonas vaginalis cyclin B, putative 0.0069 0.013 0.0389
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.004 0.0051
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0069 0.013 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.013 0.0389
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0661 0.2692
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0109 0.0274 0.1016
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0621 0.2519
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0274 0.5
Plasmodium vivax glycogen synthase kinase 3, putative 0.0095 0.0222 0.8094
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.068 0.2346 1
Trichomonas vaginalis CMGC family protein kinase 0.0085 0.0187 0.0638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Trichomonas vaginalis cyclins, putative 0.0069 0.013 0.0389
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0109 0.0274 0.0615
Loa Loa (eye worm) hypothetical protein 0.0109 0.0274 0.1169
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0568 0.1938 0.4985
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0109 0.0274 0.1169
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0357 0.1173 0.4999
Onchocerca volvulus 0.0095 0.0222 0.1881
Echinococcus granulosus cyclin B 0.0069 0.013 0.013
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0085 0.0187 0.0798
Echinococcus granulosus cyclin dependent kinase 5 0.0085 0.0187 0.0187
Schistosoma mansoni hypothetical protein 0.0041 0.0027 0.0071
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0109 0.0274 0.0713
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.101 0.4207
Trichomonas vaginalis cyclin B, putative 0.0069 0.013 0.0389
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0109 0.0274 0.0615
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0109 0.0274 0.0274
Brugia malayi Cyclin, N-terminal domain containing protein 0.0069 0.013 0.0337
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0109 0.0274 0.0274
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0085 0.0187 0.0187
Mycobacterium tuberculosis Conserved hypothetical protein 0.0109 0.0274 0.5
Trichomonas vaginalis cyclins, putative 0.0069 0.013 0.0389
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.1905 0.1905
Echinococcus multilocularis cyclin B 0.0069 0.013 0.013
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0109 0.0274 0.1415
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0109 0.0274 0.0713
Loa Loa (eye worm) hypothetical protein 0.0364 0.1199 0.5113
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0109 0.0274 0.0713
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0109 0.0274 0.1016
Trypanosoma cruzi cdc2-related kinase 1 0.0085 0.0187 0.0387
Leishmania major hypothetical protein, conserved 0.1059 0.3722 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0078 0.0334
Entamoeba histolytica cyclin, putative 0.0069 0.013 0.0521
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0085 0.0187 0.0966
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.032 0.104 0.2626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Leishmania major phosphatidylinositol kinase, putative 0.0109 0.0274 0.0636
Entamoeba histolytica protein kinase domain containing protein 0.0095 0.0222 0.1005
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0109 0.0274 0.1016
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.1905 0.1905
Loa Loa (eye worm) hypothetical protein 0.0112 0.0285 0.1216
Entamoeba histolytica cell division protein kinase 2, putative 0.0085 0.0187 0.0822
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0109 0.0274 0.1169
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1094 0.3848 0.3848
Brugia malayi cell division control protein 2 homolog 0.0085 0.0187 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.032 0.104 0.4337
Trichomonas vaginalis cyclins, putative 0.0069 0.013 0.0389
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0109 0.0274 0.1016
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.2346 1
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0095 0.0222 0.0494
Echinococcus granulosus cyclin dependent kinase 0.0085 0.0187 0.0187
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.1905 0.1905
Plasmodium falciparum cyclin 0.0069 0.013 0.4727
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.004 0.0104
Echinococcus multilocularis cyclins 0.0069 0.013 0.013
Echinococcus granulosus cyclins 0.0069 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.0553
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0109 0.0274 0.1234
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0109 0.0274 0.0713
Echinococcus multilocularis Zinc finger, PHD finger 0.0109 0.0274 0.0274
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0109 0.0274 0.1169
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0027 0.0071
Echinococcus multilocularis cyclins 0.0069 0.013 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0109 0.0274 0.0713
Giardia lamblia Phosphatidylinositol 4-kinase 0.0109 0.0274 0.1234
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0109 0.0274 0.1016
Trypanosoma brucei protein kinase, putative 0.0095 0.0222 0.0946
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0187 0.0486
Entamoeba histolytica cyclin family protein 0.0069 0.013 0.0521
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0568 0.1938 0.1938
Echinococcus granulosus protein kinase shaggy 0.0095 0.0222 0.0222
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0621 0.2519
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0568 0.1938 0.5155
Giardia lamblia Kinase, CMGC CDK 0.0085 0.0187 0.0776
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1094 0.3848 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0095 0.0222 0.0577
Trichomonas vaginalis cyclins, putative 0.0069 0.013 0.0389
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1094 0.3848 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.004 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0078 0.0204
Giardia lamblia Kinase, CMGC CDK 0.0085 0.0187 0.0776
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0109 0.0274 0.1279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.0776 0.3193
Echinococcus multilocularis protein kinase shaggy 0.0095 0.0222 0.0222
Trichomonas vaginalis CMGC family protein kinase 0.0095 0.0222 0.0789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0473 0.1596 0.6748
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0109 0.0274 0.1016
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0109 0.0274 0.1016
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0621 0.2519
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1094 0.3848 0.3848
Entamoeba histolytica hypothetical protein 0.0109 0.0274 0.1279
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0109 0.0274 0.1279
Trichomonas vaginalis cyclin D, putative 0.0069 0.013 0.0389
Trichomonas vaginalis CMGC family protein kinase 0.0085 0.0187 0.0638
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0109 0.0274 0.0713
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0359 0.1182 0.504
Leishmania major phosphatidylinositol 3-kinase, putative 0.0568 0.1938 0.5155
Echinococcus multilocularis cyclin dependent kinase 1 0.0085 0.0187 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0621 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0109 0.0274 0.0274
Schistosoma mansoni hypothetical protein 0.0359 0.1182 0.3072
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0109 0.0274 0.1415
Loa Loa (eye worm) phosphatidylinositol 3 0.0568 0.1938 0.8263
Loa Loa (eye worm) hypothetical protein 0.0357 0.1173 0.4999
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0109 0.0274 0.0274
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0085 0.0187 0.0798
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0109 0.0274 0.0713
Loa Loa (eye worm) hypothetical protein 0.0247 0.0776 0.3309
Entamoeba histolytica hypothetical protein 0.0109 0.0274 0.1279
Schistosoma mansoni hypothetical protein 0.0109 0.0274 0.0713
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0109 0.0274 0.0274
Trypanosoma cruzi cdc2-related kinase 3 0.0085 0.0187 0.0387
Echinococcus multilocularis cyclins 0.0069 0.013 0.013
Giardia lamblia Kinase, CMGC GSK 0.0095 0.0222 0.0959
Echinococcus multilocularis 0.0109 0.0274 0.0274
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0568 0.1938 1
Trichomonas vaginalis cyclin B, putative 0.0069 0.013 0.0389
Echinococcus granulosus cyclins 0.0069 0.013 0.013
Toxoplasma gondii hypothetical protein 0.0053 0.0069 0.0355
Loa Loa (eye worm) cyclin domain-containing protein 0.0069 0.013 0.0553
Brugia malayi FAT domain containing protein 0.0247 0.0776 0.2017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0109 0.0274 0.0713
Schistosoma mansoni cyclins 0.0069 0.013 0.0337
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.2788 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0109 0.0274 0.1169
Echinococcus multilocularis cyclin dependent kinase 0.0085 0.0187 0.0187
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0568 0.1938 0.5155
Trichomonas vaginalis cyclin B, putative 0.0069 0.013 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Loa Loa (eye worm) phosphatidylinositol kinase 0.0109 0.0274 0.1169
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0568 0.1938 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0621 0.2519
Loa Loa (eye worm) hypothetical protein 0.006 0.0096 0.0411
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0621 0.2519
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0568 0.1938 0.5037
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0109 0.0274 1
Echinococcus granulosus neuropeptide s receptor 0.0558 0.1905 0.1905
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0568 0.1938 0.8263
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0109 0.0274 0.0713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0211 0.0643 0.2617
Trichomonas vaginalis CMGC family protein kinase 0.0095 0.0222 0.0789
Leishmania major phosphatidylinositol 3-kinase, putative 0.0109 0.0274 0.0636
Plasmodium vivax protein kinase Crk2 0.0085 0.0187 0.6825
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0568 0.1938 0.8263
Echinococcus multilocularis cyclin dependent kinase 1 0.0085 0.0187 0.0187
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0109 0.0274 0.0615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0109 0.0274 0.1415
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.004 0.004
Trichomonas vaginalis CMGC family protein kinase 0.0085 0.0187 0.0638
Plasmodium vivax hypothetical protein 0.0109 0.0274 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0109 0.0274 0.1016
Giardia lamblia Cyclin A 0.0069 0.013 0.0472
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0109 0.0274 0.1016
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0109 0.0274 0.1169
Toxoplasma gondii target of rapamycin (TOR), putative 0.0568 0.1938 1
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0095 0.0222 0.0222
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0095 0.0222 0.0946
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0109 0.0274 0.0615
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.101 0.4207
Echinococcus multilocularis cyclins 0.0069 0.013 0.013
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0109 0.0274 0.0713
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0109 0.0274 0.0713
Leishmania major phosphatidylinositol kinase related protein, putative 0.0262 0.083 0.2146
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0109 0.0274 0.1415
Brugia malayi Cyclin, N-terminal domain containing protein 0.0478 0.1613 0.4192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0078 0.0204
Loa Loa (eye worm) phosphatidylinositol 3 0.068 0.2346 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.032 0.104 0.104
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0109 0.0274 1
Echinococcus multilocularis serine protein kinase ATM 0.0473 0.1596 0.1596
Trypanosoma cruzi cdc2-related kinase 3 0.0085 0.0187 0.0387
Leishmania major cyclin 0.0069 0.013 0.0244
Echinococcus granulosus serine protein kinase ATM 0.0473 0.1596 0.1596
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0109 0.0274 0.1415
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.101 0.4207
Giardia lamblia Hypothetical protein 0.0109 0.0274 0.1234
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0096 0.025
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0109 0.0274 0.1279
Trichomonas vaginalis cyclin A, putative 0.0069 0.013 0.0389
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0078 0.0078
Leishmania major phosphatidylinositol 3-related kinase, putative 0.068 0.2346 0.6262
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.004 0.004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0109 0.0274 0.0713
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.003 0.0079
Schistosoma mansoni fkbp-rapamycin associated protein 0.032 0.104 0.2702
Trichomonas vaginalis cyclin B3, putative 0.0069 0.013 0.0389
Loa Loa (eye worm) hypothetical protein 0.0109 0.0274 0.1169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0109 0.0274 0.0615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0432 0.1447 0.7427
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0095 0.0222 0.0222
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.004 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0211 0.0643 0.2617
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0109 0.0274 0.0274
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0661 0.2692
Trichomonas vaginalis conserved hypothetical protein 0.0357 0.1173 0.4912
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0109 0.0274 0.1279
Giardia lamblia G2/mitotic-specific cyclin B 0.0069 0.013 0.0472
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.0553
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.101 0.4207
Brugia malayi Cyclin, N-terminal domain containing protein 0.0069 0.013 0.0337
Echinococcus multilocularis cyclins 0.0069 0.013 0.013
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0568 0.1938 0.5155
Echinococcus multilocularis snurportin 1 0.0359 0.1182 0.1182
Onchocerca volvulus 0.0109 0.0274 0.2945
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0069 0.013 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0109 0.0274 1
Schistosoma mansoni cyclin B 0.0069 0.013 0.0337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0568 0.1938 0.8233
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0109 0.0274 0.0274
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0274 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0247 0.0776 0.0776
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0109 0.0274 0.0274
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0078 0.0078
Brugia malayi hypothetical protein 0.0042 0.003 0.0079
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0069 0.013 0.013
Entamoeba histolytica protein kinase rad3, putative 0.032 0.104 0.5291
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0078 0.0078
Toxoplasma gondii FATC domain-containing protein 0.0473 0.1596 0.8234
Echinococcus multilocularis cyclin b3 0.0069 0.013 0.013
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0109 0.0274 1
Brugia malayi intracellular kinase 0.0095 0.0222 0.0577
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0109 0.0274 0.0636
Entamoeba histolytica protein kinase domain containing protein 0.0095 0.0222 0.1005
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0109 0.0274 0.1016
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0085 0.0187 0.04
Entamoeba histolytica cell division protein kinase 2, putative 0.0085 0.0187 0.0822
Echinococcus granulosus cyclin B3 1 0.0069 0.013 0.013

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.2589 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3048 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: Ub-rhodamine 110 based assay for inhibitors Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2281, AID463106, AID463254] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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