Detailed information for compound 1281205

Basic information

Technical information
  • TDR Targets ID: 1281205
  • Name: 5-amino-1-[2-[(2,5-dimethylphenyl)amino]-2-ox oethyl]-N-[(4-methylphenyl)methyl]triazole-4- carboxamide
  • MW: 392.454 | Formula: C21H24N6O2
  • H donors: 3 H acceptors: 4 LogP: 3.1 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)CNC(=O)c1nnn(c1N)CC(=O)Nc1cc(C)ccc1C
  • InChi: 1S/C21H24N6O2/c1-13-5-8-16(9-6-13)11-23-21(29)19-20(22)27(26-25-19)12-18(28)24-17-10-14(2)4-7-15(17)3/h4-10H,11-12,22H2,1-3H3,(H,23,29)(H,24,28)
  • InChiKey: PVPCNOONQWYIBC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-amino-1-[2-[(2,5-dimethylphenyl)amino]-2-oxo-ethyl]-N-[(4-methylphenyl)methyl]triazole-4-carboxamide
  • 5-amino-1-[2-[(2,5-dimethylphenyl)amino]-2-oxoethyl]-N-[(4-methylphenyl)methyl]-4-triazolecarboxamide
  • 5-amino-1-[2-[(2,5-dimethylphenyl)amino]-2-keto-ethyl]-N-(4-methylbenzyl)triazole-4-carboxamide
  • 5-amino-1-[2-[(2,5-dimethylphenyl)amino]-2-oxo-ethyl]-N-[(4-methylphenyl)methyl]-1,2,3-triazole-4-carboxamide
  • E919-1178
  • NCGC00126418-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0108 0.0735
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0028 0.0066 0.126
Echinococcus multilocularis dna polymerase kappa 0.004 0.0108 0.0447
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0996 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0032 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0108 0.0735
Trypanosoma cruzi aurora B kinase, putative 0.012 0.0399 0.3011
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0032 0.0374
Trypanosoma cruzi metacaspase, putative 0.0043 0.0119 0.0822
Echinococcus granulosus caspase 8 0.0043 0.0119 0.0494
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0119 0.0286
Echinococcus granulosus aurora kinase A 0.012 0.0399 0.166
Mycobacterium ulcerans succinate dehydrogenase flavoprotein subunit 0.0021 0.0037 0.0074
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0028 0.0066 0.0059
Echinococcus multilocularis dna polymerase eta 0.0014 0.0013 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0108 0.0735
Plasmodium vivax aspartyl protease, putative 0.011 0.0365 0.9116
Onchocerca volvulus Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial homolog 0.0021 0.0037 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0108 0.0735
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0034 0.014
Onchocerca volvulus 0.011 0.0365 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.011 0.0365 0.0365
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0177 0.0177
Mycobacterium ulcerans hypothetical protein 0.0192 0.0664 0.1358
Trypanosoma brucei metacaspase MCA2 0.0043 0.0119 0.0822
Trypanosoma brucei metacaspase 5, putative 0.0043 0.0119 0.0822
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0044 0.0125 0.0868
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0148 0.0148
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.0044 0.0125 0.0262
Leishmania major metacaspase, putative 0.0043 0.0119 0.0822
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0845
Trypanosoma brucei succinate dehydrogenase iron-sulfur subunit 0.0027 0.006 0.0367
Onchocerca volvulus Cell death protein 3 homolog 0.0083 0.0264 0.6974
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0108 0.0449
Schistosoma mansoni cpg binding protein 0.0029 0.007 0.007
Mycobacterium leprae Probable succinate dehydrogenase (iron-sulfur protein subunit) SdhB (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHY 0.0027 0.006 0.0048
Schistosoma mansoni succinate dehydrogenase iron-sulfur protein 0.0049 0.014 0.014
Brugia malayi nuclear hormone receptor 0.002 0.0034 0.0845
Onchocerca volvulus 0.0028 0.0064 0.0955
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0108 0.0735
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0444
Plasmodium falciparum plasmepsin II 0.011 0.0365 0.9116
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0018 0.0409
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.012 0.0399 0.3924
Schistosoma mansoni cpg binding protein 0.0028 0.0064 0.0064
Brugia malayi TAZ zinc finger family protein 0.0098 0.0321 0.804
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0044 0.0125 0.3122
Echinococcus multilocularis caspase 0.0113 0.0376 0.1564
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0093 0.062
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0119 0.0286
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0444
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0845
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0108 0.0735
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.019 0.1382
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0034 0.014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0034 0.0845
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0593 0.4522
Trichomonas vaginalis AGC family protein kinase 0.012 0.0399 0.3389
Loa Loa (eye worm) succinate dehydrogenase flavoprotein subunit 0.0013 0.0011 0.0275
Loa Loa (eye worm) hypothetical protein 0.0043 0.0119 0.2975
Onchocerca volvulus 0.011 0.0365 1
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0034 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0119 0.0286
Echinococcus granulosus caspase 0.0113 0.0376 0.1564
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0044 0.0125 0.0253
Echinococcus granulosus dnaJ subfamily B 0.0396 0.1409 0.5863
Toxoplasma gondii aurora kinase 0.012 0.0399 1
Brugia malayi polk-prov protein 0.003 0.0072 0.1809
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0108 0.0735
Giardia lamblia Aurora kinase 0.012 0.0399 0.3776
Brugia malayi nuclear receptor NHR-88 0.002 0.0034 0.0845
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.1294 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0148 0.0606
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.011 0.0365 0.0365
Echinococcus multilocularis CREB binding protein 0.0067 0.0208 0.0866
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0034 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0996 1
Brugia malayi Doublecortin family protein 0.0019 0.0032 0.0801
Echinococcus multilocularis succinate dehydrogenase (ubiquinone) 0.0021 0.0037 0.0155
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0165 0.0348
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.011 0.0365 0.9152
Schistosoma mansoni caspase-7 (C14 family) 0.0113 0.0376 0.0376
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0018 0.0444
Mycobacterium tuberculosis Probable fumarate reductase [iron-sulfur subunit] FrdB (fumarate dehydrogenase) (fumaric hydrogenase) 0.0027 0.006 0.0126
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0028 0.0066 0.0137
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0018 0.0444
Brugia malayi Inositol-1 0.0036 0.0093 0.2328
Echinococcus granulosus dna polymerase kappa 0.004 0.0108 0.0447
Loa Loa (eye worm) AUR protein kinase 0.012 0.0399 1
Plasmodium falciparum plasmepsin IX 0.011 0.0365 0.9116
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0337
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0148 0.1048
Brugia malayi ecdysteroid receptor 0.002 0.0034 0.0845
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0032 0.0133
Echinococcus granulosus CREB binding protein 0.0016 0.0021 0.0087
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0028 0.0066 0.1618
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0034 0.014
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.0996 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0148 0.3701
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0034 0.0845
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0044 0.0125 0.0125
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0177 0.0361
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0018 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0108 0.0735
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0018 0.0018
Echinococcus multilocularis caspase 8 0.0043 0.0119 0.0494
Trypanosoma brucei protein kinase, putative 0.0051 0.0148 0.1048
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0845
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0044 0.0125 0.1131
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0018 0.0018
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0152 0.3797
Schistosoma mansoni lipoxygenase 0.0053 0.0158 0.0158
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0098 0.0321 0.0321
Trypanosoma cruzi NADH dehydrogenase, putative 0.0028 0.0066 0.0409
Loa Loa (eye worm) succinate-ubiquinone oxidoreductase 0.0021 0.0037 0.0936
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0044 0.0125 0.1131
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0177 0.0737
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0013 0.0013
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.011 0.0365 0.0365
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.011 0.0365 0.0365
Loa Loa (eye worm) CBP-B 0.0068 0.0211 0.5294
Loa Loa (eye worm) hypothetical protein 0.011 0.0365 0.9156
Trypanosoma cruzi metacaspase, putative 0.0043 0.0119 0.0822
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.1409 0.5863
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0018 0.0074
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0044 0.0125 0.0518
Trichomonas vaginalis STE family protein kinase 0.0073 0.023 0.1518
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0043 0.0119 0.0119
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0013 0.0337
Loa Loa (eye worm) succinate dehydrogenase flavoprotein subunit 0.0013 0.0011 0.0275
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0034 0.0845
Plasmodium vivax metacaspase 1, putative 0.0043 0.0119 0.2649
Brugia malayi succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial 0.0049 0.014 0.3501
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0044 0.0125 0.2803
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0108 0.0218
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0018 0.0033
Plasmodium vivax aspartyl proteinase, putative 0.011 0.0365 0.9116
Plasmodium vivax aspartyl protease, putative 0.011 0.0365 0.9116
Echinococcus granulosus RUN 0.0019 0.0032 0.0133
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0034 0.014
Trypanosoma brucei metacaspase 0.0043 0.0119 0.0822
Echinococcus granulosus FTZ F1 alpha 0.002 0.0034 0.014
Toxoplasma gondii aspartyl protease ASP3 0.011 0.0365 0.9152
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0996 1
Wolbachia endosymbiont of Brugia malayi succinate dehydrogenase iron-sulfur subunit 0.0049 0.014 1
Brugia malayi MAP kinase sur-1 0.0051 0.0148 0.3701
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0034 0.014
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0044 0.0125 0.3097
Plasmodium falciparum plasmepsin VIII, putative 0.011 0.0365 0.9116
Loa Loa (eye worm) hypothetical protein 0.0083 0.0264 0.6628
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0018 0.0033
Echinococcus granulosus succinate dehydrogenase ubiquinone iron sulfur 0.0049 0.014 0.0581
Brugia malayi CXXC zinc finger family protein 0.0028 0.0064 0.1599
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.0044 0.0125 0.018
Echinococcus granulosus CREB binding protein 0.0098 0.0321 0.1335
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0108 0.0735
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0034 0.0034
Loa Loa (eye worm) aspartic protease BmAsp-1 0.011 0.0365 0.9156
Loa Loa (eye worm) aspartyl protease 6 0.011 0.0365 0.9156
Schistosoma mansoni protein kinase 0.0073 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0046 0.0131 0.3272
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0034 0.014
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0018 0.0074
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0034 0.014
Echinococcus multilocularis dual specificity mitogen activated protein 0.0073 0.023 0.0957
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.0996 1
Schistosoma mansoni cathepsin D (A01 family) 0.011 0.0365 0.0365
Echinococcus granulosus succinate dehydrogenase (ubiquinone) iron sulfur 0.0049 0.014 0.0581
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.0664 0.1404
Echinococcus granulosus microtubule associated protein 2 0.0669 0.2404 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0996 1
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.2404 0.2404
Echinococcus granulosus dna polymerase eta 0.0014 0.0013 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0034 0.0845
Loa Loa (eye worm) succinate dehydrogenase iron-sulfur protein 0.0049 0.014 0.3501
Echinococcus multilocularis aurora kinase A 0.012 0.0399 0.166
Brugia malayi hypothetical protein 0.0019 0.0032 0.0801
Brugia malayi serine/threonine-protein kinase 6 0.012 0.0399 1
Plasmodium falciparum serine/threonine protein kinase, putative 0.012 0.0399 1
Mycobacterium ulcerans succinate dehydrogenase iron-sulfur subunit 0.0027 0.006 0.0122
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0148 0.0606
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0165 0.0336
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0119 0.0286
Loa Loa (eye worm) inositol-1 0.0036 0.0093 0.2328
Echinococcus granulosus caspase 3 0.007 0.022 0.0913
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0034 0.014
Trypanosoma brucei unspecified product 0.0033 0.0084 0.0552
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0034 0.0034
Echinococcus multilocularis cpg binding protein 0.0029 0.007 0.029
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0013 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0119 0.0286
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.012 0.0399 0.166
Loa Loa (eye worm) AUR protein kinase 0.012 0.0399 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.011 0.0365 0.0365
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0034 0.014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0034 0.0845
Echinococcus multilocularis succinate dehydrogenase iron sulfur protein 0.0027 0.006 0.0251
Trypanosoma brucei Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0021 0.0037 0.0187
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0018 0.0409
Entamoeba histolytica protein kinase domain containing protein 0.012 0.0399 0.3924
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0108 0.0162
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.2404 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0034 0.0845
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.0182
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0018 0.0074
Mycobacterium tuberculosis Conserved hypothetical protein 0.0014 0.0013 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0996 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0177 0.0373
Loa Loa (eye worm) hypothetical protein 0.011 0.0365 0.9156
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0108 0.0735
Echinococcus granulosus cpg binding protein 0.0029 0.007 0.029
Trypanosoma cruzi succinate dehydrogenase iron-sulfur subunit 0.0027 0.006 0.0367
Brugia malayi Eukaryotic aspartyl protease family protein 0.011 0.0365 0.9156
Plasmodium falciparum plasmepsin I 0.011 0.0365 0.9116
Onchocerca volvulus 0.002 0.0034 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0034 0.0845
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.0058
Leishmania major NADH dehydrogenase, putative 0.0028 0.0066 0.0409
Brugia malayi Pepsin A precursor 0.011 0.0365 0.9156
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.011 0.0365 0.152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0034 0.0845
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0119 0.0822
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0119 0.0286
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0996 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.011 0.0365 0.0365
Brugia malayi hypothetical protein 0.004 0.0108 0.2706
Schistosoma mansoni hypothetical protein 0.004 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0845
Trypanosoma cruzi NADH dehydrogenase, putative 0.0028 0.0066 0.0409
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0044 0.0125 0.0868
Plasmodium falciparum plasmepsin VI 0.011 0.0365 0.9116
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0034 0.0845
Plasmodium falciparum plasmepsin X 0.011 0.0365 0.9116
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0148 0.1048
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0119 0.0286
Schistosoma mansoni inositol monophosphatase 0.0036 0.0093 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0034 0.0845
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0032 0.0133
Mycobacterium tuberculosis Probable succinate dehydrogenase (flavoprotein subunit) SdhA (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogena 0.0021 0.0037 0.0077
Schistosoma mansoni caspase-3 (C14 family) 0.0113 0.0376 0.0376
Echinococcus granulosus phd:f box containing protein 0.0015 0.0018 0.0074
Plasmodium falciparum metacaspase-like protein 0.0043 0.0119 0.2649
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0043 0.0119 0.2975
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.0996 0.5
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.0996 1
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0148 0.1156
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0044 0.0125 0.3122
Toxoplasma gondii flavoprotein subunit of succinate dehydrogenase 0.0021 0.0037 0.0903
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.015 0.1062
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0108 0.0735
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0034 0.0845
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0093 0.0188
Plasmodium vivax flavoprotein subunit of succinate dehydrogenase, putative 0.0021 0.0037 0.0515
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0148 0.0606
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0018 0.0018
Echinococcus multilocularis RUN 0.0019 0.0032 0.0133
Trichomonas vaginalis STE family protein kinase 0.0073 0.023 0.1518
Plasmodium vivax iron-sulfur subunit of succinate dehydrogenase, putative 0.0049 0.014 0.3199
Schistosoma mansoni loxhd1 0.0019 0.0032 0.0032
Giardia lamblia Kinase, STE STE20 0.0073 0.023 0.2014
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0034 0.014
Plasmodium falciparum metacaspase 1 0.0043 0.0119 0.2649
Leishmania major hypothetical protein, conserved 0.0027 0.006 0.0367
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0034 0.014
Schistosoma mansoni cpg binding protein 0.0029 0.007 0.007
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0044 0.0125 0.0868
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0034 0.0845
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0034 0.0034
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0177 0.1277
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0024 0.0098
Plasmodium vivax plasmepsin IV, putative 0.011 0.0365 0.9116
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0093 0.062
Loa Loa (eye worm) hypothetical protein 0.003 0.0072 0.1809
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0119 0.0286
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0093 0.5426
Echinococcus multilocularis succinate dehydrogenase (ubiquinone) iron sulfur 0.0049 0.014 0.0581
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.011 0.0365 0.0365
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0108 0.0735
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0034 0.014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0177 0.0361
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0176 0.0733
Onchocerca volvulus Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial homolog 0.0021 0.0037 0.0161
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0032 0.0374
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0119 0.0822
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0119 0.0286
Schistosoma mansoni thyroid hormone receptor 0.002 0.0034 0.0034
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0108 0.0218
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.012 0.0399 0.3924
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.011 0.0365 0.3016
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0037 0.0182
Schistosoma mansoni succinate dehydrogenase 0.0021 0.0037 0.0037
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0177 0.0737
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0079 0.0086
Leishmania major hypothetical protein, conserved 0.0015 0.0018 0.0033
Schistosoma mansoni jumonji domain containing protein 0.0057 0.017 0.017
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.017 0.0708
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0093 0.062
Entamoeba histolytica protein kinase, putative 0.012 0.0399 0.3924
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0108 0.0735
Trichomonas vaginalis AGC family protein kinase 0.012 0.0399 0.3389
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0165 0.4139
Brugia malayi steroid hormone receptor 0.002 0.0034 0.0845
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0028 0.0066 0.126
Brugia malayi serine/threonine protein kinase 6 0.012 0.0399 1
Echinococcus multilocularis caspase 2 0.0083 0.0264 0.11
Plasmodium falciparum plasmepsin III 0.011 0.0365 0.9116
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0032 0.0133
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0034 0.0034
Brugia malayi jmjC domain containing protein 0.0015 0.0018 0.0444
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.0058
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0801
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0064 0.1599
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0018 0.0074
Trypanosoma cruzi metacaspase, putative 0.0043 0.0119 0.0822
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0176 0.0176
Schistosoma mansoni coup transcription factor 0.002 0.0034 0.0034
Echinococcus multilocularis CREB binding protein 0.0016 0.0021 0.0087
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0018 0.0033
Entamoeba histolytica protein kinase , putative 0.012 0.0399 0.3924
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.1294 1
Brugia malayi aspartic protease BmAsp-2, identical 0.011 0.0365 0.9156
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0165 0.0165
Brugia malayi succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0021 0.0037 0.0936
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0072 0.0459
Mycobacterium ulcerans fumarate reductase iron-sulfur subunit 0.0017 0.0026 0.0051
Mycobacterium leprae Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) 0.1347 0.4883 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0158 0.0655
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0467 0.0887
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0044 0.0125 0.0915
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0093 0.0809
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0034 0.0845
Mycobacterium ulcerans succinate dehydrogenase flavoprotein subunit 0.0021 0.0037 0.0074
Loa Loa (eye worm) aspartic protease BmAsp-2 0.011 0.0365 0.9156
Echinococcus granulosus succinate dehydrogenase ubiquinone iron sulfur 0.0022 0.0042 0.0173
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0148 0.3677
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1294 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0176 0.0176
Echinococcus multilocularis succinate dehydrogenase (ubiquinone) iron sulfur 0.0031 0.0076 0.0316
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0108 0.0735
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0044 0.0125 0.0868
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0034 0.0845
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0593 0.4522
Brugia malayi jmjC domain containing protein 0.0057 0.017 0.4268
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0165 0.0687
Toxoplasma gondii aspartyl protease ASP1 0.011 0.0365 0.9152
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0399 0.0399
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0177 0.0361
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0093 0.0386
Echinococcus granulosus tumor protein p63 0.0327 0.1158 0.4816
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0013 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0178 0.0178
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0093 0.062
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.1303 0.4721 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0148 0.1048
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0037 0.0076
Onchocerca volvulus 0.004 0.0108 0.228
Schistosoma mansoni inositol monophosphatase 0.0036 0.0093 0.0093
Echinococcus granulosus caspase 2 0.0083 0.0264 0.11
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0137 0.0137
Mycobacterium tuberculosis Probable fumarate reductase [flavoprotein subunit] FrdA (fumarate dehydrogenase) (fumaric hydrogenase) 0.0021 0.0037 0.0077
Plasmodium falciparum plasmepsin V 0.011 0.0365 0.9116
Trypanosoma brucei aurora B kinase 0.012 0.0399 0.3011
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0119 0.0286
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0108 0.0449
Leishmania major succinate dehydrogenase, putative 0.0031 0.0076 0.0489
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0165 0.0336
Schistosoma mansoni CREB-binding protein 2 0.0098 0.0321 0.0321
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0034 0.0845
Brugia malayi jmjC domain containing protein 0.0015 0.0018 0.0444
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.011 0.0365 0.0365
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0148 0.1048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0034 0.014
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0148 0.0614
Schistosoma mansoni lipoxygenase 0.0019 0.0032 0.0032
Plasmodium vivax plasmepsin V, putative 0.011 0.0365 0.9116
Echinococcus granulosus dual specificity mitogen activated protein 0.0073 0.023 0.0957
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0073 0.023 0.1691
Plasmodium falciparum flavoprotein subunit of succinate dehydrogenase 0.0021 0.0037 0.0515
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0018 0.0074
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0044 0.0125 0.2803
Loa Loa (eye worm) AUR protein kinase 0.012 0.0399 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0177 0.0177
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0996 1
Trypanosoma brucei Metacaspase-4 0.0043 0.0119 0.0822
Plasmodium falciparum plasmepsin IV 0.011 0.0365 0.9116
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0073 0.023 0.5765
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0176 0.4413
Schistosoma mansoni rab6-interacting 0.0019 0.0032 0.0032
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0165 0.1185
Schistosoma mansoni thyroid hormone receptor 0.002 0.0034 0.0034
Echinococcus multilocularis CREB binding protein 0.0016 0.0021 0.0087
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.011 0.0365 0.9152
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0108 0.0162
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0024 0.0098
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0148 0.1048
Schistosoma mansoni caspase-7 (C14 family) 0.0083 0.0264 0.0264
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0034 0.0845
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1294 1
Schistosoma mansoni hypothetical protein 0.0396 0.1409 0.1409
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.011 0.0365 0.0365
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.017 0.0708
Brugia malayi succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0021 0.0037 0.0936
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.1347 0.4883 1
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.011 0.0365 0.152
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0113 0.0376 0.1564
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0119 0.0286
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0018 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0845
Loa Loa (eye worm) hypothetical protein 0.0048 0.0137 0.3438
Trypanosoma brucei NADH dehydrogenase 0.0028 0.0066 0.0409
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0034 0.014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0034 0.0845
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0845
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0034 0.0053
Plasmodium vivax aspartyl protease, putative 0.011 0.0365 0.9116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0996 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0119 0.2949
Leishmania major succinate dehydrogenase flavoprotein, putative 0.0021 0.0037 0.0187
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.015 0.1062
Entamoeba histolytica protein kinase, putative 0.012 0.0399 0.3924
Brugia malayi serine/threonine kinase 12 0.012 0.0399 1
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0018 0.0018
Plasmodium falciparum plasmepsin VII 0.011 0.0365 0.9116
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0072 0.0459
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0028 0.0066 0.0137
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0093 0.23
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0593 0.4522
Brugia malayi hypothetical protein 0.011 0.0365 0.9156
Schistosoma mansoni DNA polymerase eta 0.0014 0.0013 0.0013
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0073 0.023 0.5765
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0119 0.2649
Trichomonas vaginalis AGC family protein kinase 0.012 0.0399 0.3389
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0108 0.0735
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0034 0.0034
Mycobacterium tuberculosis Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) 0.0021 0.0037 0.0077
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0113 0.0376 0.1564
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0625
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0119 0.0286
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0148 0.0614
Schistosoma mansoni hypothetical protein 0.0019 0.0032 0.0032
Schistosoma mansoni polycystin 1-related 0.0019 0.0032 0.0032
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0034 0.0034
Trichomonas vaginalis STE family protein kinase 0.0073 0.023 0.1518
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.0084 0.0552
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0034 0.0845
Schistosoma mansoni succinate dehydrogenase iron-sulfur protein 0.0027 0.006 0.006
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0028 0.0066 0.0133
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0044 0.0125 0.0518
Plasmodium vivax aspartyl proteinase, putative 0.011 0.0365 0.9116
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0044 0.0125 0.0351
Plasmodium vivax serine/threonine protein kinase 6, putative 0.012 0.0399 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0013 0.0056
Schistosoma mansoni protein kinase 0.012 0.0399 0.0399
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0034 0.014
Brugia malayi jmjC domain containing protein 0.0059 0.0176 0.4413
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0034 0.014
Echinococcus granulosus CREB binding protein 0.0061 0.0183 0.0763
Leishmania major DNA polymerase kappa, putative 0.002 0.0037 0.0182
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0018 0.0444
Chlamydia trachomatis succinate dehydrogenase iron sulfur subunit 0.0027 0.006 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0034 0.0845
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0034 0.0845
Brugia malayi jmjC domain containing protein 0.0015 0.0018 0.0444
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0034 0.0845
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0148 0.1048
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0073 0.023 0.1691
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0148 0.0606
Leishmania major protein kinase, putative 0.012 0.0399 0.3011
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0158 0.0655
Echinococcus multilocularis caspase 3 0.007 0.022 0.0913
Trypanosoma brucei succinate dehydrogenase iron-sulfur subunit, putative 0.0031 0.0076 0.0489
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0467 0.0988
Schistosoma mansoni rab6-interacting 0.0019 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0801
Toxoplasma gondii succinate dehydrogenase [ubiquinone] iron-sulfur protein 0.0049 0.014 0.3477
Brugia malayi jmjC domain containing protein 0.0015 0.0018 0.0444
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0018 0.0074
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0444
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0845
Trypanosoma cruzi Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0021 0.0037 0.0187
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0093 0.0386
Brugia malayi aspartic protease BmAsp-1, identical 0.011 0.0365 0.9156
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.012 0.0399 0.3924
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0034 0.014
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.015 0.1062
Brugia malayi Cell death protein 3 precursor 0.0083 0.0264 0.6628
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0034 0.0034
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0177 0.4416
Loa Loa (eye worm) hypothetical protein 0.004 0.0108 0.2706
Schistosoma mansoni cathepsin D (A01 family) 0.011 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.011 0.0365 0.9156
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.015 0.1062
Trypanosoma cruzi metacaspase, putative 0.0043 0.0119 0.0822
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0148 0.0614
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0119 0.2949
Echinococcus multilocularis CREB binding protein 0.0016 0.0021 0.0087
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0032 0.0133
Trichomonas vaginalis AGC family protein kinase 0.012 0.0399 0.3389
Mycobacterium tuberculosis Conserved hypothetical protein 0.0044 0.0125 0.0262
Echinococcus granulosus succinate dehydrogenase ubiquinone 0.0021 0.0037 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0034 0.0845
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0467 0.0955
Trypanosoma brucei metacaspase MCA3 0.0043 0.0119 0.0822
Brugia malayi hypothetical protein 0.0019 0.0032 0.0801
Toxoplasma gondii aspartyl protease 0.011 0.0365 0.9152
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0845
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0165 0.0687
Trypanosoma cruzi succinate dehydrogenase iron-sulfur subunit 0.0031 0.0076 0.0489
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0032 0.0133
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0034 0.0034
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0013 0.0337
Toxoplasma gondii hypothetical protein 0.0059 0.0177 0.4417
Plasmodium falciparum iron-sulfur subunit of succinate dehydrogenase 0.0049 0.014 0.3199
Echinococcus multilocularis tumor protein p63 0.0327 0.1158 0.4816
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0148 0.1048
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0032 0.0801
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0161 0.4013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0034 0.0845
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.017 0.0708
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0013 0.0337
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0148 0.0614
Brugia malayi hypothetical protein 0.011 0.0365 0.9156
Schistosoma mansoni nuclear hormone receptor 0.002 0.0034 0.0034
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0119 0.0286
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0119 0.0286
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0028 0.0066 0.1618
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.0058
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0119 0.0286
Mycobacterium tuberculosis Probable succinate dehydrogenase (iron-sulphur protein subunit) SdhB (succinic dehydrogenase) (fumarate reductase) (fumarate deh 0.0027 0.006 0.0126
Echinococcus granulosus serine:threonine protein kinase 12 B 0.012 0.0399 0.166
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0079 0.0166
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0119 0.2949
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0034 0.0845
Onchocerca volvulus 0.0048 0.0137 0.3156
Mycobacterium tuberculosis Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) 0.0017 0.0026 0.0053
Echinococcus granulosus CREB binding protein 0.0016 0.0021 0.0087
Trypanosoma cruzi succinate dehydrogenase, putative 0.0031 0.0076 0.0489
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0073 0.023 0.1691

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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