Detailed information for compound 1306561

Basic information

Technical information
  • TDR Targets ID: 1306561
  • Name: 1-methyl-3-phenylpyrazolo[4,5-b]quinoxaline
  • MW: 260.293 | Formula: C16H12N4
  • H donors: 0 H acceptors: 3 LogP: 2.66 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1nc(c2c1nc1ccccc1n2)c1ccccc1
  • InChi: 1S/C16H12N4/c1-20-16-15(14(19-20)11-7-3-2-4-8-11)17-12-9-5-6-10-13(12)18-16/h2-10H,1H3
  • InChiKey: KSVFYQHAVVMFSC-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-methyl-3-phenyl-pyrazolo[4,5-b]quinoxaline
  • STOCK4S-59525
  • ZINC00540769
  • MLS000040579
  • SMR000045078

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens tumor susceptibility 101 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens caspase 1, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens nuclear factor, erythroid 2-like 2 No references
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) Starlite/ChEMBL No references
Homo sapiens caspase 7, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens kelch-like ECH-associated protein 1 No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans UDP-galactopyranose mutase Glf Get druggable targets OG5_139595 All targets in OG5_139595
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) Get druggable targets OG5_139595 All targets in OG5_139595
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K01931 tumor suppressor protein 101 [EC:6.3.2.19], putative Get druggable targets OG5_128950 All targets in OG5_128950
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Kelch-like ECH-associated protein 1, putative Get druggable targets OG5_134673 All targets in OG5_134673
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus kelch ECH associated protein 1 Get druggable targets OG5_134673 All targets in OG5_134673
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus kelch ECH associated protein 1 like Get druggable targets OG5_134673 All targets in OG5_134673
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis kelch ECH associated protein 1 Get druggable targets OG5_134673 All targets in OG5_134673
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134673 All targets in OG5_134673
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) Get druggable targets OG5_139595 All targets in OG5_139595
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma japonicum ko:K10456 kelch-like protein 19, putative Get druggable targets OG5_134673 All targets in OG5_134673
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis Kelch repeat type 1 Get druggable targets OG5_134673 All targets in OG5_134673
Echinococcus granulosus kelch ECH associated protein 1 like Get druggable targets OG5_134673 All targets in OG5_134673
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis kelch ECH associated protein 1 Get druggable targets OG5_134673 All targets in OG5_134673
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cell death protein 3 precursor caspase 7, apoptosis-related cysteine peptidase 303 aa 256 aa 37.1 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Echinococcus granulosus caspase 8 caspase 1, apoptosis-related cysteine peptidase 383 aa 312 aa 26.6 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Brugia malayi Kelch motif family protein kelch-like ECH-associated protein 1 624 aa 565 aa 31.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0141 0.1976 0.3688
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.042 0.0784
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0078 0.1132
Entamoeba histolytica hypothetical protein 0.0014 0.011 0.1476
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0279 0.0521
Schistosoma mansoni hypothetical protein 0.005 0.0634 0.1182
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0078 0.0965
Chlamydia trachomatis DNA ligase 0.0012 0.0078 0.5
Schistosoma mansoni hypothetical protein 0.0372 0.5359 1
Trypanosoma cruzi metacaspase, putative 0.0053 0.0687 0.8383
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.011 0.1358
Brugia malayi PHD-finger family protein 0.0035 0.042 0.2025
Schistosoma mansoni importin beta-1 0.0035 0.0414 0.0773
Schistosoma mansoni DNA ligase IV 0.0012 0.0078 0.0145
Echinococcus granulosus caspase 2 0.0103 0.1418 0.2645
Schistosoma mansoni caspase-7 (C14 family) 0.0103 0.1418 0.2645
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0318 0.394
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0318 0.394
Schistosoma mansoni hypothetical protein 0.0035 0.042 0.0784
Echinococcus multilocularis JmjC domain containing protein 4 0.0011 0.007 0.0131
Brugia malayi Importin beta-1 subunit 0.0035 0.0414 0.1997
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0529 0.0987
Plasmodium falciparum metacaspase 1 0.0053 0.0687 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.011 0.0535
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0807 1
Trypanosoma cruzi metacaspase, putative 0.0053 0.0687 0.8383
Echinococcus granulosus importin subunit beta 1 0.0035 0.0414 0.0773
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0807 0.1505
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0318 0.3363
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0852 0.1589
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0078 0.0965
Echinococcus granulosus apoptotic protease activating factor 1 0.005 0.0634 0.1182
Leishmania major hypothetical protein, conserved 0.0027 0.0298 0.3233
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.042 0.0784
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0687 0.8523
Brugia malayi AF-10 protein 0.0012 0.0072 0.0348
Schistosoma mansoni phosphatidylserine receptor 0.0011 0.007 0.0131
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.007 0.0131
Echinococcus granulosus nibrin 0.0012 0.0078 0.0145
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0687 0.8523
Schistosoma mansoni tsg101-related 0.007 0.093 0.1735
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0687 0.8523
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.011 0.0535
Onchocerca volvulus 0.005 0.0634 0.2783
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0145
Loa Loa (eye worm) hypothetical protein 0.005 0.0634 0.1182
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0687 0.8383
Loa Loa (eye worm) hypothetical protein 0.006 0.0789 0.1473
Echinococcus granulosus caspase 3 0.0088 0.1192 0.2225
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0529 0.0987
Echinococcus granulosus kelch ECH associated protein 1 0.0114 0.1577 0.2943
Trypanosoma cruzi metacaspase, putative 0.0053 0.0687 0.8383
Brugia malayi hypothetical protein 0.0043 0.0541 0.2608
Echinococcus multilocularis phd:f box containing protein 0.0011 0.007 0.0131
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1248 0.2329
Schistosoma mansoni caspase-3 (C14 family) 0.0141 0.1976 0.3688
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0807 0.1505
Echinococcus multilocularis lysine specific demethylase 6a 0.0011 0.007 0.0131
Schistosoma mansoni tsg101-related 0.0057 0.0742 0.1384
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0687 1
Leishmania major importin beta-1 subunit, putative 0.0028 0.0318 0.3453
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0687 0.8523
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0078 0.0965
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0279 0.2843
Brugia malayi hypothetical protein 0.0012 0.0078 0.0375
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.011 0.0535
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0078 0.0965
Plasmodium falciparum importin beta, putative 0.0035 0.0414 0.6029
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0687 0.8523
Schistosoma mansoni hypothetical protein 0.0043 0.0541 0.1009
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0012 0.0072 0.0896
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0687 0.8523
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0011 0.007 0.087
Schistosoma mansoni topbp1 0.0012 0.0078 0.0145
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0078 0.0105
Trichomonas vaginalis ran, putative 0.0026 0.0279 0.3465
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0007 0.0008 0.0101
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0414 0.5139
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0279 0.3465
Trichomonas vaginalis hypothetical protein 0.0041 0.0504 0.6245
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0414 0.5139
Trypanosoma brucei protein kinase, putative 0.0062 0.0807 1
Brugia malayi jmjC domain containing protein 0.0011 0.007 0.0338
Echinococcus multilocularis kelch ECH associated protein 1 0.0114 0.1577 0.2943
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0131
Echinococcus granulosus kelch ECH associated protein 1 like 0.0114 0.1577 0.2943
Plasmodium vivax JmjC domain containing protein 0.0011 0.007 0.102
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0078 0.0965
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0807 1
Echinococcus granulosus caspase 0.0141 0.1976 0.3688
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.042 0.5209
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0078 0.0965
Entamoeba histolytica hypothetical protein 0.0014 0.011 0.1476
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0687 0.8523
Brugia malayi Bromodomain containing protein 0.0035 0.042 0.2025
Entamoeba histolytica hypothetical protein 0.0014 0.011 0.1476
Trypanosoma brucei metacaspase 5, putative 0.0053 0.0687 0.8523
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0414 0.0773
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.042 0.0784
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0145
Brugia malayi topoisomerase 0.0012 0.0078 0.0375
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0011 0.007 0.087
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0807 0.1505
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0078 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.011 0.1358
Brugia malayi MAP kinase sur-1 0.0062 0.0807 0.3887
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.092 0.1717
Brugia malayi PHD-finger family protein 0.0012 0.0072 0.0348
Onchocerca volvulus Alhambra homolog 0.0035 0.042 0.1714
Echinococcus granulosus peregrin 0.0035 0.042 0.0784
Brugia malayi Cell death protein 3 precursor 0.0103 0.1418 0.6833
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.092 0.1717
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0078 0.0965
Plasmodium vivax importin-beta 2, putative 0.0035 0.0414 0.6029
Schistosoma mansoni jumonji domain containing protein 0.0011 0.007 0.0131
Brugia malayi hypothetical protein 0.005 0.0634 0.3054
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0807 1
Brugia malayi RNA, U transporter 1 0.0099 0.1357 0.6539
Echinococcus multilocularis snurportin 1 0.0372 0.5359 1
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0012 0.0078 0.5
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.5359 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0145
Entamoeba histolytica hypothetical protein 0.0043 0.0541 0.7294
Onchocerca volvulus Huntingtin homolog 0.0148 0.2075 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0541 0.1009
Brugia malayi hypothetical protein 0.0084 0.1136 0.5475
Toxoplasma gondii PHD-finger domain-containing protein 0.0012 0.0072 0.0896
Schistosoma mansoni ran 0.0026 0.0279 0.0521
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.042 0.0784
Echinococcus granulosus kelch ECH associated protein 1 like 0.0114 0.1577 0.2943
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0027 0.0298 0.3088
Giardia lamblia PHD finger protein 15 0.0035 0.042 0.4697
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.011 0.0535
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.011 0.0535
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0011 0.007 0.087
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0687 0.8523
Echinococcus multilocularis kelch ECH associated protein 1 0.0114 0.1577 0.2943
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0687 0.8383
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0807 0.1505
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1596 0.2978
Brugia malayi jmjC domain containing protein 0.0011 0.007 0.0338
Loa Loa (eye worm) hypothetical protein 0.0053 0.0687 0.1283
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0807 1
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0078 0.0965
Echinococcus granulosus snurportin 1 0.0372 0.5359 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.011 0.0535
Loa Loa (eye worm) hypothetical protein 0.0103 0.1418 0.2645
Echinococcus granulosus JmjC domain containing protein 4 0.0011 0.007 0.0131
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0807 1
Leishmania major hypothetical protein, conserved 0.0011 0.007 0.0762
Echinococcus multilocularis jumonji domain containing 1A 0.0011 0.007 0.0131
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.007 0.0131
Echinococcus multilocularis caspase 3 0.0088 0.1192 0.2225
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.092 0.0849
Echinococcus granulosus jumonji domain containing 1A 0.0011 0.007 0.0131
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.0072 0.1051
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.011 0.0535
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0078 0.0105
Trypanosoma brucei Metacaspase-4 0.0053 0.0687 0.8523
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0131
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0078 0.0105
Leishmania major metacaspase, putative 0.0053 0.0687 0.7471
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0807 0.8765
Echinococcus multilocularis caspase 8 0.0053 0.0687 0.1283
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.011 0.0535
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0807 0.8765
Treponema pallidum DNA ligase (lig) 0.0012 0.0078 0.5
Schistosoma mansoni tsg101-related 0.007 0.093 0.1735
Onchocerca volvulus Huntingtin homolog 0.0148 0.2075 1
Onchocerca volvulus Cell death protein 3 homolog 0.0103 0.1418 0.6709
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0687 0.8523
Trypanosoma brucei metacaspase 0.0053 0.0687 0.8523
Echinococcus multilocularis peregrin 0.0035 0.042 0.0784
Echinococcus granulosus caspase 8 0.0053 0.0687 0.1283
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0529 0.0987
Echinococcus granulosus phd:f box containing protein 0.0011 0.007 0.0131
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0078 0.0965
Echinococcus multilocularis caspase 0.0141 0.1976 0.3688
Schistosoma mansoni ran 0.0026 0.0279 0.0521
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0078 0.0105
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0027 0.0298 0.3689
Plasmodium falciparum JmjC domain-containing protein, putative 0.0011 0.007 0.102
Loa Loa (eye worm) hypothetical protein 0.0148 0.2075 0.3871
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0012 0.0072 0.0896
Trypanosoma brucei metacaspase MCA2 0.0053 0.0687 0.8523
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0279 0.2843
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.011 0.1358
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0807 1
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0688 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.092 0.0849
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0011 0.007 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0078 0.0965
Echinococcus granulosus lysine specific demethylase 6a 0.0011 0.007 0.0131
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0807 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0807 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.007 0.0131
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0414 0.5139
Echinococcus multilocularis apoptotic protease activating factor 1 0.005 0.0634 0.1182
Entamoeba histolytica hypothetical protein 0.0043 0.0541 0.7294
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0687 0.8523
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0529 0.0987
Schistosoma mansoni caspase-7 (C14 family) 0.0141 0.1976 0.3688
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.092 0.4435
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0078 0.0965
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0053 0.0687 0.3313
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1596 0.2978
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0687 0.8523
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0687 0.8523
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0807 0.1505
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0807 0.1505
Leishmania major GTP-binding protein, putative 0.0026 0.0279 0.3037
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0078 0.0375
Entamoeba histolytica hypothetical protein 0.0014 0.011 0.1476
Brugia malayi DKFZp564C0469 protein 0.0012 0.0078 0.0375
Entamoeba histolytica Ran family GTPase 0.0026 0.0279 0.3768
Echinococcus multilocularis Kelch repeat type 1 0.0114 0.1582 0.2952
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0807 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0318 0.394
Plasmodium vivax hypothetical protein, conserved 0.0035 0.042 0.6111
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0053 0.0687 0.1283
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0078 0.0145
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0078 0.0145
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0072 0.0348
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0807 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0078 0.0965
Loa Loa (eye worm) hypothetical protein 0.0035 0.042 0.0784
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0084 0.1136 0.212
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0807 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0145
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0279 0.2767
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0687 0.8523
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0279 0.4066
Schistosoma mansoni topbp1 0.0012 0.0078 0.0145
Plasmodium falciparum phd finger protein, putative 0.0035 0.042 0.6111
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0529 0.0987
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0084 0.1136 0.212
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0687 0.8523
Brugia malayi jmjC domain containing protein 0.0115 0.1596 0.7691
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.007 0.0131
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0279 0.0521
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0072 0.0135
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0078 0.1049
Schistosoma mansoni protein phosphatase 2C 0.0011 0.007 0.0131
Loa Loa (eye worm) hypothetical protein 0.0084 0.1136 0.212
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0279 0.3465
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0622 0.1161
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0279 0.0521
Entamoeba histolytica hypothetical protein 0.0028 0.0318 0.4284
Plasmodium vivax metacaspase 1, putative 0.0053 0.0687 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0687 0.8523
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0141 0.1976 0.3688
Loa Loa (eye worm) hypothetical protein 0.0148 0.2075 0.3871
Trypanosoma brucei metacaspase MCA3 0.0053 0.0687 0.8523
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0279 0.1347
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0687 0.8523
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.011 0.0535
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.011 0.0535
Brugia malayi hypothetical protein 0.0012 0.0078 0.0375
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0078 0.1132
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0541 0.1009
Loa Loa (eye worm) hypothetical protein 0.0035 0.0414 0.0773
Schistosoma mansoni hypothetical protein 0.0012 0.0072 0.0135
Schistosoma mansoni hypothetical protein 0.0114 0.1582 0.2952
Brugia malayi jmjC domain containing protein 0.0043 0.0529 0.2549
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0145
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0687 0.8523
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0078 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0687 0.8523
Brugia malayi jmjC domain containing protein 0.0011 0.007 0.0338
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0072 0.1051
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.092 0.1717
Entamoeba histolytica hypothetical protein 0.0043 0.0541 0.7294
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0622 0.1161
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0279 0.4066
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.011 0.0535
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0057 0.0742 1
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0688 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.042 0.5209
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0135
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.092 1
Entamoeba histolytica hypothetical protein 0.0043 0.0541 0.7294
Echinococcus multilocularis caspase 2 0.0103 0.1418 0.2645
Brugia malayi jmjC domain containing protein 0.0011 0.007 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0078 0.0965
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0012 0.0072 0.0896
Plasmodium falciparum metacaspase-like protein 0.0053 0.0687 1
Entamoeba histolytica hypothetical protein 0.0012 0.0078 0.1049
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.097 0.181
Brugia malayi hypothetical protein 0.0148 0.2075 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.007 0.0131
Trypanosoma cruzi metacaspase, putative 0.0053 0.0687 0.8383
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.011 0.0535
Echinococcus multilocularis nibrin 0.0012 0.0078 0.0145
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.011 0.0535
Schistosoma mansoni phd/f-box containing protein 0.0011 0.007 0.0131
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0145
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0541 0.1009

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 11.28 uM PUBCHEM_BIOASSAY: Inhibitors of Mycobacterium tuberculosis UDP-galactopyranose mutase (UGM) enzyme Measured in Biochemical System Using Plate Reader - 2105-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504439] ChEMBL. No reference
AC50 (binding) = 13.99 uM PUBCHEM_BIOASSAY: Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504540] ChEMBL. No reference
AC50 (binding) = 42.529 uM PUBCHEM_BIOASSAY: C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504431] ChEMBL. No reference
AC50 (functional) = 44.532 uM PUBCHEM_BIOASSAY: 24 hour HeLa Cytotox assay Measured in Cell-Based System Using Plate Reader - 2117-03_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504431] ChEMBL. No reference
AC50 (functional) > 350 uM PUBCHEM_BIOASSAY: Luminescent Cell-Based Counter Screen to Identify Non-Cytotoxic Compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2629, AID2659] ChEMBL. No reference
EC50 (functional) > 99 uM PUBCHEM_BIOASSAY: Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504720, AID504743] ChEMBL. No reference
EC50 (functional) > 99 uM PUBCHEM_BIOASSAY: Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504720, AID504743] ChEMBL. No reference
Max_Activity_Concent (functional) 0.8 uM PubChem BioAssay. Thermal shift assay to identify compound binding to Kelch domain of Keap1 protein Measured in Biochemical System Using RT-PCR - 2119-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Max_Concentration (binding) 50 uM PubChem BioAssay. Counterscreen to eliminate false positive from thermal shift assay Measured in Biochemical System Using Plate Reader - 2119-07_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 16.3432 uM PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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