Detailed information for compound 1311724

Basic information

Technical information
  • TDR Targets ID: 1311724
  • Name: (8E)-4-phenyl-8-(phenylmethylidene)-1,3,4,5,6 ,7-hexahydroquinazoline-2-thione
  • MW: 332.462 | Formula: C21H20N2S
  • H donors: 1 H acceptors: 0 LogP: 4.19 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: SC1=NC2=C(C(N1)c1ccccc1)CCC/C/2=C\c1ccccc1
  • InChi: 1S/C21H20N2S/c24-21-22-19(16-10-5-2-6-11-16)18-13-7-12-17(20(18)23-21)14-15-8-3-1-4-9-15/h1-6,8-11,14,19H,7,12-13H2,(H2,22,23,24)/b17-14+
  • InChiKey: OIWFTKSWHDPJCN-SAPNQHFASA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-phenyl-8-(phenylmethylidene)-1,3,4,5,6,7-hexahydroquinazoline-2-thione
  • (8E)-4-phenyl-8-(phenylmethylene)-1,3,4,5,6,7-hexahydroquinazoline-2-thione
  • 4-phenyl-8-(phenylmethylene)-1,3,4,5,6,7-hexahydroquinazoline-2-thione
  • 8-(benzylidene)-4-phenyl-1,3,4,5,6,7-hexahydroquinazoline-2-thione
  • (8E)-8-(benzylidene)-4-phenyl-1,3,4,5,6,7-hexahydroquinazoline-2-thione
  • 65331-27-3
  • SMR000212968
  • STOCK1S-20943
  • NSC310664
  • 4-Phenyl-8-[1-phenyl-meth-(E)-ylidene]-3,4,5,6,7,8-hexahydro-1H-quinazoline-2-thione
  • MLS000589596

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens transient receptor potential cation channel, subfamily A, member 1 Starlite/ChEMBL References
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus transient receptor potential cation channel Get druggable targets OG5_132409 All targets in OG5_132409
Schistosoma mansoni transient receptor potential cation channel subfamily A member Get druggable targets OG5_132409 All targets in OG5_132409
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Transient receptor potential cation channel subfamily A member 1, putative Get druggable targets OG5_132409 All targets in OG5_132409
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis transient receptor potential cation channel Get druggable targets OG5_132409 All targets in OG5_132409
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Transient receptor potential cation channel subfamily A member 1, putative Get druggable targets OG5_132409 All targets in OG5_132409
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis ankyrin repeat protein Get druggable targets OG5_132409 All targets in OG5_132409
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus ankyrin repeat protein Get druggable targets OG5_132409 All targets in OG5_132409
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K04984 transient receptor potential cation channel, subfamily A, member 1, putative Get druggable targets OG5_132409 All targets in OG5_132409
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Transient receptor potential cation channel subfamily A member 1, putative Get druggable targets OG5_132409 All targets in OG5_132409
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0263 0.0263
Onchocerca volvulus 0.0462 1 1
Trichomonas vaginalis cyclin B, putative 0.0105 0.2085 0.2042
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0028 0.0028
Onchocerca volvulus Protein CNPPD1 homolog 0.0013 0.0055 0.0055
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0028 0.0028
Trichomonas vaginalis cyclin B3, putative 0.0054 0.0965 0.0916
Schistosoma mansoni hypothetical protein 0.0016 0.0121 0.0121
Brugia malayi Protein kinase domain containing protein 0.0092 0.1799 0.1799
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.1034 0.0984
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0055 0.0055
Giardia lamblia Hypothetical protein 0.0054 0.0965 0.0916
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0564 0.0564
Mycobacterium tuberculosis Long conserved protein 0.0462 1 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0121 0.0295
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.139 0.139
Echinococcus granulosus cyclin dependent kinase 0.0045 0.0753 0.0753
Schistosoma mansoni coup transcription factor 0.0022 0.0263 0.0263
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.02 0.02
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0013 0.0055 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0263 0.0263
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.139 0.1284
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.02 0.0645
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0889 0.0889
Trypanosoma brucei cdc2-related kinase 3 0.0045 0.0753 0.3096
Schistosoma mansoni hypothetical protein 0.0462 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0065 0.0046
Brugia malayi Cyclin, N-terminal domain containing protein 0.0105 0.2085 0.2085
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0092 0.1799 0.1799
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0121 0.0296
Brugia malayi hypothetical protein 0.0013 0.0055 0.0055
Trypanosoma brucei mitotic cyclin 6 0.0105 0.2085 0.9002
Trichomonas vaginalis cyclins, putative 0.0105 0.2085 0.2042
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0753 0.3096
Trypanosoma cruzi CYC2-like cyclin, putative 0.0105 0.2085 0.9002
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.231 1
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0192 0.4019 0.4019
Giardia lamblia Hypothetical protein 0.0462 1 1
Trypanosoma cruzi cyclin, putative 0.0105 0.2085 0.9002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0121 0.0226
Brugia malayi Pre-SET motif family protein 0.0251 0.5335 0.5335
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0263 0.0263
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.02 0.0645
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0263 0.0263
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0263 0.0263
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0055 0.0055
Echinococcus granulosus Transglutaminase 0.0462 1 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0167 0.3474 0.3474
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0121 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0263 0.0263
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0753 0.1411
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0121 0.0121
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.296 0.5548
Brugia malayi isocitrate dehydrogenase 0.0016 0.0121 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.02 0.0645
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.02 0.0645
Trypanosoma brucei unspecified product 0.0014 0.0065 0.0046
Schistosoma mansoni Cyclin fold protein 0.0013 0.0055 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0065 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0263 0.0494
Echinococcus multilocularis GPCR, family 2 0.0016 0.0121 0.0121
Trichomonas vaginalis set domain proteins, putative 0.0286 0.6104 0.6083
Echinococcus granulosus cyclin y 0.0013 0.0055 0.0055
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0263 0.0263
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.139 0.139
Brugia malayi Protein kinase domain containing protein 0.0045 0.0753 0.0753
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.02 0.0645
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0263 0.0494
Mycobacterium leprae Conserved hypothetical protein 0.0462 1 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0196 0.4106 0.4106
Echinococcus granulosus cyclin dependent kinase 1 0.0045 0.0753 0.0753
Toxoplasma gondii hypothetical protein 0.0041 0.0676 0.2767
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0263 0.0263
Echinococcus granulosus cyclin B 0.0105 0.2085 0.2085
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.02 0.0645
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 7 0.0091 0.1777 0.1777
Echinococcus multilocularis geminin 0.0205 0.43 0.43
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.02 0.0645
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0121 0.0296
Onchocerca volvulus Serine\/threonine kinase homolog 0.0115 0.231 0.231
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.231 0.231
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0121 0.0121
Schistosoma mansoni cyclin G 0.0013 0.0055 0.0055
Schistosoma mansoni cyclin k 0.0013 0.0055 0.0055
Echinococcus granulosus GPCR family 2 0.0016 0.0121 0.0121
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0263 0.0263
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0263 0.0263
Echinococcus granulosus transient receptor potential cation channel 0.0196 0.4106 0.4106
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0028 0.0053
Schistosoma mansoni hypothetical protein 0.0016 0.0121 0.0121
Echinococcus granulosus cyclin b3 0.0054 0.0965 0.0965
Echinococcus multilocularis ankyrin repeat protein 0.0192 0.4019 0.4019
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.231 0.2268
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0564 0.0564
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.02 0.0375
Leishmania major cyclin 0.0105 0.2085 0.9002
Schistosoma mansoni g1/s-specific cyclin C 0.0013 0.0055 0.0055
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0013 0.0055 0.0055
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0263 0.0263
Mycobacterium leprae Conserved hypothetical protein 0.0462 1 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0263 0.0494
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0263 0.0263
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0263 0.0263
Echinococcus multilocularis cyclins 0.0054 0.0965 0.0965
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0533 0.0533
Echinococcus multilocularis cyclin B3 1 0.0054 0.0965 0.0965
Entamoeba histolytica serine/threonine protein kinase, putative 0.0115 0.231 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0533 0.1
Onchocerca volvulus 0.0105 0.2085 0.2085
Onchocerca volvulus Cyclin L homolog 0.0013 0.0055 0.0055
Trichomonas vaginalis cyclin A, putative 0.0105 0.2085 0.2042
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0121 0.0295
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0263 0.0263
Giardia lamblia Kinase, PLK 0.0115 0.231 0.2268
Echinococcus multilocularis cyclin dependent kinase 5 0.0045 0.0753 0.0753
Schistosoma mansoni cyclin G2 0.0013 0.0055 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0263 0.0263
Schistosoma mansoni hypothetical protein 0.0205 0.43 0.43
Loa Loa (eye worm) hypothetical protein 0.0105 0.2085 0.3909
Echinococcus granulosus dna polymerase kappa 0.002 0.02 0.02
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0065 0.0046
Loa Loa (eye worm) hypothetical protein 0.0022 0.0263 0.0494
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0263 0.0263
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0121 0.0295
Loa Loa (eye worm) CYL-1 protein 0.0013 0.0055 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0263 0.0494
Echinococcus multilocularis cyclin t1 0.0013 0.0055 0.0055
Brugia malayi cell division control protein 2 homolog 0.0045 0.0753 0.0753
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0115 0.231 0.433
Plasmodium vivax SET domain protein, putative 0.0036 0.0564 0.2103
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0753 0.0702
Brugia malayi MH2 domain containing protein 0.0144 0.296 0.296
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0022 0.0263 0.0494
Loa Loa (eye worm) hypothetical protein 0.0022 0.0263 0.0494
Trichomonas vaginalis cyclin B, putative 0.0105 0.2085 0.2042
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0055 0.0102
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0121 0.0121
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0013 0.0055 0.0102
Plasmodium vivax protein kinase Crk2 0.0045 0.0753 0.2884
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0753 0.1411
Mycobacterium ulcerans transglutaminase family protein 0.0462 1 1
Trichomonas vaginalis cyclins, putative 0.0105 0.2085 0.2042
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0092 0.1799 0.3373
Echinococcus granulosus cyclins 0.0054 0.0965 0.0965
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.02 0.0645
Loa Loa (eye worm) hypothetical protein 0.0022 0.0263 0.0494
Trichomonas vaginalis peptide N-glycanase, putative 0.0462 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0263 0.0494
Echinococcus multilocularis cyclin y 0.0013 0.0055 0.0055
Echinococcus multilocularis dna polymerase kappa 0.002 0.02 0.02
Mycobacterium tuberculosis Conserved hypothetical protein 0.0462 1 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0115 0.231 1
Echinococcus multilocularis cyclins 0.0054 0.0965 0.0965
Echinococcus granulosus cyclin B3 1 0.0054 0.0965 0.0965
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0121 0.0275
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0753 0.0702
Echinococcus multilocularis cyclins 0.0054 0.0965 0.0965
Loa Loa (eye worm) hypothetical protein 0.002 0.02 0.0375
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.5335 1
Trichomonas vaginalis cyclins, putative 0.0105 0.2085 0.2042
Trichomonas vaginalis CAMK family protein kinase 0.0123 0.2488 0.2446
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0055 0.0102
Echinococcus granulosus Cyclin L1 0.0013 0.0055 0.0055
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0028 0.0028
Echinococcus granulosus cyclin G2 0.0013 0.0055 0.0055
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0121 0.0121
Brugia malayi steroid hormone receptor 0.0022 0.0263 0.0263
Echinococcus multilocularis Cyclin L1 0.0013 0.0055 0.0055
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.02 0.0146
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0564 0.2269
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0091 0.1777 0.1777
Giardia lamblia DINP protein human, muc B family 0.002 0.02 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0263 0.0494
Schistosoma mansoni kinase 0.0059 0.1067 0.1067
Trichomonas vaginalis cyclins, putative 0.0064 0.1174 0.1126
Loa Loa (eye worm) hypothetical protein 0.0051 0.0889 0.1666
Echinococcus granulosus cyclins 0.0013 0.0055 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.02 0.0645
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.139 0.592
Echinococcus granulosus 3'partial|mitogen activated protein kinase kinase kinase 0.0091 0.1777 0.1777
Plasmodium falciparum cyclin 0.0054 0.0965 0.3761
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0263 0.0263
Schistosoma mansoni cyclins 0.0054 0.0965 0.0965
Mycobacterium ulcerans hypothetical protein 0.0462 1 1
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0013 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0036 0.0564 0.1057
Echinococcus granulosus cyclin t1 0.0013 0.0055 0.0055
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0753 0.0702
Loa Loa (eye worm) hypothetical protein 0.0013 0.0055 0.0102
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0263 0.0263
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0121 0.0295
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.02 0.0645
Echinococcus granulosus ankyrin repeat protein 0.0192 0.4019 0.4019
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0263 0.0263
Echinococcus granulosus geminin 0.0205 0.43 0.43
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0091 0.1777 0.1777
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0013 0.0055 0.0055
Echinococcus multilocularis cyclin B 0.0105 0.2085 0.2085
Schistosoma mansoni hypothetical protein 0.0013 0.0055 0.0055
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.139 0.139
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0263 0.0263
Brugia malayi hypothetical protein 0.0012 0.0028 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.02 0.0645
Brugia malayi nuclear hormone receptor 0.0022 0.0263 0.0263
Mycobacterium tuberculosis Conserved hypothetical protein 0.0462 1 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0055 0.0102
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0263 0.0263
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0121 0.0121
Brugia malayi hypothetical protein 0.0013 0.0055 0.0055
Giardia lamblia G2/mitotic-specific cyclin B 0.0105 0.2085 0.2042
Loa Loa (eye worm) hypothetical protein 0.0022 0.0263 0.0494
Echinococcus multilocularis cyclin b3 0.0054 0.0965 0.0965
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0121 0.0121
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0263 0.0263
Onchocerca volvulus 0.0286 0.6104 0.6104
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0121 0.0275
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0263 0.0263
Trichomonas vaginalis cyclin B, putative 0.0054 0.0965 0.0916
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0121 0.0121
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0263 0.0263
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0055 0.0055
Echinococcus multilocularis G1:S specific cyclin D1 0.0013 0.0055 0.0055
Echinococcus multilocularis Transglutaminase 0.0462 1 1
Giardia lamblia Transglutaminase/protease, putative 0.0462 1 1
Onchocerca volvulus 0.0013 0.0055 0.0055
Echinococcus granulosus cyclin dependent kinase 5 0.0045 0.0753 0.0753
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0263 0.0263
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0115 0.231 0.231
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.139 0.139
Schistosoma mansoni cyclin B 0.0105 0.2085 0.2085
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0889 0.0889
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0263 0.0263
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.02 0.008
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0045 0.0753 0.1411
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0753 0.0702
Echinococcus multilocularis cyclin A3 4 0.0013 0.0055 0.0055
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0564 0.0564
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0055 0.0055
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0753 0.0753
Schistosoma mansoni cyclin l 0.0013 0.0055 0.0055
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.139 0.1214
Echinococcus granulosus cyclin A3 4 0.0013 0.0055 0.0055
Trypanosoma cruzi cyclin 6, putative 0.0105 0.2085 0.9002
Loa Loa (eye worm) hypothetical protein 0.0022 0.0263 0.0494
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0753 0.0753
Entamoeba histolytica cyclin, putative 0.0054 0.0965 0.4038
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.231 0.2268
Brugia malayi nuclear receptor RXR 0.0012 0.0028 0.0028
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.296 0.5548
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0263 0.0263
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0753 0.3096
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0534 0.0534
Echinococcus multilocularis cyclin y 0.0013 0.0055 0.0055
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.02 0.02
Trypanosoma brucei unspecified product 0.002 0.02 0.0645
Echinococcus multilocularis cyclins 0.0054 0.0965 0.0965
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0753 0.0753
Brugia malayi serine/threonine-protein kinase plk-2 0.0115 0.231 0.231
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0263 0.0263
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.139 0.595
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0263 0.0263
Schistosoma mansoni cyclin B3 0.0167 0.3474 0.3474
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0263 0.0263
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0753 0.0753
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0121 0.0121
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.02 0.0645
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0263 0.0494
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0013 0.0055 0.0055
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0753 0.3096
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0263 0.0263
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.02 0.0645
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0263 0.0263
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.02 0.02
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0753 0.3096
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0121 0.0226
Echinococcus granulosus cyclins 0.0054 0.0965 0.0965
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0965 0.0916
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0045 0.0753 0.3096
Echinococcus multilocularis cyclins 0.0054 0.0965 0.0965
Brugia malayi Pre-SET motif family protein 0.0036 0.0564 0.0564
Mycobacterium ulcerans hypothetical protein 0.0462 1 1
Echinococcus granulosus dna polymerase eta 0.002 0.02 0.02
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.02 0.0645
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.1034 0.0984
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0263 0.0263
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.02 0.0645
Loa Loa (eye worm) cyclin C 0.0013 0.0055 0.0102
Trypanosoma cruzi cyclin, putative 0.0105 0.2085 0.9002
Echinococcus granulosus cyclin 0.0013 0.0055 0.0055
Echinococcus granulosus G1:S specific cyclin D1 0.0013 0.0055 0.0055
Echinococcus multilocularis dna polymerase eta 0.002 0.02 0.02
Echinococcus multilocularis cyclin 0.0013 0.0055 0.0055
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.231 0.2268
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0263 0.0263
Brugia malayi ecdysteroid receptor 0.0022 0.0263 0.0263
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0045 0.0753 0.0753
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0091 0.1777 0.1777
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0121 0.0121
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0013 0.0055 0.0055
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0105 0.2085 0.3909
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.02 0.0645
Mycobacterium ulcerans putative transglutaminase-like protein 0.0462 1 1
Trichomonas vaginalis cyclin B, putative 0.0105 0.2085 0.2042
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0263 0.0263
Loa Loa (eye worm) cyclin domain-containing protein 0.0167 0.3474 0.6512
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0053
Loa Loa (eye worm) hypothetical protein 0.0043 0.0727 0.1363
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0053
Onchocerca volvulus Cyclin L homolog 0.0013 0.0055 0.0055
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0263 0.0263
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0055 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.02 0.0645
Trichomonas vaginalis cyclins, putative 0.0054 0.0965 0.0916
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.231 0.2268
Echinococcus multilocularis cyclin dependent kinase 0.0045 0.0753 0.0753
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0055 0.0102
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0753 0.0702
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.02 0.0645
Echinococcus granulosus cyclin y 0.0013 0.0055 0.0055
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0121 0.0121
Entamoeba histolytica cyclin family protein 0.0054 0.0965 0.4038
Leishmania major DNA polymerase kappa, putative 0.002 0.02 0.0645
Schistosoma mansoni hypothetical protein 0.0205 0.43 0.43
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0564 0.0564
Echinococcus multilocularis cyclin G2 0.0013 0.0055 0.0055
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0055 0.0102
Schistosoma mansoni cyclin d 0.0013 0.0055 0.0055
Giardia lamblia Cyclin A 0.0054 0.0965 0.0916
Mycobacterium tuberculosis Conserved protein 0.0462 1 1
Echinococcus granulosus cyclins 0.0054 0.0965 0.0965
Trichomonas vaginalis cyclins, putative 0.0105 0.2085 0.2042
Echinococcus granulosus cyclins 0.0054 0.0965 0.0965
Echinococcus granulosus cyclin G2 0.0013 0.0055 0.0055
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0115 0.231 0.231
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0055 0.0055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0028 0.0028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0263 0.0263
Echinococcus granulosus cyclin k 0.0013 0.0055 0.0055
Plasmodium falciparum protein kinase 5 0.0045 0.0753 0.2884
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0263 0.0263
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0114 0.2299 1
Brugia malayi Cyclin C 0.0013 0.0055 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0564 0.0564
Onchocerca volvulus 0.0022 0.0263 0.0263
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.139 0.1214
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0564 0.0564
Schistosoma mansoni DNA polymerase eta 0.002 0.02 0.02
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0263 0.0263
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0121 0.0121
Brugia malayi cyclin fold protein 1 variant b 0.0013 0.0055 0.0055
Entamoeba histolytica cyclin family protein 0.0054 0.0965 0.4038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0885 0.1658
Echinococcus multilocularis cyclin k 0.0013 0.0055 0.0055
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0045 0.0753 0.3096
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0045 0.0753 0.3111
Leishmania major DNA polymerase eta, putative 0.002 0.02 0.0645
Plasmodium falciparum MO15-related protein kinase 0.0122 0.2476 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0263 0.0494
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0263 0.0263
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0564 0.0564
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0105 0.2085 0.9002
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0167 0.3474 0.3474
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0121 0.0121
Trichomonas vaginalis cyclin B, putative 0.0105 0.2085 0.2042
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0753 0.3096
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0263 0.0263
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.231 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.02 0.0146
Schistosoma mansoni hypothetical protein 0.0035 0.0533 0.0533
Echinococcus multilocularis cyclins 0.0054 0.0965 0.0965
Onchocerca volvulus 0.0036 0.0564 0.0564
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.139 0.1214
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.231 0.2268
Trichomonas vaginalis cyclin D, putative 0.0054 0.0965 0.0916
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0013 0.0055 0.0102
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0053
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.02 0.02
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.02 0.02
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.02 0.0645
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0263 0.0263
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0263 0.0263
Echinococcus multilocularis kinase protein 0.0091 0.1777 0.1777
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0055 0.0102
Echinococcus multilocularis cyclins 0.0054 0.0965 0.0965
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0889 0.1666
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.093 0.3882
Echinococcus multilocularis kinase protein 0.0091 0.1777 0.1777
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0092 0.1799 0.1799
Echinococcus multilocularis cyclin G2 0.0013 0.0055 0.0055
Echinococcus granulosus cyclins 0.0054 0.0965 0.0965
Schistosoma mansoni hypothetical protein 0.0016 0.0121 0.0121
Echinococcus granulosus 5'partial|3'partial|mitogen activated protein kinase kinase kinase 0.0091 0.1777 0.1777
Brugia malayi hypothetical protein 0.0012 0.0028 0.0028
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.02 0.0645
Entamoeba histolytica cyclin, putative 0.0105 0.2085 0.9002
Trypanosoma brucei cdc2-related kinase 1 0.0045 0.0753 0.3096
Brugia malayi nuclear receptor NHR-88 0.0022 0.0263 0.0263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0263 0.0494
Loa Loa (eye worm) hypothetical protein 0.0022 0.0263 0.0494
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0028 0.0028
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0122 0.2476 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0105 0.2085 0.2085
Schistosoma mansoni hypothetical protein 0.0016 0.0121 0.0121
Mycobacterium tuberculosis Hypothetical protein 0.0462 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0263 0.0263
Brugia malayi Cyclin, N-terminal domain containing protein 0.0167 0.3474 0.3474
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0263 0.0263
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0121 0.0121
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.02 0.0645
Trichomonas vaginalis cyclin D, putative 0.0054 0.0965 0.0916
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0263 0.0263
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0121 0.0295
Trypanosoma brucei unspecified product 0.0014 0.0065 0.0046
Trypanosoma brucei polo-like protein kinase 0.0115 0.231 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.02 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.231 0.2268
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0055 0.0055

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 10 uM Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of 5H-dibenzo[b,e]azepine-10-carboxylic acid methyl ester-induced increase in intracellular calcium by Fluo4-AM based fluorometric assay ChEMBL. 22222037
Potency (functional) 0.0928 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 9.4662 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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