Detailed information for compound 1312280

Basic information

Technical information
  • TDR Targets ID: 1312280
  • Name: 2-(4-fluorophenoxy)ethyl 7-methyl-[1,2,4]tria zolo[1,5-a]pyrimidine-2-carboxylate
  • MW: 316.287 | Formula: C15H13FN4O3
  • H donors: 0 H acceptors: 4 LogP: 2.45 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)OCCOC(=O)c1nn2c(n1)nccc2C
  • InChi: 1S/C15H13FN4O3/c1-10-6-7-17-15-18-13(19-20(10)15)14(21)23-9-8-22-12-4-2-11(16)3-5-12/h2-7H,8-9H2,1H3
  • InChiKey: AUVAMKYGARUCMK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 7-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid 2-(4-fluorophenoxy)ethyl ester
  • MLS001003331
  • SMR000344801
  • T5279750
  • ZINC03449803

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0943 0.0876
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0049 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0029 0.0147 0.0147
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0081 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0081 0.0081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.035 0.0361
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0373 0.0295
Echinococcus multilocularis protein patched 0.0042 0.0307 0.0317
Schistosoma mansoni hypothetical protein 0.029 0.3382 1
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0307 0.0785
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.035 0.0278
Echinococcus multilocularis geminin 0.0167 0.1857 0.192
Schistosoma mansoni ap endonuclease 0.0023 0.0073 0.0217
Loa Loa (eye worm) hypothetical protein 0.007 0.0654 0.0654
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0067 0.0171
Schistosoma mansoni patched 1 0.0042 0.0307 0.0908
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0147 0.0436
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0373 0.0386
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0943 0.2413
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0081 0.0321
Echinococcus granulosus expressed conserved protein 0.0091 0.0919 0.2351
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.052 0.0537
Loa Loa (eye worm) hypothetical protein 0.0049 0.0395 0.0395
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0081 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.052 0.1329
Onchocerca volvulus 0.0049 0.0395 0.0316
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0081 0.0321
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0147 1
Schistosoma mansoni hypothetical protein 0.0167 0.1857 0.549
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0716 0.2119
Echinococcus granulosus jumonji domain containing protein 0.004 0.0287 0.0733
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0073 0.5
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.0042 0.0307 0.0307
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0007 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.035 0.1034
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0943 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0081 0.0035
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0081 0.0083
Brugia malayi Bromodomain containing protein 0.0031 0.0176 0.0104
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0147 1
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0395 0.1167
Schistosoma mansoni zinc finger protein 0.0019 0.0031 0.0091
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0307 0.0785
Giardia lamblia PHD finger protein 15 0.0029 0.0147 0.0851
Loa Loa (eye worm) hypothetical protein 0.0047 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0081 0.0035
Schistosoma mansoni hypothetical protein 0.004 0.0288 0.0853
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0067 0.0069
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0373 0.1104
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0526 0.0526
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0073 0.4691
Schistosoma mansoni hypothetical protein 0.002 0.0044 0.0129
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0081 0.0321
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0943 0.2789
Schistosoma mansoni hypothetical protein 0.004 0.0288 0.0853
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.035 0.1034
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0222 0.023
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0956 0.0988
Echinococcus granulosus geminin 0.0167 0.1857 0.475
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.035 0.1034
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.2139 0.2212
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.035 0.0894
Brugia malayi mbt repeat family protein 0.0047 0.0373 0.0302
Brugia malayi mbt repeat family protein 0.0047 0.0373 0.0302
Loa Loa (eye worm) hypothetical protein 0.0023 0.0081 0.0081
Leishmania major hypothetical protein, unknown function 0.0058 0.0508 0.1969
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0373 0.0955
Loa Loa (eye worm) hypothetical protein 0.004 0.0289 0.0289
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0073 0.4691
Echinococcus granulosus peregrin 0.0031 0.0176 0.0451
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.2139 0.5472
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.035 0.0361
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0943 0.3939
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0081 0.0321
Echinococcus multilocularis zinc finger protein 0.0019 0.0031 0.0032
Schistosoma mansoni hypothetical protein 0.004 0.0288 0.0853
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0081 0.0008
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0245 0.0726
Brugia malayi CHE-14 protein 0.0042 0.0307 0.0235
Onchocerca volvulus Alhambra homolog 0.0029 0.0147 0.0067
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpB 0.0201 0.2281 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0943 0.0869
Brugia malayi PHD-finger family protein 0.0025 0.0096 0.0022
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0307 0.0307
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.023 0.0238
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0081 0.0008
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0073 0.0188
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0956 0.2445
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0373 0.0373
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0073 0.0073
Schistosoma mansoni bromodomain containing protein 0.0062 0.0563 0.1665
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0373 0.1104
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.101 0.2987
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0362 0.1307
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0073 0.0076
Brugia malayi PHD-finger family protein 0.0029 0.0147 0.0075
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0373 0.0386
Echinococcus multilocularis expressed conserved protein 0.0091 0.0919 0.095
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase) 0.0201 0.2281 1
Brugia malayi jmjC domain containing protein 0.0094 0.0956 0.0889
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0147 0.0152
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1506 0.1558
Schistosoma mansoni ap endonuclease 0.0023 0.0073 0.0217
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0992 0.0925
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0081 0.0083
Mycobacterium ulcerans hypothetical protein 0.0023 0.0081 0.0321
Brugia malayi Bromodomain containing protein 0.0074 0.0706 0.0637
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.035 0.035
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0044 0.0044
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.023 0.0588
Loa Loa (eye worm) hypothetical protein 0.0023 0.0081 0.0081
Brugia malayi Bromodomain containing protein 0.0038 0.0259 0.0187
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0798 0.9671 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0454 0.1161
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0081 0.0321
Onchocerca volvulus 0.0824 1 1
Leishmania major phosphoinositide phosphatase 0.0201 0.2281 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.026 0.026
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0081 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0201 0.2281 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0312 0.0312
Schistosoma mansoni hypothetical protein 0.0029 0.0147 0.0436
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0245 0.0726
Schistosoma mansoni hypothetical protein 0.0167 0.1857 0.549
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0081 0.0321
Schistosoma mansoni kinase 0.0047 0.0377 0.1115
Echinococcus multilocularis tumor protein p63 0.0332 0.3909 0.4042
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0943 0.3939
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0943 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0454 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0307 0.1058
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0008 0.5
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0373 0.1104
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0943 0.0975
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0073 0.0288
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0081 0.0035
Entamoeba histolytica phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative 0.0058 0.0508 0.4735
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0943 0.3939
Loa Loa (eye worm) hypothetical protein 0.0097 0.0992 0.0992
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0362 0.1307
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0943 0.3939
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0824 1 1
Schistosoma mansoni hypothetical protein 0.004 0.0288 0.0853
Onchocerca volvulus 0.0047 0.0373 0.0295
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0081 0.0321
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0943 0.947
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0287 0.0296
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0943 0.3939
Echinococcus granulosus zinc finger protein 0.0019 0.0031 0.0079
Echinococcus multilocularis protein dispatched 1 0.0047 0.038 0.0393
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.035 0.0894
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0073 0.0288
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0245 0.0628
Loa Loa (eye worm) hypothetical protein 0.0051 0.0423 0.0423
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0373 0.0955
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0147 1
Brugia malayi jmjC domain containing protein 0.0037 0.0245 0.0173
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0307 0.0317
Giardia lamblia Kinase, PLK 0.0093 0.0943 1
Echinococcus granulosus tumor protein p63 0.0332 0.3909 1
Echinococcus multilocularis peregrin 0.0031 0.0176 0.0182
Plasmodium falciparum phd finger protein, putative 0.0029 0.0147 1
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0147 0.0147
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0067 0.0198
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0081 0.0321
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0454 0.0469
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0245 0.0245
Entamoeba histolytica hypothetical protein, conserved 0.0058 0.0508 0.4735
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0454 0.1342
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0454 0.1161
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0454 0.0469
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0081 0.0083
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1506 0.3854
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0081 0.0321
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0943 0.3939
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0943 0.3939
Loa Loa (eye worm) MBCTL1 0.0053 0.0454 0.0454
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0992 0.2537
Onchocerca volvulus 0.0824 1 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0073 0.5
Trypanosoma cruzi tyrosine phosphatase, putative 0.0058 0.0508 0.4999
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0147 0.0377
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0943 0.3939
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0992 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0992 0.1025
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0454 0.0383
Trypanosoma brucei polo-like protein kinase 0.0093 0.0943 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2818 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (binding) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) 125.8925 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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