Detailed information for compound 1312812

Basic information

Technical information
  • TDR Targets ID: 1312812
  • Name: 1-(1,3-dimethylpyrazol-4-yl)sulfonyl-4-propyl piperazine
  • MW: 286.394 | Formula: C12H22N4O2S
  • H donors: 0 H acceptors: 3 LogP: 0.49 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN1CCN(CC1)S(=O)(=O)c1cn(nc1C)C
  • InChi: 1S/C12H22N4O2S/c1-4-5-15-6-8-16(9-7-15)19(17,18)12-10-14(3)13-11(12)2/h10H,4-9H2,1-3H3
  • InChiKey: YEGSINIBIODSCL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(1,3-dimethylpyrazol-4-yl)sulfonyl-4-propyl-piperazine
  • 1-[(1,3-dimethyl-4-pyrazolyl)sulfonyl]-4-propylpiperazine
  • IVK/0016064

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.1038 0.1038
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1268 0.1274
Schistosoma mansoni tar DNA-binding protein 0.0254 0.1438 1
Onchocerca volvulus 0.0035 0.0113 0.0746
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0549 0.0549
Schistosoma mansoni hypothetical protein 0.005 0.02 0.1394
Onchocerca volvulus 0.0054 0.0227 0.1627
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0204 0.0758
Echinococcus multilocularis musashi 0.0054 0.0227 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0128 0.0121
Brugia malayi hypothetical protein 0.0107 0.0549 0.2019
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0122 0.0071
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0227 0.0835
Echinococcus granulosus lamin 0.0054 0.0227 0.1121
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0017 0.0061
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0113 0.0015
Schistosoma mansoni inositol monophosphatase 0.0037 0.0123 0.0852
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0416
Brugia malayi intermediate filament protein 0.0054 0.0227 0.0835
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0075 0.0274
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0188
Schistosoma mansoni hypothetical protein 0.0107 0.0549 0.3817
Brugia malayi Fli-1 protein 0.0224 0.1254 0.4613
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0122 0.0071
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1549 0.9272 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0057 0.0282
Echinococcus granulosus RUN 0.0019 0.0017 0.0082
Mycobacterium tuberculosis Conserved protein 0.0035 0.0113 0.0015
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0903 0.3322
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0188
Brugia malayi Pre-SET motif family protein 0.0205 0.1138 0.4185
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0076 0.0377
Loa Loa (eye worm) hypothetical protein 0.0051 0.021 0.0772
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.1038 0.7219
Schistosoma mansoni hypothetical protein 0.0031 0.0088 0.0613
Leishmania major hypothetical protein, conserved 0.0049 0.0196 0.9201
Schistosoma mansoni tar DNA-binding protein 0.0254 0.1438 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0122 0.0942
Loa Loa (eye worm) hypothetical protein 0.0155 0.0836 0.3076
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0549 0.271
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0075 0.0274
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0204 1
Brugia malayi TAR-binding protein 0.0254 0.1438 0.5289
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0204 0.0204
Entamoeba histolytica hypothetical protein 0.0107 0.0549 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0128 0.0887
Schistosoma mansoni lipoxygenase 0.0019 0.0017 0.0116
Onchocerca volvulus 0.0051 0.021 0.1495
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0204 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0196 0.0723
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1549 0.9272 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0903 0.0903
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0123 0.0605
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0122 0.0447
Schistosoma mansoni gabp alpha 0.0074 0.0345 0.2401
Onchocerca volvulus 0.0096 0.048 0.3582
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.007 0.0345
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0017 0.0082
Schistosoma mansoni hypothetical protein 0.0031 0.0088 0.0613
Loa Loa (eye worm) RNA binding protein 0.0254 0.1438 0.5289
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0113 0.0015
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0017 0.0082
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0128 0.0469
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0122 0.0071
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0113 0.0015
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0017 0.0017
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0113 0.0015
Echinococcus granulosus intermediate filament protein 0.0054 0.0227 0.1121
Brugia malayi follicle stimulating hormone receptor 0.0466 0.2718 1
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0308 0.1133
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.013 0.0478
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0123 0.0023
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0128 0.063
Schistosoma mansoni intermediate filament proteins 0.0054 0.0227 0.1579
Echinococcus multilocularis tumor protein p63 0.0351 0.2025 0.2025
Loa Loa (eye worm) TAR-binding protein 0.0254 0.1438 0.5289
Echinococcus granulosus lamin dm0 0.0054 0.0227 0.1121
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0227 0.0835
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0196 1
Brugia malayi RNA recognition motif domain containing protein 0.0254 0.1438 0.5289
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0204 0.0758
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.1038 0.5126
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0123 0.1051
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0122 0.0071
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0204 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0123 0.0852
Brugia malayi hypothetical protein 0.0019 0.0017 0.0061
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0188 0.1038 0.3818
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0061
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0122 0.06
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0416
Schistosoma mansoni alpha glucosidase 0.0037 0.0122 0.0845
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0204 0.0758
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0113 0.0015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0113 0.0786
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.013 0.0034
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0128 0.063
Echinococcus multilocularis lamin dm0 0.0054 0.0227 0.0227
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.013 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0113 0.0786
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0416
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0123 0.008
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0122 0.0447
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0088 0.0436
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0123 0.1051
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0549 0.3817
Echinococcus granulosus tar DNA binding protein 0.0254 0.1438 0.7101
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.013 0.1875
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.1038 0.1038
Loa Loa (eye worm) hypothetical protein 0.0099 0.0498 0.1831
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.013 0.0142
Loa Loa (eye worm) beta-lactamase 0.0035 0.0113 0.0416
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0345 0.0345
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0123 0.008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0416
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0076 0.0076
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0123 0.3627
Brugia malayi MAP kinase sur-1 0.005 0.0204 0.0749
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0032 0.0032
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0196 1
Brugia malayi beta-lactamase family protein 0.0035 0.0113 0.0416
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0244 0.1378 0.5069
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0196 0.9201
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0113 0.0416
Schistosoma mansoni lamin 0.0054 0.0227 0.1579
Echinococcus granulosus tumor protein p63 0.0351 0.2025 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.1038 0.7219
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0076 0.0531
Loa Loa (eye worm) hypothetical protein 0.0029 0.0076 0.0281
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0903 0.446
Brugia malayi beta-lactamase 0.0035 0.0113 0.0416
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0113 0.0416
Schistosoma mansoni ap endonuclease 0.0038 0.013 0.0904
Mycobacterium ulcerans transcriptional regulator 0.1549 0.9272 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0903 0.3322
Brugia malayi Inositol-1 0.0037 0.0123 0.0451
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0204 0.0204
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0123 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0196 0.9201
Brugia malayi Ets-domain containing protein 0.0074 0.0345 0.127
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0196 0.9431
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0113 0.0015
Echinococcus granulosus GPCR family 2 0.0031 0.0088 0.0436
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0416
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.013 0.013
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0122 0.0071
Trypanosoma brucei protein kinase, putative 0.005 0.0204 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0057 0.0057
Echinococcus multilocularis GPCR, family 2 0.0031 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0031 0.0088 0.0324
Brugia malayi hypothetical protein 0.0049 0.0196 0.0723
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.1386 0.5098
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0204 0.1006
Schistosoma mansoni alpha-glucosidase 0.0143 0.0763 0.5309
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0054 0.0227 0.0835
Entamoeba histolytica hypothetical protein 0.0107 0.0549 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0128 0.0887
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.013 0.0142
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.0116
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.013 0.6306
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.013 0.1875
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.1378 0.6806
Loa Loa (eye worm) inositol-1 0.0037 0.0123 0.0451
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0227 0.0835
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.013 0.0642
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0204 0.1417
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0122 0.0122
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0204 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0031 0.0088 0.0613
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.013 0.1875
Loa Loa (eye worm) hypothetical protein 0.0063 0.028 0.1031
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1549 0.9272 1
Onchocerca volvulus 0.0233 0.1309 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0128 0.1603
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0128 0.1603
Onchocerca volvulus 0.0035 0.0113 0.0746
Schistosoma mansoni tar DNA-binding protein 0.0254 0.1438 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0128 0.0128
Trypanosoma brucei glucosidase, putative 0.0037 0.0122 0.0942
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0113 0.536
Brugia malayi beta-lactamase family protein 0.0035 0.0113 0.0416
Mycobacterium tuberculosis Conserved protein 0.0035 0.0113 0.0015
Schistosoma mansoni rab6-interacting 0.0019 0.0017 0.0116
Schistosoma mansoni polycystin 1-related 0.0019 0.0017 0.0116
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0122 0.3549
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0123 0.1051
Schistosoma mansoni ap endonuclease 0.0038 0.013 0.0904
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0123 0.0123
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.02 0.0737
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0123 0.1051
Toxoplasma gondii ABC1 family protein 0.0035 0.0113 0.2878
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0128 0.1603
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0076 0.0531
Brugia malayi hypothetical protein 0.0032 0.0091 0.0334
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0229 0.0229
Toxoplasma gondii exonuclease III APE 0.0038 0.013 0.4214
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0204 0.0749
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0088 0.0324
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0204 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0229 0.1132
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0204 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.1386 0.5098
Schistosoma mansoni loxhd1 0.0019 0.0017 0.0116
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0113 0.0015
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0204 0.1006
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1138 0.4185
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.021 0.146
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0345 0.1705
Brugia malayi Ets-domain containing protein 0.0074 0.0345 0.127
Loa Loa (eye worm) hypothetical protein 0.0068 0.0308 0.1133
Brugia malayi hypothetical protein 0.0155 0.0836 0.3076
Schistosoma mansoni tar DNA-binding protein 0.0254 0.1438 1
Schistosoma mansoni ets-related 0.0224 0.1254 0.8723
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0076 0.0531
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0204 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0076 0.3322
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.013 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0113 0.0558
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.013 0.0325
Schistosoma mansoni lamin 0.0054 0.0227 0.1579
Brugia malayi hypothetical protein 0.0019 0.0017 0.0061
Onchocerca volvulus 0.0155 0.0836 0.6341
Onchocerca volvulus 0.005 0.02 0.1422
Schistosoma mansoni hypothetical protein 0.0031 0.0088 0.0613
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0122 0.0942
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0204 1
Schistosoma mansoni rab6-interacting 0.0019 0.0017 0.0116
Mycobacterium leprae Probable lipase LipE 0.0035 0.0113 0.0015
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0017 0.0017
Echinococcus multilocularis RUN 0.0019 0.0017 0.0017
Onchocerca volvulus 0.0054 0.0227 0.1627
Schistosoma mansoni lipoxygenase 0.0055 0.0229 0.1594
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.1038 0.7219
Trichomonas vaginalis set domain proteins, putative 0.0233 0.1309 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.013 0.0019
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0088 0.0088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0188 0.1038 0.3818
Schistosoma mansoni alpha-glucosidase 0.0143 0.0763 0.5309
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.013 0.0198
Brugia malayi Pre-SET motif family protein 0.0029 0.0076 0.0281
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0903 0.0903
Echinococcus multilocularis lamin 0.0054 0.0227 0.0227
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0128 0.0128
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0122 0.0071
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.013 0.1875
Onchocerca volvulus 0.0029 0.0076 0.0462
Onchocerca volvulus 0.0035 0.0113 0.0746
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0122 0.0071
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0498 0.1831
Mycobacterium tuberculosis Conserved protein 0.0035 0.0113 0.0015
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0128 0.0121
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0123 0.008
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0088 0.0324
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0128 0.1603
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0254 0.1438 0.5289
Schistosoma mansoni hypothetical protein 0.0068 0.0308 0.2143
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0498 0.1831
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0128 0.0121
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0128 0.063
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0416
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0076 0.0531
Brugia malayi hypothetical protein 0.0244 0.1378 0.5069
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0345 0.127
Schistosoma mansoni hypothetical protein 0.0022 0.0032 0.0224
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0017 0.0082
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.1378 0.1378
Schistosoma mansoni survival motor neuron protein 0.005 0.02 0.1394
Schistosoma mansoni tar DNA-binding protein 0.0254 0.1438 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0204 0.0758
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0032 0.0159
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0122 0.0071
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0498 0.1831
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0469
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.013 0.6306
Brugia malayi MH2 domain containing protein 0.0246 0.1386 0.5098
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0122 0.0071
Entamoeba histolytica hypothetical protein 0.0107 0.0549 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0088 0.0436
Brugia malayi RNA binding protein 0.0254 0.1438 0.5289
Brugia malayi Doublecortin family protein 0.0019 0.0017 0.0061
Loa Loa (eye worm) hypothetical protein 0.0053 0.0221 0.0813
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.1038 0.5126
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0088 0.0324
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0128 0.014
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0122 0.0942
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0113 0.0015
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0466 0.2718 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0061
Mycobacterium ulcerans TetR family transcriptional regulator 0.1549 0.9272 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0113 0.0113
Echinococcus multilocularis tar DNA binding protein 0.0254 0.1438 0.1438
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0196 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0196 0.9201
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0204 1
Entamoeba histolytica hypothetical protein 0.0107 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.021
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.013 0.0478
Loa Loa (eye worm) fli-1 protein 0.0224 0.1254 0.4613

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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