Detailed information for compound 131642

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 354.423 | Formula: C19H18N2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.17 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc2c(c1)c(O)c(c(=O)n2C)C(=O)N(c1ccccc1)C
  • InChi: 1S/C19H18N2O3S/c1-20(12-7-5-4-6-8-12)18(23)16-17(22)14-11-13(25-3)9-10-15(14)21(2)19(16)24/h4-11,22H,1-3H3
  • InChiKey: SLLIIFQCPVUDMP-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0122 0.0477 0.0477
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0143 0.0589 0.0589
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0767 0.4287
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0084 0.0276 0.0276
Brugia malayi SH2 domain containing protein 0.004 0.004 0.0072
Onchocerca volvulus 0.0769 0.3956 0.936
Echinococcus granulosus tyrosine protein kinase Src42A 0.0122 0.0477 0.0477
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0362 0.1766 0.1766
Entamoeba histolytica protein kinase, putative 0.0103 0.0378 0.2063
Brugia malayi Cyclin, N-terminal domain containing protein 0.0044 0.0058 0.0106
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.005 0.0092 0.0092
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0168 0.0726 0.4055
Brugia malayi jmjC domain containing protein 0.0143 0.0589 0.1071
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0286 0.1359 0.1359
Schistosoma mansoni cyclin B 0.0044 0.0058 0.0058
Entamoeba histolytica cell division protein kinase 2, putative 0.0116 0.0446 0.2453
Loa Loa (eye worm) hypothetical protein 0.0044 0.0056 0.0088
Trypanosoma brucei cdc2-related kinase 3 0.0116 0.0446 0.252
Echinococcus granulosus ephrin type A receptor 4 A 0.0198 0.0889 0.0889
Brugia malayi serine/threonine kinase 12 0.0287 0.1368 0.2488
Schistosoma mansoni microtubule-associated protein tau 0.1893 1 1
Loa Loa (eye worm) TK protein kinase 0.005 0.0092 0.0145
Leishmania major protein kinase, putative 0.0287 0.1368 0.7741
Echinococcus multilocularis epidermal growth factor receptor 0.1055 0.5496 0.5496
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0122 0.0477 0.0477
Loa Loa (eye worm) TK/EGFR protein kinase 0.1055 0.5496 0.8651
Toxoplasma gondii thioredoxin reductase 0.0033 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0044 0.0056 0.0088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0168 0.0726 0.4055
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0116 0.0446 0.252
Trichomonas vaginalis cyclin B, putative 0.0044 0.0058 0.0237
Loa Loa (eye worm) hypothetical protein 0.0078 0.024 0.0377
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0287 0.1368 1
Trichomonas vaginalis cyclin B, putative 0.0044 0.0058 0.0237
Schistosoma mansoni tyrosine kinase 0.004 0.004 0.004
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.0047 0.0076 0.0103
Schistosoma mansoni aldehyde dehydrogenase 0.0035 0.001 0.001
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0039 0.0034 0.0186
Loa Loa (eye worm) SRC-1 0.0122 0.0477 0.075
Schistosoma mansoni cyclin B3 0.0044 0.0058 0.0058
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.017 0.0267
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0122 0.0477 0.0477
Brugia malayi hypothetical protein 0.004 0.004 0.0072
Brugia malayi Immunoglobulin I-set domain containing protein 0.0909 0.4709 0.8568
Entamoeba histolytica protein kinase domain containing protein 0.0042 0.0045 0.0162
Echinococcus multilocularis tar DNA binding protein 0.0065 0.017 0.017
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0122 0.0477 0.0477
Echinococcus granulosus neuropeptide receptor A26 0.0535 0.2697 0.2697
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0036 0.0017 0.0027
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0287 0.1368 0.1368
Schistosoma mansoni nephrin 0.0118 0.0454 0.0454
Brugia malayi SRC-1 0.0122 0.0477 0.0867
Onchocerca volvulus 0.0044 0.0058 0.0138
Schistosoma mansoni tyrosine kinase 0.0683 0.3491 0.3491
Brugia malayi Protein kinase domain containing protein 0.0092 0.0317 0.0577
Loa Loa (eye worm) hypothetical protein 0.0078 0.0239 0.0376
Giardia lamblia Kinase, AGC PKA 0.0061 0.0151 0.085
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0122 0.0477 0.0477
Echinococcus granulosus epidermal growth factor receptor 0.1055 0.5496 0.5496
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0116 0.0446 0.0702
Echinococcus multilocularis Glutaredoxin protein 5 0.0051 0.0097 0.0097
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0767 0.4287
Loa Loa (eye worm) hypothetical protein 0.0051 0.0096 0.0151
Loa Loa (eye worm) hypothetical protein 0.0044 0.0056 0.0088
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.017 0.0309
Echinococcus multilocularis titin 0.0043 0.0056 0.0056
Schistosoma mansoni ephrin receptor 0.0045 0.0065 0.0065
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0044 0.0058 0.0324
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0767 0.4287
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.0446 0.0446
Echinococcus granulosus serine threonine protein kinase nrc 0.0061 0.0151 0.0151
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0036 0.0017 0.0017
Brugia malayi hypothetical protein 0.0078 0.0239 0.0435
Echinococcus multilocularis protein kinase c epsilon type 0.0036 0.0017 0.0017
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0089 0.0302 0.0302
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0767 0.4287
Trypanosoma cruzi polo-like protein kinase, putative 0.0362 0.1766 1
Echinococcus granulosus neuroglian 0.0104 0.0379 0.0379
Echinococcus granulosus nervana 2 0.0051 0.0095 0.0095
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0038 0.0026 0.0143
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0168 0.0726 0.4055
Schistosoma mansoni serine/threonine-protein kinase 0.0066 0.0178 0.0178
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0068 0.0187 0.0294
Echinococcus multilocularis mitogen activated protein kinase 0.0039 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0044 0.0056 0.0088
Brugia malayi Protein kinase domain containing protein 0.004 0.004 0.0072
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0116 0.0446 0.0702
Mycobacterium leprae Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) 0.1431 0.7518 1
Echinococcus granulosus tyrosine kinase 0.004 0.004 0.004
Echinococcus multilocularis cyclins 0.0044 0.0058 0.0058
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0122 0.0477 0.0477
Entamoeba histolytica protein kinase, putative 0.0092 0.0317 0.1716
Schistosoma mansoni titin 0.0043 0.0056 0.0056
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.0131 0.0239
Giardia lamblia G2/mitotic-specific cyclin B 0.0044 0.0058 0.0327
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.004 0.0062
Echinococcus granulosus cyclins 0.0044 0.0058 0.0058
Echinococcus multilocularis cyclin B 0.0044 0.0058 0.0058
Brugia malayi protein unc-22 0.0043 0.0056 0.0101
Entamoeba histolytica cyclin family protein 0.0044 0.0058 0.0237
Toxoplasma gondii CMGC kinase, CK2 family 0.0176 0.0767 0.5605
Echinococcus multilocularis geminin 0.0173 0.0753 0.0753
Echinococcus multilocularis neuropeptide receptor A26 0.0535 0.2697 0.2697
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0058 0.0131 0.0131
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0038 0.0026 0.0041
Brugia malayi ephrin receptor 1 precursor 0.0095 0.0332 0.0604
Brugia malayi cell division control protein 2 homolog 0.0116 0.0446 0.0811
Echinococcus multilocularis protein tyrosine kinase 0.0654 0.334 0.334
Echinococcus granulosus peroxidasin 0.0044 0.0056 0.0056
Echinococcus multilocularis microtubule associated protein 2 0.1893 1 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0061 0.0151 0.0151
Echinococcus granulosus c src tyrosine kinase 0.005 0.0088 0.0088
Echinococcus multilocularis cyclin dependent kinase 0.0116 0.0446 0.0446
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0035 0.001 0.0012
Trypanosoma cruzi aurora B kinase, putative 0.0287 0.1368 0.7741
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0036 0.0017 0.0027
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.092 0.477 0.477
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0036 0.0017 0.0017
Schistosoma mansoni kinase 0.0522 0.2629 0.2629
Trichomonas vaginalis cyclins, putative 0.0044 0.0058 0.0237
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0038 0.0026 0.0054
Trichomonas vaginalis cyclins, putative 0.0044 0.0058 0.0237
Loa Loa (eye worm) thioredoxin reductase 0.0033 0.0001 0.0002
Onchocerca volvulus 0.004 0.004 0.0094
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0087 0.029 0.0456
Schistosoma mansoni vesicular amine transporter 0.009 0.0305 0.0305
Schistosoma mansoni aldehyde dehydrogenase 0.0035 0.001 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.004 0.0062
Trichomonas vaginalis cyclin A, putative 0.0044 0.0058 0.0237
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0039 0.0034 0.0186
Echinococcus granulosus tyrosine protein kinase Btk29A 0.005 0.0088 0.0088
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0122 0.0477 0.0477
Echinococcus multilocularis tyrosine protein kinase ABL1 0.004 0.004 0.004
Echinococcus granulosus tyrosine protein kinase Src64B 0.0122 0.0477 0.0477
Leishmania major cyclin 0.0044 0.0058 0.0324
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0076 0.023 0.0316
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0109 0.0407 0.0407
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0287 0.1368 0.1368
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0089 0.0302 0.0302
Brugia malayi RNA binding protein 0.0065 0.017 0.0309
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0061 0.0151 0.0847
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0039 0.0034 0.0186
Loa Loa (eye worm) hypothetical protein 0.0066 0.0177 0.0278
Schistosoma mansoni hypothetical protein 0.0035 0.0009 0.0009
Entamoeba histolytica cyclin family protein 0.0044 0.0058 0.0237
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0122 0.0477 0.0477
Echinococcus multilocularis cyclins 0.0044 0.0058 0.0058
Loa Loa (eye worm) TK/EPH protein kinase 0.0203 0.0915 0.144
Echinococcus multilocularis lachesin 0.0044 0.0056 0.0056
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0317 0.1716
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0058 0.0131 0.0131
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0017 0.0017
Onchocerca volvulus 0.004 0.004 0.0094
Echinococcus multilocularis cyclins 0.0044 0.0058 0.0058
Echinococcus multilocularis cyclin dependent kinase 5 0.0116 0.0446 0.0446
Trypanosoma cruzi polo-like protein kinase, putative 0.0362 0.1766 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0038 0.0026 0.0026
Echinococcus granulosus tyrosine protein kinase shark 0.004 0.004 0.004
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0036 0.0017 0.0017
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0039 0.0034 0.0053
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.022 0.022
Toxoplasma gondii aldehyde dehydrogenase 0.0035 0.001 0.0068
Trichomonas vaginalis CAMK family protein kinase 0.0362 0.1766 1
Brugia malayi TAR-binding protein 0.0065 0.017 0.0309
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0038 0.0026 0.0143
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0036 0.0017 0.0027
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0122 0.0477 0.0477
Echinococcus granulosus tyrosine protein kinase Fyn 0.0122 0.0477 0.0477
Echinococcus granulosus cyclins 0.0044 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0128 0.051 0.0803
Schistosoma mansoni tar DNA-binding protein 0.0065 0.017 0.017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0096 0.0151
Echinococcus multilocularis cyclins 0.0044 0.0058 0.0058
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0767 0.4287
Giardia lamblia Kinase, PLK 0.0362 0.1766 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0076 0.023 0.0316
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0044 0.0058 0.0058
Schistosoma mansoni protein kinase 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0044 0.0058 0.0092
Trypanosoma brucei cdc2-related kinase 1 0.0116 0.0446 0.252
Trypanosoma brucei protein kinase, putative 0.0039 0.0034 0.0186
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0287 0.1368 0.7721
Brugia malayi Protein kinase domain containing protein 0.0036 0.0017 0.0031
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0122 0.0477 0.0477
Entamoeba histolytica cell division protein kinase 2, putative 0.0116 0.0446 0.2453
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0056 0.0102
Trypanosoma cruzi cdc2-related kinase 3 0.0116 0.0446 0.252
Entamoeba histolytica SH2-protein kinase domain containing protein 0.004 0.004 0.013
Loa Loa (eye worm) glutathione reductase 0.0033 0.0001 0.0002
Trichomonas vaginalis cyclin B3, putative 0.0044 0.0058 0.0237
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0039 0.0034 0.0186
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0909 0.4709 0.7412
Echinococcus multilocularis tyrosine protein kinase Blk 0.0113 0.0428 0.0428
Schistosoma mansoni cell adhesion molecule 0.0123 0.0483 0.0483
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0042 0.0045 0.0327
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.005 0.0092 0.0092
Schistosoma mansoni septate junction protein 0.0044 0.0056 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0065 0.017 0.017
Schistosoma mansoni tyrosine kinase 0.0122 0.0477 0.0477
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0009 0.0017
Echinococcus granulosus cyclins 0.0044 0.0058 0.0058
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.005 0.0088 0.0088
Trichomonas vaginalis AGC family protein kinase 0.0287 0.1368 0.7721
Brugia malayi SH2 domain containing protein 0.004 0.004 0.0072
Echinococcus granulosus voltage dependent calcium channel 0.0089 0.0302 0.0302
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.007 0.007
Echinococcus granulosus protein tyrosine kinase 0.0654 0.334 0.334
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0092 0.0168
Schistosoma mansoni ephrin receptor 0.0166 0.0716 0.0716
Entamoeba histolytica protein kinase 2, putative 0.0061 0.0151 0.0764
Brugia malayi protein kinase C II. 0.0036 0.0017 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0017 0.0017
Echinococcus granulosus cyclin b3 0.0044 0.0058 0.0058
Entamoeba histolytica cyclin, putative 0.0044 0.0058 0.0237
Echinococcus granulosus lachesin 0.0044 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0106 0.039 0.0614
Mycobacterium tuberculosis Probable oxidoreductase 0.0084 0.0276 0.0379
Echinococcus granulosus tar DNA binding protein 0.0065 0.017 0.017
Echinococcus granulosus neuropeptide s receptor 0.0535 0.2697 0.2697
Schistosoma mansoni lipoxygenase 0.0057 0.0127 0.0127
Trichomonas vaginalis cyclin B, putative 0.0044 0.0058 0.0237
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0089 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0035 0.0009 0.0014
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0058 0.0131 0.0131
Echinococcus multilocularis voltage dependent calcium channel 0.0089 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0089 0.0302 0.0475
Echinococcus granulosus Glutaredoxin protein 5 0.0051 0.0097 0.0097
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0038 0.0026 0.0026
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0047 0.0076 0.0552
Onchocerca volvulus 0.0043 0.0052 0.0123
Trichomonas vaginalis cyclin B, putative 0.0044 0.0058 0.0237
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0056 0.0102
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0113 0.0428 0.0428
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0044 0.0056 0.0056
Schistosoma mansoni roundabout 0.0044 0.0056 0.0056
Loa Loa (eye worm) TK/FAK protein kinase 0.0662 0.338 0.532
Echinococcus granulosus protein kinase C gamma type 0.0036 0.0017 0.0017
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0061 0.0151 0.0151
Echinococcus multilocularis roundabout 2 0.0142 0.0585 0.0585
Onchocerca volvulus 0.004 0.004 0.0094
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0116 0.0446 0.252
Brugia malayi Protein kinase domain containing protein 0.0036 0.0017 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0362 0.1766 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0116 0.0446 0.0446
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0143 0.0589 0.0589
Plasmodium vivax protein kinase Crk2 0.0116 0.0446 0.3259
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0044 0.0056 0.0133
Schistosoma mansoni tyrosine kinase 0.0654 0.334 0.334
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0317 0.1716
Schistosoma mansoni cyclins 0.0044 0.0058 0.0058
Trichomonas vaginalis cyclins, putative 0.0044 0.0058 0.0237
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0082 0.0264 0.0338
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0084 0.0276 0.0379
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0116 0.0446 0.0446
Trypanosoma cruzi cdc2-related kinase 3 0.0116 0.0446 0.252
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0767 0.4287
Loa Loa (eye worm) AUR protein kinase 0.0287 0.1368 0.2152
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.0496 0.274
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0178 0.092
Entamoeba histolytica tyrosin kinase, putative 0.0039 0.0032 0.0084
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0047 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0173 0.0753 0.0753
Brugia malayi Protein kinase domain containing protein 0.0116 0.0446 0.0811
Schistosoma mansoni serine/threonine protein kinase 0.0362 0.1766 0.1766
Plasmodium falciparum cyclin 0.0044 0.0058 0.0423
Entamoeba histolytica protein kinase , putative 0.0287 0.1368 0.7721
Schistosoma mansoni tar DNA-binding protein 0.0065 0.017 0.017
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0035 0.001 0.001
Trypanosoma cruzi cyclin, putative 0.0044 0.0058 0.0324
Brugia malayi serine/threonine-protein kinase plk-2 0.0362 0.1766 0.3213
Plasmodium vivax protein kinase, putative 0.0042 0.0047 0.0337
Loa Loa (eye worm) hypothetical protein 0.0098 0.0351 0.0553
Entamoeba histolytica protein kinase, putative 0.0287 0.1368 0.7721
Brugia malayi hypothetical protein 0.0326 0.1577 0.287
Loa Loa (eye worm) AGC/NDR protein kinase 0.0036 0.0017 0.0027
Echinococcus granulosus neuroglian 0.0058 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0098 0.0351 0.0553
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0027
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0096 0.0174
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0044 0.0056 0.0088
Loa Loa (eye worm) RNA binding protein 0.0065 0.017 0.0267
Echinococcus multilocularis protein kinase c iota type 0.0036 0.0017 0.0017
Treponema pallidum fructose-bisphosphate aldolase 0.0168 0.0726 0.5
Echinococcus multilocularis cyclins 0.0044 0.0058 0.0058
Giardia lamblia Cyclin A 0.0044 0.0058 0.0327
Entamoeba histolytica cyclin, putative 0.0044 0.0058 0.0237
Brugia malayi Thioredoxin reductase 0.0033 0.0001 0.0002
Echinococcus granulosus cyclin dependent kinase 0.0116 0.0446 0.0446
Loa Loa (eye worm) AGC/AKT protein kinase 0.0092 0.0317 0.0499
Schistosoma mansoni cell adhesion molecule 0.0044 0.0056 0.0056
Entamoeba histolytica protein kinase, putative 0.0287 0.1368 0.7721
Echinococcus granulosus plexin a4 0.0051 0.0094 0.0094
Echinococcus multilocularis tyrosine protein kinase Abl 0.005 0.0088 0.0088
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0039 0.0034 0.0186
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0038 0.0026 0.0143
Loa Loa (eye worm) hypothetical protein 0.0033 0 0.0001
Echinococcus granulosus serine:threonine protein kinase N2 0.0036 0.0017 0.0017
Brugia malayi Plexin repeat family protein 0.0043 0.0052 0.0095
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0038 0.0028 0.0028
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0047 0.0076 0.0338
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0056 0.0102
Schistosoma mansoni tyrosine kinase 0.004 0.004 0.004
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.004 0.0062
Schistosoma mansoni cell adhesion molecule 0.0058 0.0131 0.0131
Echinococcus granulosus mitogen activated protein kinase 0.0039 0.0034 0.0034
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0042 0.0045 0.025
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0039 0.0034 0.0186
Echinococcus granulosus thioredoxin glutathione reductase 0.0034 0.0003 0.0003
Giardia lamblia Hypothetical protein 0.0044 0.0058 0.0327
Loa Loa (eye worm) hypothetical protein 0.0128 0.051 0.0803
Schistosoma mansoni septate junction protein 0.0044 0.0056 0.0056
Schistosoma mansoni tyrosine kinase 0.0122 0.0477 0.0477
Trypanosoma cruzi cdc2-related kinase 1 0.0116 0.0446 0.252
Loa Loa (eye worm) PHD-finger family protein 0.0033 0 0.0001
Echinococcus granulosus tyrosine protein kinase ABL1 0.004 0.004 0.004
Brugia malayi Tyrosine-protein kinase abl-1 0.005 0.0088 0.0161
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0034 0.0097
Echinococcus granulosus Immunoglobulin 0.0084 0.0276 0.0276
Brugia malayi Protein kinase domain containing protein 0.0906 0.4695 0.8542
Leishmania major casein kinase II, putative 0.0176 0.0767 0.4338
Echinococcus multilocularis cyclins 0.0044 0.0058 0.0058
Trypanosoma cruzi CYC2-like cyclin, putative 0.0044 0.0058 0.0324
Echinococcus multilocularis c src tyrosine kinase 0.005 0.0088 0.0088
Echinococcus multilocularis cyclin B3 1 0.0044 0.0058 0.0058
Schistosoma mansoni neuroglian 0.0058 0.0131 0.0131
Echinococcus multilocularis neuroglian 0.0104 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0044 0.0056 0.0088
Brugia malayi p70 ribosomal S6 kinase beta 0.0087 0.029 0.0527
Loa Loa (eye worm) CAMK protein kinase 0.0043 0.0056 0.0088
Echinococcus multilocularis 0.0313 0.1507 0.1507
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0076 0.023 0.0316
Onchocerca volvulus 0.0326 0.1577 0.3731
Loa Loa (eye worm) hypothetical protein 0.0084 0.0276 0.0435
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0042 0.0045 0.025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0168 0.0726 0.4055
Schistosoma mansoni serine/threonine kinase 0.0036 0.0017 0.0017
Schistosoma mansoni tyrosine kinase 0.0683 0.3491 0.3491
Loa Loa (eye worm) TAR-binding protein 0.0065 0.017 0.0267
Trichomonas vaginalis AGC family protein kinase 0.0287 0.1368 0.7721
Loa Loa (eye worm) hypothetical protein 0.0058 0.0131 0.0207
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0061 0.0151 0.1098
Plasmodium vivax unspecified product 0.0176 0.0767 0.5605
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0056 0.0101
Echinococcus granulosus tyrosine protein kinase Srms 0.004 0.004 0.004
Echinococcus multilocularis serine:threonine protein kinase N2 0.0036 0.0017 0.0017
Echinococcus multilocularis neuropeptide s receptor 0.0535 0.2697 0.2697
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0362 0.1766 0.278
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0317 0.1716
Echinococcus granulosus roundabout 2 0.0058 0.0131 0.0131
Schistosoma mansoni tyrosine kinase 0.005 0.0088 0.0088
Brugia malayi Casein kinase II, alpha chain 0.0176 0.0767 0.1395
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.0446 0.0446
Plasmodium falciparum protein kinase 5 0.0116 0.0446 0.3259
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0317 0.1716
Echinococcus granulosus titin 0.0043 0.0056 0.0056
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0047 0.0076 0.0424
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0446 0.2453
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0082 0.0264 0.0252
Loa Loa (eye worm) hypothetical protein 0.0078 0.0239 0.0376
Echinococcus granulosus titin 0.0043 0.0056 0.0056
Echinococcus multilocularis tyrosine protein kinase shark 0.004 0.004 0.004
Schistosoma mansoni plexin 0.0043 0.0052 0.0052
Echinococcus granulosus tyrosine protein kinase Fyn 0.0122 0.0477 0.0477
Trypanosoma brucei rac serine-threonine kinase, putative 0.0092 0.0317 0.179
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0047 0.0076 0.0424
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0446 0.2453
Echinococcus granulosus epidermal growth factor receptor 0.0714 0.3659 0.3659
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0058 0.0131 0.0207
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0044 0.0056 0.0056
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0034 0.0097
Echinococcus granulosus cyclins 0.0044 0.0058 0.0058
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0036 0.0017 0.0017
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0047 0.0076 0.0338
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0042 0.0045 0.0045
Echinococcus granulosus tyrosine protein kinase Fps85D 0.004 0.004 0.004
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0039 0.0034 0.0186
Plasmodium falciparum protein kinase, putative 0.0042 0.0045 0.0327
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0084 0.0276 0.0276
Echinococcus granulosus Protein kinase C brain isozyme 0.0036 0.0017 0.0017
Giardia lamblia Fructose-bisphosphate aldolase 0.0168 0.0726 0.411
Echinococcus granulosus protein kinase c epsilon type 0.0036 0.0017 0.0017
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0317 0.1716
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0042 0.0045 0.0045
Brugia malayi Furin-like cysteine rich region family protein 0.1055 0.5496 1
Loa Loa (eye worm) calcium channel 0.0089 0.0302 0.0475
Trypanosoma cruzi casein kinase II, putative 0.0176 0.0767 0.4338
Onchocerca volvulus 0.0135 0.0549 0.1298
Giardia lamblia Aurora kinase 0.0287 0.1368 0.7742
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.1368 0.1368
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0042 0.0045 0.025
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0122 0.0477 0.0477
Echinococcus granulosus hemicentin 1 0.0044 0.0056 0.0056
Loa Loa (eye worm) TK/INSR protein kinase 0.0906 0.4695 0.7389
Echinococcus multilocularis serine threonine protein kinase 0.0036 0.0017 0.0017
Brugia malayi Hr1 repeat family protein 0.0036 0.0017 0.0031
Brugia malayi Peroxidasin 0.0044 0.0056 0.0102
Giardia lamblia Kinase, CMGC MAPK 0.0039 0.0034 0.0189
Loa Loa (eye worm) hypothetical protein 0.0135 0.0549 0.0863
Onchocerca volvulus 0.004 0.004 0.0094
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0287 0.1368 0.7721
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0116 0.0446 0.3259
Echinococcus granulosus insulin growth factor 1 receptor beta 0.092 0.477 0.477
Echinococcus granulosus mitogen activated protein kinase 3 0.0039 0.0034 0.0034
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.004 0.0062
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0047 0.0076 0.0424
Trichomonas vaginalis CAMK family protein kinase 0.0362 0.1766 1
Echinococcus granulosus cyclins 0.0044 0.0058 0.0058
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0047 0.0076 0.0338
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.0028 0.0045
Onchocerca volvulus 0.004 0.004 0.0094
Giardia lamblia Kinase, CMGC CDK 0.0116 0.0446 0.2523
Trypanosoma brucei protein kinase, putative 0.0042 0.0045 0.025
Entamoeba histolytica casein kinase, putative 0.0176 0.0767 0.4287
Loa Loa (eye worm) hypothetical protein 0.0326 0.1577 0.2482
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.022 0.0346
Echinococcus multilocularis rac serine:threonine kinase 0.0066 0.0178 0.0178
Onchocerca volvulus 0.0043 0.0056 0.0132
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.0131 0.0239
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.0131 0.0239
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0056 0.0102
Entamoeba histolytica protein kinase domain containing protein 0.0287 0.1368 0.7721
Brugia malayi glutathione reductase 0.0033 0.0001 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0287 0.1368 0.7721
Schistosoma mansoni atypical protein kinase C 0.0036 0.0017 0.0017
Echinococcus multilocularis serine:threonine protein kinase 38 0.0036 0.0017 0.0017
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0116 0.0446 0.0702
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0051 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0043 0.0052 0.0082
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0017 0.0017
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0089 0.0302 0.0549
Echinococcus granulosus serine/threonine protein kinase 0.0066 0.0178 0.0178
Echinococcus multilocularis aurora kinase A 0.0287 0.1368 0.1368
Echinococcus granulosus geminin 0.0173 0.0753 0.0753
Brugia malayi Immunoglobulin I-set domain containing protein 0.0098 0.0351 0.0639
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0058 0.0131 0.0131
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0036 0.0017 0.0027
Brugia malayi MAP kinase sur-1 0.0039 0.0034 0.0062
Brugia malayi Protein kinase domain containing protein 0.0385 0.189 0.3439
Brugia malayi Prion-like- 0.0044 0.0056 0.0102
Echinococcus granulosus casein kinase ii subunit alpha 0.0176 0.0767 0.0767
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0056 0.0056
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.004 0.0062
Echinococcus granulosus tyrosine protein kinase Src42A 0.0082 0.026 0.026
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0082 0.0264 0.0362
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0061 0.0151 0.1098
Loa Loa (eye worm) hypothetical protein 0.0354 0.1723 0.2712
Schistosoma mansoni tyrosine kinase 0.1055 0.5496 0.5496
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.004 0.0062
Echinococcus multilocularis tyrosine kinase 0.004 0.004 0.004
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0036 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0098 0.0351 0.0553
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0287 0.1368 0.7721
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0089 0.0302 0.0302
Echinococcus multilocularis cyclin b3 0.0044 0.0058 0.0058
Echinococcus multilocularis ephrin type A receptor 4 A 0.0198 0.0889 0.0889
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0017 0.0017
Echinococcus multilocularis voltage dependent calcium channel 0.0089 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0044 0.0156
Trichomonas vaginalis CAMK family protein kinase 0.0362 0.1766 1
Brugia malayi Protein kinase domain containing protein 0.0662 0.338 0.615
Loa Loa (eye worm) cyclin domain-containing protein 0.0044 0.0058 0.0092
Echinococcus multilocularis hemicentin 1 0.0044 0.0056 0.0056
Echinococcus granulosus tyrosine protein kinase Lyn 0.0132 0.0532 0.0532
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0047 0.0076 0.0424
Schistosoma mansoni tyrosine kinase 0.0075 0.0224 0.0224
Echinococcus granulosus lysine specific demethylase 5A 0.0074 0.022 0.022
Echinococcus multilocularis nervana 2 0.0051 0.0095 0.0095
Brugia malayi serine/threonine protein kinase 6 0.0287 0.1368 0.2488
Schistosoma mansoni protein kinase 0.0042 0.0045 0.0045
Schistosoma mansoni cell adhesion molecule 0.0058 0.0131 0.0131
Echinococcus multilocularis nervana 2 0.0051 0.0095 0.0095
Entamoeba histolytica serine/threonine protein kinase, putative 0.0362 0.1766 1
Toxoplasma gondii AGC kinase 0.0087 0.029 0.2116
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.004 0.0062
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0089 0.0302 0.0302
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0089 0.0302 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0058 0.0237
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.022 0.022
Trypanosoma brucei polo-like protein kinase 0.0362 0.1766 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.004 0.004 0.004
Brugia malayi Bromodomain containing protein 0.0033 0 0.0001
Echinococcus granulosus NDR protein kinase 0.0036 0.0017 0.0017
Echinococcus granulosus cyclin B3 1 0.0044 0.0058 0.0058
Plasmodium falciparum glutathione reductase 0.0033 0.0001 0.0004
Echinococcus multilocularis insulin receptor 0.0906 0.4695 0.4695
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0035 0.001 0.005
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0076 0.023 0.0208
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0017 0.0017
Echinococcus multilocularis roundabout 2 0.0058 0.0131 0.0131
Schistosoma mansoni serine/threonine-protein kinase 0.0067 0.018 0.018
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0028 0.0052
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0058 0.0131 0.0131
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0047 0.0076 0.0076
Brugia malayi protein-tyrosine kinase 0.0113 0.0428 0.0778
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0096 0.0174
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.004 0.0062
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0058 0.0131 0.0131
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0082 0.026 0.026
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0168 0.0726 0.4055
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0127 0.0127
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0036 0.0017 0.0017
Brugia malayi Cyclin, N-terminal domain containing protein 0.0044 0.0058 0.0106
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0084 0.0276 0.0276
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0317 0.1716
Trypanosoma cruzi cdc2-related kinase 1 0.0116 0.0446 0.252
Echinococcus multilocularis tyrosine protein kinase HCK 0.0103 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0084 0.0276 0.0435
Echinococcus multilocularis Immunoglobulin 0.0084 0.0276 0.0276
Schistosoma mansoni tyrosine kinase 0.0714 0.3659 0.3659
Echinococcus granulosus tyrosine protein kinase Fyn 0.0122 0.0477 0.0477
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0062
Brugia malayi Protein kinase domain containing protein 0.004 0.004 0.0072
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0076 0.0103
Plasmodium falciparum casein kinase 2, alpha subunit 0.0176 0.0767 0.5605
Toxoplasma gondii aurora kinase 0.0287 0.1368 1
Mycobacterium tuberculosis Probable reductase 0.0076 0.023 0.0316
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.005 0.0088 0.0088
Brugia malayi Fibronectin type III domain containing protein 0.0098 0.0351 0.0639
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0038 0.0038
Echinococcus granulosus twitchin 0.0114 0.0435 0.0435
Onchocerca volvulus Tyrosine kinase homolog 0.0819 0.4227 1
Echinococcus multilocularis epidermal growth factor receptor 0.0714 0.3659 0.3659
Echinococcus granulosus defective proboscis extension response 0.0084 0.0276 0.0276
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0084 0.0276 0.0379
Trichomonas vaginalis cyclin D, putative 0.0044 0.0058 0.0237
Loa Loa (eye worm) TK/ROR protein kinase 0.005 0.0092 0.0145
Loa Loa (eye worm) AUR protein kinase 0.0287 0.1368 0.2152
Echinococcus granulosus cyclin B 0.0044 0.0058 0.0058
Plasmodium vivax glutathione reductase, putative 0.0033 0.0001 0.0004
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0047 0.0076 0.0138
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0066 0.0178 0.1002
Schistosoma mansoni voltage-gated cation channel 0.0089 0.0302 0.0302
Echinococcus multilocularis cyclin dependent kinase 1 0.0116 0.0446 0.0446
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0176 0.0767 0.1207
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0047 0.0076 0.0552
Echinococcus granulosus tyrosine protein kinase HCK 0.0103 0.0378 0.0378
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0767 0.4287
Schistosoma mansoni nephrin 0.0058 0.0131 0.0131
Trichomonas vaginalis cyclin B, putative 0.0044 0.0058 0.0237
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0076 0.023 0.0316
Entamoeba histolytica protein kinase domain containing protein 0.0039 0.0032 0.0084
Brugia malayi Cyclin, N-terminal domain containing protein 0.0044 0.0058 0.0106
Plasmodium falciparum thioredoxin reductase 0.0033 0.0001 0.0004
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0127 0.0127
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0047 0.0076 0.0552
Echinococcus multilocularis Immunoglobulin 0.0084 0.0276 0.0276
Schistosoma mansoni titin 0.0044 0.0056 0.0056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0168 0.0726 0.4055
Loa Loa (eye worm) TK/ABL protein kinase 0.004 0.004 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0109 0.0407 0.0641
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0168 0.0726 0.4055
Trichomonas vaginalis cyclin D, putative 0.0044 0.0058 0.0237
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0035 0.001 0.001
Entamoeba histolytica protein kinase, putative 0.0043 0.0051 0.0194
Brugia malayi Protein kinase domain containing protein 0.004 0.004 0.0072
Echinococcus granulosus nervana 2 0.0051 0.0095 0.0095
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0446 0.2453
Schistosoma mansoni tar DNA-binding protein 0.0065 0.017 0.017
Echinococcus multilocularis cyclins 0.0044 0.0058 0.0058
Echinococcus multilocularis lysine specific demethylase 5A 0.0074 0.022 0.022
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0034 0.0097
Echinococcus granulosus cyclin dependent kinase 5 0.0116 0.0446 0.0446
Echinococcus multilocularis plexin a4 0.0051 0.0094 0.0094
Echinococcus multilocularis roundabout 2 0.0058 0.0131 0.0131
Brugia malayi jmjC domain containing protein 0.0074 0.022 0.04
Echinococcus multilocularis casein kinase ii subunit alpha 0.0176 0.0767 0.0767
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.0496 0.274
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0038 0.0028 0.0028
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0714 0.3659 0.3659
Leishmania major protein kinase, putative 0.0042 0.0045 0.025
Echinococcus granulosus activin receptor type 0.0042 0.0045 0.0045
Trypanosoma cruzi cyclin 6, putative 0.0044 0.0058 0.0324
Echinococcus multilocularis tyrosine protein kinase otk 0.0044 0.0056 0.0056
Mycobacterium tuberculosis Probable dehydrogenase 0.0076 0.023 0.0316
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.1431 0.7518 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0362 0.1766 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0058 0.0092
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0051 0.0095 0.0095
Plasmodium vivax thioredoxin reductase, putative 0.0033 0.0001 0.0004
Brugia malayi plexin A 0.0051 0.0094 0.0171
Trypanosoma brucei mitotic cyclin 6 0.0044 0.0058 0.0324
Echinococcus multilocularis thioredoxin glutathione reductase 0.0034 0.0003 0.0003
Echinococcus multilocularis serine:threonine protein kinase N2 0.0036 0.0017 0.0017
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0178 0.092
Echinococcus granulosus aurora kinase A 0.0287 0.1368 0.1368
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0017 0.0017
Echinococcus granulosus insulin receptor 0.0906 0.4695 0.4695
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0089 0.0302 0.0302
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0089 0.0302 0.0302
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0176 0.0767 0.5605
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0047 0.0076 0.0119
Trypanosoma brucei aurora B kinase 0.0287 0.1368 0.7741
Brugia malayi Protein kinase domain containing protein 0.004 0.004 0.0072
Loa Loa (eye worm) AGC/PKN protein kinase 0.0036 0.0017 0.0027
Echinococcus multilocularis mitogen activated protein kinase 3 0.0039 0.0034 0.0034
Echinococcus granulosus roundabout 2 0.0058 0.0131 0.0131
Trichomonas vaginalis cyclins, putative 0.0044 0.0058 0.0237
Loa Loa (eye worm) hypothetical protein 0.0044 0.0056 0.0088
Echinococcus multilocularis hemicentin 1 0.0044 0.0056 0.0056
Entamoeba histolytica protein kinase domain containing protein 0.0176 0.0767 0.4287
Trichomonas vaginalis AGC family protein kinase 0.0287 0.1368 0.7721
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0047 0.0076 0.0076
Schistosoma mansoni protein kinase 0.0042 0.0045 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0034 0.0034
Loa Loa (eye worm) CAMK/CAMKL/NUAK protein kinase 0.1215 0.6354 1
Schistosoma mansoni tyrosine kinase 0.0906 0.4695 0.4695
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.1384 0.7264 1
Schistosoma mansoni tyrosine kinase 0.0683 0.3491 0.3491
Echinococcus multilocularis tyrosine protein kinase Srms 0.0113 0.0428 0.0428
Loa Loa (eye worm) AUR protein kinase 0.0287 0.1368 0.2152
Schistosoma mansoni tyrosine kinase 0.0714 0.3659 0.3659
Echinococcus granulosus jumonji domain containing protein 0.0046 0.007 0.007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0168 0.0726 0.4055
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0039 0.0034 0.0244
Trypanosoma cruzi cyclin, putative 0.0044 0.0058 0.0324
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0043 0.0056 0.0088
Loa Loa (eye worm) TK protein kinase 0.0103 0.0378 0.0594
Loa Loa (eye worm) hypothetical protein 0.0044 0.0056 0.0088
Echinococcus granulosus protein kinase c iota type 0.0036 0.0017 0.0017
Schistosoma mansoni protein kinase 0.0287 0.1368 0.1368
Trichomonas vaginalis CAMK family protein kinase 0.0362 0.1766 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0362 0.1766 0.1766
Entamoeba histolytica protein kinase, putative 0.0087 0.029 0.156
Onchocerca volvulus Alhambra homolog 0.0033 0 0.0001
Echinococcus granulosus contactin 0.0058 0.0131 0.0131
Echinococcus multilocularis activin receptor type 0.0042 0.0045 0.0045
Schistosoma mansoni tyrosine kinase 0.005 0.0088 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0065 0.017 0.017
Toxoplasma gondii hypothetical protein 0.0033 0.0001 0.0006
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0044 0.0056 0.0088
Echinococcus granulosus roundabout 2 0.0142 0.0585 0.0585
Trypanosoma cruzi Protein kinase B 0.0066 0.0178 0.1002
Schistosoma mansoni jumonji domain containing protein 0.012 0.0468 0.0468
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0089 0.0302 0.0302
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.004 0.0062
Loa Loa (eye worm) plexin A 0.0051 0.0094 0.0148
Echinococcus granulosus cyclin dependent kinase 1 0.0116 0.0446 0.0446
Trichomonas vaginalis CAMK family protein kinase 0.0362 0.1766 1
Trichomonas vaginalis CAMK family protein kinase 0.0362 0.1766 1
Brugia malayi Protein kinase domain containing protein 0.004 0.004 0.0072
Onchocerca volvulus 0.004 0.004 0.0094
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0044 0.0058 0.0058
Onchocerca volvulus Serine\/threonine kinase homolog 0.0362 0.1766 0.4179
Echinococcus granulosus tyrosine kinase 0.0113 0.0428 0.0428
Giardia lamblia Kinase, CMGC CDK 0.0116 0.0446 0.2523
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0038 0.0026 0.0143
Echinococcus granulosus tyrosine protein kinase Blk 0.0113 0.0428 0.0428
Schistosoma mansoni tyrosine kinase 0.0906 0.4695 0.4695
Brugia malayi serine/threonine-protein kinase 6 0.0287 0.1368 0.2488
Echinococcus multilocularis peroxidasin 0.0044 0.0056 0.0056
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0084 0.0276 0.0269
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0056 0.0102
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0286 0.1359 0.1359
Trichomonas vaginalis cyclins, putative 0.0044 0.0058 0.0237
Plasmodium falciparum serine/threonine protein kinase, putative 0.0287 0.1368 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0056 0.0102
Schistosoma mansoni eyes absent homolog 0.0078 0.0239 0.0239
Entamoeba histolytica protein kinase, putative 0.0092 0.0317 0.1716
Brugia malayi PHD-finger family protein 0.0033 0 0.0001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0113 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0084 0.0276 0.0435
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0168 0.0726 0.4055
Giardia lamblia Kinase, CMGC CK2 0.0176 0.0767 0.434
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0034 0.0097
Schistosoma mansoni protein kinase 0.0176 0.0767 0.0767
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0047 0.0076 0.0427
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0191 0.03
Brugia malayi hypothetical protein 0.0098 0.0351 0.0639
Schistosoma mansoni hypothetical protein 0.0173 0.0753 0.0753
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0038 0.0026 0.0048
Echinococcus multilocularis neuroglian 0.0058 0.0131 0.0131
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.004 0.0062
Loa Loa (eye worm) TK protein kinase 0.0113 0.0428 0.0673
Echinococcus granulosus tyrosine protein kinase otk 0.0044 0.0056 0.0056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0168 0.0726 0.4055
Trypanosoma brucei Casein kinase II 0.0176 0.0767 0.4338
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0036 0.0017 0.0017
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0038 0.0026 0.0026
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0317 0.1716
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0047 0.0076 0.0088

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 11.2 % In vitro percent inhibition of tumor necrosis factor, alpha secreted by macrophage at the dose 10 ug/mL ChEMBL. 15908212
Inhibition (functional) = 11.2 % In vitro percent inhibition of tumor necrosis factor, alpha secreted by macrophage at the dose 10 ug/mL ChEMBL. 15908212
Inhibition (functional) = 13.6 % In vitro percent inhibition of LPS induced B-cell proliferation at the dose 1 ug/mL ChEMBL. 15908212
Inhibition (functional) = 14.7 % In vitro percent inhibition of tumor necrosis factor, alpha secreted by macrophage at the dose 1 ug/mL ChEMBL. 15908212
Inhibition (functional) = 14.7 % In vitro percent inhibition of tumor necrosis factor, alpha secreted by macrophage at the dose 1 ug/mL ChEMBL. 15908212
Inhibition (functional) = 18 % Activity of the compound was expressed as percent inhibition of anti-TNP IgM level in TNP-LPS immunized mice, at a dose of 0.1 mg/kg perorally ChEMBL. 12161149
Inhibition (functional) = 18 % Activity of the compound was expressed as percent inhibition of anti-TNP IgM level in TNP-LPS immunized mice, at a dose of 0.1 mg/kg perorally ChEMBL. 12161149
Inhibition (functional) = 29.7 % In vitro percent inhibition of tumor necrosis factor, alpha secreted by macrophage at the dose 100 ug/mL ChEMBL. 15908212
Inhibition (functional) = 29.7 % In vitro percent inhibition of tumor necrosis factor, alpha secreted by macrophage at the dose 100 ug/mL ChEMBL. 15908212
Inhibition (functional) = 30.3 % In vitro percent inhibition of LPS induced B-cell proliferation at the dose 10 ug/mL ChEMBL. 15908212
Inhibition (functional) = 37.8 % In vitro percent inhibition of LPS induced B-cell proliferation at the dose 100 ug/mL ChEMBL. 15908212
Inhibition (functional) = 41 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 0.1 mg/kg in murine ChEMBL. 11738579
Inhibition (functional) = 41 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 0.1 mg/kg in murine ChEMBL. 11738579
Inhibition (functional) = 49 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 0.1 mg/kg in MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 49 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 0.1 mg/kg in MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 50 % Activity of the compound was expressed as percent inhibition of anti-TNP IgM level in TNP-LPS immunized mice, at a dose of 1 mg/kg perorally ChEMBL. 12161149
Inhibition (functional) = 50 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 1 mg/kg in murine ChEMBL. 11738579
Inhibition (functional) = 50 % Activity of the compound was expressed as percent inhibition of anti-TNP IgM level in TNP-LPS immunized mice, at a dose of 1 mg/kg perorally ChEMBL. 12161149
Inhibition (functional) = 50 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 1 mg/kg in murine ChEMBL. 11738579
Inhibition (functional) = 52 % In vitro percent inhibition of ConA induced T-cell proliferation at the dose 1 ug/mL ChEMBL. 15908212
Inhibition (functional) = 66 % Percent inhibition of proteinuria by compound dose of 0.1 mg/kg given perorally to murine in chronic graft-versus-host-disease test ChEMBL. 11738579
Inhibition (functional) = 66 % Percent inhibition of proteinuria by compound dose of 0.1 mg/kg given perorally to murine in chronic graft-versus-host-disease test ChEMBL. 11738579
Inhibition (functional) = 67 % Activity expressed as percent inhibition of anti-TNP IgM level in TNP-LPS immunized mice, at a dose of 10 mg/kg perorally ChEMBL. 12161149
Inhibition (functional) = 67 % Activity expressed as percent inhibition of anti-TNP IgM level in TNP-LPS immunized mice, at a dose of 10 mg/kg perorally ChEMBL. 12161149
Inhibition (functional) = 69 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 0.32 mg/kg in MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 69 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 0.32 mg/kg in MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 75.3 % In vitro percent inhibition of ConA induced T-cell proliferation at the dose 10 ug/mL ChEMBL. 15908212
Inhibition (functional) = 76 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 1 mg/kg in MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 76 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 1 mg/kg in MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 79.6 % In vitro percent inhibition of ConA induced T-cell proliferation at the dose 100 ug/mL ChEMBL. 15908212
Inhibition (functional) = 82 % Percent inhibition of proteinuria by compound dose of 1 mg/kg given perorally to murine in chronic graft-versus-host-disease test ChEMBL. 11738579
Inhibition (functional) = 82 % Percent inhibition of proteinuria by compound dose of 1 mg/kg given perorally to murine in chronic graft-versus-host-disease test ChEMBL. 11738579
Inhibition (functional) = 88 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 10 mg/kg in murine ChEMBL. 11738579
Inhibition (functional) = 88 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 3.2 mg/kg in MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 88 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 10 mg/kg in murine ChEMBL. 11738579
Inhibition (functional) = 88 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 3.2 mg/kg in MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 93 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 10 mg/kg in MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 93 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 10 mg/kg in MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 94 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 100 mg/kg in murine ChEMBL. 11738579
Inhibition (functional) = 94 % Percent inhibition of anti-DNA antibody was evaluated by ELISA technique as a measure of auto-immune disease after injection of compound dose of 100 mg/kg in murine ChEMBL. 11738579
Inhibition (functional) = 100 % Antinephritic activity of the compound against Graft-Versus-Host Disease (GVHD) induced (C57BL/6DBA/2) F1 mice at a dose of 32 mg/kg administered perorally ChEMBL. 12161149
Inhibition (functional) = 100 % Percent inhibition of proteinuria in mice, perorally dose of 32 mg/kg ChEMBL. 11738579
Inhibition (functional) = 100 % Percent inhibition of proteinuria by compound dose of 10 mg/kg given perorally to murine in chronic graft-versus-host-disease test ChEMBL. 11738579
Inhibition (functional) = 100 % Percent inhibition of proteinuria by compound dose of 100 mg/kg given perorally to murine in chronic graft-versus-host-disease test ChEMBL. 11738579
Inhibition (functional) = 100 % Percent inhibition of proteinuria by compound dose of 0.1 mg/kg given perorally to MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 100 % Percent inhibition of proteinuria by compound dose of 0.32 mg/kg given perorally to MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 100 % Percent inhibition of proteinuria by compound dose of 1 mg/kg given perorally to MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 100 % Percent inhibition of proteinuria by compound dose of 3.2 mg/kg given perorally to MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 100 % Percent inhibition of proteinuria by compound dose of 10 mg/kg given perorally to MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 100 % Antinephritic activity of the compound against Graft-Versus-Host Disease (GVHD) induced (C57BL/6DBA/2) F1 mice at a dose of 32 mg/kg administered perorally ChEMBL. 12161149
Inhibition (functional) = 100 % Percent inhibition of proteinuria in mice, perorally dose of 32 mg/kg ChEMBL. 11738579
Inhibition (functional) = 100 % Percent inhibition of proteinuria by compound dose of 10 mg/kg given perorally to murine in chronic graft-versus-host-disease test ChEMBL. 11738579
Inhibition (functional) = 100 % Percent inhibition of proteinuria by compound dose of 100 mg/kg given perorally to murine in chronic graft-versus-host-disease test ChEMBL. 11738579
Inhibition (functional) = 100 % Percent inhibition of proteinuria by compound dose of 0.1 mg/kg given perorally to MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 100 % Percent inhibition of proteinuria by compound dose of 0.32 mg/kg given perorally to MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 100 % Percent inhibition of proteinuria by compound dose of 1 mg/kg given perorally to MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 100 % Percent inhibition of proteinuria by compound dose of 3.2 mg/kg given perorally to MRL/1 mice ChEMBL. 11738579
Inhibition (functional) = 100 % Percent inhibition of proteinuria by compound dose of 10 mg/kg given perorally to MRL/1 mice ChEMBL. 11738579

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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