Detailed information for compound 1316626

Basic information

Technical information
  • TDR Targets ID: 1316626
  • Name: 2,2-dimethyl-N-[6-methyl-1-(2-methylpropyl)py razolo[5,4-b]quinolin-3-yl]propanamide
  • MW: 338.447 | Formula: C20H26N4O
  • H donors: 1 H acceptors: 3 LogP: 4.48 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Cn1nc(c2c1nc1ccc(cc1c2)C)NC(=O)C(C)(C)C)C
  • InChi: 1S/C20H26N4O/c1-12(2)11-24-18-15(17(23-24)22-19(25)20(4,5)6)10-14-9-13(3)7-8-16(14)21-18/h7-10,12H,11H2,1-6H3,(H,22,23,25)
  • InChiKey: HHOGCIWSLGHTNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(1-isobutyl-6-methyl-pyrazolo[5,4-b]quinolin-3-yl)-2,2-dimethyl-propanamide
  • N-(1-isobutyl-6-methyl-3-pyrazolo[5,4-b]quinolinyl)-2,2-dimethylpropanamide
  • N-(1-isobutyl-6-methyl-pyrazolo[5,4-b]quinolin-3-yl)-2,2-dimethyl-propionamide
  • STOCK4S-48476
  • ZINC00538454

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0143 0.0799 0.8551
Mycobacterium tuberculosis Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) 0.0047 0.0102 0.0009
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0231 0.1444 1
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0161 0.0932 0.6423
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0231 0.1444 0.8392
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0061 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0164 0.0952
Trichomonas vaginalis set domain proteins, putative 0.0268 0.172 1
Loa Loa (eye worm) thiamine pyrophosphate enzyme 0.0063 0.022 0.1445
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0061 0.0552
Schistosoma mansoni hypothetical protein 0.0041 0.0057 0.0304
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0061 0.0552
Loa Loa (eye worm) hypothetical protein 0.0056 0.0164 0.1052
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0143 0.0799 0.4644
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0067 0.0379
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0143 0.0799 0.5492
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0061 0.0201 0.1167
Loa Loa (eye worm) hypothetical protein 0.0061 0.0201 0.1311
Brugia malayi Pre-SET motif family protein 0.0211 0.1297 0.8972
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.016 0.1025
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0161 0.0932 1
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0046 0.0094 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0182 0.1085 0.7495
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0114 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0164 0.0952
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0143 0.0799 0.4644
Brugia malayi Heterochromatin protein 1 0.0093 0.0434 0.2944
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0046 0.0094 0.0875
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0046 0.0094 0.0562
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0161 0.0932 0.6423
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0368 0.248
Mycobacterium leprae Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) 0.0111 0.0566 0.0477
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.016 0.1025
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0042 0.0061 0.0552
Toxoplasma gondii hypothetical protein 0.0042 0.0061 0.0602
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0196 0.1279
Loa Loa (eye worm) hypothetical protein 0.0061 0.0201 0.1311
Onchocerca volvulus 0.0084 0.0368 0.2078
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0201 0.2347
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0067 0.0379
Echinococcus multilocularis chromobox protein 1 0.0093 0.0434 0.0609
Echinococcus granulosus chromobox protein 1 0.0093 0.0434 0.2944
Loa Loa (eye worm) hypothetical protein 0.006 0.0197 0.1287
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0042 0.0061 0.0515
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6923 1
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0042 0.0061 0.0331
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0143 0.0799 1
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0143 0.0799 0.4644
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0061 0.0201 0.0112
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0046 0.0094 0.0975
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0057 0.0304
Mycobacterium ulcerans acetolactate synthase large subunit IlvB 0.0063 0.0219 0.0202
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0061 0.0201 0.2347
Brugia malayi Thiamine pyrophosphate enzyme, central domain containing protein 0.0111 0.0566 0.3863
Loa Loa (eye worm) hypothetical protein 0.0122 0.0645 0.442
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0061 0.0201 0.2387
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0061 0.0201 0.2041
Schistosoma mansoni chromobox protein 0.0093 0.0434 0.2944
Onchocerca volvulus 0.0182 0.1085 0.628
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0046 0.0094 0.0562
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0046 0.0094 0.0239
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0042 0.0061 0.0068
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0143 0.0799 0.4644
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0042 0.0061 0.0068
Giardia lamblia Rab geranylgeranyltransferase 0.0042 0.0061 0.0515
Plasmodium vivax geranylgeranyltransferase, putative 0.0061 0.0201 0.2041
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0195 0.1273
Trichomonas vaginalis chromobox protein, putative 0.0093 0.0434 0.2525
Plasmodium falciparum geranylgeranyltransferase, putative 0.0061 0.0201 0.2041
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0061 0.0552
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0179 0.116
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0161 0.0932 0.5417
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0061 0.0201 0.2041
Leishmania major putative pyruvate/indole-pyruvate carboxylase, putative 0.0063 0.0219 0.2582
Trichomonas vaginalis chromobox protein, putative 0.0059 0.019 0.1104
Giardia lamblia Rab geranylgeranyltransferase 0.0161 0.0932 1
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0061 0.0201 0.2387
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0046 0.0094 0.0562
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0067 0.0078
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0161 0.0932 0.5417
Trypanosoma cruzi lanosterol synthase, putative 0.0061 0.0201 0.2347
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0042 0.0061 0.0331
Schistosoma mansoni acetolactate synthase 0.0095 0.0448 0.3039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.016 0.0212
Loa Loa (eye worm) hypothetical protein 0.0037 0.0026 0.009
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0161 0.0932 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.1297 0.8972
Loa Loa (eye worm) hypothetical protein 0.0101 0.0498 0.3388
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0046 0.0094 0.0975
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.016 0.1025
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.06 0.0849
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0042 0.0061 0.0352
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0042 0.0061 0.0552
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0042 0.0061 0.0515
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0042 0.0061 0.0331
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0056 0.0164 0.0882
Trichomonas vaginalis chromobox protein, putative 0.0093 0.0434 0.2525
Leishmania major farnesyltransferase beta subunit 0.0143 0.0799 1
Onchocerca volvulus 0.0042 0.0061 0.0277
Giardia lamblia Rab geranylgeranyltransferase 0.0061 0.0201 0.2041
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0046 0.0094 0.0544
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0368 0.248
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0046 0.0094 0.0875
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0042 0.0061 0.0552
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0368 0.0513
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0061 0.0331
Plasmodium falciparum acyl-CoA synthetase 0.0063 0.0219 0.2242
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0195 0.1273
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0231 0.1444 1
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0046 0.0094 0.0562
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0231 0.1444 1
Echinococcus multilocularis chromobox protein 1 0.0093 0.0434 0.0609
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.1353 0.9662 1
Trichomonas vaginalis chromobox protein, putative 0.0059 0.019 0.1104
Plasmodium vivax SET domain protein, putative 0.006 0.0195 0.1982
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0195 0.2318
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0231 0.1444 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0195 0.0263
Loa Loa (eye worm) ILVBL protein 0.0067 0.0246 0.1628
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0046 0.0094 0.0116
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0143 0.0799 0.5492
Mycobacterium ulcerans pyruvate or indole-3-pyruvate decarboxylase Pdc 0.0063 0.0219 0.0202
Mycobacterium tuberculosis Probable oxalyl-CoA decarboxylase OxcA 0.0111 0.0566 0.0493
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0426 0.2886
Schistosoma mansoni hypothetical protein 0.0205 0.1253 0.867
Plasmodium vivax acyl-CoA synthetase, putative 0.0063 0.0219 0.2242
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0046 0.0094 0.0975
Trypanosoma cruzi protein farnesyltransferase, putative 0.0143 0.0799 1
Mycobacterium ulcerans acetolactate synthase 0.0063 0.0219 0.0202
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0042 0.0061 0.0331
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0042 0.0061 0.0552
Loa Loa (eye worm) heterochromatin protein 1 0.0093 0.0434 0.2944
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0114 0.0146
Echinococcus multilocularis geminin 0.0205 0.1253 0.1795
Echinococcus granulosus geminin 0.0205 0.1253 0.867
Leishmania major geranylgeranyltransferase, putative 0.0061 0.0201 0.2347
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0196 0.1279
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0061 0.0201 0.1311
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0046 0.0094 0.0239
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0161 0.0932 0.6423
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0046 0.0094 0.0875
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0061 0.0201 0.1311
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.016 0.1025
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0061 0.0552
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0143 0.0799 0.5492
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0368 0.248
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0061 0.0201 0.0271
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0143 0.0799 0.5338
Trypanosoma cruzi protein farnesyltransferase, putative 0.0143 0.0799 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.016 0.0212
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0061 0.0201 0.1167
Giardia lamblia Prenyltransferase 0.0143 0.0799 0.8551
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0061 0.0201 0.2347
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0201 0.2347
Mycobacterium ulcerans acetolactate synthase 1 catalytic subunit 0.0111 0.0566 0.0549
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0059 0.019 0.1035
Schistosoma mansoni chromobox protein 0.0093 0.0434 0.2944
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.1279
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0161 0.0932 0.1329
Brugia malayi jmjC domain containing protein 0.0043 0.0067 0.0379
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0143 0.0799 0.5492
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0195 0.0263
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0196 0.1279
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0082 0.0354 0.3704
Trypanosoma cruzi lanosterol synthase, putative 0.0061 0.0201 0.2347
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0161 0.0932 0.63
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0143 0.0799 0.4644
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0061 0.0552
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0143 0.0799 0.1137
Brugia malayi Pre-SET motif family protein 0.006 0.0195 0.1273
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0061 0.0201 0.1014
Mycobacterium leprae PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) 0.0111 0.0566 0.0477
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0161 0.0932 0.5417
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0195 0.1273
Loa Loa (eye worm) hypothetical protein 0.006 0.0195 0.1273
Mycobacterium ulcerans hypothetical protein 0.0111 0.0566 0.0549
Echinococcus granulosus chromobox protein 1 0.0093 0.0434 0.2944
Schistosoma mansoni acetolactate synthase 0.0095 0.0448 0.3039
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.06 0.4099
Onchocerca volvulus 0.0268 0.172 1
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0046 0.0094 0.1023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0195 0.1273
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0231 0.1444 1
Schistosoma mansoni hypothetical protein 0.0205 0.1253 0.867
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0231 0.1444 0.207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.016 0.1025
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0288 0.1918
Loa Loa (eye worm) hypothetical protein 0.0041 0.0057 0.0304
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.016 0.1025
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0143 0.0799 0.8551
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0046 0.0094 0.0975
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0067 0.0379
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.016 0.1025
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0119 0.0627 0.3645
Onchocerca volvulus 0.0037 0.0026 0.0076
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0143 0.0799 0.4644
Toxoplasma gondii hypothetical protein 0.0119 0.0627 0.7812
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0143 0.0799 1
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0161 0.0932 0.6423
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0231 0.1444 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0067 0.0379
Loa Loa (eye worm) hypothetical protein 0.0161 0.0932 0.6423
Loa Loa (eye worm) hypothetical protein 0.0084 0.0368 0.248
Brugia malayi jmjC domain containing protein 0.0115 0.06 0.4099
Brugia malayi SET domain containing protein 0.0124 0.0662 0.4533
Mycobacterium tuberculosis Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) 0.0111 0.0566 0.0493
Mycobacterium ulcerans putative oxalyl-CoA decarboxylase 0.0111 0.0566 0.0549
Brugia malayi chromobox protein homolog 3 0.0056 0.0164 0.1052
Trypanosoma brucei lanosterol synthase 0.0061 0.0201 0.2347
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.14 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.0418 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.1735 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 223.8721 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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