Detailed information for compound 1328835

Basic information

Technical information
  • TDR Targets ID: 1328835
  • Name: 2-[[4-(4-chlorophenyl)-5-pyridin-4-yl-1,2,4-t riazol-3-yl]sulfanyl]-1-morpholin-4-ylethanon e
  • MW: 415.897 | Formula: C19H18ClN5O2S
  • H donors: 0 H acceptors: 4 LogP: 2.3 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)n1c(SCC(=O)N2CCOCC2)nnc1c1ccncc1
  • InChi: 1S/C19H18ClN5O2S/c20-15-1-3-16(4-2-15)25-18(14-5-7-21-8-6-14)22-23-19(25)28-13-17(26)24-9-11-27-12-10-24/h1-8H,9-13H2
  • InChiKey: IIXUJTJIRJQLGE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[4-(4-chlorophenyl)-5-(4-pyridyl)-1,2,4-triazol-3-yl]sulfanyl]-1-morpholino-ethanone
  • 2-[[4-(4-chlorophenyl)-5-(4-pyridyl)-1,2,4-triazol-3-yl]thio]-1-morpholinoethanone
  • 2-[[4-(4-chlorophenyl)-5-(4-pyridyl)-1,2,4-triazol-3-yl]thio]-1-morpholino-ethanone
  • 2-[[4-(4-chlorophenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]-1-morpholin-4-yl-ethanone
  • BAS 05937564
  • MLS000062894
  • SMR000073854
  • ZINC00796365
  • 4-({[4-(4-chlorophenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio}acetyl)morpholine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.1082 0.153
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0115 0.0055
Schistosoma mansoni cpg binding protein 0.0037 0.1132 0.1602
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0242 0.8761 1
Schistosoma mansoni hypothetical protein 0.0035 0.1083 0.1533
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.1319 0.1266
Schistosoma mansoni hypothetical protein 0.0196 0.7068 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.1005 0.128
Trichomonas vaginalis esterase, putative 0.0042 0.1319 0.1266
Echinococcus granulosus Smad4 0.0009 0.0118 0.0004
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0115 0.0163
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0009 0.0115 0.0055
Schistosoma mansoni hypothetical protein 0.0072 0.2441 0.3454
Brugia malayi hypothetical protein 0.0035 0.1083 0.112
Echinococcus multilocularis Smad4 0.0009 0.0118 0.0004
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0578 0.0484
Mycobacterium leprae conserved hypothetical protein 0.0042 0.1319 1
Trichomonas vaginalis set domain proteins, putative 0.0275 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0578 0.0665
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0578 0.5
Schistosoma mansoni Smad4 0.0009 0.0118 0.0167
Loa Loa (eye worm) hypothetical protein 0.0033 0.1005 0.1029
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.1319 0.1392
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.1005 0.128
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0118 0.0004
Echinococcus granulosus GPCR family 2 0.0033 0.1005 0.128
Schistosoma mansoni hypothetical protein 0.0033 0.1005 0.1422
Toxoplasma gondii exonuclease III APE 0.0022 0.0578 0.2156
Onchocerca volvulus 0.0042 0.1319 0.1218
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.1319 0.1259
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0578 0.3843
Schistosoma mansoni smad 0.0009 0.0118 0.0167
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0578 0.0665
Brugia malayi Pre-SET motif family protein 0.0035 0.1082 0.1118
Loa Loa (eye worm) hypothetical protein 0.0042 0.1319 0.1392
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.1005 0.1029
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0578 0.0535
Plasmodium vivax SET domain protein, putative 0.0035 0.1082 0.8031
Brugia malayi Latrophilin receptor protein 2 0.0033 0.1005 0.1029
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.1319 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1824 0.1976
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1824 0.2457
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0578 0.3843
Brugia malayi hypothetical protein 0.0097 0.3391 0.3789
Mycobacterium tuberculosis Conserved protein 0.0042 0.1319 0.1259
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.1319 0.1392
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.1319 0.1259
Schistosoma mansoni ATPase 0.0009 0.0115 0.0163
Echinococcus granulosus cpg binding protein 0.0037 0.1132 0.1463
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.2441 0.269
Brugia malayi beta-lactamase 0.0042 0.1319 0.1392
Entamoeba histolytica hypothetical protein 0.0035 0.1083 1
Echinococcus granulosus smad 0.0009 0.0118 0.0004
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0009 0.0115 0.0055
Mycobacterium ulcerans beta-lactamase 0.0042 0.1319 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0115 0.0055
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0115 0.0055
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.4911 0.5547
Echinococcus multilocularis GPCR, family 2 0.0033 0.1005 0.128
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.1319 0.1266
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.1319 0.1259
Brugia malayi beta-lactamase family protein 0.0042 0.1319 0.1392
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0136 0.0029
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.3679 0.4122
Mycobacterium ulcerans lipase LipD 0.0042 0.1319 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0115 0.0055
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.1082 0.139
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.1319 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0115 0.0055
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.1006 0.1282
Schistosoma mansoni atpase class VI type 11c 0.0009 0.0115 0.0163
Entamoeba histolytica hypothetical protein 0.0035 0.1083 1
Schistosoma mansoni hypothetical protein 0.0196 0.7068 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.2441 0.269
Loa Loa (eye worm) beta-lactamase 0.0042 0.1319 0.1392
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0578 0.4778
Loa Loa (eye worm) hypothetical protein 0.0097 0.3391 0.3789
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.2261 1
Schistosoma mansoni type V p-type atpase isoform 0.0009 0.0115 0.0163
Schistosoma mansoni copper ABC transporter ATPase 0.0009 0.0115 0.0163
Mycobacterium tuberculosis Conserved protein 0.0042 0.1319 0.1259
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0009 0.0115 0.0163
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.1005 0.1029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.1082 0.153
Schistosoma mansoni ap endonuclease 0.0022 0.0578 0.0817
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0115 0.0055
Schistosoma mansoni smad1 5 8 and 0.0009 0.0118 0.0167
Entamoeba histolytica hypothetical protein 0.0035 0.1083 1
Brugia malayi Smad1 0.0009 0.0118 0.0003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.1319 0.1259
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.1082 0.139
Loa Loa (eye worm) hypothetical protein 0.0035 0.1082 0.1118
Schistosoma mansoni hypothetical protein 0.0033 0.1005 0.1422
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0578 0.3843
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.4911 0.5547
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0115 0.0055
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0578 0.0535
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0118 0.0004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.2553 0.3612
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.1319 0.1259
Brugia malayi MH2 domain containing protein 0.0009 0.0118 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.1082 0.153
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0214 0.0115
Plasmodium vivax hypothetical protein, conserved 0.0042 0.1319 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1824 0.258
Brugia malayi MH1 domain containing protein 0.0009 0.0118 0.0003
Toxoplasma gondii ABC1 family protein 0.0042 0.1319 0.561
Onchocerca volvulus 0.0035 0.1082 0.0978
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.1083 0.1392
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0009 0.0115 0.0163
Echinococcus multilocularis geminin 0.0196 0.7068 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1824 0.1976
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0118 0.0003
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0009 0.0115 0.0055
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.1319 0.1866
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0578 0.3843
Schistosoma mansoni hypothetical protein 0.0033 0.1005 0.1422
Schistosoma mansoni phosphoserine phosphatase 0.0009 0.0115 0.0163
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0118 0.0004
Loa Loa (eye worm) hypothetical protein 0.0105 0.3679 0.4122
Mycobacterium ulcerans hypothetical protein 0.0042 0.1319 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.1319 0.1392
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0578 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0115 0.0055
Onchocerca volvulus 0.0035 0.1059 0.0954
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0118 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.1319 0.1266
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.1319 0.1266
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.1319 0.1259
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.1319 1
Loa Loa (eye worm) Smad1 0.0009 0.0118 0.0003
Schistosoma mansoni hypothetical protein 0.0033 0.1005 0.1422
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.1319 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1824 0.2457
Brugia malayi CXXC zinc finger family protein 0.0035 0.1059 0.1091
Onchocerca volvulus 0.0042 0.1319 0.1218
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.1082 0.4505
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.1082 0.153
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.3679 0.4122
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.1083 0.1533
Loa Loa (eye worm) hypothetical protein 0.0042 0.1319 0.1392
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0115 0.0055
Onchocerca volvulus 0.0042 0.1319 0.1218
Brugia malayi beta-lactamase family protein 0.0042 0.1319 0.1392
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.1319 1
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0009 0.0115 0.0055
Mycobacterium leprae Probable lipase LipE 0.0042 0.1319 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0578 0.3843
Mycobacterium tuberculosis Conserved protein 0.0042 0.1319 0.1259
Echinococcus granulosus geminin 0.0196 0.7068 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.1005 0.128
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.3679 0.4122
Brugia malayi MH2 domain containing protein 0.0009 0.0118 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0578 0.3843
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0118 0.0004
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0118 0.0167
Loa Loa (eye worm) hypothetical protein 0.0042 0.1319 0.1392
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0136 0.0029
Echinococcus multilocularis cpg binding protein 0.0037 0.1132 0.1463
Schistosoma mansoni ap endonuclease 0.0022 0.0578 0.0817
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1824 0.2457
Entamoeba histolytica hypothetical protein 0.0035 0.1083 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1824 0.2457
Chlamydia trachomatis metal transport ATPase 0.0009 0.0115 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0266 0.9678 1
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0209 0.0109
Loa Loa (eye worm) hypothetical protein 0.0042 0.1319 0.1392
Schistosoma mansoni cpg binding protein 0.0035 0.1059 0.1498
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0136 0.0192
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.1319 0.1866
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0578 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1824 0.258
Schistosoma mansoni smad1 5 8 and 0.0009 0.0118 0.0167
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0214 0.0143
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0136 0.0029
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0136 0.0029
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.1082 0.139
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0578 0.0521
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0578 0.0521
Leishmania major hypothetical protein, conserved 0.0042 0.1319 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.0118 0.0167
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0115 0.0163
Loa Loa (eye worm) hypothetical protein 0.0097 0.3391 0.3789
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1824 0.258
Schistosoma mansoni cpg binding protein 0.0037 0.1132 0.1602
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0115 0.0055
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.1319 0.1259
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.1319 0.1731
Schistosoma mansoni ATPase 0.0009 0.0115 0.0163
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.1083 0.1392
Schistosoma mansoni cation-transporting ATPase 0.0009 0.0115 0.0163
Echinococcus multilocularis smad 0.0009 0.0118 0.0004
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.1319 0.1731
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.1059 0.1091
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.1005 0.128
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0578 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.1319 0.1392
Brugia malayi Pre-SET motif family protein 0.0242 0.8761 1
Brugia malayi MH1 domain containing protein 0.0009 0.0118 0.0003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0214 0.0143
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.1319 0.1266
Schistosoma mansoni eyes absent homolog 0.0097 0.3391 0.4798
Brugia malayi MH2 domain containing protein 0.0138 0.4911 0.5547

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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