Detailed information for compound 1330647

Basic information

Technical information
  • TDR Targets ID: 1330647
  • Name: 2-[(4-methylphenyl)amino]-3,1-benzothiazin-4- one
  • MW: 268.334 | Formula: C15H12N2OS
  • H donors: 1 H acceptors: 1 LogP: 3.56 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)Nc1nc2ccccc2c(=O)s1
  • InChi: 1S/C15H12N2OS/c1-10-6-8-11(9-7-10)16-15-17-13-5-3-2-4-12(13)14(18)19-15/h2-9H,1H3,(H,16,17)
  • InChiKey: XCUHWYYHTLENLP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • STK066735
  • Oprea1_421206
  • 2-p-Tolylamino-benzo[d][1,3]thiazin-4-one
  • BAS 02998702
  • MLS000765358
  • SMR000289463
  • ZINC00180609

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0199 0.1785
Trypanosoma brucei cysteine peptidase C (CPC) 0.0257 0.098 0.8899
Plasmodium falciparum importin beta, putative 0.0029 0.0027 0.0028
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0285 0.1095 1
Schistosoma mansoni tyrosine kinase 0.0036 0.0057 0.0057
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0285 0.1098 0.2404
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0327 0.0714
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0039 0.0039
Brugia malayi cathepsin Z-like cysteine proteinase 0.007 0.0199 0.0724
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0091 0.0808
Entamoeba histolytica cysteine protease, putative 0.0162 0.0584 0.5313
Plasmodium vivax serine-repeat antigen (SERA), putative 0.007 0.0199 0.1633
Echinococcus granulosus jumonji domain containing protein 0.0039 0.007 0.007
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0285 0.1098 0.1098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1098 1
Schistosoma mansoni chromobox protein 0.0079 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0092 0.0291 0.0635
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0208 0.0208
Schistosoma mansoni cathepsin C 0.007 0.0199 0.0199
Trypanosoma cruzi cysteine peptidase, putative 0.0285 0.1098 0.4022
Loa Loa (eye worm) hypothetical protein 0.0675 0.2725 0.5971
Entamoeba histolytica cysteine proteinase, putative 0.0162 0.0584 0.5313
Schistosoma mansoni hypothetical protein 0.0028 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0433
Brugia malayi Tyrosine-protein kinase abl-1 0.0455 0.1804 0.6609
Leishmania major cathepsin L-like protease 0.0285 0.1098 1
Trypanosoma cruzi cysteine peptidase, putative 0.0092 0.0291 0.1056
Brugia malayi Cathepsin L-like precursor 0.0285 0.1098 0.402
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0199 0.1785
Plasmodium vivax unspecified product 0.0162 0.0584 0.5217
Entamoeba histolytica cysteine protease, putative 0.0162 0.0584 0.5313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1098 1
Schistosoma mansoni chromobox protein 0.0079 0.0235 0.0235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.1098 1
Entamoeba histolytica cysteine protease, putative 0.007 0.0199 0.1801
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.0199 0.1785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1098 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0032 0.0038 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.1098 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.1098 1
Echinococcus multilocularis Smad4 0.0024 0.0008 0.0008
Mycobacterium ulcerans hypothetical protein 0.0023 0.0002 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0327 0.1194
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0199 0.1785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1098 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1098 1
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0433
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0032 0.0038 0.0079
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0675 0.2725 0.2725
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0036 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1098 1
Brugia malayi Cathepsin L-like precursor 0.0285 0.1098 0.402
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0675 0.2725 0.2725
Loa Loa (eye worm) hypothetical protein 0.0193 0.0713 0.156
Loa Loa (eye worm) hypothetical protein 0.0101 0.0327 0.0714
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0002 0.5
Onchocerca volvulus 0.0285 0.1098 1
Echinococcus multilocularis smad 0.0024 0.0008 0.0008
Entamoeba histolytica cysteine protease, putative 0.0162 0.0584 0.5313
Giardia lamblia Cathepsin L precursor 0.007 0.0199 0.1638
Giardia lamblia Cathepsin B precursor 0.007 0.0199 0.1638
Brugia malayi Heterochromatin protein 1 0.0079 0.0235 0.0855
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1098 1
Plasmodium falciparum serine repeat antigen 7 0.007 0.0199 0.1633
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0091 0.0791
Brugia malayi hypothetical protein 0.0072 0.0208 0.0756
Entamoeba histolytica cysteine protease, putative 0.007 0.0199 0.1801
Plasmodium vivax vivapain-1 0.0162 0.0584 0.5217
Entamoeba histolytica cysteine protease, putative 0.0162 0.0584 0.5313
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0675 0.2725 1
Echinococcus granulosus cathepsin L cysteine protease 0.0162 0.0584 0.0584
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0002 0.5
Loa Loa (eye worm) hypothetical protein 0.0092 0.0291 0.0635
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0257 0.098 0.098
Brugia malayi Tyrosine-protein kinase abl-1 0.0676 0.2729 1
Onchocerca volvulus 0.0035 0.0051 0.0445
Leishmania major cathepsin L-like protease 0.0285 0.1098 1
Plasmodium vivax unspecified product 0.007 0.0199 0.1633
Trypanosoma cruzi major cysteine proteinase, putative 0.007 0.0199 0.0718
Entamoeba histolytica cysteine protease, putative 0.007 0.0199 0.1801
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0199 0.1785
Entamoeba histolytica cysteine proteinase, putative 0.0162 0.0584 0.5313
Brugia malayi Cathepsin L-like precursor 0.0193 0.0713 0.2608
Echinococcus granulosus cathepsin l1 0.0285 0.1098 0.1098
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0257 0.098 0.8924
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0235 0.2111
Entamoeba histolytica cysteine proteinase 1, putative 0.0162 0.0584 0.5313
Schistosoma mansoni tyrosine kinase 0.1099 0.4496 0.4496
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0285 0.1095 0.9968
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.007 0.0199 0.0199
Entamoeba histolytica papain family cysteine protease domain containing protein 0.007 0.0199 0.1801
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0235 0.2111
Loa Loa (eye worm) hypothetical protein 0.0423 0.1673 0.3663
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.0713 0.6481
Schistosoma mansoni hypothetical protein 0.0072 0.0208 0.0208
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0036 0.0057 0.0057
Schistosoma mansoni cathepsin F (C01 family) 0.0285 0.1098 0.1098
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.007 0.0199 0.1633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1098 1
Leishmania major cathepsin L-like protease 0.0285 0.1098 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0285 0.1095 0.9968
Loa Loa (eye worm) SRC-1 0.0036 0.0057 0.012
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0027 0.0027
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.007 0.0199 0.1633
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0037 0.0299
Giardia lamblia Cysteine protease 0.007 0.0199 0.1638
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0115 0.0852
Loa Loa (eye worm) TK/ABL protein kinase 0.1115 0.4562 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0048
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0049 0.0102
Entamoeba histolytica cysteine proteinase, putative 0.0193 0.0713 0.6488
Echinococcus granulosus snurportin 1 0.0308 0.1193 0.1193
Leishmania major cysteine peptidase A (CPA) 0.0285 0.1098 1
Plasmodium falciparum serine repeat antigen 3 0.007 0.0199 0.1633
Plasmodium falciparum serine repeat antigen 5 0.007 0.0199 0.1633
Schistosoma mansoni hypothetical protein 0.0032 0.0039 0.0039
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0092 0.0291 0.1061
Entamoeba histolytica hypothetical protein 0.0072 0.0208 0.1881
Toxoplasma gondii cathepsin CPC1 0.0285 0.1095 0.9968
Echinococcus granulosus tyrosine protein kinase Lyn 0.0036 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1098 1
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.007 0.007
Echinococcus granulosus cysteine protease 0.0162 0.0584 0.0584
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0027 0.0028
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0285 0.1095 0.9968
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0285 0.1095 0.1095
Schistosoma mansoni cathepsin B (C01 family) 0.007 0.0199 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0203 0.0755 0.6863
Loa Loa (eye worm) hypothetical protein 0.0044 0.0091 0.0194
Echinococcus multilocularis chromobox protein 1 0.0079 0.0235 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.0199 0.1785
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0002 0.5
Echinococcus granulosus chromobox protein 1 0.0079 0.0235 0.0235
Brugia malayi Variant SH3 domain containing protein 0.0032 0.0038 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0162 0.0584 0.5204
Echinococcus multilocularis cathepsin b 0.0675 0.2725 0.2725
Loa Loa (eye worm) hypothetical protein 0.0122 0.0416 0.0907
Plasmodium vivax vivapain-3 0.0162 0.0584 0.5217
Giardia lamblia Cathepsin B precursor 0.007 0.0199 0.1638
Echinococcus granulosus cathepsin L cysteine proteinase 0.0285 0.1098 0.1098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1098 1
Loa Loa (eye worm) fibroinase 0.0285 0.1098 0.2404
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0152 0.0539 0.4796
Trypanosoma cruzi cruzipain precursor, putative 0.0285 0.1098 0.4022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1098 1
Leishmania major cathepsin L-like protease 0.0285 0.1098 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0327 0.1194
Toxoplasma gondii preprocathepsin c precursor, putative 0.0285 0.1095 0.9968
Plasmodium falciparum serine repeat antigen 8 0.007 0.0199 0.1633
Leishmania major cathepsin L-like protease 0.0285 0.1098 1
Loa Loa (eye worm) hypothetical protein 0.0285 0.1098 0.2404
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1098 1
Schistosoma mansoni smad 0.0024 0.0008 0.0008
Loa Loa (eye worm) cysteine protease 0.0285 0.1098 0.2404
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0235 0.0511
Entamoeba histolytica hypothetical protein 0.0072 0.0208 0.1881
Onchocerca volvulus 0.0285 0.1098 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0115 0.0852
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0115 0.0852
Plasmodium vivax unspecified product 0.0092 0.0291 0.2489
Brugia malayi hypothetical protein 0.0032 0.0041 0.0144
Echinococcus granulosus tyrosine protein kinase Fyn 0.0036 0.0057 0.0057
Onchocerca volvulus 0.0285 0.1098 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0285 0.1098 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0199 0.1785
Schistosoma mansoni cathepsin F (C01 family) 0.0285 0.1098 0.1098
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0162 0.0584 0.0584
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0199 0.1785
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.007 0.0199 0.0199
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0024 0.0024
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0149 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.0199 0.1785
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.0291 0.0291
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.007 0.0199 0.0199
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0285 0.1098 0.2404
Giardia lamblia Cathepsin L precursor 0.007 0.0199 0.1638
Giardia lamblia Cathepsin L precursor 0.007 0.0199 0.1638
Echinococcus multilocularis cathepsin L cysteine protease 0.0285 0.1098 0.1098
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0104 0.0918
Echinococcus multilocularis cysteine protease 0.0285 0.1098 0.1098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0199 0.1785
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0152 0.0539 0.4811
Echinococcus granulosus c src tyrosine kinase 0.0036 0.0057 0.0057
Brugia malayi Cathepsin L-like precursor 0.0285 0.1098 0.402
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0257 0.098 0.3589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0199 0.1785
Brugia malayi Papain family cysteine protease containing protein 0.0162 0.0584 0.2136
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0039 0.0039
Schistosoma mansoni cathepsin s 0.0092 0.0291 0.0291
Echinococcus multilocularis cathepsin b 0.0675 0.2725 0.2725
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1098 1
Brugia malayi MH2 domain containing protein 0.0024 0.0008 0.0023
Brugia malayi Cathepsin L-like precursor 0.0285 0.1098 0.402
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.1098 1
Schistosoma mansoni hypothetical protein 0.0032 0.0039 0.0039
Echinococcus multilocularis peregrin 0.0028 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1098 1
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0115 0.0852
Entamoeba histolytica cysteine proteinase 2 0.0162 0.0584 0.5313
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0162 0.0584 0.0584
Schistosoma mansoni cathepsin S (C01 family) 0.007 0.0199 0.0199
Trypanosoma cruzi cysteine peptidase, putative 0.0285 0.1098 0.4022
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0092 0.0291 0.0635
Brugia malayi cathepsin F-like cysteine proteinase 0.0092 0.0291 0.1061
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0433
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0024 0.0048
Schistosoma mansoni Smad4 0.0024 0.0008 0.0008
Loa Loa (eye worm) papain family cysteine protease containing protein 0.007 0.0199 0.0433
Schistosoma mansoni tyrosine kinase 0.0036 0.0057 0.0057
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0039 0.0138
Onchocerca volvulus 0.0285 0.1098 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0193 0.0713 0.2608
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0008 0.0014
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0193 0.0713 0.156
Entamoeba histolytica cysteine protease, putative 0.0162 0.0584 0.5313
Giardia lamblia Cathepsin L-like protease 0.007 0.0199 0.1638
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0208 0.0208
Plasmodium falciparum serine repeat antigen 6 0.007 0.0199 0.1633
Leishmania major importin beta-1 subunit, putative 0.0023 0.0004 0.0019
Onchocerca volvulus 0.007 0.0199 0.1801
Giardia lamblia Cathepsin B precursor 0.0257 0.098 0.8931
Brugia malayi Importin beta-1 subunit 0.0029 0.0027 0.0091
Schistosoma mansoni hypothetical protein 0.2417 1 1
Onchocerca volvulus 0.0285 0.1098 1
Toxoplasma gondii cathepsin CPL 0.0285 0.1098 1
Trypanosoma cruzi cruzipain precursor, putative 0.0092 0.0291 0.1056
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0036 0.0057 0.0057
Entamoeba histolytica cysteine protease, putative 0.007 0.0199 0.1801
Schistosoma mansoni hypothetical protein 0.2417 1 1
Giardia lamblia Cathepsin L precursor 0.007 0.0199 0.1638
Entamoeba histolytica hypothetical protein 0.0072 0.0208 0.1881
Entamoeba histolytica cysteine protease, putative 0.0162 0.0584 0.5313
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0008 0.0008
Entamoeba histolytica cysteine protease, putative 0.0162 0.0584 0.5313
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0039 0.0138
Brugia malayi cathepsin L precursor 0.007 0.0199 0.0724
Schistosoma mansoni hypothetical protein 0.0308 0.1193 0.1193
Giardia lamblia Cathepsin L-like protease 0.007 0.0199 0.1638
Onchocerca volvulus Huntingtin homolog 0.0122 0.0416 0.3774
Schistosoma mansoni smad1 5 8 and 0.0024 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1098 1
Schistosoma mansoni growth factor receptor-bound protein 0.0032 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0285 0.1098 1
Brugia malayi jmjC domain containing protein 0.0092 0.0291 0.1062
Echinococcus granulosus tyrosine protein kinase Src64B 0.0036 0.0057 0.0057
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0162 0.0584 0.0584
Echinococcus granulosus cathepsin l1 0.0193 0.0713 0.0713
Onchocerca volvulus 0.0193 0.0713 0.6488
Brugia malayi cathepsin B-like cysteine proteinase 0.0675 0.2725 0.9984
Echinococcus multilocularis growth factor receptor bound protein 2 0.0032 0.0038 0.0038
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0285 0.1098 1
Echinococcus granulosus Smad4 0.0024 0.0008 0.0008
Giardia lamblia Cysteine protease 0.007 0.0199 0.1638
Echinococcus granulosus cathepsin b 0.0675 0.2725 0.2725
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0257 0.098 0.8922
Brugia malayi RNA, U transporter 1 0.0082 0.0249 0.0907
Loa Loa (eye worm) cathepsin B 0.0257 0.098 0.2146
Onchocerca volvulus Protein sprint homolog 0.0028 0.0023 0.0188
Onchocerca volvulus Cathepsin F homolog 0.0285 0.1098 1
Plasmodium vivax vivapain-2 0.0285 0.1098 1
Brugia malayi Bromodomain containing protein 0.0028 0.0024 0.0081
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0036 0.0057 0.0057
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0039 0.0039
Entamoeba histolytica hypothetical protein 0.0023 0.0004 0.0019
Schistosoma mansoni nck2/grb4 0.0032 0.0038 0.0038
Schistosoma mansoni smad1 5 8 and 0.0024 0.0008 0.0008
Brugia malayi cathepsin Z-like cysteine proteinase 0.007 0.0199 0.0724
Entamoeba histolytica cysteine protease, putative 0.0162 0.0584 0.5313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0162 0.0584 0.5304
Schistosoma mansoni smad1 5 8 and 0.0024 0.0008 0.0008
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0049 0.0049
Brugia malayi chromobox protein homolog 3 0.0044 0.0091 0.0325
Plasmodium falciparum cysteine proteinase falcipain 1 0.0162 0.0584 0.5217
Trypanosoma cruzi cysteine peptidase, putative 0.0162 0.0584 0.2133
Loa Loa (eye worm) Smad1 0.0024 0.0008 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0199 0.1785
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0032 0.0038 0.0038
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.007 0.0199 0.1633
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.007 0.0199 0.1638
Echinococcus granulosus cathepsin L 0.0162 0.0584 0.0584
Brugia malayi Cathepsin L-like precursor 0.0193 0.0713 0.2608
Entamoeba histolytica cysteine protease, putative 0.0162 0.0584 0.5313
Onchocerca volvulus 0.0285 0.1098 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.007 0.0199 0.1801
Loa Loa (eye worm) hypothetical protein 0.005 0.0115 0.0249
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0049 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.1098 1
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0115 0.0409
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0049 0.0049
Onchocerca volvulus Huntingtin homolog 0.0122 0.0416 0.3774
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1098 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0036 0.0057 0.0057
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.0713 0.6481
Giardia lamblia Cathepsin B precursor 0.0257 0.098 0.8931
Echinococcus multilocularis c src tyrosine kinase 0.0036 0.0057 0.0057
Schistosoma mansoni tyrosine kinase 0.0036 0.0057 0.0057
Schistosoma mansoni tyrosine kinase 0.0036 0.0057 0.0057
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.0199 0.0199
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0115 0.0826
Giardia lamblia Hypothetical protein 0.007 0.0199 0.1638
Brugia malayi MH2 domain containing protein 0.0358 0.1403 0.5137
Plasmodium vivax serine-repeat antigen (SERA), putative 0.007 0.0199 0.1633
Schistosoma mansoni growth factor receptor-bound protein 0.0032 0.0038 0.0038
Brugia malayi Cathepsin L-like precursor 0.0092 0.0291 0.1061
Brugia malayi cathepsin L-like precursor 0.0193 0.0713 0.2608
Giardia lamblia Cathepsin B precursor 0.007 0.0199 0.1638
Brugia malayi hypothetical protein 0.005 0.0115 0.0416
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0208 0.0208
Loa Loa (eye worm) MH2 domain-containing protein 0.0358 0.1403 0.3072
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0285 0.1095 0.9968
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.007 0.0199 0.1785
Echinococcus granulosus tyrosine protein kinase Fyn 0.0036 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0032 0.0039 0.0039
Echinococcus granulosus cathepsin b 0.0675 0.2725 0.2725
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0091 0.0791
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.1098 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1098 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0285 0.1098 1
Entamoeba histolytica cysteine protease, putative 0.0285 0.1098 1
Entamoeba histolytica cysteine protease, putative 0.007 0.0199 0.1801
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0036 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0032 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0193 0.0713 0.156
Leishmania major cathepsin L-like protease 0.0285 0.1098 1
Plasmodium falciparum serine repeat antigen 1 0.007 0.0199 0.1633
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0115 0.0409
Echinococcus granulosus tyrosine protein kinase ABL1 0.1115 0.4562 0.4562
Entamoeba histolytica cysteine protease, putative 0.007 0.0199 0.1801
Brugia malayi Sex muscle abnormal protein 5 0.0032 0.0038 0.0133
Giardia lamblia Hypothetical protein 0.007 0.0199 0.1638
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0036 0.0057 0.0057
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.007 0.0199 0.1633
Brugia malayi Papain family cysteine protease containing protein 0.0285 0.1098 0.402
Echinococcus granulosus GPCR family 2 0.0032 0.0039 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0199 0.1785
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0002 0.5
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0152 0.0539 0.4811
Brugia malayi jmjC domain containing protein 0.0034 0.0049 0.0171
Brugia malayi PHD-finger family protein 0.0028 0.0024 0.0081
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0104 0.0918
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.007 0.0199 0.1785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0162 0.0584 0.5304
Giardia lamblia Cathepsin L precursor 0.007 0.0199 0.1638
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.007 0.0199 0.1633
Onchocerca volvulus Cathepsin L homolog 0.007 0.0199 0.1801
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.0199 0.0199
Echinococcus granulosus cathepsin l cysteine peptidase 0.0285 0.1098 0.1098
Giardia lamblia Cysteine protease 0.007 0.0199 0.1638
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0057 0.0057
Giardia lamblia Cathepsin L precursor 0.007 0.0199 0.1638
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.007 0.0199 0.1785
Toxoplasma gondii cathepsin CPC2 0.0152 0.0539 0.4796
Loa Loa (eye worm) papain family cysteine protease containing protein 0.007 0.0199 0.0433
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0008 0.0008
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0008 0.0008
Trypanosoma cruzi major cysteine proteinase, putative 0.007 0.0199 0.0718
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0036 0.0057 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.1098 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1098 1
Echinococcus multilocularis NCK adaptor protein 0.0032 0.0038 0.0038
Brugia malayi Variant SH3 domain containing protein 0.0032 0.0038 0.0133
Onchocerca volvulus Cathepsin L homolog 0.0285 0.1098 1
Giardia lamblia Encystation-specific protease 0.0152 0.0539 0.4811
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1098 1
Giardia lamblia Cathepsin B precursor 0.0257 0.098 0.8931
Brugia malayi cathepsin F-like cysteine proteinase 0.007 0.0199 0.0724
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0079
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.0199 0.0199
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0002 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0039 0.0039
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0008 0.0008
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0036 0.0057 0.0057
Plasmodium falciparum serine repeat antigen 4 0.007 0.0199 0.1633
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0024 0.0024
Onchocerca volvulus Cathepsin L homolog 0.0285 0.1098 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0152 0.0539 0.4796
Leishmania major cathepsin L-like protease 0.0285 0.1098 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0108 0.0232
Entamoeba histolytica cysteine protease, putative 0.0162 0.0584 0.5313
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0057 0.0057
Entamoeba histolytica hypothetical protein 0.0072 0.0208 0.1881
Entamoeba histolytica hypothetical protein 0.007 0.0199 0.1801
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0285 0.1098 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0036 0.0057 0.0057
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0212 0.0212
Plasmodium falciparum serine repeat antigen 2 0.007 0.0199 0.1633
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0107
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0433
Leishmania major hypothetical protein, conserved 0.005 0.0115 0.1035
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0024 0.0024
Brugia malayi fibroinase precursor 0.007 0.0199 0.0724
Loa Loa (eye worm) hypothetical protein 0.0122 0.0416 0.0907
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.1193 0.2613
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0285 0.1098 0.1098
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0002 0.5
Brugia malayi MH1 domain containing protein 0.0024 0.0008 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.1098 1
Entamoeba histolytica cysteine protease, putative 0.0162 0.0584 0.5313
Brugia malayi Papain family cysteine protease containing protein 0.007 0.0199 0.0724
Echinococcus granulosus chromobox protein 1 0.0079 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0069 0.0194 0.0422
Echinococcus granulosus importin subunit beta 1 0.0029 0.0027 0.0027
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0057 0.0057
Trypanosoma cruzi cysteine peptidase, putative 0.0285 0.1098 0.4022
Echinococcus granulosus NCK adaptor protein 0.0032 0.0038 0.0038
Giardia lamblia Cathepsin B precursor 0.007 0.0199 0.1638
Plasmodium falciparum serine repeat antigen 9 0.007 0.0199 0.1633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1098 1
Brugia malayi MH2 domain containing protein 0.0024 0.0008 0.0023
Brugia malayi Cathepsin L-like precursor 0.0285 0.1098 0.402
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0002 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0162 0.0584 0.5313
Giardia lamblia Cysteine protease 0.007 0.0199 0.1638
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0036 0.0057 0.0057
Giardia lamblia Cathepsin B precursor 0.007 0.0199 0.1638
Brugia malayi MH1 domain containing protein 0.0024 0.0008 0.0023
Trypanosoma cruzi cysteine protease, putative 0.0162 0.0584 0.2133
Trypanosoma cruzi cysteine proteinase, putative 0.0162 0.0584 0.2133
Onchocerca volvulus Alhambra homolog 0.0028 0.0024 0.02
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0104 0.0936
Trypanosoma cruzi cysteine proteinase, putative 0.0162 0.0584 0.2133
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0675 0.2725 0.2725
Loa Loa (eye worm) ctsf protein 0.0285 0.1098 0.2404
Echinococcus multilocularis cathepsin L cysteine protease 0.0285 0.1098 0.1098
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0092 0.0291 0.0635
Brugia malayi Papain family cysteine protease containing protein 0.007 0.0199 0.0724
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.0199 0.0199
Echinococcus multilocularis cysteine protease 0.0285 0.1098 0.1098
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0162 0.0584 0.2133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1098 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0433
Echinococcus multilocularis snurportin 1 0.0308 0.1193 0.1193
Entamoeba histolytica cysteine proteinase, putative 0.0285 0.1098 1
Entamoeba histolytica cysteine proteinase, putative 0.0285 0.1098 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0055
Brugia malayi Papain family cysteine protease containing protein 0.007 0.0199 0.0724
Brugia malayi SRC-1 0.0036 0.0057 0.0201
Onchocerca volvulus 0.0285 0.1098 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0455 0.1804 0.1804
Loa Loa (eye worm) hypothetical protein 0.0032 0.0039 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.007 0.0199 0.1785
Echinococcus multilocularis geminin 0.2417 1 1
Toxoplasma gondii cathepsin B 0.0257 0.098 0.8902
Schistosoma mansoni adapter molecule crk 0.0032 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase ABL1 0.1115 0.4562 0.4562
Brugia malayi cahepsin L-like non-peptiedase homolog 0.007 0.0199 0.0724
Echinococcus multilocularis GPCR, family 2 0.0032 0.0039 0.0039
Schistosoma mansoni cathepsin F (C01 family) 0.0193 0.0713 0.0713
Brugia malayi Papain family cysteine protease containing protein 0.0162 0.0584 0.2136
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0433
Echinococcus multilocularis chromobox protein 1 0.0079 0.0235 0.0235
Brugia malayi hypothetical protein 0.0122 0.0416 0.1517
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0037 0.0299
Loa Loa (eye worm) transcription factor SMAD2 0.0358 0.1403 0.3072
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0675 0.2725 0.2725
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.0291 0.0291
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0194 0.0705
Brugia malayi Cathepsin L-like precursor 0.0285 0.1098 0.402
Plasmodium vivax importin-beta 2, putative 0.0029 0.0027 0.0028
Entamoeba histolytica cysteine proteinase, putative 0.0162 0.0584 0.5313
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0039 0.0082
Entamoeba histolytica cysteine protease, putative 0.0162 0.0584 0.5313
Plasmodium vivax serine-repeat antigen (SERA) 0.007 0.0199 0.1633
Echinococcus granulosus smad 0.0024 0.0008 0.0008
Entamoeba histolytica cysteine protease, putative 0.0162 0.0584 0.5313
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.007 0.0199 0.0433
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1098 1
Schistosoma mansoni hypothetical protein 0.0069 0.0194 0.0194
Leishmania major cathepsin L-like protease 0.0285 0.1098 1
Brugia malayi Smad1 0.0024 0.0008 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0002 0.5
Schistosoma mansoni importin beta-1 0.0029 0.0027 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.1098 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0199 0.1785
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.0199 0.0199
Echinococcus granulosus growth factor receptor bound protein 2 0.0032 0.0038 0.0038
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0193 0.0713 0.2607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.1098 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0002 0.5
Brugia malayi cathepsin L-like cysteine proteinase 0.007 0.0199 0.0724
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.1098 1
Plasmodium vivax serine-repeat antigen (SERA) 0.007 0.0199 0.1633
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0002 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0002 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1098 1
Echinococcus multilocularis cathepsin L 0.007 0.0199 0.0199
Trypanosoma cruzi cysteine peptidase, putative 0.0285 0.1098 0.4022
Echinococcus granulosus cathepsin L 0.007 0.0199 0.0199
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0008 0.0014
Echinococcus multilocularis cathepsin L 0.0162 0.0584 0.0584
Echinococcus granulosus peregrin 0.0028 0.0024 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0162 0.0584 0.5204
Plasmodium vivax vivapain-2 0.0285 0.1098 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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