Detailed information for compound 1332235

Basic information

Technical information
  • TDR Targets ID: 1332235
  • Name: MLS001002706
  • MW: 291.326 | Formula: C13H13N3O3S
  • H donors: 2 H acceptors: 4 LogP: 0.52 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccn1)NCc1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C13H13N3O3S/c14-20(18,19)11-6-4-10(5-7-11)9-16-13(17)12-3-1-2-8-15-12/h1-8H,9H2,(H,16,17)(H2,14,18,19)
  • InChiKey: KTDXQAXRIPJFHA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-sulfamoylbenzyl)picolinamide
  • N-[(4-sulfamoylphenyl)methyl]pyridine-2-carboxamide
  • N-[(4-sulfamoylphenyl)methyl]-2-pyridinecarboxamide
  • SMR000369165
  • T5304862
  • ZINC03455617

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens galactosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Glycoside hydrolase, family 27 Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus granulosus Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Alpha-N-acetylgalactosaminidase precursor, putative Get druggable targets OG5_127620 All targets in OG5_127620
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Brugia malayi Melibiase family protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Toxoplasma gondii melibiase subfamily protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum ko:K01204 alpha-N-acetylgalactosaminidase [EC3.2.1.49], putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum expressed protein Get druggable targets OG5_127620 All targets in OG5_127620
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0065 0.00000000055101
Echinococcus multilocularis geminin 0.0171 0.3827 0.3825
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0261 0.0426
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0261 0.0258
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0016 0.0261 0.0258
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0128 0.021
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0293 0.6879
Echinococcus multilocularis tar DNA binding protein 0.0061 0.1299 0.1296
Mycobacterium ulcerans beta-lactamase 0.0035 0.0688 0.5
Echinococcus granulosus orexin receptor type 2 0.0016 0.0261 0.0258
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0293 0.0747
Loa Loa (eye worm) RNA binding protein 0.0061 0.1299 0.2121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1069 0.1068
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0114 0.0186
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0016 0.0261 0.026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Schistosoma mansoni hypothetical protein 0.0016 0.0261 0.026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Entamoeba histolytica hypothetical protein 0.0036 0.0721 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0261 0.0258
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0261 0.0426
Schistosoma mansoni amine GPCR 0.0016 0.0261 0.026
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0005
Echinococcus multilocularis Smad4 0.0009 0.0094 0.0091
Schistosoma mansoni neuropeptide receptor 0.0437 1 1
Onchocerca volvulus 0.0016 0.0261 0.0421
Schistosoma mansoni neuropeptide receptor 0.0016 0.0261 0.026
Echinococcus granulosus geminin 0.0171 0.3827 0.3825
Echinococcus granulosus cpg binding protein 0.0037 0.0731 0.0728
Brugia malayi MH2 domain containing protein 0.0009 0.0094 0.0154
Onchocerca volvulus 0.0035 0.0688 0.1119
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0442 0.2184
Echinococcus granulosus smad 0.0009 0.0094 0.0091
Brugia malayi MH2 domain containing protein 0.0009 0.0094 0.0154
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0016 0.0261 0.0258
Brugia malayi vab-3 gene. 0.0005 0.0003 0.0005
Brugia malayi AKH receptor 0.0016 0.0261 0.0426
Echinococcus granulosus Smad4 0.0009 0.0094 0.0091
Schistosoma mansoni neuropeptide receptor 0.0016 0.0261 0.026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1069 0.1068
Mycobacterium leprae Probable lipase LipE 0.0035 0.0688 0.5
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.1791 0.179
Brugia malayi Melatonin receptor type 1A 0.0016 0.0261 0.0426
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0261 0.026
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0293 0.2197
Echinococcus multilocularis g-protein coupled receptor 0.0016 0.0261 0.0258
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0261 0.026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0261 0.026
Loa Loa (eye worm) hypothetical protein 0.0035 0.0688 0.1123
Brugia malayi neuropeptide F receptor 0.0016 0.0261 0.0426
Schistosoma mansoni paired box protein pax-6 0.0005 0.0003 0.0002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0132 0.0129
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0261 0.0258
Schistosoma mansoni opsin-like receptor 0.0016 0.0261 0.026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0065 0.00000000055101
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0688 0.3608
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0132 0.0215
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0016 0.0261 0.0426
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Loa Loa (eye worm) hypothetical protein 0.0035 0.0688 0.1123
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.1176 0.192
Schistosoma mansoni neuropeptide receptor 0.0016 0.0261 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0261 0.0258
Schistosoma mansoni biogenic amine receptor 0.0016 0.0261 0.026
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0124 0.2744 0.2742
Schistosoma mansoni neuropeptide f receptor 76f 0.0016 0.0261 0.026
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0442 0.0439
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0005
Onchocerca volvulus 0.0016 0.0261 0.0421
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0261 0.0258
Mycobacterium tuberculosis Conserved protein 0.0035 0.0688 0.0835
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0688 0.0685
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0688 0.3608
Onchocerca volvulus 0.0016 0.0261 0.0421
Echinococcus multilocularis G protein coupled receptor 139 0.0437 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0688 0.1123
Loa Loa (eye worm) hypothetical protein 0.0018 0.0292 0.0477
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0293 0.029
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0114 0.0186
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0688 1
Echinococcus multilocularis serotonin receptor 0.0016 0.0261 0.0258
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0688 0.3608
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0016 0.0261 0.026
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0016 0.0261 0.026
Leishmania major hypothetical protein, conserved 0.0035 0.0688 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0261 0.0258
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0016 0.0261 0.0258
Schistosoma mansoni cpg binding protein 0.0035 0.0685 0.0685
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0114 0.0111
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0016 0.0261 0.0426
Echinococcus multilocularis G-protein coupled receptor, putative 0.0016 0.0261 0.0258
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0018 0.0288 0.0287
Echinococcus granulosus neuropeptide receptor A26 0.0016 0.0261 0.0258
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0292 0.0477
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0261 0.0258
Onchocerca volvulus 0.0035 0.0688 0.1119
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1299 0.1298
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0293 0.4252
Entamoeba histolytica hypothetical protein 0.0036 0.0721 1
Loa Loa (eye worm) TAR-binding protein 0.0061 0.1299 0.2121
Schistosoma mansoni smad1 5 8 and 0.0009 0.0094 0.0093
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.1176 0.192
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0065 0.00000000055101
Echinococcus granulosus serotonin receptor 0.0016 0.0261 0.0258
Brugia malayi hypothetical protein 0.0016 0.0261 0.0426
Brugia malayi Tachykinin-like peptides receptor 99D 0.0016 0.0261 0.0426
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0083 0.008
Schistosoma mansoni growth hormone secretagogue receptor 0.0016 0.0261 0.026
Brugia malayi MH2 domain containing protein 0.0134 0.2979 0.4864
Brugia malayi follicle stimulating hormone receptor 0.0016 0.0261 0.0426
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0016 0.0261 0.0426
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0016 0.0261 0.0426
Schistosoma mansoni DNA helicase recq1 0.001 0.0114 0.0113
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0016 0.0261 0.0426
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0688 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0016 0.0261 0.0258
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1069 0.1068
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0293 0.4252
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Echinococcus multilocularis neuropeptide s receptor 0.0016 0.0261 0.0258
Echinococcus multilocularis neuropeptide receptor 0.0437 1 1
Brugia malayi GnHR receptor homolog 0.0016 0.0261 0.0426
Onchocerca volvulus 0.0016 0.0261 0.0421
Onchocerca volvulus 0.0016 0.0261 0.0421
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0688 1
Schistosoma mansoni opsin-like receptor 0.0016 0.0261 0.026
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.2979 0.4864
Loa Loa (eye worm) vab-3 0.0005 0.0003 0.0005
Schistosoma mansoni hypothetical protein 0.0018 0.0292 0.0291
Echinococcus granulosus 7TM GPCR rhodopsin 0.0016 0.0261 0.0258
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0261 0.0258
Brugia malayi hypothetical protein 0.0016 0.0261 0.0426
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0261 0.0258
Echinococcus granulosus neuropeptide FF receptor 2 0.0016 0.0261 0.0258
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0114 0.0111
Brugia malayi hypothetical protein 0.0016 0.0261 0.0426
Echinococcus multilocularis neuropeptide receptor A26 0.0016 0.0261 0.0258
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.2744 0.2743
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0016 0.0261 0.0421
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0124 0.2744 0.2742
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.2979 0.4864
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0261 0.0258
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.1791 0.179
Brugia malayi hypothetical protein 0.0016 0.0261 0.0426
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0688 0.1123
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0688 0.0835
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0114 0.0111
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0065 0.00000000055101
Echinococcus granulosus tar DNA binding protein 0.0061 0.1299 0.1296
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0293 0.0478
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0016 0.0261 0.0426
Echinococcus granulosus GPCR family 2 0.0018 0.0292 0.0289
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0261 0.0258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0261 0.0258
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0293 0.029
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0293 0.029
Schistosoma mansoni paired box protein pax-6 0.0005 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0171 0.3827 0.3826
Brugia malayi hypothetical protein 0.0016 0.0261 0.0426
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0292 0.0477
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0688 0.3608
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0114 0.0412
Echinococcus granulosus g protein coupled receptor 0.0016 0.0261 0.0258
Brugia malayi paired box protein 0.0005 0.0003 0.0005
Brugia malayi MH1 domain containing protein 0.0009 0.0094 0.0154
Schistosoma mansoni hypothetical protein 0.0016 0.0261 0.026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Brugia malayi G-protein coupled receptor 0.0016 0.0261 0.0426
Schistosoma mansoni opsin-like receptor 0.0016 0.0261 0.026
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0293 0.2197
Brugia malayi putative neuropeptide receptor 0.0016 0.0261 0.0426
Onchocerca volvulus 0.0016 0.0261 0.0421
Onchocerca volvulus 0.0016 0.0261 0.0421
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0261 0.0258
Schistosoma mansoni hypothetical protein 0.0018 0.0292 0.0291
Brugia malayi hypothetical protein 0.0016 0.0261 0.0426
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0016 0.0261 0.0258
Onchocerca volvulus 0.0016 0.0261 0.0421
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.2744 0.2743
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1299 0.1298
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0261 0.0258
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0083 0.008
Schistosoma mansoni hypothetical protein 0.0018 0.0292 0.0291
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.1069 0.1746
Schistosoma mansoni biogenic amine receptor 0.0016 0.0261 0.026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0261 0.0426
Schistosoma mansoni smad 0.0009 0.0094 0.0093
Onchocerca volvulus 0.0016 0.0261 0.0421
Schistosoma mansoni cpg binding protein 0.0037 0.0731 0.073
Mycobacterium tuberculosis Conserved protein 0.0035 0.0688 0.0835
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0114 0.5
Loa Loa (eye worm) beta-lactamase 0.0035 0.0688 0.1123
Brugia malayi G-protein coupled receptor 0.0016 0.0261 0.0426
Mycobacterium ulcerans hypothetical protein 0.0035 0.0688 0.5
Brugia malayi TAR-binding protein 0.0061 0.1299 0.2121
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.1176 0.192
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0016 0.0261 0.0426
Schistosoma mansoni amine GPCR 0.0016 0.0261 0.026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0182 0.2634
Schistosoma mansoni hypothetical protein 0.0018 0.0292 0.0291
Treponema pallidum ATP-dependent DNA helicase 0.0005 0.0001 0.5
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0182 0.2514
Brugia malayi ORL1-like opioid receptor 0.0016 0.0261 0.0426
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0261 0.026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.1299 0.2121
Echinococcus granulosus bloom syndrome protein 0.0024 0.0442 0.0439
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.1299 0.2121
Onchocerca volvulus 0.0016 0.0261 0.0421
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0083 0.008
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0261 0.026
Brugia malayi larval opioid receptor 0.0016 0.0261 0.0426
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0016 0.0261 0.026
Echinococcus multilocularis neuropeptide FF receptor 2 0.0016 0.0261 0.0258
Loa Loa (eye worm) hypothetical protein 0.0035 0.0688 0.1123
Loa Loa (eye worm) hypothetical protein 0.0035 0.0688 0.1123
Onchocerca volvulus 0.0016 0.0261 0.0421
Schistosoma mansoni smad1 5 8 and 0.0009 0.0094 0.0093
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0261 0.0258
Brugia malayi Dopamine receptor 0.0016 0.0261 0.0426
Schistosoma mansoni hypothetical protein 0.0038 0.0767 0.0766
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0016 0.0261 0.026
Brugia malayi 'Paired box' domain containing protein 0.0005 0.0003 0.0005
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0016 0.0261 0.0258
Echinococcus granulosus g-protein coupled receptor 0.0016 0.0261 0.0258
Echinococcus granulosus neuropeptide receptor 0.0016 0.0261 0.0258
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.1069 0.1746
Echinococcus granulosus G protein coupled receptor 139 0.0016 0.0261 0.0258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0082 0.1791 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Loa Loa (eye worm) paired box protein 0.0005 0.0003 0.0005
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0261 0.0258
Echinococcus granulosus peptide allatostatin:somatostatin 0.0016 0.0261 0.0258
Schistosoma mansoni amine GPCR 0.0016 0.0261 0.026
Echinococcus multilocularis cpg binding protein 0.0037 0.0731 0.0728
Mycobacterium ulcerans lipase LipD 0.0035 0.0688 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0261 0.0258
Loa Loa (eye worm) pax transcription factor protein 2 0.027 0.6123 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0124 0.2744 0.2742
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0094 0.0154
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0261 0.0258
Brugia malayi RE15519p 0.0016 0.0261 0.0426
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0114 0.0186
Brugia malayi Dopamine receptor protein 2 0.0016 0.0261 0.0426
Echinococcus granulosus sex peptide receptor 0.0016 0.0261 0.0258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Echinococcus granulosus fmrfamide receptor 0.0016 0.0261 0.0258
Onchocerca volvulus 0.0016 0.0261 0.0421
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0721 0.0718
Echinococcus granulosus alpha 1A adrenergic receptor 0.0016 0.0261 0.0258
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0083 0.008
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1403 0.5111
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0688 0.0835
Schistosoma mansoni adenoreceptor 0.0016 0.0261 0.026
Schistosoma mansoni myosin xvIII 0.0016 0.0261 0.026
Schistosoma mansoni smad1 5 8 and 0.0009 0.0094 0.0093
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0261 0.0258
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0016 0.0261 0.0258
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0261 0.0426
Onchocerca volvulus 0.0035 0.0685 0.1115
Brugia malayi neuropeptide F receptor 0.0016 0.0261 0.0426
Echinococcus multilocularis allatostatin A receptor 0.0016 0.0261 0.0258
Echinococcus multilocularis smad 0.0009 0.0094 0.0091
Onchocerca volvulus 0.0016 0.0261 0.0421
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0292 0.0477
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0261 0.026
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0261 0.0258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Loa Loa (eye worm) hypothetical protein 0.0038 0.0767 0.1252
Onchocerca volvulus 0.027 0.6123 1
Toxoplasma gondii melibiase subfamily protein 0.0124 0.2744 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0065 0.00000000055101
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1069 0.1067
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1069 0.1067
Schistosoma mansoni hypothetical protein 0.0036 0.0721 0.072
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0261 0.0258
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0261 0.0258
Brugia malayi G protein-coupled receptor 0.0016 0.0261 0.0426
Brugia malayi Gooseberry protein 0.0005 0.0003 0.0005
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0261 0.026
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0132 0.0129
Brugia malayi Pax transcription factor protein 2 0.027 0.6123 1
Loa Loa (eye worm) Smad1 0.0009 0.0094 0.0154
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0261 0.026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0261 0.0258
Echinococcus multilocularis dro:myosuppressin receptor 0.0016 0.0261 0.0258
Loa Loa (eye worm) hypothetical protein 0.001 0.0114 0.0186
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0688 0.3608
Onchocerca volvulus 0.0016 0.0261 0.0421
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0094 0.0091
Brugia malayi beta-lactamase family protein 0.0035 0.0688 0.1123
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0685 0.1119
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0688 0.0687
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0293 0.029
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0374 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.2744 0.2743
Brugia malayi Serotonin receptor 0.0016 0.0261 0.0426
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0261 0.0258
Schistosoma mansoni amine GPCR 0.0016 0.0261 0.026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1299 0.1298
Toxoplasma gondii Alpha-galactosidase 0.0018 0.0288 0.1048
Brugia malayi CXXC zinc finger family protein 0.0035 0.0685 0.1119
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Onchocerca volvulus 0.0016 0.0261 0.0421
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0261 0.0258
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0261 0.0258
Echinococcus granulosus neuropeptide s receptor 0.0016 0.0261 0.0258
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0016 0.0261 0.0426
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0293 0.2197
Brugia malayi MH1 domain containing protein 0.0009 0.0094 0.0154
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Echinococcus multilocularis GPCR, family 2 0.0018 0.0292 0.0289
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0293 0.029
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0094 0.0091
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0016 0.0261 0.0258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0016 0.0261 0.0426
Brugia malayi hypothetical protein 0.0036 0.0721 0.1177
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0688 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0016 0.0261 0.0258
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0261 0.0258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Schistosoma mansoni paired box protein pax-1-related 0.0005 0.0003 0.0002
Brugia malayi RNA binding protein 0.0061 0.1299 0.2121
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0065 0.00000000055101
Echinococcus granulosus dro:myosuppressin receptor 0.0016 0.0261 0.0258
Brugia malayi Serotonin receptor 0.0016 0.0261 0.0426
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0094 0.0154
Echinococcus granulosus tachykinin peptides receptor 99D 0.0016 0.0261 0.0258
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0688 0.0687
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0261 0.0258
Brugia malayi hypothetical protein 0.0016 0.0261 0.0426
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0688 0.0835
Loa Loa (eye worm) hypothetical protein 0.0082 0.1791 0.2925
Onchocerca volvulus 0.0016 0.0261 0.0421
Trichomonas vaginalis esterase, putative 0.0035 0.0688 0.3608
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Mycobacterium tuberculosis Conserved protein 0.0035 0.0688 0.0835
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1299 0.1298
Echinococcus granulosus allatostatin A receptor 0.0016 0.0261 0.0258
Loa Loa (eye worm) hypothetical protein 0.0035 0.0688 0.1123
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0688 0.0835
Schistosoma mansoni amine GPCR 0.0016 0.0261 0.026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Schistosoma mansoni cpg binding protein 0.0037 0.0731 0.073
Brugia malayi beta-lactamase 0.0035 0.0688 0.1123
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1585 0.1584
Brugia malayi beta-lactamase family protein 0.0035 0.0688 0.1123
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0292 0.0289
Onchocerca volvulus 0.0016 0.0261 0.0421
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0016 0.0261 0.026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0261 0.026
Loa Loa (eye worm) hypothetical protein 0.0035 0.0688 0.1123
Schistosoma mansoni DNA helicase recq5 0.001 0.0114 0.0113
Echinococcus granulosus g protein coupled receptor 0.0016 0.0261 0.0258
Schistosoma mansoni paired box protein pax-6 0.0005 0.0003 0.0002
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0261 0.0258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0688 0.0835
Echinococcus multilocularis orexin receptor type 2 0.0016 0.0261 0.0258
Echinococcus granulosus somatostatin receptor 0.0016 0.0261 0.0258
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0688 0.0835
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0261 0.0258
Echinococcus multilocularis somatostatin receptor 0.0016 0.0261 0.0258
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0261 0.0258
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0261 0.0258
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0005
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0094 0.0091
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0293 0.029
Schistosoma mansoni hypothetical protein 0.0016 0.0261 0.026
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0016 0.0261 0.0258
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0688 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0261 0.0258
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0767 0.1252
Entamoeba histolytica hypothetical protein 0.0036 0.0721 1
Echinococcus multilocularis sex peptide receptor 0.0016 0.0261 0.0258
Brugia malayi sulfakinin receptor protein 0.0016 0.0261 0.0426
Schistosoma mansoni hypothetical protein 0.0171 0.3827 0.3826
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0293 0.1065
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0016 0.0261 0.026
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.5023 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0293 0.0478
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0292 0.0289
Brugia malayi 'Paired box' domain containing protein 0.0005 0.0003 0.0005
Onchocerca volvulus Neuropeptide F receptor homolog 0.0016 0.0261 0.0421
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Brugia malayi putative neuropeptide receptor NPR1 0.0016 0.0261 0.0426
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0261 0.026
Loa Loa (eye worm) TYRA-2 protein 0.0016 0.0261 0.0426
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0293 0.1065
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0016 0.0261 0.0426
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0016 0.0261 0.0258
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0293 0.0292
Brugia malayi Dopamine receptor protein 1 0.0016 0.0261 0.0426
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0261 0.0258
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0257 0.0932
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0261 0.026
Echinococcus multilocularis serotonin receptor 0.0016 0.0261 0.0258
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0261 0.026
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0721 0.0718
Echinococcus granulosus hypothetical protein 0.0016 0.0261 0.0258
Brugia malayi G protein-coupled receptor F59B2.13 0.0016 0.0261 0.0426
Brugia malayi Melibiase family protein 0.0082 0.1791 0.2925
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0688 0.0685
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0261 0.0258
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0114 0.0412
Loa Loa (eye worm) RecQ helicase 0.0024 0.0442 0.0722
Brugia malayi isocitrate dehydrogenase 0.0018 0.0293 0.0478
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0261 0.026
Loa Loa (eye worm) hypothetical protein 0.0122 0.2696 0.4402
Schistosoma mansoni Smad4 0.0009 0.0094 0.0093
Echinococcus granulosus g protein coupled receptor 0.0016 0.0261 0.0258
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0261 0.0258
Brugia malayi Smad1 0.0009 0.0094 0.0154
Schistosoma mansoni biogenic amine receptor 0.0016 0.0261 0.026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0261 0.026
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0261 0.0258
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0261 0.026
Schistosoma mansoni hypothetical protein 0.0016 0.0261 0.026
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0324 0.0324
Schistosoma mansoni alpha-1 adrenergic receptor 0.0016 0.0261 0.026
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.2744 0.2743
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0261 0.0258
Brugia malayi hypothetical protein 0.0016 0.0261 0.0426
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0261 0.0258
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0442 0.2184
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0065 0.00000000055101
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0083 0.0082
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0182 0.0676
Entamoeba histolytica hypothetical protein 0.0036 0.0721 1
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0442 0.0722
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1069 0.1067
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0688 0.5
Brugia malayi 'Paired box' domain containing protein 0.0005 0.0003 0.0005
Schistosoma mansoni histamine h1 receptor 0.0016 0.0261 0.026
Brugia malayi hypothetical protein 0.0016 0.0261 0.0426
Loa Loa (eye worm) hypothetical protein 0.0056 0.1176 0.192
Loa Loa (eye worm) melatonin receptor type 1A 0.0016 0.0261 0.0426
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1299 0.1298
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0292 0.0289
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0688 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0261 0.026
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0094 0.0093
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0114 0.0111
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0261 0.0258
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0688 0.0835
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1069 0.1067
Brugia malayi paired box pox-meso protein 0.0005 0.0003 0.0005
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0721 0.072
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0094 0.0091
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0261 0.0258
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0261 0.026
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0016 0.0261 0.0258
Toxoplasma gondii ABC1 family protein 0.0035 0.0688 0.2504
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0261 0.0258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0426
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0261 0.026
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0065 0.00000000055101
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0016 0.0261 0.026
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0292 0.0289
Onchocerca volvulus 0.0035 0.0688 0.1119
Brugia malayi hypothetical protein 0.0016 0.0261 0.0426
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0261 0.0258

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3981 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.