Detailed information for compound 1335999

Basic information

Technical information
  • TDR Targets ID: 1335999
  • Name: 2-[[(2Z)-3-oxo-2-(thiophen-2-ylmethylidene)-1 -benzofuran-6-yl]oxy]acetic acid
  • MW: 302.302 | Formula: C15H10O5S
  • H donors: 1 H acceptors: 3 LogP: 2.88 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)COc1ccc2c(c1)O/C(=C\c1cccs1)/C2=O
  • InChi: 1S/C15H10O5S/c16-14(17)8-19-9-3-4-11-12(6-9)20-13(15(11)18)7-10-2-1-5-21-10/h1-7H,8H2,(H,16,17)/b13-7-
  • InChiKey: HHFRACDVWIASET-QPEQYQDCSA-N  


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Synonyms

  • 2-[(2Z)-3-oxo-2-(2-thienylmethylene)benzofuran-6-yl]oxyacetic acid
  • 2-[[(2Z)-3-oxo-2-(2-thienylmethylene)-6-benzofuranyl]oxy]acetic acid
  • 2-[(2Z)-3-keto-2-(2-thienylmethylene)benzofuran-6-yl]oxyacetic acid
  • 2-[[(2Z)-3-oxo-2-(thiophen-2-ylmethylidene)-1-benzofuran-6-yl]oxy]ethanoic acid
  • MLS000779264
  • SMR000415957
  • {3-Oxo-2-[1-thiophen-2-yl-meth-(Z)-ylidene]-2,3-dihydro-benzofuran-6-yloxy}-acetic acid
  • BB_NC-1725

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.001 0.0031 0.0792
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0338 1
Brugia malayi RE15519p 0.001 0.0031 0.0026
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0031 0.0026
Onchocerca volvulus 0.001 0.0031 0.0792
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0031 0.0026
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0332 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0026
Echinococcus granulosus serotonin receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0332 1
Brugia malayi hypothetical protein 0.001 0.0031 0.0026
Brugia malayi hypothetical protein 0.001 0.0031 0.0026
Echinococcus multilocularis snurportin 1 0.0372 0.6005 0.6003
Schistosoma mansoni serine/threonine protein kinase 0.0614 1 1
Brugia malayi sulfakinin receptor protein 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0338 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0026
Echinococcus multilocularis importin subunit beta 1 0.0035 0.044 0.0436
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.0031 0.0026
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0031 0.0026
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0289 0.0285
Onchocerca volvulus 0.001 0.0031 0.0792
Echinococcus granulosus neuropeptide receptor 0.001 0.0031 0.0026
Onchocerca volvulus 0.001 0.0031 0.0792
Schistosoma mansoni hypothetical protein 0.0372 0.6005 0.6003
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0031 0.0026
Brugia malayi larval opioid receptor 0.001 0.0031 0.0026
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0332 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0026
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0031 0.0026
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0219 0.4916
Loa Loa (eye worm) hypothetical protein 0.0029 0.0338 0.0334
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0219 0.0215
Echinococcus multilocularis fmrfamide receptor 0.001 0.0031 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0199 0.5844
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0031 0.0026
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.044 1
Brugia malayi hypothetical protein 0.001 0.0031 0.0026
Echinococcus multilocularis g protein coupled receptor 0.001 0.0031 0.0026
Echinococcus multilocularis sex peptide receptor 0.001 0.0031 0.0026
Schistosoma mansoni biogenic amine receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0031 0.0026
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0031 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0026
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0031 0.0026
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0031 0.0026
Brugia malayi Dopamine receptor protein 1 0.001 0.0031 0.0026
Echinococcus granulosus fmrfamide receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.0035 0.044 0.0436
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0031 0.0026
Brugia malayi neuropeptide F receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0614 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.0031 0.0026
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0031 0.0026
Leishmania major importin beta-1 subunit, putative 0.0028 0.0332 0.9805
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0338 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Echinococcus multilocularis muscleblind protein 0.018 0.2845 0.2842
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0289 0.0285
Plasmodium vivax importin-beta 2, putative 0.0035 0.044 1
Onchocerca volvulus 0.001 0.0031 0.0792
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.0031 0.0026
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0031 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0338 0.0334
Brugia malayi Melatonin receptor type 1A 0.001 0.0031 0.0026
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0031 0.0026
Mycobacterium ulcerans hypothetical protein 0.0029 0.0338 1
Echinococcus granulosus g protein coupled receptor 0.001 0.0031 0.0026
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0338 1
Schistosoma mansoni amine GPCR 0.001 0.0031 0.0026
Brugia malayi Dopamine receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0338 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Onchocerca volvulus 0.001 0.0031 0.0792
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0026
Echinococcus granulosus sex peptide receptor 0.001 0.0031 0.0026
Onchocerca volvulus 0.001 0.0031 0.0792
Brugia malayi Importin beta-1 subunit 0.0035 0.044 0.0436
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Brugia malayi hypothetical protein 0.001 0.0031 0.0026
Schistosoma mansoni opsin-like receptor 0.001 0.0031 0.0026
Brugia malayi G-protein coupled receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Brugia malayi Serotonin receptor 0.001 0.0031 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0026
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0031 0.0026
Schistosoma mansoni hypothetical protein 0.0205 0.3245 0.3242
Schistosoma mansoni ran 0.0026 0.0289 0.0285
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0026
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0031 0.0026
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0289 0.6552
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0031 0.0026
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0031 0.0026
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0031 0.0026
Entamoeba histolytica Ran family GTPase 0.0026 0.0289 0.8515
Echinococcus granulosus g protein coupled receptor 0.001 0.0031 0.0026
Schistosoma mansoni neuropeptide receptor 0.001 0.0031 0.0026
Schistosoma mansoni hypothetical protein 0.0205 0.3245 0.3242
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0338 1
Schistosoma mansoni hypothetical protein 0.001 0.0031 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0338 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0219 0.0215
Schistosoma mansoni myosin xvIII 0.001 0.0031 0.0026
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0031 0.0026
Brugia malayi hypothetical protein 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0338 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0199 0.5844
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0031 0.0026
Schistosoma mansoni neuropeptide receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0031 0.0026
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0031 0.0026
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0332 1
Schistosoma mansoni histamine h1 receptor 0.001 0.0031 0.0026
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0219 0.6421
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0026
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0031 0.0026
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0338 1
Echinococcus multilocularis g protein coupled receptor 0.001 0.0031 0.0026
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0031 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0338 1
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0031 0.0026
Echinococcus granulosus importin subunit beta 1 0.0035 0.044 0.0436
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0031 0.0026
Schistosoma mansoni hypothetical protein 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0289 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0031 0.0026
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.001 0.0031 0.0792
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0026
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.0031 0.0026
Brugia malayi hypothetical protein 0.001 0.0031 0.0026
Onchocerca volvulus 0.001 0.0031 0.0792
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0031 0.0026
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0031 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0026
Echinococcus granulosus g protein coupled receptor 0.001 0.0031 0.0026
Echinococcus granulosus hypothetical protein 0.001 0.0031 0.0026
Leishmania major GTP-binding protein, putative 0.0026 0.0289 0.8515
Loa Loa (eye worm) hypothetical protein 0.0029 0.0338 0.0334
Echinococcus granulosus g-protein coupled receptor 0.001 0.0031 0.0026
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0031 0.0026
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Trichomonas vaginalis ran, putative 0.0026 0.0289 0.8685
Brugia malayi G-protein coupled receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0031 0.0026
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Schistosoma mansoni hypothetical protein 0.001 0.0031 0.0026
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0289 0.652
Echinococcus granulosus allatostatin A receptor 0.001 0.0031 0.0026
Echinococcus granulosus orexin receptor type 2 0.001 0.0031 0.0026
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0031 0.0026
Echinococcus multilocularis neuropeptide receptor 0.001 0.0031 0.0026
Echinococcus multilocularis orexin receptor type 2 0.001 0.0031 0.0026
Echinococcus granulosus snurportin 1 0.0372 0.6005 0.6003
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0031 0.0026
Entamoeba histolytica hypothetical protein 0.0028 0.0332 0.9805
Loa Loa (eye worm) hypothetical protein 0.018 0.2845 0.2842
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0031 0.0026
Onchocerca volvulus 0.001 0.0031 0.0792
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0031 0.0026
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0031 0.0026
Onchocerca volvulus 0.001 0.0031 0.0792
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0031 0.0026
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0031 0.0026
Echinococcus multilocularis somatostatin receptor 0.001 0.0031 0.0026
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0031 0.0026
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0289 0.8685
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.044 1
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0031 0.0026
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0338 1
Echinococcus granulosus neuropeptide s receptor 0.001 0.0031 0.0026
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0031 0.0026
Onchocerca volvulus 0.001 0.0031 0.0792
Schistosoma mansoni importin beta-1 0.0035 0.044 0.0436
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0199 0.5844
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0031 0.0026
Brugia malayi ORL1-like opioid receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Brugia malayi Serotonin receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0219 0.0215
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0338 0.0334
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.018 0.2845 0.2842
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0031 0.0026
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.0031 0.0026
Brugia malayi hypothetical protein 0.001 0.0031 0.0026
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.044 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0338 1
Schistosoma mansoni neuropeptide receptor 0.001 0.0031 0.0026
Echinococcus multilocularis serotonin receptor 0.001 0.0031 0.0026
Schistosoma mansoni neuropeptide receptor 0.001 0.0031 0.0026
Onchocerca volvulus 0.0029 0.0338 1
Schistosoma mansoni biogenic amine receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0338 1
Onchocerca volvulus 0.001 0.0031 0.0792
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Brugia malayi hypothetical protein 0.001 0.0031 0.0026
Brugia malayi follicle stimulating hormone receptor 0.001 0.0031 0.0026
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.0031 0.0026
Onchocerca volvulus 0.001 0.0031 0.0792
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Schistosoma mansoni opsin-like receptor 0.001 0.0031 0.0026
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0031 0.0026
Brugia malayi Dopamine receptor protein 2 0.001 0.0031 0.0026
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0289 0.0285
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0338 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0031 0.0026
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0289 0.0285
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0219 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.0031 0.0026
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0614 1 1
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0219 0.4916
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0338 0.0334
Echinococcus multilocularis neuropeptide receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0219 0.0215
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0031 0.0026
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0031 0.0026
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Onchocerca volvulus 0.001 0.0031 0.0792
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0338 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0338 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0026
Schistosoma mansoni amine GPCR 0.001 0.0031 0.0026
Schistosoma mansoni hypothetical protein 0.001 0.0031 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0026
Echinococcus multilocularis muscleblind protein 1 0.018 0.2845 0.2842
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.0029 0.0338 0.0334
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0031 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0199 0.5844
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0289 0.652
Echinococcus multilocularis allatostatin A receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.0031 0.0026
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0031 0.0026
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0031 0.0026
Brugia malayi neuropeptide F receptor 0.001 0.0031 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0026
Brugia malayi RNA, U transporter 1 0.0099 0.1501 0.1497
Echinococcus granulosus geminin 0.0205 0.3245 0.3242
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0004 0.0094
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0031 0.0026
Schistosoma mansoni adenoreceptor 0.001 0.0031 0.0026
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0031 0.0026
Brugia malayi hypothetical protein 0.001 0.0031 0.0026
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0004 0.0094
Onchocerca volvulus 0.001 0.0031 0.0792
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Brugia malayi Muscleblind-like protein 0.018 0.2845 0.2842
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0031 0.0026
Plasmodium falciparum importin beta, putative 0.0035 0.044 1
Schistosoma mansoni amine GPCR 0.001 0.0031 0.0026
Echinococcus granulosus muscleblind protein 0.018 0.2845 0.2842
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0031 0.0026
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0031 0.0026
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0219 0.6421
Brugia malayi GnHR receptor homolog 0.001 0.0031 0.0026
Brugia malayi G protein-coupled receptor 0.001 0.0031 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0026
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0031 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0031 0.0026
Schistosoma mansoni amine GPCR 0.001 0.0031 0.0026
Schistosoma mansoni amine GPCR 0.001 0.0031 0.0026
Echinococcus granulosus somatostatin receptor 0.001 0.0031 0.0026
Onchocerca volvulus 0.001 0.0031 0.0792
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0031 0.0026
Schistosoma mansoni ran 0.0026 0.0289 0.0285
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0031 0.0026
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0031 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0026
Echinococcus multilocularis g protein coupled receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0219 0.0215
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.6005 0.6003
Echinococcus multilocularis serotonin receptor 0.001 0.0031 0.0026
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0031 0.0026
Echinococcus granulosus neuropeptide receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0026
Echinococcus multilocularis fmrfamide receptor 0.001 0.0031 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0338 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0026
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0289 0.652
Brugia malayi AKH receptor 0.001 0.0031 0.0026
Onchocerca volvulus Neuropeptide F receptor homolog 0.001 0.0031 0.0792
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0614 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0026
Brugia malayi hypothetical protein 0.001 0.0031 0.0026
Onchocerca volvulus 0.001 0.0031 0.0792
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0031 0.0026
Echinococcus multilocularis geminin 0.0205 0.3245 0.3242
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0289 0.8685
Brugia malayi putative neuropeptide receptor 0.001 0.0031 0.0026
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0031 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0026
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0026
Schistosoma mansoni biogenic amine receptor 0.001 0.0031 0.0026
Schistosoma mansoni opsin-like receptor 0.001 0.0031 0.0026
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0031 0.0026

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 81.2 uM PUBCHEM_BIOASSAY: SAR LYP1 Fluorescent Assay using pCAP substrate for In Vitro dose response studies - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1779, AID1784, AID2135, AID449727] ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: SAR LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1779, AID1784, AID2140, AID2686] ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: SAR LYP1 Fluorescent Assay using pCAP substrate for In Vitro dose response studies - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1779, AID1784, AID2135, AID2682] ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: SAR Selectivity Analysis of small molecule inhibitors of PEST using pCAP in a fluorescence assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1779, AID1784, AID2135] ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit HePTP - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1059, AID1077, AID1784, AID2085, AID521] ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: SAR LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1779, AID1784, AID2140, AID449726, AID488869] ChEMBL. No reference
Potency (functional) 1.9012 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 15.8489 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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