TDR Targets

Basic information

Technical information

TDR Targets ID: 1340126
Name: (3-chlorophenyl)-(5-nitro-1-benzofuran-2-yl)m ethanol
MW: 303.697 | Formula: C15H10ClNO4
H donors: 1 H acceptors: 3 LogP: 3.63 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)C(c1cc2c(o1)ccc(c2)[N+](=O)[O-])O
InChi: 1S/C15H10ClNO4/c16-11-3-1-2-9(6-11)15(18)14-8-10-7-12(17(19)20)4-5-13(10)21-14/h1-8,15,18H
InChiKey: LZUJVVSSNKDVHT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3-chlorophenyl)-(5-nitrobenzofuran-2-yl)methanol
(3-chlorophenyl)-(5-nitro-2-benzofuranyl)methanol
Oprea1_866722

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Saccharomyces cerevisiae	protein transporter TIM10	Starlite/ChEMBL	No references
Homo sapiens	multiple endocrine neoplasia I		No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	synuclein, alpha (non A4 component of amyloid precursor)	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	expressed protein	Get druggable targets OG5_128839	All targets in OG5_128839
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Babesia bovis	mitochondrial transport complex Tim10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Plasmodium yoelii	small zinc finger-like protein-related	Get druggable targets OG5_128839	All targets in OG5_128839
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	Menin, putative	Get druggable targets OG5_133913	All targets in OG5_133913
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	Mitochondrial import inner membrane translocase subunit TIM10	Get druggable targets OG5_128839	All targets in OG5_128839
Toxoplasma gondii	mitochondrial import inner membrane translocase subunit TIM10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Neospora caninum	Tim10/DDP family zinc finger containing protein, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Theileria parva	mitochondrial import inner membrane translocase subunit tim10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Neospora caninum	mitochondrial import inner membrane translocase subunit tim10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Candida albicans	protein trans. across mito. Intermembrane space	Get druggable targets OG5_128839	All targets in OG5_128839
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium berghei	mitochondrial import inner membrane translocase subunit TIM10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Schistosoma japonicum	Mitochondrial import inner membrane translocase subunit Tim10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Echinococcus multilocularis	expressed protein	Get druggable targets OG5_128839	All targets in OG5_128839
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Toxoplasma gondii	TIM10 family protein, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Plasmodium vivax	mitochondrial import inner membrane translocase subunit TIM10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	mitochondrial import inner membrane translocase subunit tim10	Get druggable targets OG5_128839	All targets in OG5_128839
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Candida albicans	protein trans. across mito. Intermembrane space	Get druggable targets OG5_128839	All targets in OG5_128839
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium knowlesi	mitochondrial import inner membrane translocase subunit TIM10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium falciparum	mitochondrial import inner membrane translocase subunit TIM10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_133913	All targets in OG5_133913
Loa Loa (eye worm)	transport to inner mitochondrial membrane family member	Get druggable targets OG5_128839	All targets in OG5_128839

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	G protein coupled receptor 139	0.0035	0.0422	0.0365
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0118	0.0931
Schistosoma mansoni	hypothetical protein	0.0019	0.0123	0.0136
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0118	0.5
Echinococcus granulosus	fmrfamide receptor	0.0035	0.0422	0.0365
Onchocerca volvulus		0.0035	0.0422	0.1174
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0016	0.006	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0281	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Schistosoma mansoni	hypothetical protein	0.0167	0.29	0.32
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.0422	0.0365
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0019	0.0117	0.0347
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0662	0.073
Brugia malayi	putative neuropeptide receptor NPR1	0.0035	0.0422	0.0696
Echinococcus multilocularis	neuropeptide Y receptor	0.0035	0.0422	0.0365
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.0422	0.0365
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0118	0.0531
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0442	0.0814
Schistosoma mansoni	mitochondrial import inner membrane translocase subunit tim10	0.0058	0.085	0.0938
Echinococcus granulosus	g protein coupled receptor	0.0035	0.0422	0.0365
Echinococcus granulosus	7TM GPCR rhodopsin	0.0035	0.0422	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Echinococcus multilocularis	expressed protein	0.0019	0.0117	0.0057
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0027	0.0281	0.0222
Onchocerca volvulus		0.0048	0.0662	0.2007
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0035	0.0422	0.0365
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0035	0.0422	0.0365
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0035	0.0422	0.0365
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.0019	0.0117	0.0109
Echinococcus multilocularis	geminin	0.0167	0.29	0.2858
Echinococcus granulosus	GPCR family 2	0.0019	0.0123	0.0064
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0422	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Echinococcus multilocularis	fmrfamide receptor	0.0035	0.0422	0.0365
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0035	0.0422	0.0365
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0442	1
Brugia malayi	RE15519p	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0442	0.0384
Brugia malayi	beta-lactamase family protein	0.0036	0.0442	0.0733
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0422	0.0365
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.1205	0.2198
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0019	0.0117	0.0347
Brugia malayi	beta-lactamase family protein	0.0036	0.0442	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Echinococcus multilocularis	somatostatin receptor	0.0035	0.0422	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0117	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0442	0.0733
Echinococcus granulosus	polycomb protein SCMH1	0.0048	0.0662	0.0605
Schistosoma mansoni	neuropeptide receptor	0.0035	0.0422	0.0466
Schistosoma mansoni	hypothetical protein	0.0041	0.0539	0.0595
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0422	0.0466
Schistosoma mansoni	neuropeptide receptor	0.0035	0.0422	0.0466
Echinococcus multilocularis	follistatin	0.0019	0.0117	0.0057
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0035	0.0422	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0123	0.0122
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0123	0.0064
Brugia malayi	larval opioid receptor	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0442	0.0733
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0035	0.0422	0.0365
Schistosoma mansoni	voltage-gated potassium channel	0.0023	0.0197	0.0217
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0035	0.0422	0.0466
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0054	0.0786	0.1393
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0079	0.1257	0.2298
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0035	0.0422	0.0466
Schistosoma mansoni	growth hormone secretagogue receptor	0.0035	0.0422	0.0466
Loa Loa (eye worm)	neuropeptide F receptor	0.0035	0.0422	0.0696
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0054	0.0786	0.073
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0035	0.0422	0.0365
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0662	0.073
Brugia malayi	prostaglandin transporter	0.0027	0.0281	0.0424
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0019	0.0117	0.0109
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0019	0.0117	0.0109
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0118	0.5
Schistosoma mansoni	inhibitor of apoptosis protein	0.0158	0.2741	0.3024
Schistosoma mansoni	hypothetical protein	0.0494	0.9064	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0422	0.0365
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.1002	1
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.1205	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.0158	0.2741	0.3024
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0035	0.0422	0.0696
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0035	0.0422	0.0365
Echinococcus multilocularis	expressed protein	0.0058	0.085	0.0795
Onchocerca volvulus	Putative organic anion transporter	0.0027	0.0281	0.0681
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0422	0.0466
Echinococcus multilocularis	max protein X	0.0292	0.5269	0.5241
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0019	0.0117	0.0347
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0442	0.4662
Schistosoma mansoni	hypothetical protein	0.0019	0.0123	0.0136
Schistosoma mansoni	neuropeptide receptor	0.0035	0.0422	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0117	0.0109
Brugia malayi	hypothetical protein	0.0035	0.0422	0.0696
Schistosoma mansoni	ap endonuclease	0.0019	0.0118	0.0131
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0019	0.0117	0.0109
Echinococcus granulosus	g protein coupled receptor	0.0035	0.0422	0.0365
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0123	0.0122
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0422	0.0365
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0048	0.0662	0.073
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Schistosoma mansoni	hypothetical protein	0.0019	0.0123	0.0136
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0422	0.0466
Toxoplasma gondii	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0058	0.085	0.8347
Loa Loa (eye worm)	G-protein coupled receptor	0.0035	0.0422	0.0696
Schistosoma mansoni	hypothetical protein	0.0035	0.0422	0.0466
Schistosoma mansoni	amine GPCR	0.0035	0.0422	0.0466
Schistosoma mansoni	bhlhzip transcription factor bigmax	0.0292	0.5269	0.5813
Schistosoma mansoni	biogenic amine receptor	0.0035	0.0422	0.0466
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0422	0.0365
Loa Loa (eye worm)	mbt repeat family protein	0.0048	0.0662	0.1155
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0422	0.0365
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0442	0.0814
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0123	0.0064
Schistosoma mansoni	adenoreceptor	0.0035	0.0422	0.0466
Brugia malayi	mbt repeat family protein	0.0048	0.0662	0.1155
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0442	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0035	0.0422	0.0696
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.115	0.1268
Loa Loa (eye worm)	RNA binding protein	0.0076	0.1205	0.2198
Brugia malayi	neuropeptide F receptor	0.0035	0.0422	0.0696
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0898	0.1609
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0019	0.0117	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0442	0.0733
Onchocerca volvulus		0.0027	0.0281	0.0681
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0442	0.5
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0118	0.0434
Echinococcus multilocularis	neuropeptide receptor	0.0035	0.0422	0.0365
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0805	0.0888
Schistosoma mansoni	organic anion transporter	0.0027	0.0281	0.031
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0442	0.0814
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0023	0.0197	0.0138
Brugia malayi	Mitochondrial import inner membrane translocase subunit TIM10	0.0058	0.085	0.1517
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0158	0.2741	0.2698
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0422	0.0365
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0035	0.0422	0.0696
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0035	0.0422	0.0365
Brugia malayi	SPARC precursor	0.0019	0.0117	0.0109
Brugia malayi	TAR-binding protein	0.0076	0.1205	0.2198
Echinococcus multilocularis	sex peptide receptor	0.0035	0.0422	0.0365
Mycobacterium ulcerans	lipase LipD	0.0036	0.0442	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0442	0.3474
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0118	0.0931
Brugia malayi	hypothetical protein	0.0035	0.0422	0.0696
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.1205	0.2198
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0281	0.0424
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0442	0.3474
Onchocerca volvulus		0.0035	0.0422	0.1174
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0035	0.0422	0.0365
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.0422	0.0365
Echinococcus granulosus	expressed protein	0.0058	0.085	0.0795
Echinococcus granulosus	biogenic amine 5HT receptor	0.0035	0.0422	0.0365
Brugia malayi	hypothetical protein	0.0027	0.0281	0.0424
Brugia malayi	Kringle domain containing protein	0.0017	0.0085	0.0048
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0422	0.0365
Schistosoma mansoni	myosin xvIII	0.0035	0.0422	0.0466
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0418	0.0687
Brugia malayi	hypothetical protein	0.0035	0.0422	0.0696
Schistosoma mansoni	bhlhzip transcription factor bigmax	0.0292	0.5269	0.5813
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0422	0.0466
Schistosoma mansoni	neuropeptide receptor	0.0035	0.0422	0.0466
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0442	0.0384
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0027	0.0281	0.0222
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0442	0.0814
Echinococcus granulosus	voltage gated potassium channel	0.0023	0.0197	0.0138
Trichomonas vaginalis	esterase, putative	0.0036	0.0442	0.3474
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0123	0.0064
Onchocerca volvulus		0.0035	0.0422	0.1174
Schistosoma mansoni	cpg binding protein	0.0037	0.0455	0.0502
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0016	0.006	0.0066
Echinococcus multilocularis	allatostatin A receptor	0.017	0.2958	0.2915
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Schistosoma mansoni	opsin-like receptor	0.0035	0.0422	0.0466
Brugia malayi	AKH receptor	0.0035	0.0422	0.0696
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0079	0.1257	0.1204
Echinococcus granulosus	serotonin receptor	0.0035	0.0422	0.0365
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0035	0.0422	0.0466
Onchocerca volvulus		0.0035	0.0422	0.1174
Brugia malayi	hypothetical protein	0.0035	0.0422	0.0696
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0442	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0418	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0442	0.0733
Onchocerca volvulus		0.0035	0.0422	0.1174
Brugia malayi	G protein-coupled receptor	0.0035	0.0422	0.0696
Brugia malayi	hypothetical protein	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Onchocerca volvulus		0.0035	0.0422	0.1174
Onchocerca volvulus		0.0019	0.0117	0.0111
Schistosoma mansoni	hypothetical protein	0.0158	0.2741	0.3024
Onchocerca volvulus		0.0027	0.0281	0.0681
Brugia malayi	sulfakinin receptor protein	0.0035	0.0422	0.0696
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0035	0.0422	0.0365
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0422	0.0365
Onchocerca volvulus	Putative organic anion transporter	0.0027	0.0281	0.0681
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0035	0.0422	0.0466
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0048	0.0662	0.2007
Brugia malayi	sodium-independent organic anion transporter family protein	0.0027	0.0281	0.0424
Echinococcus granulosus	biogenic amine 5HT receptor	0.0035	0.0422	0.0365
Brugia malayi	putative neuropeptide receptor	0.0035	0.0422	0.0696
Brugia malayi	hypothetical protein	0.0035	0.0422	0.0696
Schistosoma mansoni	biogenic amine receptor	0.0035	0.0422	0.0466
Brugia malayi	follicle stimulating hormone receptor	0.0035	0.0422	0.0696
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.0158	0.2741	0.2698
Leishmania major	hypothetical protein, conserved	0.0036	0.0442	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0281	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Schistosoma mansoni	neuropeptide f receptor 76f	0.0035	0.0422	0.0466
Toxoplasma gondii	transporter, major facilitator family protein	0.0027	0.0281	0.2133
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0442	0.0733
Brugia malayi	hypothetical protein	0.0035	0.0422	0.0696
Brugia malayi	mbt repeat family protein	0.0048	0.0662	0.1155
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Echinococcus multilocularis	fmrfamide receptor	0.0035	0.0422	0.0365
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0442	1
Schistosoma mansoni	voltage-gated potassium channel	0.0087	0.1394	0.1538
Echinococcus multilocularis	polycomb protein SCMH1	0.0048	0.0662	0.0605
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0442	0.0487
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1205	0.1329
Onchocerca volvulus	Deterin homolog	0.0158	0.2741	0.9247
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0442	0.0814
Echinococcus granulosus	sex peptide receptor	0.0035	0.0422	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0118	0.0531
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0805	0.0888
Brugia malayi	RNA binding protein	0.0076	0.1205	0.2198
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0118	0.5
Schistosoma mansoni	hypothetical protein	0.0035	0.0422	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Brugia malayi	GnHR receptor homolog	0.0035	0.0422	0.0696
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0422	0.0466
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0422	0.0365
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0054	0.0786	0.073
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0123	0.0064
Schistosoma mansoni	hypothetical protein	0.0035	0.0422	0.0466
Echinococcus granulosus	neuropeptides capa receptor	0.0035	0.0422	0.0365
Brugia malayi	neuropeptide F receptor	0.0035	0.0422	0.0696
Brugia malayi	Dopamine receptor protein 1	0.0035	0.0422	0.0696
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0422	0.0365
Schistosoma mansoni	ap endonuclease	0.0019	0.0118	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0117	0.0109
Echinococcus granulosus	g-protein coupled receptor	0.0035	0.0422	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0281	0.0424
Schistosoma mansoni	neuropeptide F-like receptor	0.0035	0.0422	0.0466
Loa Loa (eye worm)	TYRA-2 protein	0.0035	0.0422	0.0696
Onchocerca volvulus	Putative organic anion transporter	0.0027	0.0281	0.0681
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0035	0.0422	0.0696
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0118	0.0059
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0035	0.0422	0.0365
Onchocerca volvulus		0.0027	0.0281	0.0681
Onchocerca volvulus		0.0035	0.0422	0.1174
Onchocerca volvulus		0.0035	0.0422	0.1174
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0422	0.0466
Trypanosoma cruzi	MFS transporter, putative	0.0027	0.0281	0.5482
Onchocerca volvulus		0.0035	0.0422	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0442	0.0814
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0019	0.0117	0.0109
Echinococcus granulosus	dro:myosuppressin receptor	0.0035	0.0422	0.0365
Echinococcus multilocularis	neuropeptide s receptor	0.0035	0.0422	0.0365
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0035	0.0422	0.0696
Echinococcus multilocularis	neuropeptide receptor A26	0.0035	0.0422	0.0365
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0035	0.0422	0.0365
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0898	0.1609
Schistosoma mansoni	amine GPCR	0.0035	0.0422	0.0466
Brugia malayi	beta-lactamase	0.0036	0.0442	0.0733
Plasmodium vivax	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0058	0.085	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0079	0.1257	0.2298
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0805	0.0749
Echinococcus granulosus	max protein X	0.0292	0.5269	0.5241
Onchocerca volvulus		0.017	0.2958	1
Loa Loa (eye worm)	MBCTL1	0.0054	0.0786	0.1393
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0048	0.0662	0.0605
Echinococcus multilocularis	voltage gated potassium channel	0.0023	0.0197	0.0138
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.0422	0.0466
Onchocerca volvulus		0.0036	0.0442	0.1242
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0539	0.092
Schistosoma mansoni	voltage-gated potassium channel	0.0087	0.1394	0.1538
Onchocerca volvulus		0.0035	0.0422	0.1174
Schistosoma mansoni	agrin	0.0019	0.0117	0.0129
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0422	0.0466
Echinococcus multilocularis	dro:myosuppressin receptor	0.0035	0.0422	0.0365
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0035	0.0422	0.0365
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0079	0.1257	0.1204
Schistosoma mansoni	amine GPCR	0.0035	0.0422	0.0466
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0442	0.0487
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1205	0.1329
Echinococcus granulosus	orexin receptor type 2	0.0035	0.0422	0.0365
Onchocerca volvulus		0.0035	0.0422	0.1174
Echinococcus granulosus	g protein coupled receptor	0.0035	0.0422	0.0365
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0805	0.0749
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0118	0.0112
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0544	1	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0035	0.0422	0.0365
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.0422	0.0466
Brugia malayi	G-protein coupled receptor	0.0035	0.0422	0.0696
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.0422	0.0365
Echinococcus granulosus	neuropeptide receptor A26	0.0035	0.0422	0.0365
Toxoplasma gondii	ABC1 family protein	0.0036	0.0442	0.3891
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0123	0.0064
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0158	0.2741	0.5147
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0035	0.0422	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0442	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Toxoplasma gondii	protease inhibitor PI2	0.0019	0.0117	0.0347
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0035	0.0422	0.0365
Echinococcus multilocularis	orexin receptor type 2	0.0035	0.0422	0.0365
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.0422	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0442	0.0733
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0118	0.5
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0118	0.0059
Schistosoma mansoni	amine GPCR	0.0035	0.0422	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0158	0.2741	0.5147
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0035	0.0422	0.1174
Echinococcus multilocularis	neuropeptides capa receptor	0.0035	0.0422	0.0365
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0292	0.5269	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Brugia malayi	hypothetical protein	0.0035	0.0422	0.0696
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0016	0.006	0.0066
Echinococcus multilocularis	g-protein coupled receptor	0.0035	0.0422	0.0365
Echinococcus multilocularis	tissue type plasminogen activator	0.0017	0.0085	0.0025
Schistosoma mansoni	cpg binding protein	0.0035	0.0418	0.0461
Echinococcus granulosus	neuropeptide receptor	0.0035	0.0422	0.0365
Echinococcus granulosus	hypothetical protein	0.0035	0.0422	0.0365
Echinococcus multilocularis	neuropeptide Y receptor	0.0035	0.0422	0.0365
Onchocerca volvulus		0.0035	0.0422	0.1174
Echinococcus granulosus	neuropeptide Y receptor	0.0035	0.0422	0.0365
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.0422	0.0365
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0118	0.0112
Echinococcus multilocularis	serotonin receptor	0.0035	0.0422	0.0365
Echinococcus multilocularis	agrin	0.0019	0.0117	0.0057
Schistosoma mansoni	opsin-like receptor	0.0035	0.0422	0.0466
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.1205	0.2198
Echinococcus granulosus	inhibitor of apoptosis protein	0.0158	0.2741	0.2698
Onchocerca volvulus		0.0027	0.0281	0.0681
Echinococcus multilocularis	cpg binding protein	0.0037	0.0455	0.0397
Schistosoma mansoni	hypothetical protein	0.0051	0.0733	0.0809
Echinococcus granulosus	histone acetyltransferase MYST2	0.0054	0.0786	0.073
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0442	0.0814
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0016	0.006	0.0066
Echinococcus granulosus	neuropeptide s receptor	0.0035	0.0422	0.0365
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0898	0.1609
Brugia malayi	ORL1-like opioid receptor	0.0035	0.0422	0.0696
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0035	0.0422	0.0466
Onchocerca volvulus		0.0027	0.0281	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0117	0.0109
Plasmodium falciparum	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0058	0.085	1
Echinococcus multilocularis	dnaJ subfamily B	0.0494	0.9064	0.9058
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1205	0.1329
Brugia malayi	G-protein coupled receptor	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Loa Loa (eye worm)	G-protein coupled receptor	0.0035	0.0422	0.0696
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0035	0.0422	0.0466
Brugia malayi	hypothetical protein	0.0027	0.0281	0.0424
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0192	0.3371	0.3331
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0035	0.0422	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0422	0.0365
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0035	0.0422	0.0365
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0422	0.0365
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0023	0.0197	0.0138
Loa Loa (eye worm)	hypothetical protein	0.017	0.2958	0.5562
Brugia malayi	Protein kinase domain containing protein	0.0017	0.0085	0.0048
Onchocerca volvulus		0.0035	0.0422	0.1174
Echinococcus granulosus	tar DNA binding protein	0.0076	0.1205	0.1152
Echinococcus granulosus	cpg binding protein	0.0037	0.0455	0.0397
Echinococcus granulosus	allatostatin A receptor	0.017	0.2958	0.2915
Loa Loa (eye worm)	agrin synaptic family protein	0.0019	0.0117	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Schistosoma mansoni	amine GPCR	0.0035	0.0422	0.0466
Brugia malayi	Dopamine receptor	0.0035	0.0422	0.0696
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0035	0.0422	0.0365
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0035	0.0422	0.0466
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0442	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0662	0.1155
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.017	0.2958	0.3263
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0118	0.0434
Echinococcus multilocularis	serotonin receptor	0.0035	0.0422	0.0365
Loa Loa (eye worm)	TK/ROR protein kinase	0.0017	0.0085	0.0048
Brugia malayi	secreted modular calcium-binding protein 1	0.0019	0.0117	0.0109
Echinococcus granulosus	neuropeptide receptor	0.0035	0.0422	0.0365
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0442	0.3474
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.0422	0.0466
Brugia malayi	Dopamine receptor protein 2	0.0035	0.0422	0.0696
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0158	0.2741	0.5147
Toxoplasma gondii	TIM10 family protein, putative	0.0058	0.085	0.8347
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0281	0.0424
Echinococcus granulosus	agrin	0.0019	0.0117	0.0057
Echinococcus granulosus	neuropeptides capa receptor	0.0035	0.0422	0.0365
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1205	0.1329
Onchocerca volvulus		0.0158	0.2741	0.9247
Onchocerca volvulus		0.0035	0.0422	0.1174
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0035	0.0422	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Brugia malayi	hypothetical protein	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0786	0.1393
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0123	0.0122
Brugia malayi	sodium-independent organic anion transporter family protein	0.0027	0.0281	0.0424
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0035	0.0422	0.0365
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0442	0.3474
Schistosoma mansoni	hypothetical protein	0.0019	0.0123	0.0136
Onchocerca volvulus		0.0035	0.0418	0.1157
Schistosoma mansoni	neuropeptide F-like receptor	0.0035	0.0422	0.0466
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0118	0.0931
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0422	0.0365
Echinococcus granulosus	dnaJ subfamily B	0.0494	0.9064	0.9058
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0197	0.0263
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0292	0.5269	1
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0442	0.0733
Brugia malayi	sodium-independent organic anion transporter family protein	0.0027	0.0281	0.0424
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0442	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0035	0.0422	0.0466
Echinococcus granulosus	neuropeptide Y receptor	0.0035	0.0422	0.0365
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0074	0.1159	1
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0027	0.0281	0.0222
Toxoplasma gondii	exonuclease III APE	0.0019	0.0118	0.0362
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0027	0.0281	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0158	0.2741	0.5147
Loa Loa (eye worm)	neuropeptide F receptor	0.0035	0.0422	0.0696
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0158	0.2741	0.2698
Schistosoma mansoni	hypothetical protein	0.0167	0.29	0.32
Schistosoma mansoni	opsin-like receptor	0.0035	0.0422	0.0466
Schistosoma mansoni	cpg binding protein	0.0037	0.0455	0.0502
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0023	0.0197	0.0263
Loa Loa (eye worm)	transport to inner mitochondrial membrane family member	0.0058	0.085	0.1517
Echinococcus granulosus	SAM and MBT domain containing protein	0.0048	0.0662	0.0605
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0035	0.0422	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0069	0.106	0.192
Schistosoma mansoni	follistatin	0.0019	0.0117	0.0129
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0422	0.0365
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0035	0.0422	0.0365
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0035	0.0422	0.0466
Schistosoma mansoni	voltage-gated potassium channel	0.0016	0.006	0.0066
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0027	0.0281	0.0424
Schistosoma mansoni	biogenic amine receptor	0.0035	0.0422	0.0466
Echinococcus granulosus	neuropeptide FF receptor 2	0.0035	0.0422	0.0365
Onchocerca volvulus		0.0035	0.0422	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0281	0.0424
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0805	0.0888
Schistosoma mansoni	hypothetical protein	0.0293	0.5289	0.5835
Echinococcus granulosus	follistatin	0.0019	0.0117	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0048
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.0422	0.0365
Brugia malayi	hypothetical protein	0.0035	0.0422	0.0696
Schistosoma mansoni	organic anion transporter	0.0027	0.0281	0.031
Echinococcus granulosus	G protein coupled receptor 139	0.0035	0.0422	0.0365
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0123	0.0122
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0192	0.3371	0.3331
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0442	0.0814
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0016	0.006	0.0066
Loa Loa (eye worm)	hypothetical protein	0.006	0.0898	0.1609
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0442	0.3474
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0074	0.1159	1
Schistosoma mansoni	voltage-gated potassium channel	0.0023	0.0197	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0035	0.0422	0.0696
Echinococcus granulosus	somatostatin receptor	0.0035	0.0422	0.0365
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0422	0.0365
Echinococcus granulosus	tissue type plasminogen activator	0.0017	0.0085	0.0025
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0035	0.0422	0.1174
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0442	0.0814
Schistosoma mansoni	hypothetical protein	0.0017	0.0085	0.0094
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0035	0.0422	0.0466
Brugia malayi	G protein-coupled receptor F59B2.13	0.0035	0.0422	0.0696
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0805	0.0749
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0805	0.143
Echinococcus granulosus	geminin	0.0167	0.29	0.2858
Schistosoma mansoni	hypothetical protein	0.0035	0.0422	0.0466
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.023	0.4091	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0805	0.0749
Brugia malayi	Melatonin receptor type 1A	0.0035	0.0422	0.0696
Schistosoma mansoni	histamine h1 receptor	0.0035	0.0422	0.0466
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0442	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0281	0.0424
Onchocerca volvulus		0.0035	0.0422	0.1174
Onchocerca volvulus		0.0036	0.0442	0.1242
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0054	0.0786	0.073
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1205	0.1329
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0054	0.0786	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0035	0.0422	0.0365
Brugia malayi	Serotonin receptor	0.0035	0.0422	0.0696
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0442	1
Echinococcus multilocularis	neuropeptide receptor	0.0035	0.0422	0.0365
Echinococcus multilocularis	neuropeptides capa receptor	0.0035	0.0422	0.0365
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0422	0.0466
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0442	0.5
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0805	0.143
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0539	0.092
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0422	0.0696
Onchocerca volvulus		0.0036	0.0442	0.1242
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0035	0.0422	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0442	0.0733
Brugia malayi	Serotonin receptor	0.0035	0.0422	0.0696

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 15.1 uM	PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463190, AID463194, AID504542, AID504544]	ChEMBL.	No reference
Potency (functional)	0.8913 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 17.7828 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (binding)	22.3872 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	23.9341 uM	PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	= 89.1251 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1483829

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1340126