Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0123 | 0.1032 | 0.5 |
Onchocerca volvulus | 0.0058 | 0.0408 | 0.0251 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0162 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1269 | 0.144 |
Schistosoma mansoni | fatty acid desaturase | 0.0123 | 0.1032 | 0.1132 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0017 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1269 | 0.144 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1233 | 0.1399 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0379 | 0.0483 |
Onchocerca volvulus | 0.1057 | 1 | 1 | |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0123 | 0.1032 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.1269 | 0.1126 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0162 | 0.0165 |
Brugia malayi | Fatty acid desaturase family protein | 0.0123 | 0.1032 | 0.1154 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0934 | 0.8817 | 0.8681 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0123 | 0.1032 | 0.1154 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.259 | 0.33 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0379 | 0.043 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0379 | 0.041 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0379 | 0.0483 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0379 | 0.041 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0123 | 0.1032 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0162 | 0.0175 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.7849 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.925 | 1 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0123 | 0.1032 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0379 | 0.0283 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0934 | 0.8817 | 0.8681 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.7849 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1233 | 0.1399 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0123 | 0.1032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0156 | 0.0177 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0162 | 0.0206 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0162 | 0.0175 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0408 | 0.0445 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0123 | 0.1032 | 0.1315 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0162 | 0.0175 |
Onchocerca volvulus | 0.0123 | 0.1032 | 0.0884 | |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1057 | 1 | 1 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0123 | 0.1032 | 0.5 |
Brugia malayi | hypothetical protein | 0.0148 | 0.1269 | 0.1424 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0162 | 0.0183 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0123 | 0.1032 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0162 | 0.0206 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0379 | 0.0412 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0123 | 0.1032 | 0.1115 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0379 | 0.0283 |
Mycobacterium ulcerans | hypothetical protein | 0.0123 | 0.1032 | 0.5 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0123 | 0.1032 | 0.117 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1057 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0123 | 0.1032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.259 | 0.2938 |
Loa Loa (eye worm) | FAT-3 protein | 0.0123 | 0.1032 | 0.117 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1032 | 0.117 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.7849 | 0.8486 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0934 | 0.8817 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0162 | 0.0165 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0408 | 0.0321 |
Brugia malayi | acyl-CoA desaturase | 0.0934 | 0.8817 | 1 |
Onchocerca volvulus | 0.1057 | 1 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0379 | 0.0283 |
Leishmania major | fatty-acid desaturase, putative | 0.1057 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.0162 | 0.0206 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0408 | 0.0321 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0123 | 0.1032 | 0.1115 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0123 | 0.1032 | 0.5 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0123 | 0.1032 | 0.1315 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.259 | 0.2801 |
Brugia malayi | Fatty acid desaturase family protein | 0.0123 | 0.1032 | 0.1154 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1233 | 0.1382 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0934 | 0.8817 | 0.5 |
Brugia malayi | hypothetical protein | 0.0286 | 0.259 | 0.2925 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0123 | 0.1032 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0934 | 0.8817 | 0.5 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0123 | 0.1032 | 0.117 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0162 | 0.0183 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.1269 | 0.1126 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0123 | 0.1032 | 0.1115 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.