TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 352.362 | Formula: C19H17FN4O2
H donors: 4 H acceptors: 2 LogP: 1.93 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)NCCNc1cc(c2ccc[nH]2)c2c3c1c(F)ccc3[nH]c2=O
InChi: 1S/C19H17FN4O2/c1-10(25)21-7-8-23-15-9-11(13-3-2-6-22-13)16-18-14(24-19(16)26)5-4-12(20)17(15)18/h2-6,9,22-23H,7-8H2,1H3,(H,21,25)(H,24,26)
InChiKey: RMTMSYZHBIXLDA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cyclin-dependent kinase 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K02087 cyclin-dependent kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium vivax	protein kinase Crk2	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium yoelii	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania braziliensis	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei gambiense	cell division related protein kinase 2, putative,CDC2-related protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Theileria parva	cell division control protein 2 related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania donovani	cell division protein kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania infantum	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Neospora caninum	CMGC kinase, CDK family TgPK2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K02090 cyclin-dependent kinase 5, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania major	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium parvum	Cdc2-like CDK2/CDC28 like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium falciparum	protein kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania infantum	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania braziliensis	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei gambiense	cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Babesia bovis	cell division control protein 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium berghei	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	cdc2-related kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania donovani	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium hominis	cdc2-like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium knowlesi	Cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	cyclin-dependent kinase 3	305 aa	303 aa	32.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	amine GPCR	0.0024	0.0207	0.0311
Echinococcus granulosus	neuropeptides capa receptor	0.0024	0.0207	0.029
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0024	0.0207	0.0207
Schistosoma mansoni	histamine h1 receptor	0.0024	0.0207	0.0311
Brugia malayi	hypothetical protein	0.0024	0.0207	0.036
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0207	0.0311
Echinococcus multilocularis	serotonin receptor	0.0024	0.0207	0.0207
Brugia malayi	hypothetical protein	0.006	0.0669	0.1271
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0357	0.5865
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.015	0.1821	0.2729
Echinococcus granulosus	dnaJ subfamily B	0.048	0.6066	0.8483
Schistosoma mansoni	hypothetical protein	0.0024	0.0207	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0207	0.0311
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0494	0.0925
Schistosoma mansoni	amine GPCR	0.0024	0.0207	0.0311
Echinococcus multilocularis	expressed protein	0.0018	0.013	0.013
Schistosoma mansoni	agrin	0.0018	0.013	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0357	0.5865
Echinococcus multilocularis	neuropeptide s receptor	0.0564	0.7151	0.7151
Echinococcus granulosus	inhibitor of apoptosis protein	0.03	0.3745	0.5238
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.015	0.1821	0.3545
Entamoeba histolytica	hypothetical protein	0.0025	0.0209	0.2884
Schistosoma mansoni	hypothetical protein	0.03	0.3745	0.5612
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0229	0.284	0.5554
Schistosoma mansoni	importin beta-1	0.003	0.0283	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0324	0.0588
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0018	0.013	0.0207
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0024	0.0207	0.0207
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0064	0.0713	0.9627
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0024	0.0207	0.029
Onchocerca volvulus		0.006	0.0669	0.1639
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0154	0.0175
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0024	0.0207	0.0311
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0024	0.0207	0.0311
Schistosoma mansoni	opsin-like receptor	0.0024	0.0207	0.0311
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0154	0.0175
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0154	0.0175
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0357	0.1042
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.015	0.1821	0.2729
Schistosoma mansoni	amine GPCR	0.0024	0.0207	0.0311
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0154	0.0215
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0052	0.0562	0.1058
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0207	0.029
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.018	0.1694
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0207	0.029
Plasmodium falciparum	protein kinase 5	0.0052	0.0562	1
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.0018	0.013	0.0204
Echinococcus multilocularis	caspase 2	0.006	0.0669	0.0669
Echinococcus granulosus	cyclin dependent kinase 1	0.0052	0.0562	0.0786
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0018	0.013	0.095
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0024	0.0207	0.0385
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.017	0.2079	0.2079
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.017	0.2079	0.2907
Mycobacterium ulcerans	lipase LipD	0.0036	0.0357	0.4329
Entamoeba histolytica	Ran family GTPase	0.0022	0.018	0.2295
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0357	0.0535
Loa Loa (eye worm)	agrin synaptic family protein	0.0018	0.013	0.0204
Brugia malayi	secreted modular calcium-binding protein 1	0.0018	0.013	0.0207
Schistosoma mansoni	hypothetical protein	0.0527	0.6674	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0207	0.0207
Brugia malayi	G protein-coupled receptor	0.0024	0.0207	0.036
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0154	0.0175
Schistosoma mansoni	hypothetical protein	0.006	0.0669	0.1002
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0283	0.3226
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0154	0.023
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0154	0.0175
Brugia malayi	RE15519p	0.0024	0.0207	0.036
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0357	0.0652
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0357	0.5865
Echinococcus multilocularis	agrin	0.0018	0.013	0.013
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0207	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Brugia malayi	MH2 domain containing protein	0.0116	0.138	0.2675
Echinococcus multilocularis	dro:myosuppressin receptor	0.0024	0.0207	0.0207
Echinococcus granulosus	g-protein coupled receptor	0.0024	0.0207	0.029
Echinococcus multilocularis	snurportin 1	0.0324	0.406	0.406
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Onchocerca volvulus		0.0024	0.0207	0.0385
Onchocerca volvulus		0.0024	0.0207	0.0385
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0135	0.1032
Brugia malayi	hypothetical protein	0.0024	0.0207	0.036
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0357	0.1042
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0357	0.4329
Echinococcus multilocularis	somatostatin receptor	0.0024	0.0207	0.0207
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0207	0.0207
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0357	0.1042
Loa Loa (eye worm)	hypothetical protein	0.006	0.0669	0.1268
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0357	0.0652
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0207	0.029
Echinococcus granulosus	dna polymerase eta	0.002	0.0154	0.0215
Schistosoma mansoni	hypothetical protein	0.0324	0.406	0.6083
Onchocerca volvulus		0.0024	0.0207	0.0385
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0357	0.058
Echinococcus granulosus	7tm_1 domain containing protein	0.0024	0.0207	0.029
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0357	0.0652
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0207	0.029
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0027	0.024	0.0335
Schistosoma mansoni	hypothetical protein	0.0034	0.0324	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0018	0.013	0.0204
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0027	0.024	0.024
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Echinococcus multilocularis	apoptotic protease activating factor 1	0.006	0.0669	0.0669
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0027	0.024	0.024
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.138	0.2673
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0052	0.0562	0.7382
Schistosoma mansoni	adenoreceptor	0.0024	0.0207	0.0311
Schistosoma mansoni	ap endonuclease	0.0019	0.0135	0.0202
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0207	0.0207
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0024	0.0207	0.0311
Echinococcus granulosus	importin subunit beta 1	0.003	0.0283	0.0395
Echinococcus granulosus	fmrfamide receptor	0.0024	0.0207	0.029
Echinococcus granulosus	neuropeptide receptor	0.0024	0.0207	0.029
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0154	0.0175
Echinococcus granulosus	cpg binding protein	0.0036	0.035	0.049
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.018	0.0302
Schistosoma mansoni	neuropeptide F-like receptor	0.0024	0.0207	0.0311
Trypanosoma cruzi	cdc2-related kinase 3	0.0052	0.0562	0.0988
Brugia malayi	hypothetical protein	0.0024	0.0207	0.036
Schistosoma mansoni	neuropeptide f receptor 76f	0.0024	0.0207	0.0311
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0209	0.0285
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0266	0.3316	0.6493
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.0739	0.0739
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0026	0.0026
Trypanosoma brucei	unspecified product	0.002	0.0154	0.0175
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0207	0.0207
Brugia malayi	hypothetical protein	0.0024	0.0207	0.036
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0057	0.0627	0.8347
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0013	0.0066	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0066	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0357	0.0652
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0207	0.0207
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0207	0.0311
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0135	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0135	0.1397
Trichomonas vaginalis	esterase, putative	0.0036	0.0357	0.5865
Onchocerca volvulus		0.0027	0.024	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0027	0.024	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Trypanosoma cruzi	cdc2-related kinase 1	0.0052	0.0562	0.0988
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0057	0.0627	0.0877
Brugia malayi	hypothetical protein	0.0027	0.024	0.0424
Trypanosoma brucei	cdc2-related kinase 1	0.0052	0.0562	0.0988
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0024	0.0207	0.0311
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0324	0.0592
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0154	0.0175
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0135	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0018	0.013	0.0204
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0207	0.0207
Echinococcus multilocularis	cyclin dependent kinase 1	0.0052	0.0562	0.0562
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0154	0.0175
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0562	1
Brugia malayi	G-protein coupled receptor	0.0024	0.0207	0.036
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0357	0.0652
Brugia malayi	hypothetical protein	0.0229	0.284	0.5555
Toxoplasma gondii	exonuclease III APE	0.0019	0.0135	0.1032
Schistosoma mansoni	hypothetical protein	0.0034	0.0324	0.0486
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0357	0.058
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.03	0.3745	0.7342
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0018	0.013	0.095
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0135	0.0135
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0357	0.1042
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0024	0.0207	0.029
Leishmania major	DNA polymerase kappa, putative	0.002	0.0154	0.0175
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0357	0.0357
Echinococcus multilocularis	neuropeptide receptor	0.0024	0.0207	0.0207
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0562	1
Echinococcus granulosus	orexin receptor type 2	0.0024	0.0207	0.029
Brugia malayi	putative neuropeptide receptor NPR1	0.0024	0.0207	0.036
Loa Loa (eye worm)	hypothetical protein	0.006	0.0669	0.1268
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0357	1
Brugia malayi	Cell death protein 3 precursor	0.006	0.0669	0.1271
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0073	0.0014
Schistosoma mansoni	biogenic amine receptor	0.0024	0.0207	0.0311
Brugia malayi	hypothetical protein	0.0024	0.0207	0.036
Brugia malayi	hypothetical protein	0.0024	0.0207	0.036
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Echinococcus multilocularis	prolyl endopeptidase	0.0013	0.0066	0.0066
Onchocerca volvulus		0.0024	0.0207	0.0385
Brugia malayi	neuropeptide F receptor	0.0024	0.0207	0.036
Brugia malayi	prolyl oligopeptidase family protein	0.0013	0.0066	0.0081
Echinococcus granulosus	acylamino acid releasing enzyme	0.0013	0.0066	0.0092
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0135	0.1397
Loa Loa (eye worm)	G-protein coupled receptor	0.0024	0.0207	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0027	0.024	0.0421
Brugia malayi	AKH receptor	0.0024	0.0207	0.036
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0588
Echinococcus granulosus	neuropeptide Y receptor	0.0024	0.0207	0.029
Schistosoma mansoni	DNA polymerase eta	0.002	0.0154	0.023
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0135	0.0248
Brugia malayi	Serotonin receptor	0.0024	0.0207	0.036
Echinococcus multilocularis	neuropeptide receptor	0.0024	0.0207	0.0207
Leishmania major	hypothetical protein, conserved	0.0036	0.0357	0.058
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0154	0.0154
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0562	0.0843
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0207	0.0207
Toxoplasma gondii	transporter, major facilitator family protein	0.0027	0.024	0.2588
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0357	1
Echinococcus granulosus	sex peptide receptor	0.0024	0.0207	0.029
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0357	0.1042
Schistosoma mansoni	cpg binding protein	0.0036	0.035	0.0525
Echinococcus granulosus	biogenic amine 5HT receptor	0.0024	0.0207	0.029
Loa Loa (eye worm)	hypothetical protein	0.03	0.3745	0.7341
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0135	0.1397
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0024	0.0207	0.029
Echinococcus granulosus	hypothetical protein	0.0024	0.0207	0.029
Onchocerca volvulus	Putative organic anion transporter	0.0027	0.024	0.0473
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0024	0.0207	0.0207
Schistosoma mansoni	biogenic amine receptor	0.0024	0.0207	0.0311
Brugia malayi	hypothetical protein	0.0024	0.0207	0.036
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0207	0.029
Loa Loa (eye worm)	hypothetical protein	0.0027	0.024	0.0421
Echinococcus multilocularis	cpg binding protein	0.0036	0.035	0.035
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0357	0.0652
Schistosoma mansoni	hypothetical protein	0.0024	0.0207	0.0311
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0357	0.0656
Trypanosoma cruzi	MFS transporter, putative	0.0027	0.024	0.0347
Echinococcus granulosus	allatostatin A receptor	0.0024	0.0207	0.029
Brugia malayi	Dopamine receptor protein 2	0.0024	0.0207	0.036
Onchocerca volvulus		0.0024	0.0207	0.0385
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0154	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Brugia malayi	GnHR receptor homolog	0.0024	0.0207	0.036
Schistosoma mansoni	hypothetical protein	0.0024	0.0207	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0207	0.255	0.4982
Onchocerca volvulus		0.0027	0.024	0.0473
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0154	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0024	0.0207	0.0311
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.0739	0.2408
Brugia malayi	neuropeptide F receptor	0.0024	0.0207	0.036
Brugia malayi	larval opioid receptor	0.0024	0.0207	0.036
Loa Loa (eye worm)	hypothetical protein	0.0027	0.024	0.0421
Brugia malayi	G-protein coupled receptor	0.0024	0.0207	0.036
Echinococcus multilocularis	fmrfamide receptor	0.0024	0.0207	0.0207
Echinococcus granulosus	caspase 2	0.006	0.0669	0.0935
Schistosoma mansoni	inhibitor of apoptosis protein	0.03	0.3745	0.5612
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.0154	0.1771
Plasmodium falciparum	importin beta, putative	0.003	0.0283	0.437
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0562	0.0843
Giardia lamblia	Kinase, CMGC CDK	0.0052	0.0562	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0024	0.0207	0.036
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0024	0.0207	0.029
Loa Loa (eye worm)	prolyl oligopeptidase	0.0013	0.0066	0.0077
Giardia lamblia	Kinase, CMGC CDK	0.0052	0.0562	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0024	0.0207	0.0207
Loa Loa (eye worm)	prolyl oligopeptidase	0.017	0.2079	0.4051
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.03	0.3745	0.7342
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.0826	0.1581
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0024	0.0207	0.0311
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0135	0.1397
Trypanosoma brucei	cdc2-related kinase 3	0.0052	0.0562	0.0988
Brugia malayi	sodium-independent organic anion transporter family protein	0.0027	0.024	0.0424
Onchocerca volvulus		0.0024	0.0207	0.0385
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.138	0.2673
Echinococcus granulosus	GPCR family 2	0.0034	0.0324	0.0454
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0209	0.2884
Echinococcus granulosus	prolyl endopeptidase	0.0013	0.0066	0.0092
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0207	0.0311
Echinococcus granulosus	biogenic amine 5HT receptor	0.0024	0.0207	0.029
Onchocerca volvulus		0.0047	0.0494	0.1163
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0209	0.2884
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.017	0.2079	0.3115
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0207	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0263	0.327	0.327
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0052	0.0562	0.1058
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.018	0.0227
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0562	0.1061
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0154	0.1308
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0207	0.029
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.015	0.1821	0.2547
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0207	0.0311
Schistosoma mansoni	bhlhzip transcription factor bigmax	0.0305	0.3811	0.5711
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0027	0.024	0.0335
Brugia malayi	hypothetical protein	0.0024	0.0207	0.036
Loa Loa (eye worm)	melatonin receptor type 1A	0.0024	0.0207	0.0357
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0357	0.5865
Onchocerca volvulus		0.0027	0.024	0.0473
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0071	0.0812	0.1216
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0013	0.0066	0.0098
Leishmania major	DNA polymerase eta, putative	0.002	0.0154	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Schistosoma mansoni	follistatin	0.0018	0.013	0.0194
Onchocerca volvulus	Deterin homolog	0.03	0.3745	1
Echinococcus multilocularis	sex peptide receptor	0.0024	0.0207	0.0207
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0013	0.0066	0.0098
Echinococcus multilocularis	allatostatin A receptor	0.0024	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0357	0.1042
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0357	0.0535
Echinococcus multilocularis	orexin receptor type 2	0.0024	0.0207	0.0207
Brugia malayi	sodium-independent organic anion transporter family protein	0.0027	0.024	0.0424
Brugia malayi	CXXC zinc finger family protein	0.0034	0.0326	0.0594
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0207	0.0311
Brugia malayi	SPARC precursor	0.0018	0.013	0.0207
Trypanosoma cruzi	cdc2-related kinase 1	0.0052	0.0562	0.0988
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0154	0.0154
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.018	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0018	0.013	0.0204
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0357	0.5865
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0057	0.0627	0.1118
Echinococcus granulosus	snurportin 1	0.0324	0.406	0.5678
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0135	0.5
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0027	0.024	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0454	0.0844
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0024	0.0207	0.036
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0013	0.0066	0.0098
Echinococcus granulosus	neuropeptide receptor	0.0024	0.0207	0.029
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0154	0.0315
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0024	0.0207	0.0311
Echinococcus granulosus	serotonin receptor	0.0024	0.0207	0.029
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0154	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Schistosoma mansoni	hypothetical protein	0.0034	0.0324	0.0486
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0024	0.0207	0.0207
Echinococcus multilocularis	neuropeptides capa receptor	0.0024	0.0207	0.0207
Echinococcus granulosus	neuropeptide Y receptor	0.0024	0.0207	0.029
Echinococcus multilocularis	g-protein coupled receptor	0.0024	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Echinococcus multilocularis	cyclin dependent kinase	0.0052	0.0562	0.0562
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0135	0.0138
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0526	0.6657	0.6657
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0154	0.0175
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0207	0.0207
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0135	0.0218
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.018	0.0251
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0135	0.0138
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.015	0.1821	0.1821
Brugia malayi	putative neuropeptide receptor	0.0024	0.0207	0.036
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0024	0.0207	0.036
Trypanosoma brucei	unspecified product	0.0014	0.0073	0.0014
Onchocerca volvulus		0.0024	0.0207	0.0385
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0207	0.0311
Echinococcus multilocularis	follistatin	0.0018	0.013	0.013
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0324	0.0592
Echinococcus granulosus	7TM GPCR rhodopsin	0.0024	0.0207	0.029
Schistosoma mansoni	neuropeptide F-like receptor	0.0024	0.0207	0.0311
Echinococcus multilocularis	inhibitor of apoptosis protein	0.03	0.3745	0.3745
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0154	0.0175
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0263	0.327	0.4574
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0739	1
Echinococcus granulosus	apoptotic protease activating factor 1	0.006	0.0669	0.0935
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0057	0.0627	0.1118
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0562	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0207	0.0207
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0024	0.0207	0.0207
Brugia malayi	G protein-coupled receptor F59B2.13	0.0024	0.0207	0.036
Loa Loa (eye worm)	TYRA-2 protein	0.0024	0.0207	0.0357
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0024	0.0207	0.0207
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0024	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.002	0.0154	0.0251
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0207	0.0207
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0135	0.0189
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0357	0.5865
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.018	0.2295
Schistosoma mansoni	ran	0.0022	0.018	0.0269
Schistosoma mansoni	hypothetical protein	0.0034	0.0324	0.0486
Brugia malayi	hypothetical protein	0.0024	0.0207	0.036
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0024	0.0207	0.0311
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0154	0.0175
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.018	0.2295
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0154	0.0175
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0154	0.0175
Onchocerca volvulus		0.0018	0.013	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Brugia malayi	Dopamine receptor protein 1	0.0024	0.0207	0.036
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0207	0.0207
Onchocerca volvulus		0.0024	0.0207	0.0385
Entamoeba histolytica	cell division protein kinase 2, putative	0.0052	0.0562	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0154	0.0251
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0057	0.0627	0.1118
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0404	0.5092	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0024	0.0207	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Brugia malayi	sodium-independent organic anion transporter family protein	0.0027	0.024	0.0424
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0263	0.327	0.49
Leishmania major	C-8 sterol isomerase-like protein	0.0404	0.5092	1
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0057	0.0627	0.1118
Schistosoma mansoni	organic anion transporter	0.0027	0.024	0.0359
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0207	0.029
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0024	0.0207	0.0311
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.018	0.018
Loa Loa (eye worm)	neuropeptide F receptor	0.0024	0.0207	0.0357
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0357	0.1042
Echinococcus multilocularis	serotonin receptor	0.0024	0.0207	0.0207
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0324	0.0324
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0283	0.0432
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0404	0.5092	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0207	0.029
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0106	0.1258	0.2434
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0018	0.013	0.0207
Echinococcus granulosus	dro:myosuppressin receptor	0.0024	0.0207	0.029
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0024	0.0207	0.029
Onchocerca volvulus		0.0024	0.0207	0.0385
Echinococcus granulosus	survival motor neuron protein 1	0.0229	0.284	0.3972
Brugia malayi	prolyl oligopeptidase family protein	0.0013	0.0066	0.0081
Echinococcus multilocularis	neuropeptide receptor A26	0.0564	0.7151	0.7151
Loa Loa (eye worm)	hypothetical protein	0.0027	0.024	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Loa Loa (eye worm)	neuropeptide F receptor	0.0024	0.0207	0.0357
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.03	0.3745	0.5238
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0057	0.0627	0.0627
Echinococcus multilocularis	fmrfamide receptor	0.0024	0.0207	0.0207
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0052	0.0562	0.0988
Onchocerca volvulus		0.0034	0.0326	0.0707
Onchocerca volvulus	Putative organic anion transporter	0.0027	0.024	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Loa Loa (eye worm)	hypothetical protein	0.03	0.3745	0.7341
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0357	0.0652
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0024	0.0207	0.0357
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0207	0.0311
Plasmodium vivax	protein kinase Crk2	0.0052	0.0562	1
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0154	0.1308
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0357	0.0499
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0826	0.1578
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0135	0.1397
Onchocerca volvulus	Cell death protein 3 homolog	0.006	0.0669	0.1639
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0026	0.0037
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.0739	1
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0404	0.5092	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0526	0.6657	0.931
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0207	0.0311
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.015	0.1821	0.2547
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0324	0.0324
Onchocerca volvulus	Putative organic anion transporter	0.0027	0.024	0.0473
Brugia malayi	hypothetical protein	0.0044	0.0454	0.0847
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0024	0.0207	0.0357
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0106	0.1258	0.2431
Onchocerca volvulus		0.03	0.3745	1
Schistosoma mansoni	hypothetical protein	0.0054	0.0582	0.0872
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.018	0.0227
Schistosoma mansoni	cpg binding protein	0.0036	0.035	0.0525
Onchocerca volvulus		0.0024	0.0207	0.0385
Schistosoma mansoni	opsin-like receptor	0.0024	0.0207	0.0311
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0357	0.1042
Onchocerca volvulus		0.0027	0.024	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0066	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0066	0.0077
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0305	0.3811	0.7471
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0209	0.2884
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0154	0.0175
Echinococcus granulosus	geminin	0.0527	0.6674	0.9333
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0324	0.0324
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0207	0.0311
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0357	0.4329
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Onchocerca volvulus		0.0027	0.024	0.0473
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0324	0.0454
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0154	0.0175
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0024	0.0207	0.029
Echinococcus multilocularis	cyclin dependent kinase 5	0.0052	0.0562	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0052	0.0562	0.0988
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0024	0.0207	0.036
Brugia malayi	Importin beta-1 subunit	0.003	0.0283	0.0509
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0024	0.0207	0.0207
Schistosoma mansoni	ap endonuclease	0.0019	0.0135	0.0202
Echinococcus multilocularis	max protein X	0.0305	0.3811	0.3811
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0207	0.029
Loa Loa (eye worm)	hypothetical protein	0.0027	0.024	0.0421
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0057	0.0627	0.094
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0154	0.0175
Echinococcus granulosus	follistatin	0.0018	0.013	0.0181
Onchocerca volvulus		0.0024	0.0207	0.0385
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0231	0.2861	1
Schistosoma mansoni	hypothetical protein	0.0073	0.0826	0.1238
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0207	0.029
Echinococcus multilocularis	neuropeptides capa receptor	0.0024	0.0207	0.0207
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0357	0.4329
Echinococcus multilocularis	neuropeptide Y receptor	0.0024	0.0207	0.0207
Echinococcus granulosus	neuropeptide s receptor	0.0564	0.7151	1
Echinococcus granulosus	dna polymerase kappa	0.002	0.0154	0.0215
Onchocerca volvulus		0.0024	0.0207	0.0385
Brugia malayi	ORL1-like opioid receptor	0.0024	0.0207	0.036
Leishmania major	GTP-binding protein, putative	0.0022	0.018	0.0227
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0357	0.1042
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Brugia malayi	hypothetical protein	0.0024	0.0207	0.036
Brugia malayi	beta-lactamase family protein	0.0036	0.0357	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0207	0.0311
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.015	0.1821	0.3543
Brugia malayi	cell division control protein 2 homolog	0.0052	0.0562	0.1061
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.017	0.2079	0.547
Schistosoma mansoni	ran	0.0022	0.018	0.0269
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0357	0.1042
Schistosoma mansoni	myosin xvIII	0.0024	0.0207	0.0311
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0154	0.023
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Trypanosoma cruzi	cdc2-related kinase 3	0.0052	0.0562	0.0988
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0013	0.0066	0.0066
Echinococcus multilocularis	dnaJ subfamily B	0.048	0.6066	0.6066
Trichomonas vaginalis	ran, putative	0.0022	0.018	0.2295
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0154	0.0175
Echinococcus multilocularis	geminin	0.0527	0.6674	0.6674
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0739	1
Echinococcus granulosus	G protein coupled receptor 139	0.0024	0.0207	0.029
Brugia malayi	prostaglandin transporter	0.0027	0.024	0.0424
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0024	0.0207	0.0311
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0024	0.0207	0.0311
Echinococcus multilocularis	G protein coupled receptor 139	0.0024	0.0207	0.0207
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0283	0.0432
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0135	0.0138
Onchocerca volvulus		0.0024	0.0207	0.0385
Schistosoma mansoni	hypothetical protein	0.0024	0.0207	0.0311
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0739	1
Onchocerca volvulus		0.0036	0.0357	0.0792
Schistosoma mansoni	organic anion transporter	0.0027	0.024	0.0359
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0018	0.013	0.0207
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0135	0.1397
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0057	0.0627	0.1118
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0154	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Echinococcus granulosus	cyclin dependent kinase 5	0.0052	0.0562	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Trypanosoma brucei	unspecified product	0.0014	0.0073	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0555	0.1044
Brugia malayi	prolyl oligopeptidase family protein	0.0013	0.0066	0.0081
Plasmodium vivax	importin-beta 2, putative	0.003	0.0283	0.437
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0283	0.0283
Brugia malayi	beta-lactamase	0.0036	0.0357	0.0656
Toxoplasma gondii	ABC1 family protein	0.0036	0.0357	0.4329
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0154	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0357	0.0652
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0024	0.0207	0.036
Loa Loa (eye worm)	hypothetical protein	0.0027	0.024	0.0421
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0052	0.0562	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0494	0.074
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.0739	0.1033
Schistosoma mansoni	amine GPCR	0.0024	0.0207	0.0311
Onchocerca volvulus		0.0036	0.0357	0.0792
Brugia malayi	follicle stimulating hormone receptor	0.0266	0.3316	0.6494
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0739	0.1107
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0052	0.0562	0.1058
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Brugia malayi	beta-lactamase family protein	0.0036	0.0357	0.0656
Onchocerca volvulus		0.0024	0.0207	0.0385
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0106	0.1258	0.2434
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0305	0.3811	0.7472
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.0739	0.1339
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0209	0.0285
Echinococcus multilocularis	neuropeptide Y receptor	0.0024	0.0207	0.0207
Schistosoma mansoni	hypothetical protein	0.048	0.6066	0.9089
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0024	0.0207	0.0207
Brugia malayi	RNA, U transporter 1	0.0086	0.1002	0.1929
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0207	0.0207
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0357	0.058
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0034	0.0326	0.0591
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0024	0.0207	0.0311
Schistosoma mansoni	biogenic amine receptor	0.0024	0.0207	0.0311
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0739	0.1107
Echinococcus multilocularis	cyclin dependent kinase 1	0.0052	0.0562	0.0562
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0018	0.013	0.095
Loa Loa (eye worm)	hypothetical protein	0.003	0.0283	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Schistosoma mansoni	amine GPCR	0.0024	0.0207	0.0311
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0357	0.4329
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0024	0.0207	0.0311
Echinococcus granulosus	neuropeptide FF receptor 2	0.0024	0.0207	0.029
Giardia lamblia	DINP protein human, muc B family	0.002	0.0154	0.1771
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0073	0.0014
Echinococcus multilocularis	survival motor neuron protein 1	0.0229	0.284	0.284
Onchocerca volvulus		0.0024	0.0207	0.0385
Brugia malayi	hypothetical protein	0.0027	0.024	0.0424
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.03	0.3745	0.3745
Echinococcus multilocularis	dna polymerase eta	0.002	0.0154	0.0154
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.018	0.2295
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0073	0.0014
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0018	0.013	0.0207
Schistosoma mansoni	hypothetical protein	0.0047	0.0494	0.074
Schistosoma mansoni	growth hormone secretagogue receptor	0.0024	0.0207	0.0311
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0024	0.0207	0.036
Brugia malayi	sulfakinin receptor protein	0.0024	0.0207	0.036
Toxoplasma gondii	protease inhibitor PI2	0.0018	0.013	0.095
Brugia malayi	Dopamine receptor	0.0024	0.0207	0.036
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1258	0.2431
Echinococcus granulosus	max protein X	0.0305	0.3811	0.533
Loa Loa (eye worm)	hypothetical protein	0.0404	0.5092	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0324	0.0454
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0024	0.0207	0.0357
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0024	0.0207	0.0357
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.0154	0.0315
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.0154	0.1771
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0024	0.0207	0.029
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.018	0.0227
Brugia malayi	Serotonin receptor	0.0024	0.0207	0.036
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0024	0.0207	0.0207
Onchocerca volvulus		0.0024	0.0207	0.0385
Echinococcus granulosus	agrin	0.0018	0.013	0.0181
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0135	0.0138
Schistosoma mansoni	bhlhzip transcription factor bigmax	0.0305	0.3811	0.5711
Onchocerca volvulus		0.0036	0.0357	0.0792
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.015	0.1821	0.2729
Echinococcus granulosus	neuropeptides capa receptor	0.0024	0.0207	0.029
Brugia malayi	prolyl oligopeptidase family protein	0.0057	0.0627	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0324	0.406	0.7962
Schistosoma mansoni	caspase-7 (C14 family)	0.006	0.0669	0.1002
Loa Loa (eye worm)	G-protein coupled receptor	0.0024	0.0207	0.0357
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0024	0.0207	0.0207
Onchocerca volvulus		0.0024	0.0207	0.0385
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.015	0.1821	0.1821
Schistosoma mansoni	opsin-like receptor	0.0024	0.0207	0.0311
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0207	0.029
Loa Loa (eye worm)	hypothetical protein	0.0018	0.013	0.0204
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0018	0.013	0.095
Brugia malayi	prolyl oligopeptidase family protein	0.017	0.2079	0.4053
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0024	0.0207	0.0385
Brugia malayi	Melatonin receptor type 1A	0.0024	0.0207	0.036
Echinococcus granulosus	cyclin dependent kinase	0.0052	0.0562	0.0786
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0207	0.029
Echinococcus granulosus	somatostatin receptor	0.0024	0.0207	0.029
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.03	0.3745	0.5612
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0207	0.0357
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0024	0.0207	0.029
Echinococcus granulosus	neuropeptide receptor A26	0.0564	0.7151	1
Schistosoma mansoni	cpg binding protein	0.0034	0.0326	0.0488
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0024	0.0207	0.0311
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.0154	0.1771
Schistosoma mansoni	hypothetical protein	0.0527	0.6674	1
Entamoeba histolytica	cell division protein kinase 2, putative	0.0052	0.0562	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 127 nM	In vitro inhibition of Cyclin-dependent kinase 2	ChEMBL.	12852944
IC50 (binding)	= 127 nM	In vitro inhibition of Cyclin-dependent kinase 2	ChEMBL.	12852944

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10132679

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 134171