Detailed information for compound 1347770

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 334.733 | Formula: C15H12ClFN4O2
  • H donors: 2 H acceptors: 4 LogP: 2.2 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)CNC(=O)c1cnn2c1nc(C)c(c2O)Cl
  • InChi: 1S/C15H12ClFN4O2/c1-8-12(16)15(23)21-13(20-8)11(7-19-21)14(22)18-6-9-2-4-10(17)5-3-9/h2-5,7,23H,6H2,1H3,(H,18,22)
  • InChiKey: YGZUZUYUSBPDNL-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni protein kinase 0.041 0.0795 0.2051
Entamoeba histolytica protein kinase, putative 0.0555 0.1213 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0244 0.0311 0.065
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0541 0.1175 0.1168
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0147 0.0031 0.005
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0338 0.0583 0.1234
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.024 0.0299 0.2465
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0031 0.0043
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0255 0.0344 0.0337
Trypanosoma cruzi casein kinase, putative 0.0266 0.0375 0.1263
Trichomonas vaginalis CMGC family protein kinase 0.0477 0.0987 0.5916
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0377 0.0699 0.0683
Leishmania major protein kinase A catalytic subunit isoform 2 0.024 0.0299 0.0949
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0293 0.0453 0.0955
Echinococcus granulosus casein kinase I delta 0.0266 0.0375 0.0787
Entamoeba histolytica protein kinase, putative 0.0203 0.0192 0.1436
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0509 0.108 0.9625
Echinococcus multilocularis dual specificity protein kinase clk2 0.0522 0.1119 0.1112
Echinococcus multilocularis protein kinase c epsilon type 0.0197 0.0175 0.0168
Brugia malayi probable protein kinase 0.0515 0.1097 0.1083
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0522 0.1119 0.4353
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0328 0.0555 0.0539
Loa Loa (eye worm) hypothetical protein 0.0151 0.0042 0.0025
Onchocerca volvulus 0.0181 0.0129 0.0129
Echinococcus granulosus activated cdc42 kinase 1 0.0817 0.1975 0.4218
Echinococcus granulosus casein kinase i 0.0266 0.0375 0.0787
Brugia malayi Protein kinase domain containing protein 0.0181 0.0129 0.0112
Giardia lamblia Kinase, CMGC CDK 0.0293 0.0453 0.2303
Schistosoma mansoni tyrosine kinase 0.0193 0.0164 0.0392
Schistosoma mansoni serine/threonine protein kinase 0.0305 0.0488 0.1246
Entamoeba histolytica cell division protein kinase 2, putative 0.0293 0.0453 0.3624
Loa Loa (eye worm) TK/INSR protein kinase 0.0529 0.114 0.1126
Echinococcus multilocularis cyclin dependent kinase 5 0.0293 0.0453 0.0446
Onchocerca volvulus 0.0202 0.019 0.019
Brugia malayi Immunoglobulin I-set domain containing protein 0.0278 0.0409 0.0393
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0031 0.0043
Loa Loa (eye worm) hypothetical protein 0.0458 0.0934 0.0919
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0294 0.0456 0.0961
Brugia malayi hypothetical protein 0.1268 0.3284 0.3276
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0328 0.0555 0.0539
Echinococcus granulosus tyrosine protein kinase shark 0.0181 0.0129 0.026
Trichomonas vaginalis AGC family protein kinase 0.0164 0.0078 0.0292
Echinococcus granulosus mitogen activated protein kinase 11 0.099 0.2478 0.5296
Schistosoma mansoni serine/threonine protein kinase 0.0618 0.1397 0.3636
Brugia malayi protein C17H12.11 0.0264 0.037 0.0354
Loa Loa (eye worm) TK/FAK protein kinase 0.1468 0.3864 0.3857
Trichomonas vaginalis STE family protein kinase 0.0704 0.1646 1
Schistosoma mansoni tyrosine kinase 0.04 0.0764 0.197
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0555 0.1213 0.1199
Echinococcus granulosus TGF beta receptor type 1 0.0373 0.0687 0.1456
Entamoeba histolytica cell division protein kinase 2, putative 0.0302 0.0479 0.3839
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0192 0.016 0.0326
Echinococcus multilocularis casein kinase I delta 0.0266 0.0375 0.0367
Plasmodium vivax serine/threonine kinase-1, putative 0.0522 0.1119 1
Onchocerca volvulus 0.0163 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0308 0.0498 0.0482
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0179 0.0122 0.0246
Schistosoma mansoni tyrosine kinase 0.0294 0.0456 0.1161
Plasmodium vivax casein kinase 1, putative 0.0266 0.0375 0.2722
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0202 0.019 0.0496
Brugia malayi Protein kinase domain containing protein 0.0147 0.0031 0.0014
Echinococcus multilocularis twitchin 0.0142 0.0015 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0164 0.0078 0.0292
Echinococcus multilocularis casein kinase I alpha 0.0266 0.0375 0.0367
Schistosoma mansoni protein kinase 0.0994 0.249 0.6509
Brugia malayi Cam kinase protein 1 0.0203 0.0192 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.0192 0.0999
Loa Loa (eye worm) hypothetical protein 0.0181 0.0129 0.0112
Echinococcus granulosus roundabout 2 0.0398 0.0759 0.1611
Brugia malayi Protein kinase domain containing protein 0.0256 0.0347 0.0331
Trypanosoma brucei cdc2-related kinase 1 0.0293 0.0453 0.1589
Echinococcus granulosus casein kinase I alpha 0.0266 0.0375 0.0787
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0477 0.0987 0.098
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0143 0.0017 0.0007
Loa Loa (eye worm) CAMK protein kinase 0.0154 0.0049 0.0032
Schistosoma mansoni protein kinase C mu 0.0377 0.0699 0.1799
Echinococcus multilocularis tyrosine protein kinase Blk 0.0338 0.0583 0.0576
Onchocerca volvulus 0.0151 0.0042 0.0042
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0377 0.0696 0.1476
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.024 0.0299 0.2181
Echinococcus multilocularis cyclin dependent kinase 7 0.0396 0.0752 0.0745
Echinococcus granulosus aurora kinase A 0.0369 0.0675 0.1431
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.099 0.2478 1
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0266 0.0375 0.0358
Leishmania major protein kinase, putative 0.0369 0.0675 0.251
Loa Loa (eye worm) hypothetical protein 0.0192 0.016 0.0143
Echinococcus granulosus serine:threonine protein kinase N2 0.0147 0.0031 0.005
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0618 0.1397 0.1384
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0161 0.0071 0.0054
Echinococcus multilocularis serine:threonine protein kinase N2 0.0147 0.0031 0.0023
Brugia malayi Furin-like cysteine rich region family protein 0.0294 0.0456 0.044
Loa Loa (eye worm) AGC/PKA protein kinase 0.024 0.0299 0.0283
Echinococcus multilocularis casein kinase I alpha 0.0266 0.0375 0.0367
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.024 0.0299 0.0292
Loa Loa (eye worm) hypothetical protein 0.0264 0.037 0.0354
Echinococcus multilocularis neuroglian 0.0344 0.0601 0.0594
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0192 0.016 0.037
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0293 0.0453 0.1589
Schistosoma mansoni serine/threonine protein kinase 0.0694 0.1618 0.4215
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.0071 0.0147
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0256 0.0347 0.034
Schistosoma mansoni tyrosine kinase 0.0181 0.0129 0.03
Schistosoma mansoni tyrosine kinase 0.0294 0.0456 0.1161
Trypanosoma brucei aurora B kinase 0.0369 0.0675 0.251
Brugia malayi Protein kinase domain containing protein 0.0181 0.0129 0.0112
Trichomonas vaginalis CK1 family protein kinase 0.0266 0.0375 0.2127
Loa Loa (eye worm) hypothetical protein 0.0308 0.0497 0.0481
Echinococcus multilocularis tyrosine protein kinase shark 0.0181 0.0129 0.0121
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.04 0.0764 0.0757
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0299 0.0748
Loa Loa (eye worm) AGC/PKA protein kinase 0.024 0.0299 0.0283
Brugia malayi hypothetical protein 0.0151 0.0042 0.0025
Echinococcus granulosus cyclin dependent kinase 1 0.0293 0.0453 0.0955
Onchocerca volvulus 0.0181 0.0129 0.0129
Loa Loa (eye worm) TK/FER protein kinase 0.0181 0.0129 0.0112
Loa Loa (eye worm) TK protein kinase 0.0338 0.0583 0.0568
Schistosoma mansoni tyrosine kinase 0.0193 0.0164 0.0392
Echinococcus multilocularis cyclin dependent kinase 0.0293 0.0453 0.0446
Schistosoma mansoni hypothetical protein 0.0151 0.0042 0.0072
Loa Loa (eye worm) AGC/PKN protein kinase 0.0147 0.0031 0.0014
Entamoeba histolytica protein kinase, putative 0.0148 0.0032 0.0086
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.051 0.1085 0.2309
Echinococcus granulosus tyrosine protein kinase Src64B 0.04 0.0764 0.1621
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0147 0.0031 0.005
Toxoplasma gondii AGC kinase 0.024 0.0299 0.2465
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0202 0.0189 0.0172
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0323 0.0541 0.0525
Onchocerca volvulus 0.0181 0.0129 0.0129
Brugia malayi C1-like domain containing protein 0.0377 0.0699 0.0683
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0477 0.0987 0.2099
Brugia malayi Protein kinase domain containing protein 0.0181 0.0129 0.0112
Brugia malayi putative serine/threonine kinase SADA gamma 0.0161 0.0071 0.0054
Plasmodium falciparum glycogen synthase kinase 3 0.0477 0.0987 0.8741
Schistosoma mansoni rap gtpase-activating protein 0.0192 0.016 0.0381
Loa Loa (eye worm) TK/FER protein kinase 0.0181 0.0129 0.0112
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0522 0.1119 0.4353
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0338 0.0583 0.0576
Echinococcus granulosus protein tyrosine kinase 0.1452 0.3817 0.8168
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.0175 0.0422
Loa Loa (eye worm) TK/FER protein kinase 0.0181 0.0129 0.0112
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Brugia malayi Protein kinase domain containing protein 0.062 0.1402 0.1389
Loa Loa (eye worm) hypothetical protein 0.0276 0.0404 0.0388
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Onchocerca volvulus 0.0694 0.1618 0.1619
Echinococcus granulosus mitogen activated protein kinase 14 0.099 0.2478 0.5296
Schistosoma mansoni serine/threonine protein kinase 0.1062 0.2685 0.7022
Brugia malayi serine/threonine protein kinase 6 0.0369 0.0675 0.066
Echinococcus granulosus tyrosine protein kinase Srms 0.0181 0.0129 0.026
Brugia malayi casein kinase I 0.0266 0.0375 0.0358
Trypanosoma cruzi casein kinase, putative 0.0266 0.0375 0.1263
Onchocerca volvulus 0.3578 0.9989 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0164 0.008 0.004
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.0175 0.0422
Echinococcus granulosus twitchin 0.0407 0.0786 0.1668
Trichomonas vaginalis AGC family protein kinase 0.0164 0.0078 0.0292
Plasmodium falciparum serine/threonine protein kinase, putative 0.0369 0.0675 0.5767
Echinococcus granulosus protein kinase shaggy 0.0477 0.0987 0.2099
Brugia malayi Protein kinase domain containing protein 0.0529 0.114 0.1126
Trypanosoma brucei protein kinase, putative 0.0164 0.008 0.004
Trypanosoma cruzi cdc2-related kinase 1 0.0293 0.0453 0.1589
Loa Loa (eye worm) hypothetical protein 0.0264 0.037 0.0354
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Trichomonas vaginalis CMGC family protein kinase 0.0293 0.0453 0.2614
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0522 0.1119 0.4353
Loa Loa (eye worm) TK/FER protein kinase 0.0181 0.0129 0.0112
Schistosoma mansoni vav2 0.0146 0.0028 0.0034
Brugia malayi Protein kinase domain containing protein 0.0181 0.0129 0.0112
Echinococcus multilocularis aurora kinase A 0.0369 0.0675 0.0668
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0257 0.0348 0.0729
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.024 0.0299 0.0949
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.024 0.0299 0.0949
Loa Loa (eye worm) AGC/NDR protein kinase 0.0147 0.0031 0.0014
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0618 0.1397 0.1384
Echinococcus granulosus titin 0.0154 0.0049 0.0089
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0563 0.1236 0.1223
Entamoeba histolytica serine/threonine protein kinase, putative 0.0161 0.0071 0.0415
Giardia lamblia Kinase, CMGC CLK 0.0522 0.1119 0.6596
Echinococcus multilocularis tyrosine protein kinase Abl 0.0504 0.1065 0.1058
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0299 0.0748
Trichomonas vaginalis STE family protein kinase 0.0704 0.1646 1
Trypanosoma cruzi aurora B kinase, putative 0.0369 0.0675 0.251
Schistosoma mansoni cell adhesion molecule 0.032 0.0532 0.1361
Brugia malayi Immunoglobulin I-set domain containing protein 0.0202 0.0189 0.0172
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.024 0.0299 0.0625
Echinococcus multilocularis mitogen activated protein kinase 14 0.099 0.2478 0.2472
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0203 0.0192 0.1483
Trypanosoma cruzi cdc2-related kinase 3 0.0293 0.0453 0.1589
Entamoeba histolytica protein kinase domain containing protein 0.0477 0.0987 0.8098
Echinococcus multilocularis casein kinase I alpha 0.0266 0.0375 0.0367
Plasmodium falciparum calcium-dependent protein kinase 1 0.0203 0.0192 0.1162
Brugia malayi serine/threonine-protein kinase 6 0.0369 0.0675 0.066
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.062 0.1402 0.299
Brugia malayi serine/threonine kinase 12 0.0369 0.0675 0.066
Echinococcus multilocularis tyrosine protein kinase Fyn 0.04 0.0764 0.0757
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.051 0.1085 0.107
Schistosoma mansoni protein kinase 0.062 0.1402 0.3649
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0293 0.0453 0.0437
Echinococcus granulosus protein kinase c epsilon type 0.0197 0.0175 0.0359
Schistosoma mansoni serine/threonine protein kinase 0.1268 0.3284 0.8597
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0255 0.0344 0.0722
Trichomonas vaginalis AGC family protein kinase 0.0369 0.0675 0.3987
Trichomonas vaginalis CMGC family protein kinase 0.0522 0.1119 0.6733
Giardia lamblia Kinase, NEK 0.0509 0.108 0.6348
Loa Loa (eye worm) hypothetical protein 0.0386 0.0725 0.0709
Loa Loa (eye worm) hypothetical protein 0.024 0.0299 0.0283
Echinococcus granulosus epidermal growth factor receptor 0.0294 0.0456 0.0961
Echinococcus multilocularis tyrosine protein kinase Fyn 0.04 0.0764 0.0757
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0192 0.016 0.037
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0203 0.0192 0.0396
Echinococcus granulosus TGF-beta receptor type-1 0.0373 0.0687 0.1456
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.099 0.2478 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.024 0.0299 0.0949
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0196 0.0173 0.0156
Schistosoma mansoni serine/threonine protein kinase 0.0522 0.1119 0.2903
Loa Loa (eye worm) AUR protein kinase 0.0369 0.0675 0.066
Schistosoma mansoni serine/threonine protein kinase 0.0396 0.0752 0.1939
Leishmania major protein kinase A catalytic subunit isoform 1 0.024 0.0299 0.0949
Entamoeba histolytica protein kinase, putative 0.0147 0.0031 0.0083
Echinococcus multilocularis MAM 0.0151 0.0042 0.0034
Brugia malayi Immunoglobulin I-set domain containing protein 0.0607 0.1364 0.135
Trichomonas vaginalis STE family protein kinase 0.0509 0.108 0.6496
Brugia malayi bone morphogenetic protein type 1 receptor 0.041 0.0795 0.078
Echinococcus multilocularis serine:threonine protein kinase N2 0.0147 0.0031 0.0023
Loa Loa (eye worm) hypothetical protein 0.0308 0.0497 0.0481
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0522 0.1119 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0479 0.0994 0.0979
Trichomonas vaginalis AGC family protein kinase 0.0164 0.0078 0.0292
Echinococcus multilocularis epidermal growth factor receptor 0.0294 0.0456 0.0449
Brugia malayi SRC-1 0.04 0.0764 0.0749
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0179 0.0122 0.0115
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0522 0.1119 0.4353
Loa Loa (eye worm) hypothetical protein 0.0314 0.0514 0.0498
Schistosoma mansoni nephrin 0.0356 0.0636 0.1633
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Brugia malayi SH2 domain containing protein 0.0181 0.0129 0.0112
Loa Loa (eye worm) hypothetical protein 0.2022 0.5474 0.5472
Echinococcus multilocularis protein kinase c iota type 0.0197 0.0175 0.0168
Toxoplasma gondii casein kinase I 0.0266 0.0375 0.3159
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.04 0.0764 0.0757
Brugia malayi Protein kinase domain containing protein 0.2025 0.548 0.5478
Schistosoma mansoni serine/threonine protein kinase 0.0555 0.1213 0.3152
Schistosoma mansoni tyrosine kinase 0.0529 0.114 0.296
Loa Loa (eye worm) hypothetical protein 0.0817 0.1975 0.1963
Plasmodium vivax protein kinase Crk2 0.0293 0.0453 0.3492
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0161 0.0071 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0164 0.0078 0.0292
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0369 0.0675 0.0668
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0577 0.1278 0.1264
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Loa Loa (eye worm) hypothetical protein 0.0308 0.0497 0.0481
Echinococcus granulosus cyclin dependent kinase 5 0.0293 0.0453 0.0955
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.2025 0.548 0.5478
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0369 0.0675 0.5661
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0741 0.1754 0.1747
Loa Loa (eye worm) hypothetical protein 0.0278 0.0409 0.0393
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Brugia malayi Protein kinase domain containing protein 0.0164 0.0078 0.0061
Brugia malayi Protein kinase domain containing protein 0.0328 0.0555 0.0539
Loa Loa (eye worm) TK/ROR protein kinase 0.0179 0.0122 0.0105
Entamoeba histolytica protein kinase, putative 0.0164 0.0078 0.0479
Loa Loa (eye worm) hypothetical protein 0.0192 0.016 0.0143
Onchocerca volvulus 0.0314 0.0514 0.0515
Echinococcus granulosus casein kinase I alpha 0.0266 0.0375 0.0787
Leishmania major protein kinase, putative 0.0164 0.008 0.004
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0528 0.1137 0.113
Echinococcus multilocularis c Jun NH2 terminal kinase 0.1062 0.2685 0.2679
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0192 0.016 0.0381
Echinococcus multilocularis Immunoglobulin 0.0266 0.0374 0.0367
Echinococcus multilocularis raf serine:threonine protein kinase 0.015 0.004 0.0032
Echinococcus multilocularis cyclin dependent kinase 1 0.0293 0.0453 0.0446
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0256 0.0347 0.0331
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0147 0.0031 0.0014
Schistosoma mansoni tyrosine kinase 0.09 0.2216 0.5789
Trichomonas vaginalis CK1 family protein kinase 0.0266 0.0375 0.2127
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.04 0.0764 0.0757
Echinococcus multilocularis serine threonine protein kinase 0.0147 0.0031 0.0023
Schistosoma mansoni protein kinase 0.0164 0.008 0.0172
Trypanosoma brucei cdc2-related kinase 3 0.0293 0.0453 0.1589
Echinococcus multilocularis tyrosine protein kinase Src42A 0.04 0.0764 0.0757
Schistosoma mansoni serine/threonine protein kinase 0.0396 0.0752 0.1939
Loa Loa (eye worm) hypothetical protein 0.0236 0.0287 0.0271
Brugia malayi Protein kinase domain containing protein 0.0817 0.1975 0.1963
Echinococcus multilocularis serine:threonine protein kinase 38 0.0147 0.0031 0.0023
Brugia malayi P38 map kinase family protein 2 0.099 0.2478 0.2468
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0479 0.0994 0.0979
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0377 0.0699 0.0683
Schistosoma mansoni adapter molecule crk 0.0143 0.0017 0.0007
Entamoeba histolytica protein kinase, putative 0.0164 0.0078 0.0479
Loa Loa (eye worm) hypothetical protein 0.0151 0.0042 0.0025
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0787 0.1889 0.1883
Echinococcus multilocularis rho associated protein kinase 0.0694 0.1618 0.1611
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.099 0.2478 0.2468
Echinococcus multilocularis activated cdc42 kinase 1 0.0817 0.1975 0.1969
Schistosoma mansoni protein kinase 0.0682 0.1583 0.4124
Trichomonas vaginalis CK1 family protein kinase 0.0266 0.0375 0.2127
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0563 0.1236 0.1223
Brugia malayi Temporarily assigned gene name protein 59 0.0192 0.016 0.0143
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.024 0.0299 0.0949
Echinococcus granulosus epidermal growth factor receptor 0.0294 0.0456 0.0961
Loa Loa (eye worm) AUR protein kinase 0.0369 0.0675 0.066
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0788 0.1889 0.1877
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0203 0.0192 0.0176
Onchocerca volvulus 0.0192 0.016 0.016
Schistosoma mansoni atypical protein kinase C 0.0197 0.0175 0.0422
Schistosoma mansoni protein kinase 0.0373 0.0687 0.1768
Trypanosoma cruzi cdc2-related kinase 1 0.0293 0.0453 0.1589
Loa Loa (eye worm) hypothetical protein 0.0455 0.0925 0.091
Loa Loa (eye worm) AUR protein kinase 0.0369 0.0675 0.066
Echinococcus granulosus defective proboscis extension response 0.0266 0.0374 0.0786
Brugia malayi Immunoglobulin I-set domain containing protein 0.0154 0.0049 0.0032
Loa Loa (eye worm) hypothetical protein 0.0451 0.0912 0.0898
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0147 0.0031 0.0023
Echinococcus multilocularis dual specificity 0.0555 0.1213 0.1206
Brugia malayi Protein kinase domain containing protein 0.0555 0.1213 0.1199
Echinococcus multilocularis protein KINase family member (kin 25) 0.0377 0.0696 0.0689
Brugia malayi Protein kinase domain containing protein 0.0293 0.0453 0.0437
Brugia malayi Protein kinase domain containing protein 0.0147 0.0031 0.0014
Loa Loa (eye worm) hypothetical protein 0.0264 0.037 0.0354
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.062 0.1402 0.1389
Plasmodium falciparum calcium-dependent protein kinase 5 0.0203 0.0192 0.1162
Loa Loa (eye worm) TK/FER protein kinase 0.0181 0.0129 0.0112
Toxoplasma gondii AGC kinase 0.024 0.0299 0.2465
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1465 0.3856 0.385
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0994 0.249 0.5321
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0704 0.1646 0.6545
Leishmania major protein kinase, putative 0.0522 0.1119 0.4353
Echinococcus multilocularis TGF beta receptor type 1 0.0373 0.0687 0.068
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0181 0.0129 0.0903
Brugia malayi Tyrosine-protein kinase abl-1 0.0421 0.0824 0.0809
Onchocerca volvulus 0.0154 0.0049 0.0049
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0427 0.0841 0.0826
Echinococcus multilocularis tyrosine protein kinase Src64B 0.04 0.0764 0.0757
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0528 0.1137 0.113
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.024 0.0299 0.0625
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0266 0.0375 0.0358
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0541 0.1175 0.2502
Schistosoma mansoni growth factor receptor-bound protein 0.0143 0.0017 0.0007
Loa Loa (eye worm) hypothetical protein 0.0386 0.0725 0.0709
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0305 0.0488 0.0481
Loa Loa (eye worm) hypothetical protein 0.0203 0.0192 0.0176
Onchocerca volvulus 0.0308 0.0497 0.0497
Loa Loa (eye worm) IKK protein kinase 0.3578 0.9989 1
Brugia malayi Protein kinase domain containing protein 0.0181 0.0129 0.0112
Entamoeba histolytica protein kinase, putative 0.0369 0.0675 0.5484
Loa Loa (eye worm) TK/FER protein kinase 0.0181 0.0129 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0428 0.0846 0.2185
Brugia malayi Protein kinase domain containing protein 0.3578 0.9989 1
Schistosoma mansoni serine/threonine protein kinase 0.051 0.1085 0.2814
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.0049 0.0091
Brugia malayi casein kinase 1, delta 0.0266 0.0375 0.0358
Echinococcus multilocularis NCK adaptor protein 0.015 0.0037 0.0029
Schistosoma mansoni tyrosine kinase 0.04 0.0764 0.197
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Schistosoma mansoni hypothetical protein 0.0192 0.016 0.0381
Leishmania major protein kinase A catalytic subunit 0.024 0.0299 0.0949
Schistosoma mansoni serine/threonine protein kinase 0.0305 0.0488 0.1246
Brugia malayi Stress-activated protein kinase jnk-1 0.1062 0.2685 0.2675
Giardia lamblia Kinase, AGC AKT 0.0427 0.0841 0.4807
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.1268 0.3284 0.3276
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Echinococcus granulosus MAM 0.0151 0.0042 0.0074
Echinococcus granulosus insulin receptor 0.0529 0.114 0.2428
Onchocerca volvulus 0.0181 0.0129 0.0129
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Entamoeba histolytica hypothetical protein 0.0555 0.1213 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0203 0.0192 0.1483
Loa Loa (eye worm) TK/FER protein kinase 0.0181 0.0129 0.0112
Echinococcus granulosus growth factor receptor bound protein 2 0.015 0.0037 0.0063
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0577 0.1278 0.2723
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0741 0.1754 0.1741
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1467 0.3862 0.8265
Loa Loa (eye worm) TK/EGFR protein kinase 0.0294 0.0456 0.044
Trichomonas vaginalis AGC family protein kinase 0.0509 0.108 0.6496
Echinococcus multilocularis casein kinase I delta 0.0266 0.0375 0.0367
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.024 0.0299 0.0949
Trypanosoma cruzi casein kinase, putative 0.0266 0.0375 0.1263
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0192 0.016 0.0152
Brugia malayi hypothetical protein 0.0278 0.0409 0.0393
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.024 0.0299 0.0292
Loa Loa (eye worm) hypothetical protein 0.0491 0.1029 0.1014
Toxoplasma gondii histone kinase SNF1, putative 0.0161 0.0071 0.0363
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0577 0.1278 0.1264
Schistosoma mansoni protein kinase 0.0369 0.0675 0.1736
Schistosoma mansoni tyrosine kinase 0.0193 0.0164 0.0392
Echinococcus multilocularis Immunoglobulin 0.0266 0.0374 0.0367
Entamoeba histolytica protein kinase domain containing protein 0.0477 0.0987 0.8098
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0704 0.1646 0.6545
Brugia malayi SH2 domain containing protein 0.0181 0.0129 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0293 0.0453 0.1153
Trichomonas vaginalis AGC family protein kinase 0.0156 0.0057 0.0159
Schistosoma mansoni serine/threonine kinase 0.0147 0.0031 0.0043
Echinococcus granulosus fibroblast growth factor receptor 4 0.0528 0.1137 0.2421
Schistosoma mansoni titin 0.0154 0.0049 0.0091
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0522 0.1119 0.1104
Loa Loa (eye worm) hypothetical protein 0.0377 0.0696 0.0681
Trypanosoma cruzi cdc2-related kinase 3 0.0293 0.0453 0.1589
Trypanosoma cruzi casein kinase, putative 0.0266 0.0375 0.1263
Brugia malayi cell division control protein 2 homolog 0.0293 0.0453 0.0437
Onchocerca volvulus 0.0266 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0266 0.0374 0.0358
Entamoeba histolytica protein kinase , putative 0.0369 0.0675 0.5484
Onchocerca volvulus 0.0181 0.0129 0.0129
Echinococcus multilocularis cyclin dependent kinase 19 0.0898 0.221 0.2204
Leishmania major casein kinase, putative 0.0266 0.0375 0.1263
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0293 0.0453 0.0437
Onchocerca volvulus Tyrosine kinase homolog 0.1235 0.3189 0.3192
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0031 0.0043
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0682 0.1583 0.1576
Loa Loa (eye worm) hypothetical protein 0.0266 0.0374 0.0358
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0203 0.0192 0.0185
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0308 0.0498 0.105
Trichomonas vaginalis AGC family protein kinase 0.0164 0.0078 0.0292
Loa Loa (eye worm) hypothetical protein 0.0161 0.0071 0.0054
Brugia malayi Protein kinase domain containing protein 0.2275 0.6207 0.6207
Schistosoma mansoni serine/threonine protein kinase 0.0293 0.0453 0.1153
Echinococcus multilocularis cyclin dependent kinase 1 0.0293 0.0453 0.0446
Echinococcus multilocularis roundabout 2 0.0398 0.0759 0.0752
Leishmania major protein kinase, putative 0.0203 0.0192 0.0506
Onchocerca volvulus 0.033 0.0561 0.0562
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.0192 0.0467
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.0273 0.0678
Entamoeba histolytica protein kinase domain containing protein 0.0164 0.008 0.0495
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0203 0.0192 0.094
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0477 0.0987 0.0972
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0369 0.0675 0.5484
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0299 0.0748
Giardia lamblia Kinase, CMGC GSK 0.0477 0.0987 0.5745
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0369 0.0675 0.5484
Echinococcus granulosus protein kinase c iota type 0.0197 0.0175 0.0359
Schistosoma mansoni protein kinase 0.0323 0.0541 0.1383
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0555 0.1213 0.4747
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.0071 0.0147
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.099 0.2478 1
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0787 0.1889 0.4034
Echinococcus granulosus casein kinase I delta 0.0266 0.0375 0.0787
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.0375 0.0946
Echinococcus granulosus titin 0.0154 0.0049 0.0089
Echinococcus multilocularis protein kinase shaggy 0.0477 0.0987 0.098
Loa Loa (eye worm) hypothetical protein 0.0361 0.0651 0.0636
Giardia lamblia Kinase, CMGC CDK 0.0293 0.0453 0.2303
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.062 0.1402 0.1395
Trypanosoma brucei casein kinase I, isoform 2 0.0266 0.0375 0.1263
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0147 0.0031 0.0014
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0522 0.1119 0.4353
Giardia lamblia Kinase, CMGC GSK 0.0477 0.0987 0.5745
Entamoeba histolytica protein kinase, putative 0.0555 0.1213 1
Entamoeba histolytica casein kinase, putative 0.0266 0.0375 0.2964
Loa Loa (eye worm) SRC-1 0.04 0.0764 0.0749
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0994 0.249 0.2484
Loa Loa (eye worm) hypothetical protein 0.0278 0.0409 0.0393
Echinococcus granulosus protein kinase C gamma type 0.0147 0.0031 0.005
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.1062 0.2685 0.2675
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0563 0.1236 0.1223
Echinococcus granulosus c src tyrosine kinase 0.0243 0.031 0.0647
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0477 0.0987 0.8787
Echinococcus multilocularis tyrosine protein kinase HCK 0.0257 0.035 0.0342
Loa Loa (eye worm) AGC/AKT protein kinase 0.0164 0.0078 0.0061
Giardia lamblia Kinase, CK1 Casein kinase 0.0266 0.0375 0.1796
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0369 0.0675 0.5484
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0862 0.2105 0.2099
Entamoeba histolytica p21-activated kinase 0.0148 0.0032 0.0086
Onchocerca volvulus 0.1056 0.2669 0.2672
Echinococcus multilocularis growth factor receptor bound protein 2 0.0143 0.0017 0.0009
Brugia malayi Protein kinase domain containing protein 0.0788 0.1889 0.1877
Echinococcus granulosus Immunoglobulin 0.0266 0.0374 0.0786
Echinococcus granulosus dual specificity mitogen activated protein 0.0704 0.1646 0.3513
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0293 0.0453 0.1589
Trichomonas vaginalis AGC family protein kinase 0.0164 0.0078 0.0292
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.024 0.0299 0.0625
Schistosoma mansoni tyrosine kinase 0.0243 0.031 0.0775
Echinococcus granulosus tyrosine protein kinase Fyn 0.04 0.0764 0.1621
Trichomonas vaginalis CMGC family protein kinase 0.0293 0.0453 0.2614
Schistosoma mansoni tyrosine kinase 0.0294 0.0456 0.1161
Loa Loa (eye worm) hypothetical protein 0.0229 0.0269 0.0252
Schistosoma mansoni serine/threonine protein kinase 0.0577 0.1278 0.3322
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0164 0.008 0.004
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0443 0.0888 0.3397
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0477 0.0987 0.2556
Schistosoma mansoni serine/threonine protein kinase 0.0898 0.221 0.5774
Trichomonas vaginalis AGC family protein kinase 0.0164 0.0078 0.0292
Entamoeba histolytica protein kinase, putative 0.0148 0.0032 0.0086
Brugia malayi Serine/threonine-protein kinase SULU 0.1268 0.3284 0.3276
Loa Loa (eye worm) hypothetical protein 0.033 0.0561 0.0545
Echinococcus granulosus tyrosine protein kinase HCK 0.0257 0.035 0.0734
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Echinococcus multilocularis mitogen activated protein kinase 11 0.099 0.2478 0.2472
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0369 0.0675 0.1431
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0577 0.1278 0.1271
Giardia lamblia Kinase, NEK 0.0509 0.108 0.6348
Brugia malayi Protein kinase domain containing protein 0.0336 0.058 0.0564
Echinococcus granulosus raf serine:threonine protein kinase 0.015 0.004 0.0068
Echinococcus granulosus NDR protein kinase 0.0147 0.0031 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.0175 0.0422
Loa Loa (eye worm) hypothetical protein 0.0192 0.016 0.0143
Loa Loa (eye worm) TK/ALK protein kinase 0.2274 0.6205 0.6205
Echinococcus multilocularis casein kinase i 0.0266 0.0375 0.0367
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0396 0.0752 0.0737
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0555 0.1213 0.4747
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.1268 0.3284 0.3279
Entamoeba histolytica protein kinase, putative 0.0477 0.0987 0.8098
Onchocerca volvulus 0.0264 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0151 0.0042 0.0025
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0563 0.1236 0.123
Echinococcus multilocularis 0.0458 0.0934 0.0927
Brugia malayi Immunoglobulin I-set domain containing protein 0.1465 0.3856 0.385
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0373 0.0687 0.068
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0192 0.016 0.037
Echinococcus multilocularis mitogen activated protein kinase 14 0.099 0.2478 0.2472
Brugia malayi protein-tyrosine kinase 0.0338 0.0583 0.0568
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.024 0.0299 0.1984
Entamoeba histolytica casein kinase 1, putative 0.0266 0.0375 0.2964
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0522 0.1119 0.4353
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0203 0.0192 0.094
Brugia malayi Protein kinase domain containing protein 0.0522 0.1119 0.1104
Echinococcus granulosus casein kinase I alpha 0.0266 0.0375 0.0787
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0704 0.1646 0.1633
Echinococcus granulosus cyclin dependent kinase 7 0.0396 0.0752 0.1596
Plasmodium falciparum protein kinase, putative 0.0164 0.008 0.0091
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0328 0.0555 0.0539
Trichomonas vaginalis AGC family protein kinase 0.024 0.0299 0.1659
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Echinococcus multilocularis tyrosine protein kinase Srms 0.0338 0.0583 0.0576
Echinococcus multilocularis titin 0.0154 0.0049 0.0041
Echinococcus multilocularis dual specificity mitogen activated protein 0.0704 0.1646 0.164
Brugia malayi Tyrosine-protein kinase abl-1 0.0504 0.1065 0.1051
Loa Loa (eye worm) gastrulation defective protein 1 0.0834 0.2026 0.2014
Entamoeba histolytica PH domain containing protein kinase, putative 0.0256 0.0346 0.2727
Schistosoma mansoni tyrosine kinase 0.0168 0.0092 0.0203
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0741 0.1754 0.3743
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0147 0.0031 0.0014
Entamoeba histolytica PH domain containing protein kinase, putative 0.0256 0.0346 0.2727
Schistosoma mansoni hypothetical protein 0.0151 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0267 0.0378 0.0362
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0555 0.1213 0.4747
Brugia malayi p70 ribosomal S6 kinase beta 0.0147 0.0031 0.0014
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0203 0.0192 0.0396
Entamoeba histolytica protein kinase, putative 0.0369 0.0675 0.5484
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.04 0.0764 0.1621
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0154 0.0049 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0788 0.1889 0.4931
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.041 0.0795 0.078
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Echinococcus granulosus protein kinase 0.0323 0.0541 0.1142
Echinococcus granulosus tyrosine protein kinase Lyn 0.0463 0.0949 0.2017
Loa Loa (eye worm) hypothetical protein 0.0716 0.1683 0.167
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Giardia lamblia Kinase, STE STE20 0.0704 0.1646 1
Brugia malayi Protein kinase domain containing protein 0.1468 0.3864 0.3857
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0203 0.0192 0.0185
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0955 0.2376 0.237
Giardia lamblia Kinase, AGC PKA 0.024 0.0299 0.1309
Brugia malayi intracellular kinase 0.0477 0.0987 0.0972
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0682 0.1583 0.3377
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0704 0.1646 0.1633
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0855 0.2085 0.2074
Schistosoma mansoni protein kinase 0.0515 0.1097 0.2846
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0704 0.1646 0.6545
Schistosoma mansoni tyrosine kinase 0.0377 0.0696 0.1792
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0266 0.0375 0.1263
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0955 0.2376 0.5079
Echinococcus multilocularis activin receptor type 0.1746 0.4672 0.4667
Schistosoma mansoni protein kinase 0.0266 0.0375 0.0946
Entamoeba histolytica protein kinase, putative 0.0203 0.0192 0.1436
Plasmodium falciparum casein kinase 1 0.0266 0.0375 0.2901
Schistosoma mansoni protein kinase 0.0994 0.249 0.6509
Trichomonas vaginalis AGC family protein kinase 0.0369 0.0675 0.3987
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0477 0.0987 0.3805
Schistosoma mansoni tyrosine kinase 0.1452 0.3817 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0203 0.0192 0.1162
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0293 0.0453 0.0437
Echinococcus multilocularis transfer RNA-Thr 0.0817 0.1975 0.1969
Echinococcus granulosus dual specificity 0.0555 0.1213 0.2585
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0203 0.0192 0.0176
Schistosoma mansoni serine/threonine protein kinase 0.0522 0.1119 0.2903
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0197 0.0175 0.0168
Echinococcus granulosus activin receptor type 0.1746 0.4672 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.024 0.0299 0.0292
Trichomonas vaginalis CMGC family protein kinase 0.0293 0.0453 0.2614
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0203 0.0192 0.0396
Echinococcus multilocularis tyrosine protein kinase Fgr 0.04 0.0764 0.0757
Schistosoma mansoni vam6/vps39 related 0.0192 0.016 0.0381
Loa Loa (eye worm) TK/ABL protein kinase 0.0862 0.2105 0.2094
Trichomonas vaginalis AGC family protein kinase 0.0369 0.0675 0.3987
Echinococcus granulosus tyrosine protein kinase Blk 0.0338 0.0583 0.1234
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0555 0.1213 0.4747
Schistosoma mansoni protein kinase 0.0682 0.1583 0.4124
Trypanosoma brucei rac serine-threonine kinase, putative 0.0164 0.0078 0.0032
Plasmodium falciparum calcium-dependent protein kinase 2 0.0203 0.0192 0.1162
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.051 0.1085 0.1078
Loa Loa (eye worm) TK/FER protein kinase 0.0181 0.0129 0.0112
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0203 0.0192 0.0506
Brugia malayi serine/threonine-protein kinase PAK 7 0.0855 0.2085 0.2074
Schistosoma mansoni tyrosine kinase 0.0528 0.1137 0.2952
Echinococcus granulosus tyrosine protein kinase Fyn 0.04 0.0764 0.1621
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0176 0.0115 0.0107
Echinococcus granulosus serine:threonine protein kinase TAO1 0.1268 0.3284 0.7024
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0203 0.0192 0.0176
Echinococcus multilocularis tyrosine protein kinase Fyn 0.04 0.0764 0.0757
Schistosoma mansoni tyrosine kinase 0.0243 0.031 0.0775
Onchocerca volvulus 0.063 0.1433 0.1434
Loa Loa (eye worm) TK protein kinase 0.0257 0.035 0.0334
Brugia malayi hypothetical protein 0.0264 0.037 0.0354
Echinococcus multilocularis tyrosine kinase 0.0181 0.0129 0.0121
Echinococcus multilocularis 0.0323 0.0541 0.0533
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0898 0.221 0.2199
Echinococcus granulosus Vam6:Vps39 protein 0.0192 0.016 0.0326
Brugia malayi hypothetical protein 0.0192 0.016 0.0143
Echinococcus granulosus hypothetical protein 0.0458 0.0934 0.1986
Echinococcus granulosus rho-associated protein kinase 1 0.0694 0.1618 0.3451
Echinococcus multilocularis epidermal growth factor receptor 0.0294 0.0456 0.0449
Echinococcus granulosus serine:threonine kinase SAD 1 0.0161 0.0071 0.0135
Echinococcus granulosus NCK adaptor protein 0.0143 0.0017 0.002
Leishmania major protein kinase, putative 0.0522 0.1119 0.4353
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.0071 0.0147
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0192 0.016 0.0381
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0197 0.0175 0.0158
Schistosoma mansoni serine/threonine protein kinase 0.0741 0.1754 0.4573
Schistosoma mansoni tyrosine kinase 0.0782 0.1872 0.4884
Echinococcus multilocularis protein tyrosine kinase 0.1452 0.3817 0.3812
Trypanosoma brucei protein kinase, putative 0.0477 0.0987 0.3805
Brugia malayi cyclin-dependent kinase 7 homolog 0.0405 0.0778 0.0763
Schistosoma mansoni vesicular amine transporter 0.0266 0.0374 0.0946
Loa Loa (eye worm) hypothetical protein 0.0491 0.1029 0.1014
Schistosoma mansoni tyrosine kinase 0.0529 0.114 0.296
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0071 0.0245
Loa Loa (eye worm) hypothetical protein 0.0357 0.0641 0.0625
Plasmodium vivax glycogen synthase kinase 3, putative 0.0477 0.0987 0.871
Trichomonas vaginalis STE family protein kinase 0.0704 0.1646 1
Brugia malayi protein kinase C II. 0.0197 0.0175 0.0158
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.099 0.2478 1
Loa Loa (eye worm) TK/FER protein kinase 0.0181 0.0129 0.0112
Brugia malayi Protein kinase domain containing protein 0.0898 0.221 0.2199
Entamoeba histolytica protein kinase, putative 0.0147 0.0031 0.0083
Schistosoma mansoni nck2/grb4 0.0143 0.0017 0.0007
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0477 0.0987 0.3805
Toxoplasma gondii aurora kinase 0.0369 0.0675 0.5921
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0741 0.1754 0.1741
Schistosoma mansoni serine/threonine protein kinase 0.015 0.004 0.0066
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0266 0.0374 0.0946
Entamoeba histolytica protein kinase domain containing protein 0.0369 0.0675 0.5484
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0181 0.0129 0.026
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0563 0.1236 0.2634
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0451 0.0912 0.1939
Echinococcus granulosus cyclin dependent kinase 0.0293 0.0453 0.0955
Echinococcus granulosus tyrosine protein kinase Src42A 0.04 0.0764 0.1621
Schistosoma mansoni protein kinase 0.0682 0.1583 0.4124
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0293 0.0453 0.3882
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0741 0.1754 0.1755
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.04 0.0764 0.1621
Plasmodium vivax calcium-dependent protein kinase, putative 0.0203 0.0192 0.094
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.0071 0.0147
Echinococcus granulosus tyrosine protein kinase Fyn 0.04 0.0764 0.1621
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0244 0.0311 0.0303
Echinococcus granulosus c-Jun N-terminal kinases 0.1062 0.2685 0.574
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0509 0.108 0.9647
Echinococcus granulosus neuroglian 0.0344 0.0601 0.1272
Plasmodium falciparum NIMA related kinase 1 0.0509 0.108 0.9634
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0203 0.0192 0.1483
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0203 0.0192 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0369 0.0675 0.1736
Onchocerca volvulus 0.0477 0.0987 0.0988
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0266 0.0375 0.0358
Echinococcus multilocularis mitogen activated protein kinase 11 0.099 0.2478 0.2472
Loa Loa (eye worm) TK protein kinase 0.0607 0.1364 0.135
Brugia malayi Hr1 repeat family protein 0.0147 0.0031 0.0014
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0243 0.031 0.0775
Echinococcus granulosus activated cdc42 kinase 1 0.0817 0.1975 0.4218
Plasmodium falciparum calcium-dependent protein kinase 3 0.0203 0.0192 0.1162
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0181 0.0129 0.0121
Schistosoma mansoni growth factor receptor-bound protein 0.015 0.0037 0.0059
Echinococcus granulosus cyclin dependent kinase 19 0.0898 0.221 0.4722
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0305 0.0488 0.1031
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.024 0.0299 0.0292
Echinococcus granulosus dual specificity protein kinase clk2 0.0522 0.1119 0.2382
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0147 0.0031 0.0023
Plasmodium falciparum protein kinase 5 0.0293 0.0453 0.3651
Echinococcus multilocularis c src tyrosine kinase 0.0243 0.031 0.0302
Loa Loa (eye worm) TK/FER protein kinase 0.0181 0.0129 0.0112
Giardia lamblia Aurora kinase 0.0369 0.0675 0.3734
Brugia malayi Fibronectin type III domain containing protein 0.0278 0.0409 0.0393
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.024 0.0299 0.0949
Plasmodium falciparum protein serine/threonine kinase-1 0.0522 0.1119 1
Entamoeba histolytica protein kinase domain containing protein 0.0555 0.1213 1
Echinococcus multilocularis insulin receptor 0.0529 0.114 0.1133
Trichomonas vaginalis AGC family protein kinase 0.0369 0.0675 0.3987
Trypanosoma cruzi casein kinase, putative 0.0266 0.0375 0.1263
Echinococcus granulosus tyrosine kinase 0.0181 0.0129 0.026
Entamoeba histolytica protein kinase, putative 0.0257 0.035 0.2757
Schistosoma mansoni tyrosine kinase 0.0221 0.0246 0.0608
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0164 0.008 0.004
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0164 0.008 0.0451
Loa Loa (eye worm) hypothetical protein 0.0276 0.0404 0.0388
Onchocerca volvulus 0.0181 0.0129 0.0129
Schistosoma mansoni protein kinase 0.0704 0.1646 0.429
Brugia malayi hypothetical protein 0.0181 0.0129 0.0112
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0741 0.1754 0.1741
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.024 0.0299 0.0949
Brugia malayi protein unc-22 0.0154 0.0049 0.0032
Giardia lamblia Kinase, NEK 0.0509 0.108 0.6348
Trichomonas vaginalis CMGC family protein kinase 0.0477 0.0987 0.5916
Echinococcus granulosus tyrosine kinase 0.0338 0.0583 0.1234
Loa Loa (eye worm) hypothetical protein 0.0278 0.0409 0.0393
Brugia malayi Protein kinase domain containing protein 0.0741 0.1754 0.1741
Echinococcus granulosus tyrosine protein kinase ABL1 0.0862 0.2105 0.4497
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0266 0.0374 0.0367
Echinococcus granulosus Protein kinase C brain isozyme 0.0197 0.0175 0.0359
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0203 0.0192 0.094
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0176 0.0115 0.0229
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0528 0.1137 0.2421
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0477 0.0987 0.0972
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0266 0.0374 0.0946
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.024 0.0299 0.0283

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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