Detailed information for compound 1350256

Basic information

Technical information
  • TDR Targets ID: 1350256
  • Name: 2-[[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl] sulfanyl]propanoic acid
  • MW: 280.3 | Formula: C12H12N2O4S
  • H donors: 1 H acceptors: 4 LogP: 2.22 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1nnc(o1)SC(C(=O)O)C
  • InChi: 1S/C12H12N2O4S/c1-7(11(15)16)19-12-14-13-10(18-12)8-3-5-9(17-2)6-4-8/h3-7H,1-2H3,(H,15,16)
  • InChiKey: GZSVKOUUPWNZEO-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]thio]propanoic acid
  • 2-[[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]thio]propionic acid
  • STK245265
  • NCGC00103120-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.013 0.2921 0.3013
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0117 0.2589 0.061
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0366 0.8931 0.8931
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0117 0.2589 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0366 0.8931 1
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.2485 0.2214
Loa Loa (eye worm) hypothetical protein 0.013 0.2921 0.3271
Entamoeba histolytica P-glycoprotein 6, putative 0.0117 0.2589 0.2626
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.013 0.2921 0.1102
Loa Loa (eye worm) hypothetical protein 0.0029 0.033 0.0369
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0366 0.8931 1
Schistosoma mansoni smdr2 0.0366 0.8931 1
Onchocerca volvulus 0.0366 0.8931 1
Plasmodium falciparum multidrug resistance-associated protein 1 0.0117 0.2589 0.2781
Trichomonas vaginalis ABC transporter, putative 0.0366 0.8931 1
Brugia malayi multidrug resistance related protein 1 0.013 0.2921 0.3271
Trichomonas vaginalis taga, putative 0.0366 0.8931 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.033 0.0755
Plasmodium vivax multidrug resistance protein 2, putative 0.0117 0.2589 0.2781
Leishmania major p-glycoprotein 0.0366 0.8931 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.033 0.0755
Loa Loa (eye worm) hypothetical protein 0.0366 0.8931 1
Entamoeba histolytica multidrug resistance protein, putative 0.013 0.2921 0.3013
Trypanosoma brucei p-glycoprotein 0.013 0.2921 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0362 0.8827 0.8827
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0366 0.8931 0.8931
Entamoeba histolytica P-glyco protein 6, putative 0.0366 0.8931 1
Echinococcus granulosus multidrug resistance protein 1 0.0253 0.6047 0.6047
Plasmodium falciparum multidrug resistance-associated protein 2 0.0117 0.2589 0.2781
Brugia malayi hypothetical protein 0.0117 0.2589 0.2898
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0117 0.2589 1
Plasmodium falciparum ABC transporter B family member 6, putative 0.0117 0.2589 0.2781
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0113 0.2485 0.2214
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0117 0.2589 0.2805
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.013 0.2921 1
Brugia malayi ABC transporter family protein 0.0117 0.2589 0.2898
Brugia malayi ABC transporter transmembrane region family protein 0.013 0.2921 0.3271
Entamoeba histolytica P-glycoprotein 6, putative 0.0117 0.2589 0.2626
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.033 0.0243
Plasmodium vivax ABC transporter B family member 7, putative 0.0117 0.2589 0.2781
Plasmodium vivax ABC transporter B family member 4, putative 0.0117 0.2589 0.2781
Schistosoma mansoni multidrug resistance protein 0.0366 0.8931 1
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0117 0.2589 1
Echinococcus multilocularis sodium channel protein 0.0048 0.0818 0.0818
Entamoeba histolytica P-glycoprotein-2 0.0366 0.8931 1
Plasmodium falciparum ABC transporter B family member 4, putative 0.0117 0.2589 0.2781
Echinococcus granulosus multidrug resistance associated protein 7 0.013 0.2921 0.2921
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.033 0.0755
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0117 0.2589 0.2898
Loa Loa (eye worm) hypothetical protein 0.0021 0.0145 0.0163
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0366 0.8931 1
Echinococcus granulosus multidrug resistance protein 1 0.0253 0.6047 0.6047
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0366 0.8931 1
Entamoeba histolytica P-glycoprotein-5 0.0366 0.8931 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.2177 0.2437
Loa Loa (eye worm) hypothetical protein 0.0366 0.8931 1
Plasmodium falciparum multidrug resistance protein 2 0.0117 0.2589 0.2781
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0366 0.8931 1
Trypanosoma cruzi multidrug resistance protein E, putative 0.013 0.2921 1
Trichomonas vaginalis abcb9, putative 0.0366 0.8931 1
Entamoeba histolytica P-glycoprotein-1 0.0366 0.8931 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0145 0.0163
Plasmodium falciparum ABC transporter B family member 7, putative 0.0117 0.2589 0.2781
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.033 0.0755
Trichomonas vaginalis ABC transporter, putative 0.0366 0.8931 1
Trichomonas vaginalis ABC transporter, putative 0.0366 0.8931 1
Trichomonas vaginalis abcb9, putative 0.0366 0.8931 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.013 0.2921 1
Schistosoma mansoni voltage-gated potassium channel 0.0051 0.0902 0.101
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0117 0.2589 0.2805
Plasmodium falciparum multidrug resistance protein 1 0.0366 0.8931 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0113 0.2485 0.2505
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0366 0.8931 1
Schistosoma mansoni multidrug resistance protein 0.0366 0.8931 1
Leishmania major p-glycoprotein e 0.013 0.2921 0.3013
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0117 0.2589 0.061
Loa Loa (eye worm) ABC transporter 0.0117 0.2589 0.2898
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0117 0.2589 0.5
Brugia malayi AMP-binding enzyme family protein 0.0029 0.033 0.0369
Plasmodium falciparum ABC transporter B family member 5, putative 0.0117 0.2589 0.2781
Leishmania major ABC-thiol transporter 0.013 0.2921 0.3013
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0366 0.8931 1
Giardia lamblia Multidrug resistance-associated protein 1 0.013 0.2921 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0117 0.2589 0.2589
Brugia malayi ABC transporter family protein 0.0117 0.2589 0.2898
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0117 0.2589 0.234
Entamoeba histolytica P-glycoprotein 5, putative 0.0366 0.8931 1
Echinococcus granulosus multidrug resistance protein 1 0.0366 0.8931 0.8931
Echinococcus granulosus ATP binding cassette sub family B 0.0113 0.2485 0.2485
Echinococcus multilocularis multidrug resistance associated protein 7 0.013 0.2921 0.2921
Echinococcus granulosus multidrug resistance associated protein 1 0.013 0.2921 0.2921
Schistosoma mansoni multidrug resistance protein 0.0366 0.8931 1
Leishmania major pentamidine resistance protein 1 0.013 0.2921 0.3013
Loa Loa (eye worm) hypothetical protein 0.0101 0.2177 0.2437
Giardia lamblia MRP-like ABC transporter 0.013 0.2921 1
Trichomonas vaginalis ABC transporter, putative 0.0366 0.8931 1
Loa Loa (eye worm) hypothetical protein 0.013 0.2921 0.3271
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0362 0.8827 0.8827
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0366 0.8931 1
Echinococcus multilocularis tumor protein p63 0.0408 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0366 0.8931 1
Echinococcus granulosus multidrug resistance protein 1 0.0366 0.8931 0.8931
Echinococcus granulosus sodium channel protein 0.0048 0.0818 0.0818
Brugia malayi ABC transporter 0.0117 0.2589 0.2898
Echinococcus granulosus ATP binding cassette sub family B 0.0117 0.2589 0.2589
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0366 0.8931 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.033 0.0755
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0366 0.8931 1
Echinococcus granulosus multidrug resistance protein 1 0.0366 0.8931 0.8931
Loa Loa (eye worm) hypothetical protein 0.006 0.1122 0.1257
Loa Loa (eye worm) hypothetical protein 0.0021 0.0145 0.0163
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0101 0.2177 0.2437
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0117 0.2589 0.061
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.013 0.2921 1
Brugia malayi ABC transporter family protein 0.0117 0.2589 0.2898
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0366 0.8931 0.8931
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0117 0.2589 0.2781
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0117 0.2589 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.033 0.0369
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0145 0.0034
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0117 0.2589 0.5
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0117 0.2589 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0047 0.0799 0.0799
Schistosoma mansoni voltage-gated potassium channel 0.0051 0.0902 0.101
Giardia lamblia Multidrug resistance-associated protein 1 0.013 0.2921 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0366 0.8931 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0366 0.8931 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.033 0.0369
Schistosoma mansoni smdr1 0.0117 0.2589 0.2898
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0366 0.8931 0.8931
Schistosoma mansoni multidrug resistance protein 0.013 0.2921 0.3271
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.033 0.0755
Brugia malayi ABC transporter transmembrane region family protein 0.0117 0.2589 0.2898
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0366 0.8931 0.8931
Loa Loa (eye worm) hypothetical protein 0.0029 0.033 0.0369
Plasmodium falciparum ABC transporter B family member 3, putative 0.0117 0.2589 0.2781
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0117 0.2589 0.2781
Plasmodium vivax multidrug resistance protein 1, putative 0.0366 0.8931 1
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0113 0.2485 0.2782
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0117 0.2589 0.2626
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0366 0.8931 0.8931
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0366 0.8931 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0113 0.2485 0.2505
Echinococcus multilocularis multidrug resistance protein 1 0.0366 0.8931 0.8931
Loa Loa (eye worm) ABC transporter 0.0117 0.2589 0.2898
Loa Loa (eye worm) hypothetical protein 0.0021 0.0145 0.0163
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0366 0.8931 1
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0117 0.2589 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.033 0.0369
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0366 0.8931 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.2589 0.2898
Brugia malayi multidrug resistance protein 3 0.0366 0.8931 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0366 0.8931 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0117 0.2589 0.061
Trichomonas vaginalis abcb9, putative 0.0366 0.8931 1
Toxoplasma gondii ABC transporter family protein 0.0117 0.2589 0.061
Loa Loa (eye worm) hypothetical protein 0.0113 0.2485 0.2782
Giardia lamblia ABC transporter, putative 0.013 0.2921 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.033 0.0243
Loa Loa (eye worm) hypothetical protein 0.0362 0.8827 0.9883
Schistosoma mansoni multidrug resistance protein 0.013 0.2921 0.3271
Brugia malayi ABC transporter transmembrane region family protein 0.0113 0.2485 0.2782
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0366 0.8931 0.8931
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0117 0.2589 0.2626
Echinococcus multilocularis ATP binding cassette sub family B 0.0117 0.2589 0.2589
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0113 0.2485 0.2214
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0366 0.8931 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0366 0.8931 0.8931
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0366 0.8931 1
Echinococcus multilocularis multidrug resistance protein 1 0.0253 0.6047 0.6047
Echinococcus multilocularis ATP binding cassette sub family B 0.0117 0.2589 0.2589
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0117 0.2589 0.061
Giardia lamblia Multidrug resistance-associated protein 1 0.0126 0.2817 0.7615
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0117 0.2589 0.2626
Schistosoma mansoni multidrug resistance protein 0.0113 0.2485 0.2782
Schistosoma mansoni multidrug resistance protein 0.013 0.2921 0.3271
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0117 0.2589 0.2898
Loa Loa (eye worm) hypothetical protein 0.0101 0.2177 0.2437
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0366 0.8931 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.033 0.0755
Echinococcus multilocularis 0.0117 0.2589 0.2589
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.013 0.2921 0.3013
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0366 0.8931 1
Brugia malayi P-glycoprotein-like protein 0.0117 0.2589 0.2898
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.013 0.2921 0.3013
Brugia malayi ABC transporter 0.0113 0.2485 0.2782
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0366 0.8931 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0145 0.0163
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0047 0.0799 0.0895
Entamoeba histolytica ATP-binding cassette protein, putative 0.013 0.2921 0.3013
Onchocerca volvulus 0.006 0.1122 0.0921
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0366 0.8931 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.013 0.2921 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.013 0.2921 0.3013
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0113 0.2485 0.2214
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0117 0.2589 0.061
Loa Loa (eye worm) hypothetical protein 0.0041 0.065 0.0728
Plasmodium vivax ABC transporter B family member 5, putative 0.0117 0.2589 0.2781
Echinococcus granulosus ATP binding cassette sub family B 0.0117 0.2589 0.2589
Plasmodium vivax ABC transporter B family member 3, putative 0.0117 0.2589 0.2781
Schistosoma mansoni multidrug resistance protein 0.013 0.2921 0.3271
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.013 0.2921 0.3271
Echinococcus multilocularis multidrug resistance associated protein 1 0.013 0.2921 0.2921
Loa Loa (eye worm) hypothetical protein 0.0126 0.2817 0.3154
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.013 0.2921 0.3013
Entamoeba histolytica ATP-binding cassette protein, putative 0.013 0.2921 0.3013
Schistosoma mansoni multidrug resistance protein 0.0117 0.2589 0.2898
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0048 0.0818 0.0818
Schistosoma mansoni cellular tumor antigen P53 0.006 0.1122 0.1257
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0048 0.0818 0.0568
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0366 0.8931 1
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.013 0.2921 0.3013
Entamoeba histolytica P-glycoprotein-2, putative 0.0366 0.8931 1
Plasmodium vivax ABC transporter B family member 6, putative 0.0117 0.2589 0.2781
Loa Loa (eye worm) ABC transporter 0.0117 0.2589 0.2898
Trypanosoma brucei multidrug resistance protein E 0.013 0.2921 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0366 0.8931 1
Brugia malayi ABC transporter family protein 0.0366 0.8931 1
Entamoeba histolytica ABC transporter, putative 0.013 0.2921 0.3013
Entamoeba histolytica ATP-binding cassette protein, putative 0.013 0.2921 0.3013
Toxoplasma gondii ABC transporter, putative 0.0117 0.2589 0.061
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0117 0.2589 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0047 0.0799 0.0895
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0366 0.8931 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0366 0.8931 0.8931
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0366 0.8931 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0117 0.2589 0.2589
Loa Loa (eye worm) multidrug resistance-associated protein 0.0017 0.0037 0.0041
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.033 0.0755
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0253 0.6047 0.6517
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0366 0.8931 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0047 0.0799 0.0799
Entamoeba histolytica P-glycoprotein-2 0.0366 0.8931 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0366 0.8931 1
Echinococcus multilocularis multidrug resistance protein 1 0.0366 0.8931 0.8931

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.9955 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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