Detailed information for compound 1353056

Basic information

Technical information
  • TDR Targets ID: 1353056
  • Name: 2-(4-chlorophenoxy)-2-methyl-N-(2-oxothiolan- 3-yl)propanamide
  • MW: 313.8 | Formula: C14H16ClNO3S
  • H donors: 1 H acceptors: 2 LogP: 3.08 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(Oc1ccc(cc1)Cl)(C)C)NC1CCSC1=O
  • InChi: 1S/C14H16ClNO3S/c1-14(2,19-10-5-3-9(15)4-6-10)13(18)16-11-7-8-20-12(11)17/h3-6,11H,7-8H2,1-2H3,(H,16,18)
  • InChiKey: WUXYICQFHVPMFN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-chlorophenoxy)-2-methyl-N-(2-oxotetrahydrothiophen-3-yl)propanamide
  • 2-(4-chlorophenoxy)-2-methyl-N-(2-oxo-3-tetrahydrothiophenyl)propanamide
  • 2-(4-chlorophenoxy)-N-(2-ketotetrahydrothiophen-3-yl)-2-methyl-propionamide
  • ST5278206
  • 2-(4-Chloro-phenoxy)-2-methyl-N-(2-oxo-tetrahydro-thiophen-3-yl)-propionamide
  • BAS 05599329
  • 2-(4-chlorophenoxy)-2-methyl-N-(2-oxotetrahydro-3-thienyl)propanamide
  • MLS000088616
  • SMR000072612

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0462 0.214
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0063 0.117 0.5263
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0522
Echinococcus multilocularis ATP binding cassette sub family B 0.002 0.0185 0.0378
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0214
Leishmania major pentamidine resistance protein 1 0.002 0.0185 0.1205
Echinococcus granulosus multidrug resistance associated protein 1 0.002 0.0185 0.0378
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0582 1
Giardia lamblia ABC transporter, putative 0.002 0.0185 0.2816
Loa Loa (eye worm) ABC transporter 0.002 0.0185 0.0522
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2154 0.4406
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0079 0.1527 1
Schistosoma mansoni multidrug resistance protein 0.0063 0.117 0.1521
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.1225 0.2505
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0477 0.0975
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.002 0.0185 0.2147
Plasmodium falciparum protein kinase 7 0.0301 0.6569 0.6568
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0063 0.117 0.5263
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0019 0.0169 0.2411
Trypanosoma brucei glucose transporter 1E 0.0033 0.0486 0.8107
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.1044 0.2135
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0276 0.0564
Echinococcus multilocularis ATP binding cassette sub family B 0.002 0.0185 0.0378
Echinococcus granulosus General substrate transporter 0.0092 0.1814 0.3711
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0522
Schistosoma mansoni multidrug resistance protein 0.002 0.0185 0.0239
Entamoeba histolytica P-glycoprotein-2 0.0063 0.117 1
Giardia lamblia Hypothetical protein 0.0019 0.0169 0.2411
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0486 0.1973
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0477 0.0404
Trypanosoma brucei glucose transporter, putative 0.0033 0.0486 0.8107
Brugia malayi ABC transporter transmembrane region family protein 0.0019 0.0169 0.0781
Echinococcus granulosus solute carrier family 22 0.0015 0.0076 0.0156
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.002 0.0185 0.1205
Onchocerca volvulus 0.0058 0.1044 0.8847
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0079 0.1527 0.3123
Schistosoma mansoni voltage-gated potassium channel 0.0084 0.1651 0.2147
Brugia malayi multidrug resistance protein 3 0.0063 0.117 0.5429
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.002 0.0185 0.028
Echinococcus multilocularis hyperpolarization activated cyclic 0.0019 0.0172 0.0352
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0214
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.1044 0.2135
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0063 0.117 0.5263
Toxoplasma gondii hypothetical protein 0.0167 0.3525 0.5366
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0477 0.0725
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0486 0.8107
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.002 0.0185 0.0854
Trypanosoma brucei glucose transporter, putative 0.0033 0.0486 0.8107
Schistosoma mansoni glucose transport protein 0.0107 0.2154 0.2802
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.002 0.0185 0.5435
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0477 0.0725
Brugia malayi ABC transporter family protein 0.002 0.0185 0.0854
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0063 0.117 0.5263
Schistosoma mansoni glucose transport protein 0.0107 0.2154 0.2802
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.4889 1
Trichomonas vaginalis taga, putative 0.0063 0.117 0.5263
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.002 0.0185 0.0993
Loa Loa (eye worm) hypothetical protein 0.0019 0.0169 0.0478
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0462 0.1855
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0106 0.0137
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0582 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0172 0.0486
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0019 0.0169 0.0447
Brugia malayi Sugar transporter family protein 0.0107 0.2154 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0477 0.135
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0019 0.0172 0.0462
Trypanosoma brucei multidrug resistance-associated protein, putative 0.002 0.0185 0.2147
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0063 0.117 0.5263
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0477 0.0975
Loa Loa (eye worm) hypothetical protein 0.0019 0.0169 0.0478
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0214
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.1044 0.1357
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0001 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0477 0.1927
Echinococcus granulosus cGMP dependent protein kinase 0.0012 0.0001 0.0002
Loa Loa (eye worm) multidrug resistance protein 3 0.0063 0.117 0.3317
Echinococcus granulosus ATP binding cassette sub family B 0.002 0.0185 0.0378
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0019 0.0172 0.0352
Entamoeba histolytica protein kinase, putative 0.0033 0.0477 0.3073
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.002 0.0185 0.5435
Plasmodium falciparum multidrug resistance-associated protein 1 0.002 0.0185 0.0184
Brugia malayi ABC transporter family protein 0.002 0.0185 0.0854
Plasmodium falciparum ABC transporter B family member 4, putative 0.002 0.0185 0.0184
Toxoplasma gondii protein kinase, putative 0.0301 0.6569 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0063 0.117 0.5263
Entamoeba histolytica hypothetical protein 0.002 0.0185 0.0156
Schistosoma mansoni sugar transporter 0.0015 0.0076 0.0098
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0276 0.395
Echinococcus granulosus multidrug resistance protein 1 0.0044 0.0737 0.1507
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0486 0.8107
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0214
Brugia malayi major facilitator superfamily protein 0.0015 0.0076 0.035
Echinococcus granulosus sodium channel protein 0.0079 0.1527 0.3123
Schistosoma mansoni sugar transporter 0.0015 0.0076 0.0098
Schistosoma mansoni sugar transporter 0.0015 0.0076 0.0098
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0076 0.0214
Plasmodium falciparum hexose transporter 0.0107 0.2154 0.2154
Loa Loa (eye worm) hypothetical protein 0.0058 0.1044 0.296
Brugia malayi Sugar transporter family protein 0.0015 0.0076 0.035
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0486 0.318
Trypanosoma brucei glucose transporter, putative 0.0033 0.0486 0.8107
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0063 0.117 0.5263
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0276 0.0201
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.002 0.0185 0.0522
Loa Loa (eye worm) sugar transporter 0.0107 0.2154 0.6111
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0462 0.2923
Giardia lamblia MRP-like ABC transporter 0.002 0.0185 0.2816
Entamoeba histolytica ATP-binding cassette protein, putative 0.002 0.0185 0.0156
Trypanosoma cruzi hexose transporter 0.0033 0.0486 0.8107
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0063 0.117 0.2393
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0063 0.117 0.5263
Echinococcus multilocularis multidrug resistance protein 1 0.0063 0.117 0.2393
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0063 0.117 0.2393
Brugia malayi Cam kinase protein 1 0.0033 0.0477 0.221
Toxoplasma gondii ABC transporter, putative 0.002 0.0185 0.028
Schistosoma mansoni 60S ribosomal protein L21 0.0016 0.0106 0.0137
Plasmodium falciparum multidrug resistance protein 1 0.0063 0.117 0.1169
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0462 0.0944
Loa Loa (eye worm) hypothetical protein 0.0062 0.1154 0.3273
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0214
Echinococcus granulosus solute carrier family 22 0.0015 0.0076 0.0156
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0063 0.117 1
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0076 0.0494
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0462 0.1308
Trypanosoma brucei glucose transporter, putative 0.0033 0.0486 0.8107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0477 0.0975
Schistosoma mansoni multidrug resistance protein 0.0019 0.0169 0.0219
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.002 0.0185 0.1205
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0063 0.117 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0063 0.117 0.2393
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.002 0.0185 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0477 0.0975
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0063 0.117 0.2393
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0324 0.0421
Entamoeba histolytica P-glycoprotein 6, putative 0.002 0.0185 0.0156
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0019 0.0172 0.0352
Brugia malayi mbt repeat family protein 0.0058 0.1044 0.4843
Brugia malayi Sugar transporter family protein 0.0015 0.0076 0.035
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0214
Plasmodium falciparum ABC transporter B family member 6, putative 0.002 0.0185 0.0184
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0019 0.0169 0.0447
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.1225 0.2505
Trypanosoma brucei glucose transporter 2A 0.0033 0.0486 0.8107
Toxoplasma gondii ABC transporter family protein 0.002 0.0185 0.028
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.1225 0.2505
Brugia malayi ABC transporter 0.0019 0.0169 0.0781
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0582 0.0581
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0063 0.117 0.5263
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0477 0.0725
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.002 0.0185 0.1205
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0477 0.221
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0172 0.0223
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0062 0.1154 0.2361
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0063 0.117 0.5263
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0076 0.0115
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0172 0.0223
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.002 0.0185 0.2147
Loa Loa (eye worm) hypothetical protein 0.0167 0.3525 1
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0276 0.1802
Entamoeba histolytica multidrug resistance protein, putative 0.002 0.0185 0.0156
Toxoplasma gondii sugar transporter ST2 0.0015 0.0076 0.0115
Giardia lamblia Multidrug resistance-associated protein 1 0.002 0.0185 0.2816
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0477 0.0404
Trypanosoma brucei multidrug resistance-associated protein, putative 0.002 0.0185 0.2147
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0276 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0019 0.0172 0.0223
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0477 0.0975
Plasmodium vivax hexose transporter 0.0107 0.2154 0.2094
Entamoeba histolytica P-glycoprotein-5 0.0063 0.117 1
Plasmodium vivax ABC transporter B family member 6, putative 0.002 0.0185 0.0109
Echinococcus multilocularis voltage gated potassium channel 0.0026 0.0324 0.0663
Echinococcus granulosus solute carrier family 22 0.0015 0.0076 0.0156
Loa Loa (eye worm) hypothetical protein 0.0167 0.3525 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0276 0.0781
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0019 0.0172 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.2154 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0477 0.135
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0462 0.214
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0477 0.0975
Plasmodium vivax CDK-related protein kinase 6, putative 0.0452 1 1
Leishmania major ABC-thiol transporter 0.002 0.0185 0.1205
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0477 0.0404
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0107 0.2154 0.4406
Brugia malayi P-glycoprotein-like protein 0.002 0.0185 0.0854
Echinococcus granulosus voltage gated potassium channel 0.0026 0.0324 0.0663
Entamoeba histolytica protein kinase, putative 0.0033 0.0477 0.3073
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0063 0.117 0.5263
Trypanosoma brucei multidrug resistance protein E 0.002 0.0185 0.2147
Trypanosoma brucei p-glycoprotein 0.002 0.0185 0.2147
Trichomonas vaginalis abcb9, putative 0.0063 0.117 0.5263
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.002 0.0185 0.5435
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0063 0.117 0.178
Plasmodium falciparum ABC transporter B family member 3, putative 0.002 0.0185 0.0184
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0146 0.1383
Brugia malayi Cyclic-nucleotide gated cation channel 0.0019 0.0172 0.0796
Trichomonas vaginalis abcb9, putative 0.0063 0.117 0.5263
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0276 0.5182
Toxoplasma gondii sugar transporter ST3 0.0015 0.0076 0.0115
Schistosoma mansoni multidrug resistance protein 0.002 0.0185 0.0239
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0462 0.06
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.4889 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0044 0.0737 0.318
Brugia malayi hypothetical protein 0.0015 0.0076 0.035
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0324 0.0421
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0172 0.0223
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.002 0.0185 0.1205
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0462 1
Entamoeba histolytica ABC transporter, putative 0.002 0.0185 0.0156
Echinococcus granulosus multidrug resistance associated protein 7 0.002 0.0185 0.0378
Brugia malayi ABC transporter transmembrane region family protein 0.002 0.0185 0.0854
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0477 0.0476
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0486 0.1973
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0486 0.1973
Schistosoma mansoni glucose transporter 0.0015 0.0076 0.0098
Loa Loa (eye worm) ABC transporter 0.002 0.0185 0.0522
Echinococcus multilocularis solute carrier family 22 0.0015 0.0076 0.0156
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0276 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0486 0.1973
Echinococcus multilocularis multidrug resistance associated protein 1 0.002 0.0185 0.0378
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0172 0.3644 0.5547
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.1281 0.5799
Plasmodium falciparum multidrug resistance protein 2 0.002 0.0185 0.0184
Entamoeba histolytica P-glycoprotein-2, putative 0.0063 0.117 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.002 0.0185 0.0156
Brugia malayi ABC transporter 0.002 0.0185 0.0854
Loa Loa (eye worm) MBCTL1 0.0066 0.1225 0.3473
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0486 0.1973
Echinococcus granulosus multidrug resistance protein 1 0.0063 0.117 0.2393
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.002 0.0185 0.2147
Toxoplasma gondii facilitative glucose transporter GT1 0.0107 0.2154 0.3279
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.002 0.0185 0.0109
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2154 0.4406
Plasmodium vivax ABC transporter B family member 3, putative 0.002 0.0185 0.0109
Plasmodium falciparum multidrug resistance-associated protein 2 0.002 0.0185 0.0184
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0019 0.0169 0.0447
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0522
Brugia malayi ABC transporter transmembrane region family protein 0.002 0.0185 0.0854
Echinococcus granulosus hyperpolarization activated cyclic 0.0019 0.0172 0.0352
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0486 0.8107
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0276 0.0358
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0214
Trichomonas vaginalis ABC transporter, putative 0.0063 0.117 0.5263
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0063 0.117 0.2393
Echinococcus granulosus multidrug resistance protein 1 0.0044 0.0737 0.1507
Entamoeba histolytica P-glycoprotein 6, putative 0.002 0.0185 0.0156
Toxoplasma gondii sugar transporter ST1 0.0015 0.0076 0.0115
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0026 0.0324 0.0663
Leishmania major protein kinase, putative 0.0033 0.0477 0.3117
Plasmodium vivax ABC transporter B family member 5, putative 0.002 0.0185 0.0109
Entamoeba histolytica ATP-binding cassette protein, putative 0.002 0.0185 0.0156
Schistosoma mansoni glucose transport protein 0.0107 0.2154 0.2802
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0486 0.8107
Echinococcus granulosus ATP binding cassette sub family B 0.0019 0.0169 0.0346
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0063 0.117 0.5263
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0063 0.117 0.2393
Leishmania major hypothetical protein, conserved 0.0015 0.0076 0.0494
Entamoeba histolytica ATP-binding cassette protein, putative 0.002 0.0185 0.0156
Brugia malayi multidrug resistance related protein 1 0.002 0.0185 0.0854
Schistosoma mansoni multidrug resistance protein 0.0063 0.117 0.1521
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2154 0.4406
Schistosoma mansoni multidrug resistance protein 0.002 0.0185 0.0239
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0019 0.0172 0.0462
Leishmania major p-glycoprotein 0.0063 0.117 0.766
Echinococcus granulosus multidrug resistance protein 1 0.0063 0.117 0.2393
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0019 0.0172 0.0486
Entamoeba histolytica P-glycoprotein-2 0.0063 0.117 1
Brugia malayi hypothetical protein 0.0015 0.0076 0.035
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.002 0.0185 0.1205
Loa Loa (eye worm) sugar transporter 0.0015 0.0076 0.0214
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0063 0.117 0.2393
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0063 0.117 0.5263
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0063 0.117 0.3317
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0063 0.117 0.5263
Schistosoma mansoni hypothetical protein 0.0107 0.2154 0.2802
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0078 0.1499 0.3066
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0063 0.117 0.5263
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.002 0.0185 0.0109
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2154 0.4406
Plasmodium falciparum mitogen-activated protein kinase 2 0.0172 0.3644 0.3643
Echinococcus multilocularis expressed conserved protein 0.0012 0.0001 0.0002
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.002 0.0185 0.2147
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0195 0.1082
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0486 0.8107
Echinococcus multilocularis sodium channel protein 0.0079 0.1527 0.3123
Plasmodium falciparum ABC transporter B family member 5, putative 0.002 0.0185 0.0184
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.002 0.0185 0.5435
Echinococcus granulosus ATP binding cassette sub family B 0.002 0.0185 0.0378
Schistosoma mansoni hypothetical protein 0.035 0.7686 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0172 0.3644 0.3595
Loa Loa (eye worm) hypothetical protein 0.0068 0.1281 0.3631
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0214
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0076 0.0214
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.1225 0.2505
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.1281 0.5799
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.002 0.0185 0.028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0214
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0477 0.0476
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0477 0.0476
Leishmania major p-glycoprotein e 0.002 0.0185 0.1205
Plasmodium vivax ABC transporter B family member 7, putative 0.002 0.0185 0.0109
Trichomonas vaginalis ABC transporter, putative 0.0063 0.117 0.5263
Loa Loa (eye worm) hypothetical protein 0.0167 0.3525 1
Echinococcus multilocularis multidrug resistance protein 1 0.0063 0.117 0.2393
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0019 0.0172 0.0352
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0276 0.0419
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0034 0.0094
Brugia malayi mbt repeat family protein 0.0058 0.1044 0.4843
Echinococcus multilocularis General substrate transporter 0.0092 0.1814 0.3711
Plasmodium falciparum ABC transporter B family member 7, putative 0.002 0.0185 0.0184
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0431 0.0881
Echinococcus multilocularis ATP binding cassette sub family B 0.002 0.0185 0.0378
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.002 0.0185 1
Giardia lamblia Multidrug resistance-associated protein 1 0.002 0.0185 0.2816
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0477 0.0975
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0076 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0169 0.0447
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.1044 0.1357
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0486 0.8107
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0026 0.0324 0.0663
Schistosoma mansoni multidrug resistance protein 0.0063 0.117 0.1521
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2154 0.4406
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0214
Echinococcus multilocularis multidrug resistance protein 1 0.0044 0.0737 0.1507
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0019 0.0172 0.0223
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0276 0.1277
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0019 0.0172 0.0486
Trypanosoma brucei glucose transporter, putative 0.0033 0.0486 0.8107
Echinococcus multilocularis hyperpolarization activated cyclic 0.0019 0.0172 0.0352
Loa Loa (eye worm) hypothetical protein 0.0063 0.117 0.3317
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0063 0.117 0.766
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0076 0.0156
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0076 0.035
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.002 0.0185 0.028
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0076 0.0156
Schistosoma mansoni smdr2 0.0063 0.117 0.1521
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0063 0.117 0.5263
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0167 0.3525 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0486 0.1973
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0276 0.0961
Loa Loa (eye worm) hypothetical protein 0.0026 0.0326 0.0922
Trichomonas vaginalis ABC transporter, putative 0.0063 0.117 0.5263
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0063 0.117 0.5263
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.002 0.0185 0.1205
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0582 0.0885
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0477 0.0619
Brugia malayi major facilitator superfamily protein 0.0015 0.0076 0.035
Giardia lamblia Multidrug resistance-associated protein 1 0.0019 0.0169 0.2411
Echinococcus granulosus multidrug resistance protein 1 0.0063 0.117 0.2393
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.1044 0.2135
Schistosoma mansoni sugar transporter 0.0015 0.0076 0.0098
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0019 0.0172 0.0352
Echinococcus granulosus solute carrier family 22 0.0015 0.0076 0.0156
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.002 0.0185 0.028
Entamoeba histolytica hypothetical protein 0.0024 0.0276 0.1067
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0063 0.117 0.5263
Loa Loa (eye worm) hypothetical protein 0.0032 0.0462 0.1308
Brugia malayi ABC transporter family protein 0.002 0.0185 0.0854
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.1044 0.2135
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0214
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.002 0.0185 0.2147
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0214
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.1044 0.296
Entamoeba histolytica P-glyco protein 6, putative 0.0063 0.117 1
Plasmodium vivax multidrug resistance protein 2, putative 0.002 0.0185 0.0109
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0063 0.117 0.5263
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0214
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0019 0.0172 0.0352
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0063 0.117 0.2393
Trypanosoma brucei glucose transporter, putative 0.0033 0.0486 0.8107
Echinococcus multilocularis solute carrier family 22 0.0015 0.0076 0.0156
Leishmania major glucose transporter, lmgt3 0.0033 0.0486 0.318
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0214
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0214
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0582 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0462 0.06
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0582 0.3807
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0477 0.0476
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.002 0.0185 0.0239
Entamoeba histolytica P-glycoprotein 5, putative 0.0063 0.117 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0019 0.0172 0.0352
Schistosoma mansoni multidrug resistance protein 0.002 0.0185 0.0239
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0918
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0477 0.0975
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2154 0.4406
Plasmodium vivax multidrug resistance protein 1, putative 0.0063 0.117 0.1102
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0063 0.117 0.178
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0276 0.395
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0078 0.1499 0.6957
Trypanosoma brucei glucose transporter, putative 0.0033 0.0486 0.8107
Echinococcus multilocularis 0.002 0.0185 0.0378
Trichomonas vaginalis ABC transporter, putative 0.0063 0.117 0.5263
Echinococcus multilocularis solute carrier family 22 0.0015 0.0076 0.0156
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.002 0.0185 0.1205
Trypanosoma cruzi multidrug resistance protein E, putative 0.002 0.0185 0.2147
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0582 0.3807
Echinococcus multilocularis solute carrier family 22 0.0015 0.0076 0.0156
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0063 0.117 0.5263
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0076 0.0156
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0195 0.0355
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0462 0.0944
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0019 0.0169 0.0219
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0477 0.7919
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.002 0.0185 0.5435
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.002 0.0185 0.028
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0063 0.117 0.5263
Plasmodium vivax ABC transporter B family member 4, putative 0.002 0.0185 0.0109
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.002 0.0185 0.028
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0019 0.0172 0.0352
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0076 0.0156
Echinococcus multilocularis ATP binding cassette sub family B 0.0062 0.1154 0.2361
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0195 0.1082
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0462 1
Schistosoma mansoni voltage-gated potassium channel 0.0084 0.1651 0.2147
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0276 1
Echinococcus multilocularis multidrug resistance associated protein 7 0.002 0.0185 0.0378
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0076 0.035
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0172 0.0223
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.002 0.0185 0.028
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0276 0.0275
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0078 0.1499 0.3066
Entamoeba histolytica P-glycoprotein-1 0.0063 0.117 1
Leishmania major glucose transporter, lmgt1 0.0033 0.0486 0.318
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0477 0.0476
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0063 0.117 0.5263
Trichomonas vaginalis abcb9, putative 0.0063 0.117 0.5263
Schistosoma mansoni protein kinase 0.0033 0.0477 0.0619
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0063 0.117 0.2393
Schistosoma mansoni protein kinase 0.0033 0.0477 0.0619
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0486 0.1973
Brugia malayi hypothetical protein 0.002 0.0185 0.0854
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0185 0.0522
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.1044 0.8847
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0582 0.051
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0431 0.0881
Loa Loa (eye worm) hypothetical protein 0.0063 0.117 0.3317
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0477 0.0404
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0076 0.035
Leishmania major glucose transporter, lmgt2 0.0033 0.0486 0.318
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.1225 0.1593
Onchocerca volvulus 0.0063 0.117 1
Schistosoma mansoni multidrug resistance protein 0.002 0.0185 0.0239
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.1225 0.5684
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0078 0.1499 0.4251
Schistosoma mansoni smdr1 0.002 0.0185 0.0239
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2154 0.4406
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0001 0.0002
Loa Loa (eye worm) ABC transporter 0.002 0.0185 0.0522
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0076 0.0075
Loa Loa (eye worm) hypothetical protein 0.0033 0.0477 0.135
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.002 0.0185 0.0993
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.002 0.0185 0.2147
Brugia malayi ABC transporter family protein 0.0063 0.117 0.5429
Schistosoma mansoni protein kinase 0.0033 0.0477 0.0619
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0026 0.0324 0.1502
Brugia malayi hypothetical protein 0.0015 0.0076 0.035
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0276 0.3293
Loa Loa (eye worm) hypothetical protein 0.0066 0.1225 0.3473
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0209 0.0641
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0276 0.0564
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.1044 0.1357
Echinococcus multilocularis ATP binding cassette sub family B 0.002 0.0185 0.0378
Trypanosoma brucei glucose transporter, putative 0.0033 0.0486 0.8107

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (binding) = 10000 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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