TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 311.246 | Formula: C16H9NO6
H donors: 1 H acceptors: 5 LogP: 3.21 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=c1oc2ccccc2c(c1C(=O)c1cccc(c1)[N+](=O)[O-])O
InChi: 1S/C16H9NO6/c18-14(9-4-3-5-10(8-9)17(21)22)13-15(19)11-6-1-2-7-12(11)23-16(13)20/h1-8,19H
InChiKey: NSVOQCVVOPNJJZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Mycobacterium leprae	Probable lipase LipE	0.004	0.0198	0.5
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.001	0.0016	0.0048
Schistosoma mansoni	scy1(yeast) protein kinase-like	0.0038	0.0184	0.0181
Onchocerca volvulus		0.004	0.0198	0.0196
Echinococcus multilocularis	muscleblind protein 1	0.0474	0.2797	1
Echinococcus granulosus	dnaJ subfamily B	0.0458	0.2697	0.9644
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0252	0.025
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.001	0.0018	0.0055
Trypanosoma brucei	hypothetical protein, conserved	0.0485	0.2862	0.2846
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0038	0.0184	0.0649
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0038	0.0184	0.0649
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0198	0.075
Loa Loa (eye worm)	transcription factor SMAD2	0.0134	0.0756	0.2698
Trichomonas vaginalis	PIKK family atypical protein kinase	0.001	0.0016	0.0061
Trypanosoma cruzi	ribonuclease H1, putative	0.0447	0.2635	1
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0038	0.0184	0.0649
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0024	0.0101	0.0099
Loa Loa (eye worm)	ets-domain-containing protein	0.001	0.0018	0.0055
Trypanosoma cruzi	ribonuclease H1, putative	0.0447	0.2635	1
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0198	0.0694
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0018	0.0062	0.0039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0018	0.0062	0.0213
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Schistosoma mansoni	ets-related	0.0214	0.1241	0.1238
Brugia malayi	beta-lactamase family protein	0.004	0.0198	0.0699
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0101	0.0385
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0062	0.0213
Brugia malayi	Pao retrotransposon peptidase family protein	0.0038	0.0184	0.0649
Brugia malayi	Pao retrotransposon peptidase family protein	0.0038	0.0184	0.0649
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Echinococcus multilocularis	serine protein kinase ATM	0.0024	0.0101	0.0354
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0198	0.5
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0004	0.0006
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0198	0.0699
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0198	0.075
Schistosoma mansoni	phosphoglucomutase	0.0447	0.2635	0.2633
Schistosoma mansoni	polyomavirus enhancer activator 3 pea3	0.001	0.0018	0.0015
Brugia malayi	MH2 domain containing protein	0.0009	0.0011	0.003
Echinococcus multilocularis	ribonuclease H1	0.0447	0.2635	0.942
Schistosoma mansoni	phosphoglucomutase	0.0447	0.2635	0.2633
Trypanosoma cruzi	target of rapamycin kinase 3	0.0018	0.0062	0.0176
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0011	0.003
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0018	0.0062	0.0177
Onchocerca volvulus		0.0038	0.0184	0.0141
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0198	0.0699
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Trichomonas vaginalis	reverse transcriptases, putative	0.0038	0.0184	0.0698
Toxoplasma gondii	ribonuclease HI protein	0.0447	0.2635	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0002	0.0009
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0016	0.0048
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Brugia malayi	reverse transcriptase	0.0038	0.0184	0.0649
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0018	0.0062	0.0176
Echinococcus multilocularis	smad	0.0009	0.0011	0.003
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0699
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0018	0.0062	0.0213
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0021	0.0081	0.0249
Echinococcus granulosus	Smad4	0.0009	0.0011	0.003
Echinococcus granulosus	RNA directed DNA polymerase	0.0038	0.0184	0.0649
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0062	0.0213
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0038	0.0184	0.0649
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0699
Giardia lamblia	Reverse transcriptase/endonuclease, putative	0.0038	0.0184	0.0474
Loa Loa (eye worm)	DNA-binding protein D-ETS-3	0.001	0.0018	0.0055
Onchocerca volvulus		0.0038	0.0184	0.0141
Brugia malayi	reverse transcriptase	0.0038	0.0184	0.0649
Schistosoma mansoni	cpg binding protein	0.0034	0.016	0.0157
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0038	0.0184	0.0141
Echinococcus multilocularis	muscleblind protein	0.0474	0.2797	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0062	0.0213
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0252	0.0895
Schistosoma mansoni	hypothetical protein	0.0458	0.2697	0.2696
Trypanosoma brucei	ribonuclease H1	0.0447	0.2635	0.2618
Brugia malayi	beta-lactamase	0.004	0.0198	0.0699
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0004	0.0006
Brugia malayi	RNase H family protein	0.0447	0.2635	0.942
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0062	0.0176
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0198	0.0699
Schistosoma mansoni	hypothetical protein	0.0038	0.0184	0.0181
Echinococcus granulosus	ribonuclease H1	0.0447	0.2635	0.942
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0018	0.0062	0.0176
Brugia malayi	hypothetical protein	0.0038	0.0184	0.0649
Trypanosoma brucei	unspecified product	0.0485	0.2862	0.2846
Echinococcus multilocularis	protein C ets 2	0.001	0.0018	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Loa Loa (eye worm)	hypothetical protein	0.001	0.0018	0.0055
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0011	0.003
Loa Loa (eye worm)	MH2 domain-containing protein	0.0134	0.0756	0.2698
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0023	0.0086
Echinococcus multilocularis	Smad4	0.0009	0.0011	0.003
Brugia malayi	Pao retrotransposon peptidase family protein	0.0038	0.0184	0.0649
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0004	0.0006
Mycobacterium tuberculosis	Conserved protein	0.004	0.0198	0.0105
Brugia malayi	Muscleblind-like protein	0.0474	0.2797	1
Echinococcus multilocularis	ETS domain containing protein Elk 1	0.001	0.0018	0.0055
Echinococcus multilocularis	ETS transcription factor Elf 2	0.001	0.0018	0.0055
Brugia malayi	beta-lactamase family protein	0.004	0.0198	0.0699
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0184	0.0181
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0038	0.0184	0.0649
Echinococcus multilocularis	dnaJ subfamily B	0.0458	0.2697	0.9644
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Giardia lamblia	Reverse transcriptase/endonuclease, putative	0.0038	0.0184	0.0474
Mycobacterium tuberculosis	Probable hydrolase	0.004	0.0198	0.0105
Loa Loa (eye worm)	D-ets-2 protein	0.001	0.0018	0.0055
Schistosoma mansoni	protein kinase	0.0038	0.0184	0.0181
Schistosoma mansoni	cpg binding protein	0.0034	0.016	0.0157
Echinococcus granulosus	KRAB A domain containing protein	0.0038	0.0184	0.0649
Schistosoma mansoni	elf1	0.001	0.0018	0.0015
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0004	0.0002
Mycobacterium leprae	conserved hypothetical protein	0.004	0.0198	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0198	0.075
Onchocerca volvulus		0.004	0.0198	0.0196
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.004	0.0198	0.0105
Trypanosoma brucei	ingi protein (ORF1)	0.0485	0.2862	0.2846
Giardia lamblia	Reverse transcriptase/endonuclease, putative	0.0038	0.0184	0.0474
Onchocerca volvulus	Ribonuclease H1 homolog	0.0447	0.2635	1
Echinococcus multilocularis	ETS transcription factor Elf 2	0.001	0.0018	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.001	0.0016	0.0061
Echinococcus multilocularis	ets variant gene 4	0.001	0.0018	0.0055
Mycobacterium tuberculosis	Probable lipase LipD	0.004	0.0198	0.0105
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Echinococcus granulosus	ETS transcription factor Elf 5	0.001	0.0018	0.0055
Echinococcus granulosus	GA binding protein alpha chain	0.0071	0.0379	0.1349
Schistosoma mansoni	phosphoglucomutase	0.0447	0.2635	0.2633
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0184	0.0641
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0018	0.0062	0.0213
Schistosoma mansoni	ets-related	0.001	0.0018	0.0015
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0018	0.0062	0.0039
Echinococcus granulosus	muscleblind protein	0.0474	0.2797	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0198	0.0195
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.0365	0.0362
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0018	0.0062	0.0001
Brugia malayi	Zinc knuckle family protein	0.0038	0.0184	0.0649
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0198	0.075
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0252	0.0895
Giardia lamblia	Reverse transcriptase/endonuclease, putative	0.0038	0.0184	0.0474
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0018	0.0062	0.0039
Echinococcus multilocularis	cpg binding protein	0.0034	0.016	0.0563
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0018	0.0062	0.0039
Loa Loa (eye worm)	beta-lactamase	0.004	0.0198	0.0699
Trichomonas vaginalis	ribonuclease H1, putative	0.0447	0.2635	1
Loa Loa (eye worm)	hypothetical protein	0.0474	0.2797	1
Brugia malayi	RNase H family protein	0.0447	0.2635	0.942
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0018	0.0062	0.5386
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0011	0.0008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.001	0.0016	0.0061
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0699
Giardia lamblia	Ribonuclease H	0.0447	0.2635	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0024	0.0101	0.0327
Mycobacterium tuberculosis	Conserved protein	0.004	0.0198	0.0105
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Trichomonas vaginalis	PIKK family atypical protein kinase	0.001	0.0016	0.0061
Brugia malayi	Pao retrotransposon peptidase family protein	0.0038	0.0184	0.0649
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0252	0.025
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0198	0.075
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0081	0.0282
Mycobacterium tuberculosis	Probable lipase LipE	0.004	0.0198	0.0105
Entamoeba histolytica	hypothetical protein	0.0024	0.0101	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0018	0.0062	0.5386
Brugia malayi	Pao retrotransposon peptidase family protein	0.0038	0.0184	0.0649
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0038	0.0184	0.0649
Trichomonas vaginalis	PIKK family atypical protein kinase	0.001	0.0016	0.0061
Echinococcus multilocularis	ETS transcription factor Elf 1	0.001	0.0018	0.0055
Schistosoma mansoni	hypothetical protein	0.001	0.0018	0.0015
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0024	0.0101	0.0354
Brugia malayi	Pao retrotransposon peptidase family protein	0.0038	0.0184	0.0649
Leishmania major	hypothetical protein, conserved	0.004	0.0198	0.0527
Trichomonas vaginalis	PIKK family atypical protein kinase	0.001	0.0016	0.0061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0062	0.0176
Brugia malayi	Ets-domain containing protein	0.0071	0.0379	0.1349
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0018	0.0062	0.015
Trichomonas vaginalis	reverse transcriptase [C. elegans], putative	0.0038	0.0184	0.0698
Echinococcus granulosus	smad	0.0009	0.0011	0.003
Schistosoma mansoni	cpg binding protein	0.0032	0.0149	0.0146
Schistosoma mansoni	smad	0.0009	0.0011	0.0008
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0038	0.0184	0.0649
Brugia malayi	hypothetical protein	0.0038	0.0184	0.0649
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0071	0.0379	0.1349
Trypanosoma brucei	SLACS retrotransposable element (part), putative	0.0038	0.0184	0.0161
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0038	0.0184	0.0649
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0198	0.0699
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0447	0.2635	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Brugia malayi	DNA-binding protein D-ETS-3	0.001	0.0018	0.0055
Treponema pallidum	ribonuclease H (rnhA)	0.0447	0.2635	0.5
Toxoplasma gondii	ABC1 family protein	0.004	0.0198	0.067
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.001	0.0016	0.0048
Brugia malayi	Pao retrotransposon peptidase family protein	0.0038	0.0184	0.0649
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0038	0.0184	0.0649
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0252	0.0895
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0699
Onchocerca volvulus		0.004	0.0198	0.0196
Trichomonas vaginalis	reverse transcriptases, putative	0.0038	0.0184	0.0698
Brugia malayi	Zinc knuckle family protein	0.0038	0.0184	0.0649
Mycobacterium ulcerans	lipase LipD	0.004	0.0198	0.5
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0018	0.0062	0.0213
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0149	0.0524
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0011	0.003
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.004	0.0198	0.0105
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0004	0.0006
Brugia malayi	RNase H family protein	0.0447	0.2635	0.942
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0257	0.1498	1
Echinococcus multilocularis	ewsr:fli fusion protein type	0.001	0.0018	0.0055
Echinococcus granulosus	ETS transcription factor Elf 2	0.001	0.0018	0.0055
Mycobacterium tuberculosis	Conserved protein	0.004	0.0198	0.0105
Echinococcus multilocularis	GA binding protein alpha chain	0.0071	0.0379	0.1349
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0018	0.0062	0.006
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0252	0.0895
Brugia malayi	MH1 domain containing protein	0.0009	0.0011	0.003
Loa Loa (eye worm)	hypothetical protein	0.006	0.0318	0.1129
Schistosoma mansoni	fkbp-rapamycin associated protein	0.001	0.0016	0.0014
Giardia lamblia	Reverse transcriptase/endonuclease	0.0038	0.0184	0.0474
Echinococcus granulosus	ewsr:fli fusion protein type	0.001	0.0018	0.0055
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0011	0.003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0252	0.0895
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0198	0.0694
Brugia malayi	Pao retrotransposon peptidase family protein	0.0038	0.0184	0.0649
Leishmania major	ribonuclease H1, putative	0.0447	0.2635	1
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0038	0.0184	0.0649
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0252	0.0895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Brugia malayi	Pao retrotransposon peptidase family protein	0.0038	0.0184	0.0649
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0699
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0011	0.0008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.001	0.0016	0.0061
Echinococcus multilocularis	ETS transcription factor Elf 5	0.001	0.0018	0.0055
Brugia malayi	hypothetical protein	0.0038	0.0184	0.0649
Brugia malayi	Pao retrotransposon peptidase family protein	0.0038	0.0184	0.0649
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.0198	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0016	0.0048
Brugia malayi	MH2 domain containing protein	0.0009	0.0011	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0023	0.0086
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0018	0.0062	0.0039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0149	0.0524
Brugia malayi	Pao retrotransposon peptidase family protein	0.0038	0.0184	0.0649
Echinococcus granulosus	cpg binding protein	0.0034	0.016	0.0563
Schistosoma mansoni	Smad4	0.0009	0.0011	0.0008
Loa Loa (eye worm)	hypothetical protein	0.001	0.0018	0.0055
Brugia malayi	Fli-1 protein	0.0214	0.1241	0.4431
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0016	0.0048
Echinococcus granulosus	ETS transcription factor Elf 1	0.001	0.0018	0.0055
Mycobacterium ulcerans	hypothetical protein	0.004	0.0198	0.5
Brugia malayi	Ets-domain containing protein	0.0071	0.0379	0.1349
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0015	0.0046
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0038	0.0184	0.0649
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0252	0.025
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.004	0.0198	0.0105
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0485	0.2862	0.2846
Trypanosoma brucei	SLACS reverse transcriptase, putative	0.0038	0.0184	0.0161
Trypanosoma brucei	ingi protein (ORF1)	0.0485	0.2862	0.2846
Echinococcus granulosus	protein C ets 2	0.001	0.0018	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Schistosoma mansoni	hypothetical protein	0.0038	0.0184	0.0181
Mycobacterium ulcerans	beta-lactamase	0.004	0.0198	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0699
Echinococcus granulosus	serine protein kinase ATM	0.0024	0.0101	0.0354
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0011	0.003
Trypanosoma brucei	Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative	0.0038	0.0184	0.0161
Brugia malayi	Pao retrotransposon peptidase family protein	0.0038	0.0184	0.0649
Toxoplasma gondii	FATC domain-containing protein	0.0024	0.0101	0.0301
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0038	0.0184	0.0649
Schistosoma mansoni	gabp alpha	0.0071	0.0379	0.0377
Brugia malayi	MH2 domain containing protein	0.0134	0.0756	0.2698
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Trichomonas vaginalis	esterase, putative	0.004	0.0198	0.075
Brugia malayi	MH1 domain containing protein	0.0009	0.0011	0.003
Schistosoma mansoni	hypothetical protein	0.001	0.0018	0.0015
Mycobacterium tuberculosis	Probable esterase LipL	0.004	0.0198	0.0105
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.0198	0.5
Brugia malayi	Pao retrotransposon peptidase family protein	0.0038	0.0184	0.0649
Brugia malayi	Ets-domain containing protein	0.001	0.0018	0.0055
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.0321	0.1142
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0018	0.0062	0.006
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0016	0.0048
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0024	0.0101	0.0079
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0011	0.003
Echinococcus granulosus	ETS domain containing protein Elk 1	0.001	0.0018	0.0055
Loa Loa (eye worm)	fli-1 protein	0.0214	0.1241	0.4431
Trypanosoma brucei	RNA helicase, putative	0.1676	1	1
Loa Loa (eye worm)	Smad1	0.0009	0.0011	0.003
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0198	0.0195
Schistosoma mansoni	ets	0.001	0.0018	0.0015
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0198	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0073
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0011	0.0008
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0011	0.0008
Brugia malayi	transcription factor E74 isoform	0.001	0.0018	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0235
Brugia malayi	Pao retrotransposon peptidase family protein	0.0038	0.0184	0.0649
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0038	0.0184	0.0649
Brugia malayi	reverse transcriptase	0.0038	0.0184	0.0649
Echinococcus multilocularis	RNA directed DNA polymerase	0.0038	0.0184	0.0649
Brugia malayi	hypothetical protein	0.0038	0.0184	0.0649
Trichomonas vaginalis	NeSL-1_NeSL reverse transcriptases, putative	0.0038	0.0184	0.0698
Brugia malayi	Smad1	0.0009	0.0011	0.003
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0038	0.0184	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0474	0.2797	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.001	0.0016	0.0048
Echinococcus granulosus	ETS transcription factor Elf 2	0.001	0.0018	0.0055
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0062	0.0213

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 100 uM	Inhibitory activity against HIV-1 integrase	ChEMBL.	8691444
IC50 (binding)	> 100 uM	Inhibitory activity against HIV-1 protease	ChEMBL.	8691444

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 231246

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 135427