Detailed information for compound 1358046

Basic information

Technical information
  • TDR Targets ID: 1358046
  • Name: 7-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin- 2-amine
  • MW: 201.185 | Formula: C9H7N5O
  • H donors: 1 H acceptors: 3 LogP: 0.51 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nn2c(n1)nccc2c1ccco1
  • InChi: 1S/C9H7N5O/c10-8-12-9-11-4-3-6(14(9)13-8)7-2-1-5-15-7/h1-5H,(H2,10,13)
  • InChiKey: VWZMXGIAIXOTIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-(2-furyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine
  • [7-(2-furyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]amine
  • 7-(2-furyl)[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine
  • MLS000691973
  • SMR000334008
  • 6H-034
  • ZINC00169633

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0761 0.1631
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0366
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0362 0.0842
Echinococcus multilocularis solute carrier family 22 0.0016 0.0107 0.0107
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0761 0.0761
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0317 0.0317
Mycobacterium tuberculosis Probable dehydrogenase 0.0214 0.3115 0.8958
Brugia malayi Pre-SET motif family protein 0.0202 0.2934 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0411 0.0956
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0317 0.0317
Leishmania major glucose transporter, lmgt1 0.0035 0.0395 0.0917
Leishmania major glucose transporter, lmgt2 0.0035 0.0395 0.0917
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0761 0.0761
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0111 0.1563 0.1563
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0016 0.0107 0.0309
Brugia malayi Cam kinase protein 1 0.0035 0.0395 0.1345
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.13 0.13
Onchocerca volvulus 0.0028 0.0291 0.0866
Schistosoma mansoni hypothetical protein 0.0041 0.0494 0.0494
Toxoplasma gondii hypothetical protein 0.0047 0.0584 0.1253
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0377 0.0377
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0212 0.0456
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.416 1
Mycobacterium ulcerans hypothetical protein 0.0154 0.2205 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0462 0.1073
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.1965 0.5651
Onchocerca volvulus 0.0016 0.0107 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0395 0.0948
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0362 0.1643
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0362 0.0871
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0462 0.1073
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Loa Loa (eye worm) histone methyltransferase 0.001 0.0016 0.0053
Brugia malayi Sugar transporter family protein 0.0016 0.0107 0.0366
Trypanosoma brucei glucose transporter, putative 0.0035 0.0395 0.0917
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.2205 0.6339
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0212 0.0963
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0362 0.0842
Onchocerca volvulus 0.0016 0.0107 0.032
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0362 0.8806
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0395 0.0917
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0395 0.0395
Echinococcus granulosus GPCR family 2 0.0019 0.0159 0.0159
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0462 0.1073
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0366
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0362 0.0513
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0107 0.0107
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0838 0.2857
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0107 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0107 0.0258
Entamoeba histolytica protein kinase, putative 0.0035 0.0395 0.0949
Plasmodium falciparum glutathione reductase 0.0094 0.1292 0.1828
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.416 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Onchocerca volvulus 0.0048 0.0595 0.1774
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0362 0.0842
Schistosoma mansoni hypothetical protein 0.0019 0.0159 0.0159
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0317 0.0317
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.065 0.065
Leishmania major glucose transporter, lmgt3 0.0035 0.0395 0.0917
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1563 0.1563
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0493 0.1145
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0395 0.0395
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0411 0.0989
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Trypanosoma brucei glucose transporter, putative 0.0035 0.0395 0.0917
Brugia malayi Sugar transporter family protein 0.0016 0.0107 0.0366
Loa Loa (eye worm) hypothetical protein 0.0033 0.0377 0.1286
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0838 0.0838
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0377 0.0377
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0247 0.0594
Mycobacterium tuberculosis Probable reductase 0.0214 0.3115 0.8958
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0395 0.0395
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0411 0.0411
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0395 0.0917
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0317 0.0679
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1967 0.4572
Toxoplasma gondii transporter, major facilitator family protein 0.0016 0.0107 0.023
Echinococcus multilocularis muscleblind protein 0.018 0.261 0.261
Echinococcus granulosus tumor protein p63 0.0326 0.483 0.483
Echinococcus multilocularis microtubule associated protein 2 0.0667 1 1
Echinococcus granulosus muscleblind protein 0.018 0.261 0.261
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0838 0.1948
Schistosoma mansoni glucose transport protein 0.0111 0.1563 0.1563
Echinococcus multilocularis cpg binding protein 0.0029 0.0315 0.0315
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Schistosoma mansoni sugar transporter 0.0016 0.0107 0.0107
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.065 0.1561
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0107 0.0366
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0107 0.0107
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Chlamydia trachomatis proline--tRNA ligase 0.0012 0.0049 0.1343
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0107 0.0107
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0761 0.1767
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.1563 0.3758
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0411 0.0989
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0395 0.0917
Onchocerca volvulus 0.0016 0.0107 0.032
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.065 0.151
Schistosoma mansoni glucose transport protein 0.0111 0.1563 0.1563
Loa Loa (eye worm) hypothetical protein 0.0019 0.0159 0.054
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0016 0.0107 0.0152
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0366
Plasmodium vivax hexose transporter 0.0111 0.1563 0.2212
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Trypanosoma brucei protein kinase, putative 0.0051 0.065 0.151
Leishmania major glucose transporter/membrane transporter D2, putative 0.0035 0.0395 0.0917
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0395 0.0949
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0247 0.0247
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0107 0.0107
Entamoeba histolytica hypothetical protein 0.0025 0.0247 0.0594
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.5874 0.5874
Plasmodium falciparum mitogen-activated protein kinase 2 0.0181 0.2614 0.3698
Echinococcus granulosus solute carrier family 22 0.0016 0.0107 0.0107
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0362 0.0842
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0362 0.1235
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0317 0.0317
Brugia malayi Muscleblind-like protein 0.018 0.261 0.8898
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.065 0.065
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0761 0.0761
Loa Loa (eye worm) hypothetical protein 0.0029 0.0317 0.1079
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0035 0.0395 0.0559
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0.0107 0.2609
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0377 0.1286
Echinococcus granulosus transcription factor Dp 1 0.0037 0.043 0.043
Onchocerca volvulus 0.0229 0.3356 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0035 0.0395 0.1345
Loa Loa (eye worm) hypothetical protein 0.0025 0.0247 0.0843
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.065 0.151
Onchocerca volvulus 0.0016 0.0107 0.032
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.1563 0.1563
Onchocerca volvulus 0.0029 0.0317 0.0943
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.416 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0247 0.1122
Brugia malayi Thioredoxin reductase 0.0094 0.1292 0.4405
Brugia malayi hypothetical protein 0.0019 0.0159 0.054
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.109 0.109
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.109 0.3714
Loa Loa (eye worm) sugar transporter 0.0111 0.1563 0.5329
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0237 0.3477 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0768 0.0768
Echinococcus multilocularis solute carrier family 22 0.0016 0.0107 0.0107
Giardia lamblia Hexose transporter 0.0016 0.0107 0.0258
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0362 0.0513
Treponema pallidum prolyl-tRNA synthetase 0.0012 0.0049 0.0117
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0838 0.1948
Trichomonas vaginalis myo-inositol transporter, putative 0.0016 0.0107 0.0258
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0159 0.0159
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0035 0.0395 0.0395
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0377 0.0907
Toxoplasma gondii protein kinase, putative 0.0315 0.4663 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0212 0.0301
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0159 0.0159
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.1967 0.4572
Trichomonas vaginalis sugar transport protein, putative 0.0016 0.0107 0.0258
Mycobacterium tuberculosis Probable oxidoreductase 0.0237 0.3477 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0035 0.0395 0.0917
Trypanosoma brucei glucose transporter, putative 0.0035 0.0395 0.0917
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0395 0.0917
Echinococcus granulosus solute carrier family 22 0.0016 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0366
Schistosoma mansoni cpg binding protein 0.0029 0.0315 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0395 0.0948
Schistosoma mansoni rab6-interacting 0.0019 0.0159 0.0159
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.1965 0.8914
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.019 0.0547
Leishmania major trypanothione reductase 0.0094 0.1292 0.3003
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.1292 0.4405
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0362 0.0777
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0362 0.0842
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0493 0.1145
Loa Loa (eye worm) sugar transporter 0.0016 0.0107 0.0366
Schistosoma mansoni hypothetical protein 0.0395 0.5874 0.5874
Plasmodium falciparum calcium-dependent protein kinase 4 0.0035 0.0395 0.0559
Onchocerca volvulus 0.0016 0.0107 0.032
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0231 0.0789
Schistosoma mansoni protein kinase 0.0035 0.0395 0.0395
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.065 0.151
Brugia malayi CXXC zinc finger family protein 0.0028 0.0291 0.0991
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0212 0.0494
Schistosoma mansoni hypothetical protein 0.0019 0.0159 0.0159
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.068 0.068
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0237 0.3477 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0411 1
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.1292 0.1828
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.416 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0355 0.1019
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0395 0.0948
Loa Loa (eye worm) glutathione reductase 0.0094 0.1292 0.4405
Onchocerca volvulus Putative transporter 0.0016 0.0107 0.032
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0159 0.0159
Plasmodium vivax glutathione reductase, putative 0.0094 0.1292 0.1828
Loa Loa (eye worm) hypothetical protein 0.006 0.0784 0.2672
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0107 0.0258
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0411 0.0956
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0159 0.0159
Brugia malayi major facilitator superfamily protein 0.0016 0.0107 0.0366
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0761 0.345
Onchocerca volvulus 0.0016 0.0107 0.032
Brugia malayi major facilitator superfamily protein 0.0016 0.0107 0.0366
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.13 0.13
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0784 0.2672
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0362 0.0842
Brugia malayi hypothetical protein 0.0019 0.0159 0.054
Onchocerca volvulus 0.0016 0.0107 0.032
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0212 0.0511
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0247 0.0247
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0784 0.2672
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0411 0.0956
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0247 0.0843
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0362 0.0842
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1967 0.4572
Loa Loa (eye worm) hypothetical protein 0.018 0.261 0.8898
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0362 0.0842
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.416 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.065 0.151
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0366
Brugia malayi Pre-SET motif family protein 0.0029 0.0317 0.1079
Trypanosoma brucei sugar transporter, putative 0.0016 0.0107 0.0249
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0411 0.1866
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0237 0.3477 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1563 0.1563
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0377 0.0907
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.416 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.065 0.1393
Trypanosoma brucei glucose transporter, putative 0.0035 0.0395 0.0917
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.019 0.0547
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.065 0.1561
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0107 0.0258
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0761 0.345
Onchocerca volvulus 0.0016 0.0107 0.032
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0377 0.0377
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0462 0.1073
Schistosoma mansoni sugar transporter 0.0016 0.0107 0.0107
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0107 0.0366
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0362 0.0362
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0247 0.035
Plasmodium falciparum protein kinase 6 0.0474 0.7067 1
Onchocerca volvulus 0.0016 0.0107 0.032
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0214 0.3115 0.8958
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0366
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0411 0.0882
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0107 0.0249
Schistosoma mansoni protein kinase 0.0035 0.0395 0.0395
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0291 0.0991
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Trypanosoma brucei glucose transporter, putative 0.0035 0.0395 0.0917
Plasmodium falciparum thioredoxin reductase 0.0032 0.0362 0.0513
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.416 1
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.065 0.065
Schistosoma mansoni cpg binding protein 0.0028 0.0291 0.0291
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.1292 0.3716
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0214 0.3115 0.8958
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0156 0.0363
Toxoplasma gondii thioredoxin reductase 0.0094 0.1292 0.2771
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.0356 0.0356
Toxoplasma gondii sugar transporter ST3 0.0016 0.0107 0.023
Plasmodium falciparum calcium-dependent protein kinase 1 0.0035 0.0395 0.0559
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0366
Schistosoma mansoni sugar transporter 0.0016 0.0107 0.0107
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0214 0.3115 0.8958
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0768 0.2208
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0366
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0362 0.0842
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0761 0.345
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0212 0.0494
Echinococcus granulosus cpg binding protein 0.0029 0.0315 0.0315
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0212 0.0301
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0362 0.0842
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0377 0.1286
Echinococcus granulosus solute carrier family 22 0.0016 0.0107 0.0107
Trypanosoma brucei glucose transporter 1E 0.0035 0.0395 0.0917
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0377 0.0907
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0768 0.0768
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0395 0.0948
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0078 0.0265
Brugia malayi Doublecortin family protein 0.0019 0.0159 0.054
Onchocerca volvulus 0.0016 0.0107 0.032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0362 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0395 0.0395
Brugia malayi Sugar transporter family protein 0.0111 0.1563 0.5329
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0395 0.0395
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.065 0.1561
Schistosoma mansoni lipoxygenase 0.0053 0.068 0.068
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0016 0.0016
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0181 0.2614 0.3698
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0362 0.0777
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0784 0.2672
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.1965 0.5651
Schistosoma mansoni inositol monophosphatase 0.0036 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0366
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0362 0.0842
Plasmodium falciparum calcium-dependent protein kinase 5 0.0035 0.0395 0.0559
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0362 0.0362
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Schistosoma mansoni hypothetical protein 0.0019 0.0159 0.0159
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0035 0.0395 0.0847
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0768 0.3484
Plasmodium vivax calcium-dependent protein kinase, putative 0.0035 0.0395 0.0559
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0107 0.0487
Plasmodium vivax SET domain protein, putative 0.0029 0.0317 0.0448
Onchocerca volvulus 0.0019 0.0159 0.0472
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0684 0.1467
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0768 0.3484
Onchocerca volvulus 0.0016 0.0107 0.032
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.068 0.068
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0838 0.1948
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.078 0.078
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.065 0.065
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0159 0.0159
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.109 0.109
Loa Loa (eye worm) hypothetical protein 0.0019 0.0159 0.054
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0838 0.2857
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0362 0.0513
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.065 0.065
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0395 0.0948
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.065 0.2214
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0411 0.0989
Onchocerca volvulus 0.0016 0.0107 0.032
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0159 0.0159
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.1292 0.3003
Leishmania major protein kinase, putative 0.0035 0.0395 0.0917
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0366
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0016 0.0016
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0107 0.0366
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0317 0.0317
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0159 0.0159
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0181 0.2614 0.5605
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0159 0.0159
Brugia malayi hypothetical protein 0.0016 0.0107 0.0366
Brugia malayi hypothetical protein 0.0016 0.0107 0.0366
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0159 0.0159
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0107 0.0107
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0247 0.0594
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0362 0.8806
Plasmodium vivax sugar transporter, putative 0.0016 0.0107 0.0152
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1563 0.1563
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2934 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0362 0.0513
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.416 1
Echinococcus multilocularis tumor protein p63 0.0326 0.483 0.483
Plasmodium falciparum calcium-dependent protein kinase 2 0.0035 0.0395 0.0559
Onchocerca volvulus 0.0016 0.0107 0.032
Schistosoma mansoni cpg binding protein 0.0029 0.0315 0.0315
Onchocerca volvulus 0.0016 0.0107 0.032
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0395 0.0948
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0159 0.0224
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.4303 1
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0247 0.035
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0014 0.0048
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0377 0.0377
Mycobacterium ulcerans sugar transporter 0.0016 0.0107 0.0487
Loa Loa (eye worm) inositol-1 0.0036 0.0411 0.1402
Echinococcus granulosus solute carrier family 22 0.0016 0.0107 0.0107
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0395 0.0917
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0362 0.0871
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0212 0.0456
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0214 0.3115 0.8958
Brugia malayi MAP kinase sur-1 0.0051 0.065 0.2214
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.4303 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.008 0.109 0.3714
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.1563 0.1563
Loa Loa (eye worm) hypothetical protein 0.0019 0.0159 0.054
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Onchocerca volvulus 0.0019 0.0159 0.0472
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0035 0.0395 0.1345
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0159 0.054
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.4303 1
Schistosoma mansoni glucose transport protein 0.0111 0.1563 0.1563
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0366
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.065 0.1561
Echinococcus granulosus RUN 0.0019 0.0159 0.0159
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0362 0.0842
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0768 0.2618
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0035 0.0395 0.0559
Plasmodium falciparum proline--tRNA ligase 0.0039 0.0462 0.0653
Echinococcus multilocularis GPCR, family 2 0.0019 0.0159 0.0159
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0362 0.1643
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0838 0.2015
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0035 0.0395 0.1345
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0362 0.0871
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.416 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.416 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0761 0.0761
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0838 0.0838
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0012 0.0049 0.0221
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0159 0.054
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0291 0.0291
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0201 0.0482
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.0356 0.0356
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0395 0.0395
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0247 0.053
Brugia malayi Inositol-1 0.0036 0.0411 0.1402
Giardia lamblia Sugar-proton symporter 0.0016 0.0107 0.0258
Echinococcus multilocularis RUN 0.0019 0.0159 0.0159
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0212 0.5864
Trypanosoma brucei trypanothione reductase 0.0094 0.1292 0.3003
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0159 0.0224
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0159 0.054
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0366
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0838 0.1948
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0366
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0838 0.0838
Echinococcus multilocularis General substrate transporter 0.0096 0.1325 0.1325
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0768 0.0768
Echinococcus multilocularis solute carrier family 22 0.0016 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0035 0.0395 0.1345
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0247 0.0575
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0035 0.0395 0.0847
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0377 0.1085
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0107 0.0249
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0247 0.0711
Schistosoma mansoni protein kinase 0.0035 0.0395 0.0395
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.416 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0462 0.1073
Schistosoma mansoni glucose transporter 0.0016 0.0107 0.0107
Schistosoma mansoni microtubule-associated protein tau 0.0667 1 1
Schistosoma mansoni loxhd1 0.0019 0.0159 0.0159
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0035 0.0395 0.0559
Schistosoma mansoni lipoxygenase 0.0019 0.0159 0.0159
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.4303 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0362 0.0842
Brugia malayi hypothetical protein 0.0016 0.0107 0.0366
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0035 0.0395 0.0847
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.416 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0362 0.0842
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.043 0.043
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0355 0.1019
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0247 0.6827
Echinococcus granulosus General substrate transporter 0.0096 0.1325 0.1325
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0016 0.0107 0.0309
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.065 0.1561
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0107 0.0487
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0362 0.0842
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0629 0.1462
Trypanosoma brucei glucose transporter, putative 0.0035 0.0395 0.0917
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0247 0.0247
Trypanosoma brucei glucose transporter, putative 0.0035 0.0395 0.0917
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0107 0.0249
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0107 0.0487
Onchocerca volvulus 0.0016 0.0107 0.032
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0212 0.0963
Trypanosoma brucei glucose transporter, putative 0.0035 0.0395 0.0917
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0362 0.1643
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0494 0.1685
Schistosoma mansoni inositol monophosphatase 0.0036 0.0411 0.0411
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0039 0.0462 0.099
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0362 0.0842
Brugia malayi glutathione reductase 0.0094 0.1292 0.4405
Onchocerca volvulus 0.008 0.109 0.3247
Trypanosoma brucei glucose transporter 2A 0.0035 0.0395 0.0917
Entamoeba histolytica protein kinase, putative 0.0035 0.0395 0.0949
Schistosoma mansoni sugar transporter 0.0016 0.0107 0.0107
Plasmodium vivax proline--tRNA ligase, putative 0.0039 0.0462 0.0653
Schistosoma mansoni hypothetical protein 0.0111 0.1563 0.1563
Onchocerca volvulus 0.0016 0.0107 0.032
Schistosoma mansoni polycystin 1-related 0.0019 0.0159 0.0159
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.065 0.151
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0395 0.0395
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0317 0.0317
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0411 0.0956
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.019 0.0547
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0411 0.0411
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.065 0.151
Loa Loa (eye worm) hypothetical protein 0.018 0.261 0.8898
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0493 0.1145
Loa Loa (eye worm) hypothetical protein 0.0048 0.0595 0.2029
Plasmodium falciparum protein kinase 7 0.0315 0.4663 0.6598
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.109 0.109
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0362 0.0362
Echinococcus granulosus dnaJ subfamily B 0.0395 0.5874 0.5874
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0411 0.0989
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0212 0.0611
Trypanosoma cruzi hexose transporter 0.0035 0.0395 0.0917
Entamoeba histolytica hypothetical protein 0.0023 0.0212 0.0511
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0107 0.0366
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0212 0.5164
Schistosoma mansoni hypothetical protein 0.0019 0.0159 0.0159
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0362 0.1042
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0107 0.0258
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0761 0.2187
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0395 0.0917
Schistosoma mansoni hypothetical protein 0.0019 0.0159 0.0159
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0362 0.0842
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0159 0.054
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Plasmodium falciparum hexose transporter 0.0111 0.1563 0.2212
Loa Loa (eye worm) hypothetical protein 0.0027 0.0282 0.0962
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0366
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0247 0.0575
Plasmodium falciparum thioredoxin reductase 0.0094 0.1292 0.1828
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0247 0.1122
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0107 0.0249
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0366
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.065 0.151
Toxoplasma gondii sugar transporter ST2 0.0016 0.0107 0.023
Toxoplasma gondii sugar transporter ST1 0.0016 0.0107 0.023
Treponema pallidum NADH oxidase 0.0032 0.0362 0.0871
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0107 0.0249
Plasmodium falciparum glutathione reductase 0.0032 0.0362 0.0513
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.1563 0.1563
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0231 0.0789
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0107 0.0366
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0247 0.0575
Plasmodium vivax CDK-related protein kinase 6, putative 0.0474 0.7067 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.261 0.261
Plasmodium falciparum calcium-dependent protein kinase 3 0.0035 0.0395 0.0559
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0395 0.0948
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0655 0.2231
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0107 0.0258
Loa Loa (eye worm) hypothetical protein 0.0041 0.0494 0.1685
Schistosoma mansoni rab6-interacting 0.0019 0.0159 0.0159
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1563 0.1563
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0247 0.0247
Trichomonas vaginalis set domain proteins, putative 0.0229 0.3356 0.8067
Loa Loa (eye worm) hypothetical protein 0.0033 0.0377 0.1286
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0212 0.0611
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0493 0.1145
Leishmania major hypothetical protein, conserved 0.0016 0.0107 0.0249
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0595 0.0595
Toxoplasma gondii facilitative glucose transporter GT1 0.0111 0.1563 0.3353
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0214 0.3115 0.8958
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0768 0.1785
Echinococcus multilocularis solute carrier family 22 0.0016 0.0107 0.0107
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0107 0.0258

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4654 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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