Detailed information for compound 1379612

Basic information

Technical information
  • TDR Targets ID: 1379612
  • Name: 2-[(6-nitro-4H-1,3-benzodioxin-8-yl)methylsul fanyl]-3-phenylquinazolin-4-one
  • MW: 447.463 | Formula: C23H17N3O5S
  • H donors: 0 H acceptors: 3 LogP: 4.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1n(c2ccccc2)c(SCc2cc(cc3c2OCOC3)[N+](=O)[O-])nc2c1cccc2
  • InChi: 1S/C23H17N3O5S/c27-22-19-8-4-5-9-20(19)24-23(25(22)17-6-2-1-3-7-17)32-13-16-11-18(26(28)29)10-15-12-30-14-31-21(15)16/h1-11H,12-14H2
  • InChiKey: BXLSIZUEGSJLNT-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[(6-nitro-4H-1,3-benzodioxin-8-yl)methylsulfanyl]-3-phenyl-quinazolin-4-one
  • 2-[(6-nitro-4H-1,3-benzodioxin-8-yl)methylthio]-3-phenyl-4-quinazolinone
  • 2-[(6-nitro-4H-1,3-benzodioxin-8-yl)methylthio]-3-phenyl-quinazolin-4-one
  • MLS000417530
  • SMR000264526
  • T5337058

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0039 0.0467 0.0933
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1168 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1168 1
Brugia malayi endoprotease bli-4 precursor 0.0039 0.0467 0.0933
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.2633
Brugia malayi Cathepsin L-like precursor 0.002 0.0123 0.0246
Loa Loa (eye worm) fibroinase 0.002 0.0123 0.0246
Toxoplasma gondii subtilisin SUB9 0.0039 0.0467 0.0348
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.2633
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Onchocerca volvulus 0.0039 0.0467 0.5677
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0039 0.0467 0.0705
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0123 0.0246
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0123 0.0246
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0039 0.0467 0.5677
Brugia malayi Cathepsin L-like precursor 0.002 0.0123 0.0246
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Brugia malayi neuroendocrine convertase 1 precursor 0.0039 0.0467 0.0933
Plasmodium vivax subtilisin-like serine protease, putative 0.0039 0.0467 0.0348
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Echinococcus granulosus cathepsin l1 0.002 0.0123 0.0246
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.2633
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0123 0.0246
Onchocerca volvulus 0.002 0.0123 0.1495
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Toxoplasma gondii subtilisin SUB5 0.0039 0.0467 0.0348
Loa Loa (eye worm) ctsf protein 0.002 0.0123 0.0246
Mycobacterium leprae Possible secreted protease 0.0039 0.0467 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0123 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0467 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0123 1
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0039 0.0467 0.3291
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0123 0.0246
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1168 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.2633
Schistosoma mansoni survival motor neuron protein 0.0058 0.0822 1
Brugia malayi celfurPC protein 0.0039 0.0467 0.0933
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0039 0.0467 0.5677
Schistosoma mansoni furin-1 (S08 family) 0.0039 0.0467 0.5677
Toxoplasma gondii subtilisin SUB12 0.0039 0.0467 0.0348
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0039 0.0467 0.5677
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.1168 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0865 0.7098
Toxoplasma gondii subtilisin SUB7 0.0039 0.0467 0.0348
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0039 0.0467 0.3291
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1168 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.2633
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0467 0.0933
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0039 0.0467 0.0933
Brugia malayi Cathepsin L-like precursor 0.002 0.0123 0.0246
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.2633
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0467 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.2633
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0123 0.2633
Loa Loa (eye worm) cysteine protease 0.002 0.0123 0.0246
Entamoeba histolytica cysteine protease, putative 0.002 0.0123 1
Plasmodium falciparum subtilisin-like protease 3 0.0039 0.0467 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.2633
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0039 0.0467 0.0933
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1168 1
Onchocerca volvulus 0.002 0.0123 0.1495
Toxoplasma gondii subtilisin SUB8 0.0039 0.0467 0.0348
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0039 0.0467 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Onchocerca volvulus 0.002 0.0123 0.1495
Toxoplasma gondii subtilisin SUB10 0.0039 0.0467 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.2633
Onchocerca volvulus 0.002 0.0123 0.1495
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0123 0.0246
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0822 0.1644
Brugia malayi Subtilase family protein 0.0039 0.0467 0.0933
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0467 1
Echinococcus granulosus Furin 1 0.0039 0.0467 0.0933
Trypanosoma cruzi subtilisin peptidase 0.0039 0.0467 0.3291
Schistosoma mansoni site-1 peptidase (S08 family) 0.0039 0.0467 0.5677
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1168 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.2633
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0039 0.0467 0.3291
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0123 0.0246
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.1045 0.8824
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.2633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.2633
Schistosoma mansoni site-1 peptidase (S08 family) 0.0039 0.0467 0.5677
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.2633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.2633
Echinococcus granulosus membrane bound transcription factor site 1 0.0039 0.0467 0.0933
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0039 0.0467 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.2633
Plasmodium vivax subtilisin-like protease 2, putative 0.0039 0.0467 0.0348
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1168 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0467 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0123 0.0246
Leishmania major cathepsin L-like protease 0.0077 0.1168 1
Schistosoma mansoni hypothetical protein 0.0058 0.0822 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0123 0.1495
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1168 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.2633
Toxoplasma gondii subtilisin SUB4 0.0039 0.0467 0.0348
Brugia malayi hypothetical protein 0.0286 0.5004 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Brugia malayi proprotein convertase 2 0.0039 0.0467 0.0933
Echinococcus multilocularis 0.0039 0.0467 0.0705
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0123 0.0246
Toxoplasma gondii subtilisin SUB2 0.0039 0.0467 0.0348
Echinococcus multilocularis membrane bound transcription factor site 1 0.0039 0.0467 0.0705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.2633
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.5004 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1168 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0467 1
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0039 0.0467 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0123 0.2633
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.5004 1
Loa Loa (eye worm) proprotein convertase 2 0.0039 0.0467 0.0933
Leishmania major cathepsin L-like protease 0.0077 0.1168 1
Plasmodium vivax subtilisin-like protease 1 0.0557 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.2633
Echinococcus granulosus neuroendocrine convertase 2 0.0039 0.0467 0.0933
Leishmania major cathepsin L-like protease 0.0077 0.1168 1
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0039 0.0467 0.5
Echinococcus granulosus furin 0.0039 0.0467 0.0933
Onchocerca volvulus Cathepsin F homolog 0.002 0.0123 0.1495
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0123 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1168 1
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0039 0.0467 0.5677
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0123 0.1495
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0039 0.0467 0.0705
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0123 0.1495
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0039 0.0467 0.0933
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0039 0.0467 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Toxoplasma gondii subtilisin SUB6 0.0039 0.0467 0.0348
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0039 0.0467 0.5
Onchocerca volvulus 0.0058 0.0822 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.2633
Plasmodium falciparum subtilisin-like protease 2 0.0039 0.0467 0.0348
Echinococcus multilocularis Furin 1 0.0039 0.0467 0.0705
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Toxoplasma gondii subtilisin SUB11 0.0039 0.0467 0.0348
Loa Loa (eye worm) hypothetical protein 0.0039 0.0467 0.0933
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.2633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.2633
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1168 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1168 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0039 0.0467 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0123 0.1495
Toxoplasma gondii subtilisin SUB1 0.0557 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1168 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1168 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Onchocerca volvulus 0.002 0.0123 0.1495
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Echinococcus multilocularis neuroendocrine convertase 2 0.0039 0.0467 0.0705
Loa Loa (eye worm) hypothetical protein 0.0286 0.5004 1
Onchocerca volvulus 0.002 0.0123 0.1495
Leishmania major subtilisin-like serine peptidase 0.0039 0.0467 0.3291
Onchocerca volvulus 0.002 0.0123 0.1495
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.2633
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.2633
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0039 0.0467 0.5
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0039 0.0467 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0467 1
Loa Loa (eye worm) subtilase 0.0039 0.0467 0.0933
Loa Loa (eye worm) endoprotease bli-4 0.0039 0.0467 0.0933

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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