Detailed information for compound 1382103

Basic information

Technical information
  • TDR Targets ID: 1382103
  • Name: diethyl 2-methyl-6-oxo-1H-pyridine-3,5-dicarb oxylate
  • MW: 253.251 | Formula: C12H15NO5
  • H donors: 1 H acceptors: 4 LogP: 2.22 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cc(C(=O)OCC)c(nc1C)O
  • InChi: 1S/C12H15NO5/c1-4-17-11(15)8-6-9(12(16)18-5-2)10(14)13-7(8)3/h6H,4-5H2,1-3H3,(H,13,14)
  • InChiKey: FXDLBWVSYYXICK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-methyl-6-oxo-1H-pyridine-3,5-dicarboxylic acid diethyl ester
  • 2-keto-6-methyl-1H-pyridine-3,5-dicarboxylic acid diethyl ester
  • ZINC00208012
  • CBDivE_014864
  • Oprea1_326051
  • MLS000392043
  • SMR000102563

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lamin 0.0033 0.0473 0.0438
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.1777 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.1777 0.3386
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0189 0.4865 1
Leishmania major mitochondrial DNA polymerase beta 0.0326 0.8709 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0072 0.1575 0.8724
Loa Loa (eye worm) hypothetical protein 0.0072 0.1575 0.1575
Onchocerca volvulus 0.0033 0.0473 0.0146
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0351 0.037
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.085 0.14
Mycobacterium ulcerans hypothetical protein 0.0172 0.4378 0.8957
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0058 0.1194 0.2137
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0189 0.4865 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0351 0.0182
Echinococcus multilocularis GPCR, family 2 0.0017 0.0036 0.0036
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0028 0.0351 0.0331
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.395 0.395
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0351 0.0331
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0028 0.0351 0.0331
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.1069 0.119
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0473 0.0473
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0352 0.0332
Echinococcus multilocularis musashi 0.0033 0.0473 0.0473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.111 0.1078
Loa Loa (eye worm) hypothetical protein 0.0033 0.0473 0.0473
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0351 0.0331
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0537 0.2152
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0351 0.0182
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0351 0.0331
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0351 0.0978
Echinococcus multilocularis lamin dm0 0.0033 0.0473 0.0473
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.2258 0.2421
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0189 0.4865 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0591 0.0591
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0072 0.1575 0.3297
Loa Loa (eye worm) hypothetical protein 0.0028 0.0351 0.0351
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0351 0.0182
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0351 0.0362
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0096 0.2258 0.4415
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0351 0.0978
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0096 0.2258 0.4929
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.395 0.3928
Loa Loa (eye worm) hypothetical protein 0.0039 0.0666 0.0666
Echinococcus granulosus GPCR family 2 0.0017 0.0036 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.1194 0.1172
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0351 0.0362
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0351 0.0351
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0028 0.0351 0.0331
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0196 0.0196
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0351 0.0331
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.085 0.4134
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0845 0.0762
Schistosoma mansoni hypothetical protein 0.0183 0.4693 0.4673
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0278 0.0096
Trichomonas vaginalis ran, putative 0.0026 0.0278 0.0175
Brugia malayi Probable ClpP-like protease 0.0079 0.1777 0.2006
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0351 0.0978
Loa Loa (eye worm) acetyltransferase 0.0156 0.395 0.395
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0326 0.8709 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0028 0.0351 0.0331
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0131 0.3229 0.7252
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0845 0.0762
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0351 0.0331
Toxoplasma gondii hypothetical protein 0.0053 0.1034 0.5301
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0351 0.0331
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.1777 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0351 0.0331
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0537 0.04
Brugia malayi RNA, U transporter 1 0.0099 0.234 0.2654
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0351 0.037
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0351 0.0316
Toxoplasma gondii hypothetical protein 0.0027 0.0323 0.08
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.085 0.14
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0666 0.2969
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0351 0.0362
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0278 0.0278
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.085 0.4134
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0189 0.4865 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0058 0.1194 0.2137
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0351 0.0978
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0196 0.0196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.111 0.1078
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.2258 0.4415
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0351 0.0182
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.3889 0.4338
Loa Loa (eye worm) hypothetical protein 0.0195 0.5028 0.5028
Echinococcus multilocularis muscleblind protein 0.018 0.4626 0.4626
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.111 0.1237
Plasmodium falciparum acyl-CoA synthetase 0.0072 0.1575 0.8724
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0666 0.0725
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.1777 0.1777
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.1013 0.1013
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.2258 0.2421
Loa Loa (eye worm) hypothetical protein 0.0072 0.1575 0.1575
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0351 0.037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0351 0.037
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0351 0.037
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.1575 0.2953
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0036 0.0036
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0351 0.0182
Loa Loa (eye worm) hypothetical protein 0.0072 0.1575 0.1575
Echinococcus multilocularis snurportin 1 0.0372 1 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0351 0.037
Brugia malayi Muscleblind-like protein 0.018 0.4626 0.5288
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0196 0.0196
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0096 0.2258 0.4415
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0196 0.0184
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.018 0.4626 0.4626
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0036 0.0036
Entamoeba histolytica acyl-CoA synthetase, putative 0.0096 0.2258 0.4415
Schistosoma mansoni ran 0.0026 0.0278 0.0243
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0351 0.0362
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0845 0.0762
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0189 0.4865 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0323 0.08
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.3827 0.3827
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.1465 0.3034
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0189 0.4865 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.1127 0.1093
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.111 0.111
Brugia malayi AMP-binding enzyme family protein 0.0096 0.2258 0.2559
Loa Loa (eye worm) hypothetical protein 0.0096 0.2258 0.2258
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0352 0.0182
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0278 0.0096
Loa Loa (eye worm) hypothetical protein 0.0096 0.2258 0.2258
Echinococcus granulosus importin subunit beta 1 0.0035 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0054 0.1069 0.1069
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.085 0.4134
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.1194 0.1172
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0028 0.0351 0.0331
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0351 0.037
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0096 0.2258 0.4929
Schistosoma mansoni hypothetical protein 0.0372 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0096 0.2258 0.4415
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0323 0.08
Schistosoma mansoni ap endonuclease 0.0023 0.0196 0.0161
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.2258 0.2421
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0028 0.0351 0.0145
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0189 0.4865 1
Schistosoma mansoni lamin 0.0033 0.0473 0.0438
Leishmania major importin beta-1 subunit, putative 0.0028 0.0352 0.0182
Echinococcus granulosus intermediate filament protein 0.0033 0.0473 0.0473
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0049 0.0014
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0326 0.8709 1
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0352 0.0332
Loa Loa (eye worm) hypothetical protein 0.0072 0.1575 0.1575
Loa Loa (eye worm) hypothetical protein 0.0096 0.2258 0.2258
Entamoeba histolytica acyl-CoA synthetase, putative 0.0096 0.2258 0.4415
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0591 0.0639
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0278 0.0518
Schistosoma mansoni hypothetical protein 0.0183 0.4693 0.4673
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0666 0.0666
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.3889 0.4338
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0278 0.0518
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0537 0.0537
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0351 0.0351
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.1777 1
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0039 0.0666 0.2969
Schistosoma mansoni ran 0.0026 0.0278 0.0243
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0352 0.0332
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0666 0.0725
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0278 0.0518
Onchocerca volvulus 0.0096 0.2258 0.228
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0351 0.0331
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0351 0.0182
Brugia malayi Importin beta-1 subunit 0.0035 0.0537 0.0576
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0189 0.4865 0.4865
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0351 0.0331
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0351 0.0978
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.1777 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0742 0.3453
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0666 0.2969
Mycobacterium ulcerans hypothetical protein 0.0096 0.2258 0.4415
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0036
Onchocerca volvulus 0.0189 0.4865 0.5397
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0049 0.0049
Echinococcus granulosus geminin 0.0183 0.4693 0.4693
Leishmania major GTP-binding protein, putative 0.0026 0.0278 0.0096
Entamoeba histolytica hypothetical protein 0.0028 0.0352 0.0332
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.2258 0.4415
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0189 0.4865 1
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0742 0.1169
Echinococcus granulosus lamin dm0 0.0033 0.0473 0.0473
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0351 0.037
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0351 0.037
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0058 0.1194 0.1172
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.111 0.111
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0189 0.4865 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0036 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.2258 0.4415
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.1465 0.3034
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0189 0.4865 0.5564
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0096 0.2258 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0351 0.0362
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.395 0.4509
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0278 0.0279
Echinococcus multilocularis lamin 0.0033 0.0473 0.0473
Brugia malayi hypothetical protein 0.0036 0.0558 0.0601
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0326 0.8709 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0351 0.037
Loa Loa (eye worm) hypothetical protein 0.0326 0.8715 0.8715
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0351 0.0331
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0845 0.0762
Onchocerca volvulus 0.0326 0.8715 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.085 0.085
Schistosoma mansoni hypothetical protein 0.0037 0.0591 0.0557
Schistosoma mansoni ap endonuclease 0.0023 0.0196 0.0161
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.111 0.1078
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0096 0.2258 1
Echinococcus granulosus muscleblind protein 0.018 0.4626 0.4626
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0096 0.2258 0.4415
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.1465 0.3034
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0666 0.0725
Brugia malayi AMP-binding enzyme family protein 0.0096 0.2258 0.2559
Echinococcus granulosus lamin 0.0033 0.0473 0.0473
Echinococcus multilocularis geminin 0.0183 0.4693 0.4693
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0473 0.0473
Schistosoma mansoni intermediate filament proteins 0.0033 0.0473 0.0438
Brugia malayi hypothetical protein 0.0036 0.0558 0.0601
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0036 0.0036
Schistosoma mansoni importin beta-1 0.0035 0.0537 0.0502
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.1013 0.1952
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0351 0.0182
Loa Loa (eye worm) hypothetical protein 0.0072 0.1575 0.1575
Brugia malayi intermediate filament protein 0.0033 0.0473 0.0503
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0278 0.0278
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0278 0.0278
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.111 0.111
Brugia malayi hypothetical protein 0.0326 0.8715 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.1777 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0028 0.0351 0.0331
Loa Loa (eye worm) hypothetical protein 0.0035 0.0537 0.0537
Plasmodium vivax importin-beta 2, putative 0.0035 0.0537 0.2152
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0351 0.0145
Loa Loa (eye worm) hypothetical protein 0.018 0.4626 0.4626
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0195 0.5028 0.5592
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0742 0.1169
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0351 0.0182
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0351 0.037
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0028 0.0351 0.0145
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0351 0.0331
Loa Loa (eye worm) hypothetical protein 0.0032 0.0457 0.0457
Plasmodium falciparum importin beta, putative 0.0035 0.0537 0.2152
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0351 0.0331
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0473 0.0503
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.1777 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0351 0.0351
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0028 0.0351 0.0331
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0537 0.04
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0278 0.0175
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0351 0.0182
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0351 0.0351
Leishmania major hypothetical protein, conserved 0.0058 0.1194 0.1172
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.1013 0.1013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.111 0.111
Entamoeba histolytica Ran family GTPase 0.0026 0.0278 0.0175
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.111 0.111
Loa Loa (eye worm) hypothetical protein 0.0028 0.0351 0.0351
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.1777 0.1747
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.1465 0.3034
Mycobacterium tuberculosis Conserved hypothetical protein 0.0172 0.4378 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0189 0.4865 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.1013 0.1952
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.1777 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0278 0.0096
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.1013 0.3566
Brugia malayi AMP-binding enzyme family protein 0.0096 0.2258 0.2559
Brugia malayi N-terminal motif family protein 0.0195 0.5028 0.5752
Echinococcus multilocularis muscleblind protein 1 0.018 0.4626 0.4626
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0241 0.0106
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.1777 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.1777 0.7516
Entamoeba histolytica acyl-coA synthetase, putative 0.0096 0.2258 0.4415
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0323 0.08
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.1069 0.119
Onchocerca volvulus 0.0033 0.0473 0.0146
Schistosoma mansoni hypothetical protein 0.0039 0.0666 0.0632
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.1777 0.3386
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0351 0.0362
Loa Loa (eye worm) oxidoreductase 0.0028 0.0351 0.0351
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.1777 0.1777
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0154 0.3889 0.4338
Loa Loa (eye worm) hypothetical protein 0.0079 0.1777 0.1777
Mycobacterium ulcerans acetyl-CoA synthetase 0.0028 0.0351 0.0331
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.1069 0.1069

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1122 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 0.3162 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 1 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.3225 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 125.8925 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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