Detailed information for compound 1384350

Basic information

Technical information
  • TDR Targets ID: 1384350
  • Name: 2,2,2-trichloro-N-[(2,4,6-trimethylphenyl)car bamoyl]acetamide
  • MW: 323.603 | Formula: C12H13Cl3N2O2
  • H donors: 2 H acceptors: 2 LogP: 4.21 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1c(C)cc(cc1C)C)NC(=O)C(Cl)(Cl)Cl
  • InChi: 1S/C12H13Cl3N2O2/c1-6-4-7(2)9(8(3)5-6)16-11(19)17-10(18)12(13,14)15/h4-5H,1-3H3,(H2,16,17,18,19)
  • InChiKey: IRGKVHGXRKWNMU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,2,2-trichloro-N-[oxo-[(2,4,6-trimethylphenyl)amino]methyl]acetamide
  • 2,2,2-trichloro-N-[(2,4,6-trimethylphenyl)carbamoyl]ethanamide
  • 2,2,2-trichloro-N-[(mesitylamino)carbonyl]acetamide
  • MLS000674931
  • SMR000291961
  • ZINC00462644

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0571 0.3501 0.3339
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1363 0.918 0.9159
Entamoeba histolytica hypothetical protein 0.068 0.4281 0.7184
Loa Loa (eye worm) hypothetical protein 0.0217 0.0955 0.107
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1363 0.918 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0191 0.0774 0.0544
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0191 0.0774 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0636 0.3965 0.6622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0783 0.502 0.8497
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0647 0.4044 0.4405
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0302 0.1567 0.1357
Trypanosoma cruzi target of rapamycin kinase 3 0.0784 0.5023 0.5349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0599 0.3696 0.6142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.1567 0.2355
Loa Loa (eye worm) hypothetical protein 0.0117 0.0243 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0185 0.0726 0.0858
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0341 0.185 0.2859
Trichomonas vaginalis PIKK family atypical protein kinase 0.0783 0.502 0.8497
Loa Loa (eye worm) hypothetical protein 0.0334 0.1797 0.2013
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.083 0.5358 0.5723
Trichomonas vaginalis conserved hypothetical protein 0.0217 0.0955 0.1267
Onchocerca volvulus 0.0117 0.0243 0.5
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1363 0.918 0.9159
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0191 0.0774 0.0843
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0117 0.0243 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0537 0.3253 0.5354
Loa Loa (eye worm) hypothetical protein 0.0571 0.3501 0.3923
Echinococcus multilocularis geminin 0.0168 0.0605 0.037
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0352 0.1929 0.2999
Trichomonas vaginalis PIKK family atypical protein kinase 0.0901 0.5864 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0217 0.0955 0.073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0753 0.4807 0.8118
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0191 0.0774 0.0544
Trichomonas vaginalis PIKK family atypical protein kinase 0.0666 0.4178 0.7001
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0518 0.3121 0.5119
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0901 0.5864 0.5761
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0185 0.0726 0.054
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0191 0.0774 0.0944
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0191 0.0774 0.1163
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1363 0.918 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0191 0.0774 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.068 0.4281 0.7184
Entamoeba histolytica protein kinase rad3, putative 0.0302 0.1567 0.2355
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0302 0.1567 0.1482
Loa Loa (eye worm) phosphatidylinositol 3 0.0117 0.0243 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0753 0.4807 0.8118
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0191 0.0774 0.0594
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0901 0.5864 0.629
Loa Loa (eye worm) hypothetical protein 0.018 0.0694 0.0778
Trichomonas vaginalis PIKK family atypical protein kinase 0.0753 0.4807 0.8118
Echinococcus multilocularis serine protein kinase ATM 0.0302 0.1567 0.1357
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0334 0.1797 0.3404
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0191 0.0774 0.0544
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0117 0.0243 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0783 0.502 0.8497
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0901 0.5864 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0302 0.1567 0.1707
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0341 0.185 0.2859
Trichomonas vaginalis PIKK family atypical protein kinase 0.0783 0.502 0.8497
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0191 0.0774 0.0544
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0341 0.185 0.2859
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.0726 0.0858
Echinococcus granulosus serine protein kinase ATM 0.0302 0.1567 0.1357
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0452 0.2641 0.4266
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0217 0.0955 0.073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0901 0.5864 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0518 0.3121 0.5119
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0191 0.0774 0.0594
Loa Loa (eye worm) phosphatidylinositol 3 0.0901 0.5864 0.6572
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.083 0.5358 0.9099
Loa Loa (eye worm) hypothetical protein 0.0302 0.1567 0.1756
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0482 0.286 0.4655
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0302 0.1567 0.1482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0753 0.4807 0.8118
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0699 0.4413 0.7419
Leishmania major phosphatidylinositol 3-kinase, putative 0.0518 0.3121 0.5119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0636 0.3965 0.6622
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1363 0.918 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0901 0.5864 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0537 0.3253 0.5354
Loa Loa (eye worm) hypothetical protein 0.018 0.0694 0.0778
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0341 0.185 0.2859
Trichomonas vaginalis PIKK family atypical protein kinase 0.0699 0.4413 0.7419
Loa Loa (eye worm) hypothetical protein 0.0259 0.1259 0.141
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0699 0.4413 0.7419
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0191 0.0774 0.0944
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1477 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.06 0.3707 0.6162
Schistosoma mansoni fkbp-rapamycin associated protein 0.0302 0.1567 0.1357
Schistosoma mansoni hypothetical protein 0.0168 0.0605 0.037
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0224 0.1009 0.0857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0518 0.3121 0.5119
Schistosoma mansoni hypothetical protein 0.0217 0.0955 0.073
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0901 0.5864 1
Brugia malayi FAT domain containing protein 0.0217 0.0955 0.104
Loa Loa (eye worm) phosphatidylinositol 3 0.0699 0.4413 0.4946
Trichomonas vaginalis PIKK family atypical protein kinase 0.0684 0.4311 0.7236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0636 0.3965 0.6622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0783 0.502 0.8497
Entamoeba histolytica hypothetical protein 0.0302 0.1567 0.2355
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0302 0.1567 0.1707
Trichomonas vaginalis PIKK family atypical protein kinase 0.0567 0.3466 0.5734
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0341 0.185 0.1647
Onchocerca volvulus 0.0117 0.0243 0.5
Giardia lamblia GTOR 0.0901 0.5864 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0901 0.5864 0.5761
Trichomonas vaginalis PIKK family atypical protein kinase 0.0636 0.3962 0.6616
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.083 0.5358 0.5723
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.083 0.5358 0.5836
Loa Loa (eye worm) phosphatidylinositol kinase 0.0117 0.0243 0.0272
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0784 0.5023 0.8503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0753 0.4807 0.8118
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0191 0.0774 0.0544
Loa Loa (eye worm) hypothetical protein 0.0117 0.0243 0.0272
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0901 0.5864 0.5761
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0191 0.0774 0.0867
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0713 0.4516 0.7602
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0901 0.5864 1
Echinococcus granulosus geminin 0.0168 0.0605 0.037
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0421 0.2424 0.388
Leishmania major phosphatidylinositol 3-kinase, putative 0.0191 0.0774 0.0944
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0191 0.0774 0.0944
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.083 0.5358 0.9099
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0784 0.5023 0.8503
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.083 0.5358 0.9099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0482 0.286 0.4655
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0341 0.185 0.2859
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0901 0.5864 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0117 0.0243 0.0272
Toxoplasma gondii FATC domain-containing protein 0.0302 0.1567 0.2901
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0571 0.3501 0.3339
Loa Loa (eye worm) phosphatidylinositol 3 0.1327 0.8924 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.06 0.3707 0.6162
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0341 0.185 0.2859
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0901 0.5864 0.6388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0901 0.5864 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0117 0.0243 0.0265
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0302 0.1567 0.1357
Loa Loa (eye worm) phosphatidylinositol 3 0.0224 0.1009 0.113
Loa Loa (eye worm) hypothetical protein 0.0185 0.0726 0.0813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0518 0.3121 0.5119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0666 0.4178 0.7001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0518 0.3121 0.5119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0636 0.3962 0.6616
Trichomonas vaginalis conserved hypothetical protein 0.0334 0.1797 0.2764
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0901 0.5864 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0753 0.4807 0.8118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0753 0.4807 0.8118
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1363 0.918 0.9159
Mycobacterium leprae conserved hypothetical protein 0.0117 0.0243 0.5
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0267 0.132 0.1915
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.1567 0.2355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0235 0.1084 0.1497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0537 0.3253 0.5354
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0302 0.1567 0.1357
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0191 0.0774 0.1163
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0191 0.0774 0.0944
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.083 0.5358 0.9099
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.045 0.2631 0.4247
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0901 0.5864 0.629
Trichomonas vaginalis PIKK family atypical protein kinase 0.0636 0.3962 0.6616
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0191 0.0774 0.0944
Mycobacterium tuberculosis Conserved hypothetical protein 0.0117 0.0243 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0341 0.185 0.1798
Loa Loa (eye worm) phosphatidylinositol 3 0.0117 0.0243 0.0272
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0341 0.185 0.2015
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0191 0.0774 0.0944
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0571 0.3501 0.3814
Trichomonas vaginalis PIKK family atypical protein kinase 0.0636 0.3965 0.6622
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0302 0.1567 0.2355
Toxoplasma gondii target of rapamycin (TOR), putative 0.0753 0.4807 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0117 0.0243 0.0272
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1477 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0191 0.0774 0.0544
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0191 0.0774 0.0944
Schistosoma mansoni hypothetical protein 0.0168 0.0605 0.037

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 55.7 um PUBCHEM_BIOASSAY: Counterscreen assay for PERK inhibitors: Dose response cell-based high throughput screening assay to measure inhibition of PERK at 6 hours. (Class of assay: confirmatory) [Related pubchem assays: 1522, 1416 ] ChEMBL. No reference
EC50 (functional) > 55.7 um PUBCHEM_BIOASSAY: Dose response cell-based high-throughput screening assay to measure PERK inhibition. (Class of assay: confirmatory) [Related pubchem assays: 1416 ] ChEMBL. No reference
Potency (functional) 11.9955 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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