Detailed information for compound 1385118

Basic information

Technical information
  • TDR Targets ID: 1385118
  • Name: 3-[(2,4-dimethylphenyl)sulfonylamino]-1H-indo le-2-carboxylic acid
  • MW: 344.385 | Formula: C17H16N2O4S
  • H donors: 3 H acceptors: 4 LogP: 3.71 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)C)S(=O)(=O)Nc1c([nH]c2c1cccc2)C(=O)O
  • InChi: 1S/C17H16N2O4S/c1-10-7-8-14(11(2)9-10)24(22,23)19-15-12-5-3-4-6-13(12)18-16(15)17(20)21/h3-9,18-19H,1-2H3,(H,20,21)
  • InChiKey: KUNQCYZLOXEYIF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens growth factor, augmenter of liver regeneration Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hepatopoietin HPO2 Get druggable targets OG5_127535 All targets in OG5_127535
Neospora caninum hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania donovani ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Augmenter of liver regeneration Get druggable targets OG5_127535 All targets in OG5_127535
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis human hepatopoietin-like protein, putative Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum FAD-linked sulfhydryl oxidase ALR, putative Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0044 0.0044
Onchocerca volvulus 0.0035 0.0537 0.1889
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0718 0.1767
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0016 0.0158 0.0153
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0718 0.0718
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0722 1
Brugia malayi Augmenter of liver regeneration 0.0041 0.0676 0.1656
Schistosoma mansoni alpha-glucosidase 0.0169 0.3312 0.3312
Brugia malayi Importin beta-1 subunit 0.0035 0.054 0.1301
Schistosoma mansoni ran 0.0026 0.0351 0.0351
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.7482 1
Schistosoma mansoni importin beta-1 0.0035 0.054 0.054
Trypanosoma brucei glucosidase, putative 0.0044 0.0722 0.1722
Onchocerca volvulus 0.0043 0.0718 0.2791
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0722 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0722 1
Onchocerca volvulus 0.0043 0.0718 0.2791
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0722 0.0722
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0537 0.0663
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0158 0.0304
Toxoplasma gondii ABC1 family protein 0.0043 0.0718 0.0411
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1338 0.1338
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0722 1
Treponema pallidum polypeptide deformylase (def) 0.0459 0.929 0.5
Echinococcus granulosus cpg binding protein 0.0037 0.0578 0.0578
Leishmania major hypothetical protein, conserved 0.0041 0.0676 0.1582
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.3876 0.3876
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.0676 0.0364
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.054 0.0212
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0718 0.0411
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0722 0.1776
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0718 0.1711
Trypanosoma brucei Polypeptide deformylase 1 0.0175 0.3435 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0718 0.0907
Brugia malayi beta-lactamase family protein 0.0043 0.0718 0.1767
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0722 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0722 1
Plasmodium falciparum importin beta, putative 0.0035 0.054 0.0212
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0351 0.0589
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0404 0.4371
Loa Loa (eye worm) hypothetical protein 0.0035 0.054 0.0667
Plasmodium vivax peptide deformylase, putative 0.0459 0.929 1
Schistosoma mansoni ran 0.0026 0.0351 0.0351
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.054 0.1167
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.0676 0.1582
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0722 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0351 0.0351
Echinococcus multilocularis snurportin 1 0.0372 0.7482 0.7482
Leishmania major hypothetical protein, conserved 0.0043 0.0718 0.1711
Schistosoma mansoni cpg binding protein 0.0035 0.0537 0.0537
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0718 0.9935
Echinococcus granulosus snurportin 1 0.0372 0.7482 0.7482
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.0676 0.1582
Loa Loa (eye worm) hepatopoietin HPO2 0.0041 0.0676 0.085
Loa Loa (eye worm) hypothetical protein 0.0043 0.0718 0.0907
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0351 0.5
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.0676 0.0364
Trypanosoma brucei Peptide deformylase 2 0.0175 0.3435 1
Schistosoma mansoni hypothetical protein 0.0372 0.7482 0.7482
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0041 0.0676 0.0676
Brugia malayi RNA, U transporter 1 0.0099 0.1863 0.475
Plasmodium vivax importin-beta 2, putative 0.0035 0.054 0.0212
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0718 0.0718
Brugia malayi beta-lactamase family protein 0.0043 0.0718 0.1767
Echinococcus granulosus importin subunit beta 1 0.0035 0.054 0.054
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0722 1
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.0676 0.0364
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0175 0.3435 1
Schistosoma mansoni alpha glucosidase 0.0044 0.0722 0.0722
Mycobacterium ulcerans peptide deformylase 0.0459 0.929 1
Onchocerca volvulus 0.0043 0.0718 0.2791
Onchocerca volvulus 0.0114 0.2167 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0718 0.9935
Trichomonas vaginalis esterase, putative 0.0043 0.0718 0.9935
Echinococcus multilocularis cpg binding protein 0.0037 0.0578 0.0578
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0041 0.0676 0.0676
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0722 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0722 0.0722
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0459 0.929 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.5546 0.5632
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0459 0.929 1
Schistosoma mansoni cpg binding protein 0.0037 0.0578 0.0578
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0351 0.0589
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0404 0.4371
Brugia malayi CXXC zinc finger family protein 0.0035 0.0537 0.1294
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0718 0.9935
Toxoplasma gondii hypothetical protein 0.0459 0.929 1
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0459 0.929 0.5
Entamoeba histolytica Ran family GTPase 0.0026 0.0351 0.3419
Leishmania major importin beta-1 subunit, putative 0.0028 0.0404 0.0753
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.0676 0.0364
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0175 0.3435 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0722 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.3876 0.3876
Leishmania major polypeptide deformylase-like protein, putative 0.0175 0.3435 1
Plasmodium falciparum peptide deformylase 0.0459 0.929 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0351 0.0808
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0351 0.0413
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0722 0.1722
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0718 0.0718
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.3876 0.5153
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.0676 0.1582
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0722 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.3876 0.3876
Trypanosoma cruzi Peptide deformylase 2, putative 0.0175 0.3435 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0718 0.0907
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0722 0.0912
Schistosoma mansoni hypothetical protein 0.0494 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0718 0.9935
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.3876 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0722 0.1722
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0718 0.1711
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0722 0.1722
Trypanosoma cruzi Peptide deformylase 2, putative 0.0175 0.3435 1
Brugia malayi beta-lactamase 0.0043 0.0718 0.1767
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0718 0.0718
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0718 0.9935
Loa Loa (eye worm) beta-lactamase 0.0043 0.0718 0.0907
Loa Loa (eye worm) hypothetical protein 0.0043 0.0718 0.0907
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0404 0.0753
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0044 0.0044
Chlamydia trachomatis peptide deformylase 0.0459 0.929 0.5
Leishmania major GTP-binding protein, putative 0.0026 0.0351 0.0589
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0351 0.0589
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1176 0.0924
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0404 0.4371
Schistosoma mansoni cpg binding protein 0.0037 0.0578 0.0578
Trichomonas vaginalis ran, putative 0.0026 0.0351 0.3419
Entamoeba histolytica hypothetical protein 0.0028 0.0404 0.4371
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0718 0.1711
Loa Loa (eye worm) hypothetical protein 0.0043 0.0718 0.0907
Loa Loa (eye worm) hypothetical protein 0.0043 0.0718 0.0907
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.0676 0.1582
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0722 0.0416
Loa Loa (eye worm) hypothetical protein 0.0043 0.0718 0.0907
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.054 0.1167
Schistosoma mansoni alpha-glucosidase 0.0169 0.3312 0.3312
Echinococcus multilocularis importin subunit beta 1 0.0035 0.054 0.054

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 12.691 uM PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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