Detailed information for compound 138570

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 522.677 | Formula: C34H38N2O3
  • H donors: 0 H acceptors: 3 LogP: 9.18 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCOC(=O)c1ccc(cc1)n1nc(c2c1C(CCC2)Cc1cccc2c1cccc2)C=O
  • InChi: 1S/C34H38N2O3/c1-2-3-4-5-6-9-22-39-34(38)26-18-20-29(21-19-26)36-33-28(15-11-17-31(33)32(24-37)35-36)23-27-14-10-13-25-12-7-8-16-30(25)27/h7-8,10,12-14,16,18-21,24,28H,2-6,9,11,15,17,22-23H2,1H3
  • InChiKey: HFALKXKKKKVLBK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Oryctolagus cuniculus Progesterone receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor NHR-67 0.0014 0.0035 0.0072
Leishmania major glucose transporter, lmgt2 0.0073 0.063 0.8698
Echinococcus multilocularis synaptic vesicle 2 protein 0.0033 0.0226 0.0267
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0077 0.0091
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0196 0.0232
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.0194 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.063 0.274
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0101 0.0907 0.1862
Echinococcus granulosus glycyl tRNA synthetase 0.0013 0.0025 0.003
Brugia malayi nuclear hormone receptor 0.0014 0.0035 0.0072
Brugia malayi glycyl-tRNA synthetase 0.0013 0.0025 0.0051
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.016 0.1496 0.3071
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0196 0.1847
Loa Loa (eye worm) hypothetical protein 0.0111 0.1008 0.2069
Brugia malayi Calcitonin receptor-like protein seb-1 0.016 0.1496 0.3071
Echinococcus multilocularis dnaJ subfamily B 0.0851 0.8449 1
Echinococcus multilocularis neuropeptide s receptor 0.0512 0.5039 0.5964
Brugia malayi intermediate filament protein 0.0062 0.0518 0.1064
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Schistosoma mansoni glucose transport protein 0.0237 0.2273 0.269
Echinococcus multilocularis musashi 0.0062 0.0518 0.0614
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0392 0.0804
Loa Loa (eye worm) hypothetical protein 0.0033 0.0223 0.0458
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0045 0.0343 0.604
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0053 0.0423 0.1826
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0071 0.0606 1
Entamoeba histolytica hypothetical protein 0.0027 0.016 0.2271
Loa Loa (eye worm) hypothetical protein 0.0058 0.0472 0.0968
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0196 0.0232
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0083 0.0724 1
Onchocerca volvulus 0.0033 0.0226 0.219
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0067 0.0137
Echinococcus granulosus FTZ F1 alpha 0.003 0.0196 0.0232
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.088 0.1807
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0071 0.0606 0.0717
Schistosoma mansoni importin beta-1 0.0033 0.0223 0.0264
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.088 0.1042
Brugia malayi RNA binding protein 0.0062 0.0517 0.106
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0053 0.0423 0.5838
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0196 0.0232
Echinococcus granulosus short transient receptor potential channel 6 0.0073 0.063 0.0746
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0196 0.0402
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0033 0.0226 0.0201
Leishmania major importin beta-1 subunit, putative 0.0027 0.016 0.2213
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0067 0.0079
Leishmania major lysyl-tRNA synthetase, putative 0.0053 0.0423 0.5838
Brugia malayi major facilitator superfamily protein 0.0033 0.0226 0.0464
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0517 0.106
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0013 0.0025 0.0441
Loa Loa (eye worm) hypothetical protein 0.0038 0.0269 0.0553
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0073 0.062 0.1273
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0071 0.0606 0.1243
Loa Loa (eye worm) pigment dispersing factor receptor c 0.016 0.1496 0.3071
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0226 0.0956
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0052 0.0062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0035 0.0041
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0223 0.308
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0196 0.0402
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0072
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0464
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0196 0.0232
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0464
Echinococcus multilocularis General substrate transporter 0.0204 0.1938 0.2294
Echinococcus multilocularis neuropeptide receptor A26 0.0512 0.5039 0.5964
Brugia malayi hypothetical protein 0.0014 0.0035 0.0072
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0013 0.0025 0.0051
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0399 0.0472
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0027 0.0078
Echinococcus multilocularis glycyl tRNA synthetase 0.0013 0.0025 0.003
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.0402
Toxoplasma gondii facilitative glucose transporter GT1 0.0237 0.2273 0.3433
Schistosoma mansoni hypothetical protein 0.0101 0.0907 0.1074
Schistosoma mansoni nuclear receptor 0.0014 0.0035 0.0041
Plasmodium falciparum calcium-dependent protein kinase 2 0.0073 0.0621 0.0597
Brugia malayi nuclear hormone receptor 0.003 0.0196 0.0402
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0012 0.0009 0.013
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0035 0.0072
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0073 0.062 0.0734
Brugia malayi nuclear receptor RXR 0.0016 0.0052 0.0107
Trypanosoma brucei sugar transporter, putative 0.0033 0.0226 0.312
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0073 0.062 0.0734
Brugia malayi ecdysone receptor 0.0014 0.0035 0.0072
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0033 0.0226 0.312
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0073 0.0621 0.0597
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0052 0.0107
Schistosoma mansoni hypothetical protein 0.0352 0.3435 0.4065
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.088 0.1042
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Giardia lamblia Lysyl-tRNA synthetase 0.0053 0.0423 0.6849
Leishmania major protein kinase, putative 0.0073 0.062 0.8568
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0464
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0196 0.0232
Brugia malayi Sugar transporter family protein 0.0237 0.2273 0.4664
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.088 0.1042
Loa Loa (eye worm) hypothetical protein 0.0073 0.062 0.1273
Chlamydia trachomatis lysine--tRNA ligase 0.0053 0.0423 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0517 0.106
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0237 0.2273 0.269
Schistosoma mansoni hypothetical protein 0.0051 0.0399 0.0472
Brugia malayi Major Facilitator Superfamily protein 0.0033 0.0226 0.0464
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0237 0.2273 0.269
Schistosoma mansoni zinc finger protein 0.0014 0.0035 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Trypanosoma brucei glucose transporter 1E 0.0073 0.063 0.8698
Trypanosoma brucei glucose transporter, putative 0.0073 0.063 0.8698
Loa Loa (eye worm) hypothetical protein 0.0029 0.0182 0.0374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0196 0.0402
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Echinococcus multilocularis GPCR, family 2 0.0051 0.0399 0.0472
Echinococcus granulosus transient receptor potential gamma protein 0.0111 0.1008 0.1194
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0035 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0196 0.0402
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0256 1
Schistosoma mansoni cpg binding protein 0.0063 0.0526 0.0623
Trichomonas vaginalis importin beta-1, putative 0.0027 0.016 0.0666
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0067 0.118
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0196 0.0232
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0256 0.4511
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0013 0.0025 0.0345
Leishmania major hypothetical protein, conserved 0.0012 0.0009 0.013
Schistosoma mansoni transient receptor potential channel 0.0111 0.1008 0.1194
Toxoplasma gondii lysine-tRNA ligase 0.0053 0.0423 0.0638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0567 0.0671
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.0402
Schistosoma mansoni transient receptor potential channel 4 0.0111 0.1008 0.1194
Echinococcus granulosus snurportin 1 0.0352 0.3435 0.4065
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0072
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0083 0.0724 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0053 0.0423 0.05
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.0357 0.1536
Echinococcus granulosus calcium dependent protein kinase 0.0068 0.0575 0.0681
Loa Loa (eye worm) hypothetical protein 0.007 0.0593 0.1217
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0226 0.0956
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.0402
Trichomonas vaginalis sugar transporter, putative 0.0073 0.063 0.274
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.0402
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0149 0.0176
Echinococcus granulosus cpg binding protein 0.0063 0.0526 0.0623
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0196 0.0402
Brugia malayi Importin beta-1 subunit 0.0033 0.0223 0.0458
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0072
Brugia malayi hypothetical protein 0.0057 0.0465 0.0955
Schistosoma mansoni hypothetical protein 0.0051 0.0399 0.0472
Brugia malayi major facilitator superfamily protein 0.0033 0.0226 0.0464
Trichomonas vaginalis sugar transport protein, putative 0.0033 0.0226 0.0956
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0027 0.0078
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0035 0.0041
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0033 0.0226 0.3984
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0226 0.0956
Trichomonas vaginalis ran, putative 0.0024 0.0135 0.0556
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0035 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0078
Echinococcus granulosus TRP transient receptor potential channel 0.0041 0.0307 0.0363
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.062 0.2699
Echinococcus granulosus lamin dm0 0.0062 0.0518 0.0614
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0465 0.0442
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0135 0.0111
Brugia malayi steroid hormone receptor 0.003 0.0196 0.0402
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0035 0.0041
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0567 1
Schistosoma mansoni hypothetical protein 0.0051 0.0399 0.0472
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0071 0.0606 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0226 0.0956
Onchocerca volvulus 0.0101 0.0907 1
Schistosoma mansoni hypothetical protein 0.0051 0.0399 0.0472
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Schistosoma mansoni glucose transporter 0.0033 0.0226 0.0267
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0196 0.0232
Plasmodium vivax proline--tRNA ligase, putative 0.0083 0.0724 0.0701
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0383 0.374 0.5649
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0071 0.0606 0.0717
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.004 0.0048
Onchocerca volvulus 0.0062 0.0518 0.5544
Schistosoma mansoni thyroid hormone receptor 0.003 0.0196 0.0232
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0196 0.0232
Leishmania major hypothetical protein, conserved 0.0033 0.0226 0.312
Trypanosoma brucei THT1 - hexose transporter, putative 0.0073 0.063 0.8698
Brugia malayi hypothetical protein 0.0016 0.0052 0.0107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0072
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0071 0.0606 0.1243
Loa Loa (eye worm) DR-78 0.0014 0.0035 0.0072
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.0402
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.0465 0.0703
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0033 0.0226 0.3984
Echinococcus multilocularis geminin 0.0354 0.3451 0.4084
Trypanosoma brucei glucose transporter, putative 0.0073 0.063 0.8698
Brugia malayi hypothetical protein 0.0037 0.0262 0.0537
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0013 0.0025 0.0345
Trichomonas vaginalis conserved hypothetical protein 0.0237 0.2273 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.088 0.1042
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0067 0.0079
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0517 0.0611
Schistosoma mansoni glucose transport protein 0.0237 0.2273 0.269
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0107
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0071 0.0606 0.2634
Brugia malayi Sugar transporter family protein 0.0033 0.0226 0.0464
Loa Loa (eye worm) hypothetical protein 0.0029 0.0182 0.0374
Schistosoma mansoni intermediate filament proteins 0.0062 0.0518 0.0614
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0399 0.0819
Mycobacterium tuberculosis Conserved hypothetical protein 0.0012 0.0009 0.0166
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0196 0.0232
Chlamydia trachomatis proline--tRNA ligase 0.0025 0.0143 0.2978
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0067 0.0101
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0237 0.2273 0.269
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0196 0.0232
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0009 0.013
Schistosoma mansoni hypothetical protein 0.0851 0.8449 1
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0013 0.0025 0.0051
Loa Loa (eye worm) major facilitator superfamily transporter 0.0033 0.0226 0.0464
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0027 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0078
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0196 0.0232
Schistosoma mansoni ran 0.0024 0.0135 0.016
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0035 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0196 0.0402
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0067 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0078
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0567 0.0671
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0256 0.0303
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0052 0.0107
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0035 0.0072
Schistosoma mansoni hypothetical protein 0.0237 0.2273 0.269
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0073 0.062 0.1273
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Leishmania major glucose transporter/membrane transporter D2, putative 0.0073 0.063 0.8698
Echinococcus granulosus geminin 0.0354 0.3451 0.4084
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0256 0.1089
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0035 0.0072
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0196 0.0232
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0196 0.0232
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0465 0.6429
Brugia malayi conserved hypotetical protein 0.0014 0.0035 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0078
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0033 0.0226 0.3984
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Trypanosoma brucei glucose transporter, putative 0.0073 0.063 0.8698
Mycobacterium ulcerans sugar transporter 0.0033 0.0226 0.3984
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0073 0.062 0.0734
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.016 0.2213
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0196 0.0232
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0237 0.2273 0.269
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0025 0.0143 0.2529
Onchocerca volvulus 0.006 0.0492 0.5239
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0256 0.3533
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0135 0.1869
Trypanosoma cruzi glucose transporter, putative 0.0033 0.0226 0.312
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0035 0.0041
Plasmodium vivax calcium-dependent protein kinase, putative 0.0073 0.0621 0.0597
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0013 0.0025 0.0345
Plasmodium vivax lysine--tRNA ligase, putative 0.0053 0.0423 0.0399
Schistosoma mansoni nuclear hormone receptor 0.003 0.0196 0.0232
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0465 0.6429
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0237 0.2273 0.269
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0062 0.0518 0.1064
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0196 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0078
Schistosoma mansoni hypothetical protein 0.0109 0.0988 0.117
Onchocerca volvulus 0.0033 0.0226 0.219
Loa Loa (eye worm) hypothetical protein 0.0495 0.4873 1
Leishmania major myo-inositol/proton symporter (MIT) 0.0033 0.0226 0.312
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0013 0.0025 0.0441
Loa Loa (eye worm) RNA binding protein 0.0062 0.0517 0.106
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0041 0.0307 0.0363
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0013 0.0025 0.0413
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0196 0.0232
Echinococcus granulosus Sugar transporter ERD6 protein 0.0033 0.0226 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0078
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0052 0.0107
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0067 0.0079
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0196 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.063 0.274
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0464
Loa Loa (eye worm) sugar transporter 0.0033 0.0226 0.0464
Onchocerca volvulus 0.0033 0.0226 0.219
Schistosoma mansoni lamin 0.0062 0.0518 0.0614
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0071 0.0606 0.9752
Schistosoma mansoni nuclear receptor 0.0014 0.0035 0.0041
Toxoplasma gondii protein kinase, putative 0.0669 0.662 1
Entamoeba histolytica hypothetical protein 0.0053 0.0423 0.6679
Treponema pallidum prolyl-tRNA synthetase 0.0025 0.0143 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0464
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0196 0.0402
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Echinococcus multilocularis calcium dependent protein kinase 0.0068 0.0575 0.0681
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0399 0.0819
Loa Loa (eye worm) major facilitator superfamily transporter 0.0033 0.0226 0.0464
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.0988 0.2028
Onchocerca volvulus 0.0033 0.0226 0.219
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0052 0.0062
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0035 0.0041
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0083 0.0724 1
Entamoeba histolytica protein kinase, putative 0.0073 0.062 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0135 0.0204
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0051
Onchocerca volvulus 0.003 0.0196 0.1847
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0035 0.0072
Brugia malayi nuclear receptor NHR-88 0.0014 0.0035 0.0072
Echinococcus multilocularis short transient receptor potential channel 6 0.0073 0.063 0.0746
Trichomonas vaginalis glucose transporter, putative 0.0073 0.063 0.274
Onchocerca volvulus 0.0033 0.0226 0.219
Schistosoma mansoni glycyl-tRNA synthetase 0.0013 0.0025 0.003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0052 0.0062
Loa Loa (eye worm) hypothetical protein 0.0053 0.0423 0.0867
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0196 0.1847
Plasmodium falciparum proline--tRNA ligase 0.0083 0.0724 0.0701
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0073 0.062 0.0734
Echinococcus granulosus tar DNA binding protein 0.0062 0.0517 0.0611
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0256 0.3877
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0078
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0237 0.2273 0.269
Plasmodium falciparum calcium-dependent protein kinase 3 0.0073 0.0621 0.0597
Plasmodium falciparum hexose transporter 0.0237 0.2273 0.2253
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.1029 0.1555
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0035 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0135 0.0278
Schistosoma mansoni inositol monophosphatase 0.0036 0.0256 0.0303
Loa Loa (eye worm) hypothetical protein 0.0109 0.0988 0.2028
Toxoplasma gondii sugar transporter ST2 0.0033 0.0226 0.0341
Onchocerca volvulus 0.0062 0.0518 0.5544
Entamoeba histolytica protein kinase, putative 0.0073 0.062 1
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0013 0.0025 0.0051
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0227 0.0466
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0196 0.0402
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0072
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Onchocerca volvulus 0.0033 0.0226 0.219
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0073 0.062 0.0734
Echinococcus granulosus Threonyl tRNA synthetase C 0.0013 0.0025 0.003
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0073 0.062 0.0734
Schistosoma mansoni hypothetical protein 0.0026 0.0149 0.0176
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0033 0.0226 0.0267
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0196 0.1847
Trypanosoma brucei glucose transporter, putative 0.0073 0.063 0.8698
Echinococcus granulosus lamin 0.0062 0.0518 0.0614
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0135 0.19
Onchocerca volvulus 0.0033 0.0226 0.219
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0256 0.0303
Plasmodium falciparum lysine--tRNA ligase 0.0053 0.0423 0.0399
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0237 0.2273 0.269
Toxoplasma gondii sugar transporter ST3 0.0033 0.0226 0.0341
Brugia malayi nuclear receptor NHR-88 0.003 0.0196 0.0402
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0067 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0196 0.0402
Brugia malayi TAR-binding protein 0.0062 0.0517 0.106
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0072
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0045 0.0343 0.5656
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0196 0.0232
Echinococcus multilocularis survival motor neuron protein 1 0.0495 0.4873 0.5767
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0067 0.0924
Plasmodium vivax importin-beta 2, putative 0.0033 0.0223 0.0198
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0399 0.0472
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0226 0.312
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Brugia malayi Major Facilitator Superfamily protein 0.0033 0.0226 0.0464
Brugia malayi ecdysteroid receptor 0.003 0.0196 0.0402
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0517 0.0611
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.0402
Echinococcus granulosus neuropeptide receptor A26 0.0512 0.5039 0.5964
Schistosoma mansoni hypothetical protein 0.0354 0.3451 0.4084
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.088 0.1042
Plasmodium vivax hexose transporter 0.0237 0.2273 0.2253
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Brugia malayi Major Facilitator Superfamily protein 0.0033 0.0226 0.0464
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0073 0.062 0.1273
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0053 0.0423 0.7454
Trichomonas vaginalis helicase, putative 0.0014 0.0027 0.0078
Onchocerca volvulus 0.0033 0.0226 0.219
Loa Loa (eye worm) hypothetical protein 0.0071 0.0606 0.1243
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0067 0.0924
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0012 0.0009 0.013
Brugia malayi hypothetical protein 0.0033 0.0226 0.0464
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0009 0.013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0067 0.0079
Echinococcus granulosus survival motor neuron protein 1 0.0495 0.4873 0.5767
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.088 0.1042
Echinococcus granulosus solute carrier family 22 0.0033 0.0226 0.0267
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0399 0.0472
Onchocerca volvulus 0.0033 0.0226 0.219
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0135 0.1869
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0073 0.0621 0.0597
Schistosoma mansoni survival motor neuron protein 0.0101 0.0907 0.1074
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0075 0.0153
Onchocerca volvulus 0.0033 0.0226 0.219
Plasmodium falciparum calcium-dependent protein kinase 5 0.0073 0.0621 0.0597
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0383 0.374 0.3724
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0464
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0464
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0033 0.0226 0.3984
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0072
Trypanosoma brucei glucose transporter, putative 0.0073 0.063 0.8698
Plasmodium falciparum calcium-dependent protein kinase 4 0.0073 0.0621 0.0597
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0067 0.0924
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0352 0.3435 0.7049
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0256 0.0386
Schistosoma mansoni hypothetical protein 0.0354 0.3451 0.4084
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0013 0.0025 0.0069
Brugia malayi Cytochrome P450 family protein 0.005 0.0392 0.0804
Schistosoma mansoni transient receptor potential channel 0.0073 0.063 0.0746
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0077 0.0158
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0035 0.0041
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0256 0.1089
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0567 0.7832
Schistosoma mansoni sugar transporter 0.0033 0.0226 0.0267
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0135 0.016
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0083 0.0724 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0073 0.0621 0.0938
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0072
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0072
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0135 0.1869
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0073 0.062 0.0734
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0073 0.0621 0.0938
Onchocerca volvulus 0.0033 0.0226 0.219
Schistosoma mansoni ran 0.0024 0.0135 0.016
Brugia malayi Sugar transporter family protein 0.0033 0.0226 0.0464
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0035 0.0041
Onchocerca volvulus 0.0033 0.0226 0.219
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0517 0.0611
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0196 0.0232
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0464
Schistosoma mansoni cpg binding protein 0.006 0.0492 0.0582
Schistosoma mansoni inositol monophosphatase 0.0036 0.0256 0.0303
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0517 0.0611
Echinococcus multilocularis transient receptor potential ion channel A 0.0107 0.0971 0.1149
Echinococcus granulosus solute carrier family 22 0.0033 0.0226 0.0267
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.004 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0196 0.0402
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0256 0.3533
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0196 0.0232
Echinococcus granulosus intermediate filament protein 0.0062 0.0518 0.0614
Schistosoma mansoni protein kinase 0.0073 0.062 0.0734
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0067 0.0101
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.0465 0.6429
Brugia malayi Transient-receptor-potential like protein 0.0041 0.0307 0.0629
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0107
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0196 0.0232
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0033 0.0226 0.0267
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0072
Trypanosoma cruzi hexose transporter, putative 0.004 0.0295 0.4072
Schistosoma mansoni sugar transporter 0.0033 0.0226 0.0267
Echinococcus granulosus GPCR family 2 0.0051 0.0399 0.0472
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0196 0.0402
Trypanosoma brucei glucose transporter 2A 0.0073 0.063 0.8698
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0399 0.0819
Brugia malayi Inositol-1 0.0036 0.0256 0.0525
Brugia malayi CXXC zinc finger family protein 0.006 0.0492 0.1009
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Onchocerca volvulus 0.0033 0.0226 0.219
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0196 0.0232
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0027 0.0078
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0035 0.0041
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0035 0.0041
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.016 0.0666
Echinococcus multilocularis transient receptor potential gamma protein 0.0111 0.1008 0.1194
Echinococcus granulosus short transient receptor potential channel 6 0.0073 0.063 0.0746
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0517 0.0611
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0067 0.0924
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0237 0.2273 0.269
Trypanosoma cruzi hexose transporter, putative 0.0073 0.063 0.8698
Trypanosoma cruzi hexose transporter, putative 0.0073 0.063 0.8698
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0196 0.0402
Loa Loa (eye worm) hypothetical protein 0.0061 0.0507 0.104
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0107
Plasmodium falciparum importin beta, putative 0.0033 0.0223 0.0198
Echinococcus granulosus solute carrier family 22 0.0033 0.0226 0.0267
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0035 0.0072
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0073 0.0621 0.0597
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0196 0.0402
Trichomonas vaginalis glucose transporter, putative 0.0073 0.063 0.274
Trypanosoma brucei THT1 - hexose transporter, putative 0.0073 0.063 0.8698
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0073 0.062 0.0734
Leishmania major glucose transporter, lmgt3 0.0073 0.063 0.8698
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0227 0.0466
Schistosoma mansoni transient receptor potential channel 0.0073 0.063 0.0746
Trichomonas vaginalis sugar transporter, putative 0.0073 0.063 0.274
Schistosoma mansoni sugar transporter 0.0033 0.0226 0.0267
Echinococcus multilocularis solute carrier family 22 0.0033 0.0226 0.0267
Brugia malayi hypothetical protein 0.0016 0.0052 0.0107
Echinococcus multilocularis solute carrier family 22 0.0033 0.0226 0.0267
Mycobacterium ulcerans hypothetical protein 0.0012 0.0009 0.0166
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0135 0.0111
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0218 0.3593
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0196 0.0402
Giardia lamblia Sugar-proton symporter 0.0033 0.0226 0.346
Brugia malayi hypothetical protein 0.0014 0.0035 0.0072
Onchocerca volvulus 0.0033 0.0226 0.219
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0196 0.0402
Brugia malayi tailless protein 0.0014 0.0035 0.0072
Echinococcus granulosus General substrate transporter 0.0204 0.1938 0.2294
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0223 0.0264
Onchocerca volvulus Putative transporter 0.0033 0.0226 0.219
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0067 0.0924
Brugia malayi isocitrate dehydrogenase 0.0017 0.0067 0.0137
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0077 0.0091
Schistosoma mansoni protein kinase 0.0073 0.062 0.0734
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0029 0.0184 0.0378
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0053 0.0423 0.7454
Trypanosoma cruzi hexose transporter, putative 0.0073 0.063 0.8698
Schistosoma mansoni lysyl-tRNA synthetase 0.0053 0.0423 0.05
Trypanosoma cruzi hexose transporter 0.0073 0.063 0.8698
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0196 0.0402
Echinococcus granulosus solute carrier family 22 0.0033 0.0226 0.0267
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0517 0.0611
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0073 0.063 0.274
Echinococcus multilocularis solute carrier family 22 0.0033 0.0226 0.0267
Loa Loa (eye worm) intermediate filament protein 0.0062 0.0518 0.1064
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Trypanosoma brucei glucose transporter, putative 0.0073 0.063 0.8698
Echinococcus granulosus importin subunit beta 1 0.0033 0.0223 0.0264
Entamoeba histolytica Ran family GTPase 0.0024 0.0135 0.1853
Trichomonas vaginalis myo-inositol transporter, putative 0.0033 0.0226 0.0956
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0223 0.0337
Loa Loa (eye worm) hypothetical protein 0.0062 0.0518 0.1064
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0107
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0149 0.0176
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Echinococcus multilocularis lamin dm0 0.0062 0.0518 0.0614
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0073 0.0621 0.0938
Echinococcus multilocularis solute carrier family 22 0.0033 0.0226 0.0267
Plasmodium falciparum protein kinase 7 0.0669 0.662 0.6612
Echinococcus granulosus neuropeptide s receptor 0.0512 0.5039 0.5964
Loa Loa (eye worm) hypothetical protein 0.0071 0.0606 0.1243
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0035 0.0041
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0067 0.0137
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.016 0.0666
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0073 0.062 0.8568
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0196 0.0232
Schistosoma mansoni thyroid hormone receptor 0.003 0.0196 0.0232
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0013 0.0025 0.0038
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0072
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0196 0.0232
Brugia malayi Cam kinase protein 1 0.0073 0.062 0.1273
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0464
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0464
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0135 0.0278
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.004 0.0048
Leishmania major hypothetical protein, conserved 0.0012 0.0009 0.013
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0464
Brugia malayi RNA, U transporter 1 0.0094 0.0835 0.1714
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.0402
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0013 0.0025 0.003
Echinococcus granulosus synaptic vesicle 2 protein 0.0033 0.0226 0.0267
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0012 0.0009 0.0014
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0035 0.0072
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0567 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0196 0.0402
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.088 0.1807
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0223 0.308
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0399 0.0472
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0067 0.0079
Plasmodium falciparum calcium-dependent protein kinase 1 0.0073 0.0621 0.0597
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0035 0.0041
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0492 0.1009
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0135 0.016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.1166 0.138
Echinococcus granulosus dnaJ subfamily B 0.0851 0.8449 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0464
Leishmania major threonyl-tRNA synthetase, putative 0.0013 0.0025 0.0345
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0035 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0078
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0067 0.0079
Trypanosoma cruzi sugar transporter, putative 0.0033 0.0226 0.312
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0083 0.0724 1
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0013 0.0025 0.0441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0196 0.0402
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0256 0.3533
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0256 0.1089
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0196 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0196 0.0402
Schistosoma mansoni protein kinase 0.0073 0.062 0.0734
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0464
Schistosoma mansoni glucose transport protein 0.0237 0.2273 0.269
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0107
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0012 0.0009 0.013
Echinococcus granulosus transient receptor potential ion channel A 0.0107 0.0971 0.1149
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0071 0.0606 0.0717
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0218 0.3837
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0567 1
Toxoplasma gondii transporter, major facilitator family protein 0.0033 0.0226 0.0341
Loa Loa (eye worm) sugar transporter 0.0237 0.2273 0.4664
Loa Loa (eye worm) hypothetical protein 0.0041 0.0307 0.0629
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0052 0.0062
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0464
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0072
Brugia malayi hypothetical protein 0.0495 0.4873 1
Brugia malayi lysyl-tRNA synthetase 0.0053 0.0423 0.0867
Giardia lamblia Hexose transporter 0.0033 0.0226 0.346
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0226 0.0956
Plasmodium vivax CDK-related protein kinase 6, putative 0.1005 1 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.0194 0.0229
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0567 0.0671
Brugia malayi hypothetical protein 0.0033 0.0226 0.0464
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.004 0.0048
Echinococcus multilocularis snurportin 1 0.0352 0.3435 0.4065
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0517 0.106
Schistosoma mansoni sugar transporter 0.0033 0.0226 0.0267
Loa Loa (eye worm) hypothetical protein 0.0051 0.0399 0.0819
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0045 0.0343 0.604
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0398
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0027 0.0078
Toxoplasma gondii sugar transporter ST1 0.0033 0.0226 0.0341
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0053 0.0423 0.6979
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0027 0.0078
Trypanosoma brucei glucose transporter, putative 0.0073 0.063 0.8698
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0196 0.0402
Plasmodium vivax sugar transporter, putative 0.0033 0.0226 0.0201
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0465 0.0442
Schistosoma mansoni lysyl-tRNA synthetase 0.0053 0.0423 0.05
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0196 0.0402
Giardia lamblia Prolyl-tRNA synthetase 0.0071 0.0606 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0226 0.0956
Schistosoma mansoni coup transcription factor 0.003 0.0196 0.0232
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0013 0.0025 0.0051
Trypanosoma brucei THT1 - hexose transporter, putative 0.0073 0.063 0.8698
Loa Loa (eye worm) hypothetical protein 0.003 0.0196 0.0402
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0083 0.0724 0.1094
Toxoplasma gondii glycyl-tRNA synthetase 0.0013 0.0025 0.0038
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0464
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0256 0.3533
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0035 0.0041
Plasmodium falciparum mitogen-activated protein kinase 2 0.0383 0.374 0.3724
Echinococcus multilocularis cpg binding protein 0.0063 0.0526 0.0623
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0053 0.0423 0.5838
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0196 0.0402
Leishmania major GTP-binding protein, putative 0.0024 0.0135 0.1869
Leishmania major hypothetical protein, conserved 0.0057 0.0465 0.6429
Echinococcus multilocularis short transient receptor potential channel 6 0.0073 0.063 0.0746
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0078
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.062 0.0734
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.004 0.0048
Onchocerca volvulus 0.0033 0.0226 0.219
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0067 0.0079
Schistosoma mansoni cpg binding protein 0.0063 0.0526 0.0623
Loa Loa (eye worm) inositol-1 0.0036 0.0256 0.0525
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0027 0.0078
Schistosoma mansoni lamin 0.0062 0.0518 0.0614
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0567 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0027 0.0078
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0072
Loa Loa (eye worm) hypothetical protein 0.0057 0.0465 0.0955
Mycobacterium leprae conserved hypothetical protein 0.0012 0.0009 0.0155
Brugia malayi nuclear receptor RXR 0.0014 0.0035 0.0072
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0196 0.0232
Brugia malayi hypothetical protein 0.0033 0.0226 0.0464
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0033 0.0226 0.8705
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0035 0.0041
Loa Loa (eye worm) hypothetical protein 0.016 0.1496 0.3071
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0567 0.0856
Echinococcus multilocularis lamin 0.0062 0.0518 0.0614
Trypanosoma brucei glucose transporter, putative 0.0073 0.063 0.8698
Brugia malayi Intermediate filament tail domain containing protein 0.0062 0.0518 0.1064
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0035 0.0072
Mycobacterium ulcerans integral membrane transport protein 0.0033 0.0226 0.3984
Echinococcus granulosus lysyl tRNA synthetase 0.0053 0.0423 0.05
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0226 0.0956
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0196 0.0232
Onchocerca volvulus 0.0033 0.0226 0.219
Leishmania major glucose transporter, lmgt1 0.0073 0.063 0.8698
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0013 0.0025 0.0345
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.088 0.1042
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0035 0.0072
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0567 0.0671
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0196 0.0402
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.0465 0.0442

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10000 nM Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit ChEMBL. No reference
IC50 (binding) > 10000 nM Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit ChEMBL. No reference
SC200 (functional) 0 nM Agonistic activity in T47D human breast carcinoma cell proliferation assay; Not active ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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