Detailed information for compound 1387951

Basic information

Technical information
  • TDR Targets ID: 1387951
  • Name: 4-(2,3-dichlorophenyl)sulfanyl-6-(methoxymeth yl)-2-phenylpyrimidine
  • MW: 377.288 | Formula: C18H14Cl2N2OS
  • H donors: 0 H acceptors: 2 LogP: 5.21 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCc1cc(nc(n1)c1ccccc1)Sc1cccc(c1Cl)Cl
  • InChi: 1S/C18H14Cl2N2OS/c1-23-11-13-10-16(24-15-9-5-8-14(19)17(15)20)22-18(21-13)12-6-3-2-4-7-12/h2-10H,11H2,1H3
  • InChiKey: IKXBFHINRUWLOE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2,3-dichlorophenyl)sulfanyl-6-(methoxymethyl)-2-phenyl-pyrimidine
  • 4-[(2,3-dichlorophenyl)thio]-6-(methoxymethyl)-2-phenylpyrimidine
  • 4-[(2,3-dichlorophenyl)thio]-6-(methoxymethyl)-2-phenyl-pyrimidine
  • ZINC01388935
  • Bionet1_002773
  • 4L-561S
  • 4-[(2,3-dichlorophenyl)sulfanyl]-6-(methoxymethyl)-2-phenylpyrimidine
  • MLS000326156
  • SMR000170273

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi proteasome subunit beta type 2 0.0045 0.0805 0.2504
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0261 0.0649
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0261 0.0812
Plasmodium vivax proteasome subunit beta type-2, putative 0.0045 0.0805 0.2371
Brugia malayi Proteasome A-type and B-type family protein 0.0018 0.0056 0.0174
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0261 0.097
Plasmodium vivax importin-beta 2, putative 0.0035 0.052 0.1468
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0093 0.2167 1
Schistosoma mansoni hypothetical protein 0.0019 0.0076 0.0076
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0114 0.2756 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0045 0.0805 0.0805
Echinococcus multilocularis snurportin 1 0.0372 1 1
Brugia malayi Methionine aminopeptidase protein type I 0.0131 0.3213 1
Leishmania major proteasome beta 5 subunit, putative 0.0093 0.2167 0.6688
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0018 0.0056 0.0052
Brugia malayi proteasome subunit alpha type 3 0.0018 0.0056 0.0174
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0261 0.0649
Leishmania major importin beta-1 subunit, putative 0.0028 0.0334 0.0881
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0076 0.0076
Plasmodium falciparum proteasome subunit beta type-5 0.0093 0.2167 0.6688
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0018 0.0056 0.0056
Giardia lamblia Proteasome subunit beta type 2 0.0045 0.0805 0.3546
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0018 0.0056 0.0056
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0114 0.2756 1
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0045 0.0805 0.2371
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0261 0.0261
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0018 0.0056 0.0056
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0018 0.0056 0.0052
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0018 0.0056 0.0056
Echinococcus granulosus proteasome subunit alpha type 6 0.0018 0.0056 0.0056
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0018 0.0056 0.0056
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0018 0.0056 0.0056
Echinococcus granulosus proteasome subunit alpha type 2 0.0018 0.0056 0.0056
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0045 0.0805 0.3546
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0018 0.0056 0.0056
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0131 0.3213 0.3213
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0698 0.2172
Treponema pallidum methionine aminopeptidase (map) 0.0114 0.2756 0.5
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0131 0.3213 1
Brugia malayi Proteasome A-type and B-type family protein 0.0018 0.0056 0.0174
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0018 0.0056 0.0056
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0093 0.2167 0.6688
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0018 0.0056 0.0056
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0045 0.0805 0.0805
Loa Loa (eye worm) hypothetical protein 0.0019 0.0076 0.0072
Loa Loa (eye worm) proteasome subunit beta type 3 0.0018 0.0056 0.0052
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0018 0.0056 0.0056
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0093 0.2167 0.2167
Loa Loa (eye worm) hypothetical protein 0.0041 0.0698 0.0694
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.052 0.1468
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0073 0.1581 0.4831
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0261 0.0649
Loa Loa (eye worm) proteasome subunit beta type 1 0.0073 0.1581 0.1578
Brugia malayi Proteasome subunit alpha type 1 0.0018 0.0056 0.0174
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0018 0.0056 0.0056
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0018 0.0056 0.0056
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0114 0.2756 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0334 0.1318
Echinococcus granulosus GPCR family 2 0.0019 0.0076 0.0076
Brugia malayi RNA, U transporter 1 0.0099 0.2326 0.724
Entamoeba histolytica hypothetical protein 0.0028 0.0334 0.1318
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0018 0.0056 0.0056
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0018 0.0056 0.0052
Echinococcus multilocularis Ankyrin 0.0016 0.0004 0.0004
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0045 0.0805 0.2371
Toxoplasma gondii methionine aminopeptidase 0.0131 0.3213 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1234 0.384
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0045 0.0805 0.2371
Trypanosoma brucei proteasome beta 6 subunit 0.0073 0.1581 0.4831
Schistosoma mansoni ran 0.0026 0.0261 0.0261
Echinococcus multilocularis importin subunit beta 1 0.0035 0.052 0.052
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0073 0.1581 0.4831
Schistosoma mansoni hypothetical protein 0.0019 0.0076 0.0076
Leishmania major GTP-binding protein, putative 0.0026 0.0261 0.0649
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.052 0.1468
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0045 0.0805 0.3546
Loa Loa (eye worm) proteasome subunit beta type 2 0.0045 0.0805 0.0801
Giardia lamblia Proteasome subunit beta type 1 0.0073 0.1581 0.7224
Echinococcus multilocularis GPCR, family 2 0.0019 0.0076 0.0076
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0018 0.0056 0.0056
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0018 0.0056 0.0056
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0093 0.2167 1
Entamoeba histolytica Ran family GTPase 0.0026 0.0261 0.097
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0018 0.0056 0.0052
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0114 0.2756 0.8552
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1234 0.384
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0093 0.2167 0.2164
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0076 0.0236
Brugia malayi proteasome subunit beta type 3 0.0018 0.0056 0.0174
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0045 0.0805 0.0805
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0018 0.0056 0.0052
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0261 0.0257
Echinococcus multilocularis proteasome subunit beta type 6 0.0018 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0019 0.0076 0.0076
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0093 0.2167 0.7821
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0018 0.0056 0.0056
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0018 0.0056 0.0056
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0073 0.1581 0.1581
Loa Loa (eye worm) methionine aminopeptidase type I 0.0131 0.3213 0.321
Chlamydia trachomatis methionine aminopeptidase 0.0114 0.2756 0.5
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0114 0.2756 0.2756
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1234 0.123
Echinococcus granulosus proteasome subunit beta t family 0.0018 0.0056 0.0056
Mycobacterium ulcerans proteasome PrcB 0.0093 0.2167 0.7821
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0131 0.3213 1
Mycobacterium ulcerans methionine aminopeptidase 0.0114 0.2756 1
Echinococcus multilocularis proteasome (prosome, macropain) 0.0093 0.2167 0.2167
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0084 0.1898 0.1898
Brugia malayi Proteasome A-type and B-type family protein 0.0018 0.0056 0.0174
Echinococcus granulosus Proteasome subunit alpha type 7 0.0018 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0035 0.052 0.0516
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0018 0.0056 0.0056
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0114 0.2756 0.8552
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0018 0.0056 0.0056
Echinococcus granulosus subfamily T1A non peptidase ue 0.0018 0.0056 0.0056
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0334 0.1318
Plasmodium vivax proteasome subunit beta type-1, putative 0.0073 0.1581 0.4831
Echinococcus multilocularis proteasome subunit alpha type 6 0.0018 0.0056 0.0056
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0131 0.3213 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0045 0.0805 0.3546
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0334 0.0881
Echinococcus multilocularis proteasome subunit beta type 7 0.0018 0.0056 0.0056
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0114 0.2756 0.2756
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0018 0.0056 0.0056
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0261 0.0649
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0018 0.0056 0.0056
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0076 0.0076
Plasmodium falciparum importin beta, putative 0.0035 0.052 0.1468
Brugia malayi proteasome subunit beta type 1 0.0073 0.1581 0.4921
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0073 0.1581 0.4831
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0018 0.0056 0.0052
Echinococcus granulosus Ankyrin 0.0016 0.0004 0.0004
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0073 0.1581 0.4831
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0093 0.2167 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0018 0.0056 0.0052
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0131 0.3213 0.3213
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0093 0.2167 0.6688
Plasmodium vivax proteasome subunit beta type-5, putative 0.0093 0.2167 0.6688
Schistosoma mansoni hypothetical protein 0.0041 0.0698 0.0698
Brugia malayi Proteasome A-type and B-type family protein 0.0093 0.2167 0.6746
Schistosoma mansoni importin beta-1 0.0035 0.052 0.052
Schistosoma mansoni ran 0.0026 0.0261 0.0261
Brugia malayi proteasome subunit alpha type 6 0.0018 0.0056 0.0174
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0261 0.0649
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0018 0.0056 0.0056
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0114 0.2756 1
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0018 0.0056 0.0052
Schistosoma mansoni hypothetical protein 0.0372 1 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0114 0.2756 0.2756
Trichomonas vaginalis ran, putative 0.0026 0.0261 0.097
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0131 0.3213 1
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0114 0.2756 0.8552
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0073 0.1581 0.7224
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0076 0.0072
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0093 0.2167 0.6688
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.006 0.1234 0.123
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0131 0.3213 1
Onchocerca volvulus Notchless protein homolog 0.0018 0.0056 0.5
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0073 0.1581 0.1581
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0131 0.3213 1
Brugia malayi proteasome subunit alpha type 2 0.0018 0.0056 0.0174
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0004 0.0004
Echinococcus multilocularis proteasome subunit alpha type 2 0.0018 0.0056 0.0056
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.052 0.1468
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0018 0.0056 0.0056
Toxoplasma gondii methionine aminopeptidase 0.0114 0.2756 0.8552
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0114 0.2756 1
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0045 0.0805 0.2371
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0076 0.0236
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0334 0.1318
Leishmania major proteasome beta 2 subunit, putative 0.0045 0.0805 0.2371
Loa Loa (eye worm) PAS-3 protein 0.0018 0.0056 0.0052
Trypanosoma cruzi 20S proteasome subunit 0.0045 0.0805 0.2371
Echinococcus granulosus proteasome subunit beta type 6 0.0018 0.0056 0.0056
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0093 0.2167 0.7821
Schistosoma mansoni hypothetical protein 0.0019 0.0076 0.0076
Brugia malayi proteasome subunit alpha type 4 0.0018 0.0056 0.0174
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0045 0.0805 0.0805
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0073 0.1581 0.4831
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0018 0.0056 0.0056
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0018 0.0056 0.0056
Echinococcus granulosus Proteasome subunit alpha beta 0.0018 0.0056 0.0056
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0261 0.0261
Brugia malayi 20S proteasome alpha5 subunit 0.0018 0.0056 0.0174
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0073 0.1581 0.1581
Brugia malayi Importin beta-1 subunit 0.0035 0.052 0.1617
Trypanosoma brucei methionine aminopeptidase, putative 0.0131 0.3213 1
Toxoplasma gondii proteasome subunit beta type, putative 0.0093 0.2167 0.6688
Brugia malayi proteasome subunit alpha type 1 0.0018 0.0056 0.0174
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0114 0.2756 1
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0018 0.0056 0.0056
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0073 0.1581 0.7224
Echinococcus granulosus importin subunit beta 1 0.0035 0.052 0.052
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0076 0.0076
Echinococcus granulosus nuclear factor of activated T cells 5 0.0084 0.1898 0.1898
Brugia malayi Proteasome subunit alpha type 7-1 0.0018 0.0056 0.0174
Echinococcus granulosus proteasome prosome macropain 0.0093 0.2167 0.2167
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0131 0.3213 1
Echinococcus granulosus proteasome subunit beta type 7 0.0018 0.0056 0.0056
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0018 0.0056 0.0056
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0261 0.0649
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0018 0.0056 0.0052

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0657 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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