Detailed information for compound 1390461

Basic information

Technical information
  • TDR Targets ID: 1390461
  • Name: 2-[cyano-(4,6-dimethylpyrimidin-2-yl)amino]-N ,N-diethylpropanamide
  • MW: 275.349 | Formula: C14H21N5O
  • H donors: 0 H acceptors: 4 LogP: 2.17 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CN(C(C(=O)N(CC)CC)C)c1nc(C)cc(n1)C
  • InChi: 1S/C14H21N5O/c1-6-18(7-2)13(20)12(5)19(9-15)14-16-10(3)8-11(4)17-14/h8,12H,6-7H2,1-5H3
  • InChiKey: GBVUGEAFZRCMRF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[cyano-(4,6-dimethylpyrimidin-2-yl)amino]-N,N-diethyl-propanamide
  • 2-[cyano-(4,6-dimethyl-2-pyrimidinyl)amino]-N,N-diethylpropanamide
  • 2-[cyano-(4,6-dimethylpyrimidin-2-yl)amino]-N,N-diethyl-propionamide
  • 2-[Cyano-(4,6-dimethyl-pyrimidin-2-yl)-amino]-N,N-diethyl-propionamide
  • MLS000558807
  • SMR000176848
  • BAS 01321621

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.1473 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0109 0.3576 0.3576
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.2184 1
Schistosoma mansoni ap endonuclease 0.0038 0.083 0.1441
Brugia malayi MAP kinase sur-1 0.0055 0.1473 0.29
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.184 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1254 0.2179
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.1426 0.1426
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0787 0.1367
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.2184 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.083 0.5
Loa Loa (eye worm) MBCTL1 0.0052 0.1375 0.1375
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.1473 0.1473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1254 0.2179
Entamoeba histolytica hypothetical protein 0.0039 0.0846 0.0157
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.083 0.5
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.1473 0.2558
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.184 0.3196
Schistosoma mansoni hypothetical protein 0.006 0.1675 0.291
Schistosoma mansoni hypothetical protein 0.0165 0.5757 1
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.1473 1
Schistosoma mansoni ap endonuclease 0.0038 0.083 0.1441
Echinococcus multilocularis lamin 0.0026 0.0361 0.0627
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.2184 0.3794
Echinococcus granulosus nephrin 0.0018 0.002 0.0035
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.1473 0.2558
Echinococcus granulosus intermediate filament protein 0.0026 0.0361 0.0627
Schistosoma mansoni intermediate filament proteins 0.0026 0.0361 0.0627
Echinococcus multilocularis irregular chiasm roughest protein immunoglobulin set domain containing protein 0.0018 0.002 0.0035
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0361 0.0711
Loa Loa (eye worm) hypothetical protein 0.0148 0.5078 0.5078
Echinococcus multilocularis conserved hypothetical protein 0.0018 0.002 0.0035
Brugia malayi hypothetical protein 0.0148 0.5078 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.1473 0.6365
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1254 0.2179
Trypanosoma brucei protein kinase, putative 0.0055 0.1473 0.6365
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1254 0.2179
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.184 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1254 0.2179
Echinococcus granulosus Immunoglobulin 0.0018 0.002 0.0035
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.1473 0.4747
Echinococcus multilocularis Immunoglobulin 0.0018 0.002 0.0035
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0022 0.021 0.021
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.083 0.083
Echinococcus granulosus histone acetyltransferase MYST2 0.0052 0.1375 0.2388
Entamoeba histolytica hypothetical protein 0.0039 0.0846 0.0157
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.1473 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.1473 0.6365
Schistosoma mansoni hypothetical protein 0.0018 0.002 0.0035
Schistosoma mansoni lamin 0.0026 0.0361 0.0627
Brugia malayi hypothetical protein 0.0022 0.021 0.0414
Loa Loa (eye worm) hypothetical protein 0.0054 0.1426 0.1426
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.184 0.7458
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0846 0.1469
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.184 1
Schistosoma mansoni beta-galactosidase 0.0091 0.2873 0.499
Schistosoma mansoni hypothetical protein 0.0037 0.0766 0.1331
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.2184 1
Echinococcus granulosus nephrin 0.0018 0.002 0.0035
Loa Loa (eye worm) hypothetical protein 0.0037 0.0766 0.0766
Echinococcus granulosus geminin 0.0165 0.5757 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0361 0.0361
Schistosoma mansoni myelin transcription factor 1 myt1 0.0052 0.1375 0.2388
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.184 0.3623
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0022 0.021 0.021
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.184 1
Schistosoma mansoni lamin 0.0026 0.0361 0.0627
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.1473 0.6365
Echinococcus multilocularis nephrin 0.0018 0.002 0.0035
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.184 0.3196
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.021 0.0414
Echinococcus granulosus lamin dm0 0.0026 0.0361 0.0627
Onchocerca volvulus Huntingtin homolog 0.0148 0.5078 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.2184 0.3794
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.1473 0.2558
Loa Loa (eye worm) hypothetical protein 0.0026 0.0342 0.0342
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.1473 0.6365
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.1473 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.1473 0.4747
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.1254 0.1254
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.1473 1
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.083 0.1634
Brugia malayi hypothetical protein 0.0039 0.0846 0.1665
Schistosoma mansoni hypothetical protein 0.0039 0.0846 0.1469
Onchocerca volvulus Huntingtin homolog 0.0148 0.5078 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.1426 0.2809
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0109 0.3576 0.6211
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.2184 0.3794
Loa Loa (eye worm) hypothetical protein 0.0148 0.5078 0.5078
Echinococcus multilocularis geminin 0.0165 0.5757 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.2184 1
Echinococcus multilocularis beta galactosidase 0.0091 0.2873 0.499
Entamoeba histolytica hypothetical protein 0.0039 0.0846 0.0157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1254 0.2179
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.1473 0.4747
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.1473 0.2558
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.2184 0.3794
Echinococcus granulosus lamin 0.0026 0.0361 0.0627
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.2184 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0846 0.1469
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1254 0.2179
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.1473 0.2558
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.083 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0052 0.1375 0.2388
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0846 0.1469
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.184 0.184
Entamoeba histolytica hypothetical protein 0.0039 0.0846 0.0157
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.083 0.1441
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0361 0.0361
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.083 0.1441
Echinococcus multilocularis musashi 0.0026 0.0361 0.0627
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.2184 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.1426 0.2809
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0109 0.3576 0.6211
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.1254 0.247
Schistosoma mansoni hypothetical protein 0.0018 0.002 0.0035
Echinococcus multilocularis lamin dm0 0.0026 0.0361 0.0627
Echinococcus granulosus irregular chiasm roughest protein 0.0018 0.002 0.0035
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.1473 0.6365
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0766 0.1509
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0109 0.3576 0.7042
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0787 0.1367
Loa Loa (eye worm) hypothetical protein 0.0091 0.2873 0.2873
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.083 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.184 0.3196
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.021 0.0414
Schistosoma mansoni hypothetical protein 0.0165 0.5757 1
Echinococcus granulosus beta galactosidase 0.0091 0.2873 0.499
Brugia malayi intermediate filament protein 0.0026 0.0361 0.0711

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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