Detailed information for compound 1391481

Basic information

Technical information
  • TDR Targets ID: 1391481
  • Name: (3E,5E)-3,5-bis[(3-ethoxy-4-hydroxyphenyl)met hylidene]-1-methylpiperidin-4-one hydrochlori de
  • MW: 445.936 | Formula: C24H28ClNO5
  • H donors: 2 H acceptors: 3 LogP: 4.4 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(ccc1O)/C=C/1\CN(C)C/C(=C\c2ccc(c(c2)OCC)O)/C1=O.Cl
  • InChi: 1S/C24H27NO5.ClH/c1-4-29-22-12-16(6-8-20(22)26)10-18-14-25(3)15-19(24(18)28)11-17-7-9-21(27)23(13-17)30-5-2;/h6-13,26-27H,4-5,14-15H2,1-3H3;1H/b18-10+,19-11+;
  • InChiKey: WZXLOJRRXKGKJV-XGMIBILOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3E,5E)-3,5-bis[(3-ethoxy-4-hydroxy-phenyl)methylene]-1-methyl-piperidin-4-one hydrochloride
  • (3E,5E)-3,5-bis[(3-ethoxy-4-hydroxyphenyl)methylene]-1-methyl-4-piperidinone hydrochloride
  • (3E,5E)-3,5-bis(3-ethoxy-4-hydroxy-benzylidene)-1-methyl-4-piperidone hydrochloride
  • (3E,5E)-3,5-bis[(3-ethoxy-4-hydroxy-phenyl)methylidene]-1-methyl-piperidin-4-one hydrochloride
  • T0511-5015

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0321 0.0321
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.012 0.2182 0.2344
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.046 0.0494
Brugia malayi hypothetical protein 0.002 0.0074 0.0079
Schistosoma mansoni hypothetical protein 0.0205 0.3945 0.3945
Leishmania major hypothetical protein, conserved 0.003 0.03 0.0933
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0321 0.0321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108 0.1916 0.5255
Schistosoma mansoni cathepsin B (C01 family) 0.0039 0.0482 0.0482
Schistosoma mansoni hypothetical protein 0.0049 0.0692 0.0692
Echinococcus granulosus 7TM GPCR rhodopsin 0.0042 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Giardia lamblia Cathepsin B precursor 0.017 0.3212 1
Schistosoma mansoni amine GPCR 0.0042 0.054 0.054
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0321 0.0321
Entamoeba histolytica cysteine proteinase 1, putative 0.0086 0.146 0.4054
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.03 0.0839
Brugia malayi cathepsin L-like cysteine proteinase 0.0039 0.0482 0.0517
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0321 0.0345
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0619 0.0664
Brugia malayi hypothetical protein 0.0042 0.054 0.058
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.046 0.046
Onchocerca volvulus 0.0042 0.054 0.0314
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Schistosoma mansoni hypothetical protein 0.0494 1 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.073 0.0785
Echinococcus multilocularis cpg binding protein 0.0037 0.043 0.043
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0016 0 0.5
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.2087 1
Entamoeba histolytica hypothetical protein 0.0043 0.0572 0.0374
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0631 0.0631
Brugia malayi cathepsin L-like precursor 0.0108 0.1916 0.2059
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0321 0.0321
Echinococcus granulosus orexin receptor type 2 0.0042 0.054 0.054
Schistosoma mansoni biogenic amine receptor 0.0042 0.054 0.054
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0039 0.0482 0.0482
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.054 0.054
Echinococcus multilocularis protein patched 0.0051 0.073 0.073
Schistosoma mansoni hypothetical protein 0.0049 0.0692 0.0692
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0321 0.0321
Echinococcus granulosus cathepsin L cysteine proteinase 0.0154 0.2895 0.2895
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1843 0.8834
Schistosoma mansoni opsin-like receptor 0.0042 0.054 0.054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0154 0.2895 0.9012
Brugia malayi hypothetical protein 0.0042 0.054 0.058
Schistosoma mansoni hypothetical protein 0.0038 0.046 0.046
Echinococcus granulosus 7tm_1 domain containing protein 0.0042 0.054 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.2895 0.8838
Brugia malayi hypothetical protein 0.0365 0.7301 0.7842
Schistosoma mansoni amine GPCR 0.0042 0.054 0.054
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.073 0.0911
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0321 0.0321
Trypanosoma cruzi cysteine peptidase, putative 0.0154 0.2895 0.3109
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.2151 0.2151
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0062 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.054 0.054
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0062 0.0193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0042 0.054 0.054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0154 0.2895 0.8838
Echinococcus granulosus G protein coupled receptor 139 0.0042 0.054 0.054
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.054 0.054
Brugia malayi CHE-14 protein 0.0051 0.073 0.0785
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0039 0.0482 0.1482
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0042 0.054 0.058
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0039 0.0482 0.0517
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0042 0.054 0.054
Onchocerca volvulus 0.0154 0.2895 0.3687
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0042 0.054 0.054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0482 0.0482
Echinococcus granulosus tachykinin peptides receptor 99D 0.0042 0.054 0.054
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0016 0 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0321 0.0321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0321 0.0345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0154 0.2895 0.9012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0154 0.2895 0.8838
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0154 0.2895 0.8838
Loa Loa (eye worm) fibroinase 0.0154 0.2895 0.3109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0154 0.2895 0.9012
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0062 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0154 0.2895 0.8838
Entamoeba histolytica cysteine protease, putative 0.0086 0.146 0.4054
Schistosoma mansoni hypothetical protein 0.0043 0.0572 0.0572
Brugia malayi nuclear receptor NHR-88 0.0031 0.0321 0.0345
Echinococcus granulosus peptide allatostatin:somatostatin 0.0042 0.054 0.054
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0047 0.0641 0.0688
Entamoeba histolytica hypothetical protein 0.0043 0.0572 0.0374
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0042 0.054 0.054
Brugia malayi Papain family cysteine protease containing protein 0.0154 0.2895 0.3109
Loa Loa (eye worm) hypothetical protein 0.003 0.03 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.2895 0.8838
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0042 0.054 0.054
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0042 0.054 0.054
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0011 0.0011
Trypanosoma brucei trypanothione reductase 0.0046 0.0619 0.1926
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0321 0.0321
Brugia malayi neuropeptide F receptor 0.0042 0.054 0.058
Echinococcus multilocularis neuropeptide receptor 0.0042 0.054 0.054
Plasmodium falciparum serine repeat antigen 9 0.0039 0.0482 0.1482
Giardia lamblia Cathepsin B precursor 0.017 0.3212 1
Onchocerca volvulus 0.0108 0.1916 0.2286
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0321 0.0345
Schistosoma mansoni neuropeptide receptor 0.0042 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0039 0.0482 0.0517
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0016 0 0.5
Onchocerca volvulus 0.0042 0.054 0.0314
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0461 0.931 0.931
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0321 0.0345
Brugia malayi nuclear hormone receptor 0.0031 0.0321 0.0345
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.054 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.2895 0.8838
Brugia malayi CXXC zinc finger family protein 0.0035 0.0388 0.0417
Echinococcus multilocularis fmrfamide receptor 0.0042 0.054 0.054
Loa Loa (eye worm) ctsf protein 0.0154 0.2895 0.3109
Brugia malayi Cathepsin L-like cysteine proteinase 0.0108 0.1916 0.2059
Loa Loa (eye worm) hypothetical protein 0.0031 0.0321 0.0345
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0321 0.0321
Echinococcus multilocularis fmrfamide receptor 0.0042 0.054 0.054
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0321 0.0321
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0154 0.2895 1
Onchocerca volvulus 0.0042 0.054 0.0314
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0461 0.931 0.931
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0047 0.0641 0.0688
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.2151 0.6917
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1843 0.8834
Schistosoma mansoni cpg binding protein 0.0037 0.043 0.043
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.054 0.054
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0042 0.054 0.054
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.046 0.0494
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0016 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0321 0.0345
Brugia malayi fibroinase precursor 0.0039 0.0482 0.0517
Schistosoma mansoni biogenic amine receptor 0.0042 0.054 0.054
Echinococcus multilocularis cathepsin b 0.0461 0.931 0.931
Schistosoma mansoni hypothetical protein 0.0049 0.0692 0.0692
Brugia malayi hypothetical protein 0.0017 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0086 0.146 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.146 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0086 0.146 0.146
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.054 0.058
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0321 0.0345
Loa Loa (eye worm) hypothetical protein 0.0047 0.0641 0.0688
Onchocerca volvulus 0.0042 0.054 0.0314
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0619 0.1965
Brugia malayi hypothetical protein 0.003 0.03 0.0322
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0062 0.0066
Echinococcus granulosus allatostatin A receptor 0.0042 0.054 0.054
Onchocerca volvulus 0.0154 0.2895 0.3687
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.054 0.054
Entamoeba histolytica cysteine proteinase, putative 0.0108 0.1916 0.5946
Plasmodium vivax serine-repeat antigen (SERA) 0.0039 0.0482 0.1482
Echinococcus granulosus somatostatin receptor 0.0042 0.054 0.054
Onchocerca volvulus Neuropeptide F receptor homolog 0.0042 0.054 0.0314
Onchocerca volvulus 0.0154 0.2895 0.3687
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0016 0 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0042 0.054 0.054
Toxoplasma gondii preprocathepsin c precursor, putative 0.0039 0.0482 0.15
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Loa Loa (eye worm) hypothetical protein 0.0047 0.0641 0.0688
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.146 0.4054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0572 0.0572
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.017 0.3212 1
Toxoplasma gondii cathepsin CPC2 0.0039 0.0482 0.15
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0042 0.054 0.0314
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.054 0.054
Echinococcus granulosus cysteine protease 0.0086 0.146 0.146
Plasmodium vivax unspecified product 0.0047 0.0641 0.2044
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0154 0.2895 1
Plasmodium vivax vivapain-1 0.0086 0.146 0.4935
Echinococcus multilocularis g protein coupled receptor 0.0042 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Echinococcus granulosus neuropeptide FF receptor 2 0.0042 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0062 0.0971 0.1043
Brugia malayi Serotonin receptor 0.0042 0.054 0.058
Onchocerca volvulus 0.0154 0.2895 0.3687
Echinococcus multilocularis serotonin receptor 0.0042 0.054 0.054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0086 0.146 0.146
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.054 0.054
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0042 0.054 0.058
Echinococcus granulosus hypothetical protein 0.0042 0.054 0.054
Entamoeba histolytica cysteine proteinase, putative 0.0154 0.2895 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.2895 0.8838
Schistosoma mansoni hypothetical protein 0.0042 0.054 0.054
Echinococcus granulosus serotonin receptor 0.0042 0.054 0.054
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0482 0.0517
Onchocerca volvulus 0.0154 0.2895 0.3687
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0321 0.0321
Echinococcus granulosus cathepsin l1 0.0108 0.1916 0.1916
Onchocerca volvulus 0.0042 0.054 0.0314
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.054 0.054
Brugia malayi AKH receptor 0.0042 0.054 0.058
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0062 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.054 0.054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0321 0.0321
Trypanosoma cruzi cysteine peptidase, putative 0.0154 0.2895 0.3109
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Entamoeba histolytica cysteine protease, putative 0.0086 0.146 0.4054
Schistosoma mansoni hypothetical protein 0.0038 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0011
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.046 0.046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0321 0.0345
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Brugia malayi GnHR receptor homolog 0.0042 0.054 0.058
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0321 0.0321
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0039 0.0482 0.1482
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0321 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0321 0.0345
Trypanosoma cruzi cruzipain precursor, putative 0.0047 0.0641 0.0688
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.054 0.054
Entamoeba histolytica cysteine protease, putative 0.0086 0.146 0.4054
Loa Loa (eye worm) hypothetical protein 0.0108 0.1916 0.2059
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0016 0 0.5
Brugia malayi ORL1-like opioid receptor 0.0042 0.054 0.058
Brugia malayi hypothetical protein 0.0042 0.054 0.058
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0461 0.931 0.931
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0154 0.2895 0.9012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0321 0.0345
Entamoeba histolytica cysteine protease, putative 0.0154 0.2895 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0154 0.2895 0.2895
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.017 0.3212 0.345
Onchocerca volvulus 0.0042 0.054 0.0314
Onchocerca volvulus 0.0039 0.0482 0.023
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0042 0.054 0.058
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0039 0.0482 0.1482
Echinococcus multilocularis geminin 0.0205 0.3945 0.3945
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0321 0.0321
Echinococcus granulosus cpg binding protein 0.0037 0.043 0.043
Echinococcus multilocularis GPCR, family 2 0.0038 0.046 0.046
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0321 0.0345
Entamoeba histolytica cysteine protease, putative 0.0086 0.146 0.4054
Entamoeba histolytica cysteine protease, putative 0.0086 0.146 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0038 0.046 0.0494
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1843 0.8834
Echinococcus granulosus g protein coupled receptor 0.0042 0.054 0.054
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0039 0.0482 0.1482
Echinococcus multilocularis serotonin receptor 0.0042 0.054 0.054
Plasmodium falciparum serine repeat antigen 2 0.0039 0.0482 0.1482
Echinococcus multilocularis g-protein coupled receptor 0.0042 0.054 0.054
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0039 0.0482 0.1482
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0062 0.0066
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0321 0.0321
Loa Loa (eye worm) TYRA-2 protein 0.0042 0.054 0.058
Brugia malayi Cathepsin L-like precursor 0.0047 0.0641 0.0688
Plasmodium vivax vivapain-3 0.0086 0.146 0.4935
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0062 0.0193
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0062 0.0066
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0016 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.054 0.054
Echinococcus granulosus fmrfamide receptor 0.0042 0.054 0.054
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.03 0.0839
Onchocerca volvulus 0.0042 0.054 0.0314
Brugia malayi Latrophilin receptor protein 2 0.0038 0.046 0.0494
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0482 0.0482
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.054 0.054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.054 0.054
Plasmodium falciparum serine repeat antigen 3 0.0039 0.0482 0.1482
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0482 0.0517
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0042 0.054 0.058
Loa Loa (eye worm) hypothetical protein 0.0039 0.0482 0.0517
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.054 0.058
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0619 0.0664
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0039 0.0482 0.0482
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0154 0.2895 0.9012
Echinococcus multilocularis G protein coupled receptor 139 0.0042 0.054 0.054
Brugia malayi ecdysteroid receptor 0.0031 0.0321 0.0345
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.054 0.054
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0042 0.054 0.054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.054 0.054
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.054 0.054
Echinococcus granulosus g protein coupled receptor 0.0042 0.054 0.054
Echinococcus multilocularis neuropeptide FF receptor 2 0.0042 0.054 0.054
Brugia malayi Dopamine receptor 0.0042 0.054 0.058
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0011 0.0011
Schistosoma mansoni cathepsin C 0.0039 0.0482 0.0482
Trypanosoma cruzi cysteine peptidase, putative 0.0154 0.2895 0.3109
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0031 0.0321 0.0345
Echinococcus granulosus neuropeptide s receptor 0.0042 0.054 0.054
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0572 0.0572
Brugia malayi hypothetical protein 0.0042 0.054 0.058
Onchocerca volvulus 0.0042 0.054 0.0314
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0042 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0031 0.0321 0.0345
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0154 0.2895 0.8838
Onchocerca volvulus 0.0042 0.054 0.0314
Echinococcus multilocularis neuropeptide receptor 0.0042 0.054 0.054
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0321 0.0321
Entamoeba histolytica hypothetical protein 0.0043 0.0572 0.0374
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0619 0.2964
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0042 0.054 0.054
Echinococcus multilocularis g protein coupled receptor 0.0042 0.054 0.054
Schistosoma mansoni alpha-1 adrenergic receptor 0.0042 0.054 0.054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0011 0.0011
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0321 0.0321
Plasmodium falciparum cysteine proteinase falcipain 1 0.0086 0.146 0.4935
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0321 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.2895 0.8838
Brugia malayi Dopamine receptor protein 2 0.0042 0.054 0.058
Schistosoma mansoni hypothetical protein 0.0038 0.046 0.046
Echinococcus granulosus neuropeptide receptor 0.0042 0.054 0.054
Schistosoma mansoni histamine h1 receptor 0.0042 0.054 0.054
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0062 0.0062
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0016 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Schistosoma mansoni hypothetical protein 0.0042 0.054 0.054
Onchocerca volvulus 0.0035 0.0388 0.0096
Plasmodium vivax serine-repeat antigen (SERA) 0.0039 0.0482 0.1482
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.054 0.058
Trypanosoma cruzi major cysteine proteinase, putative 0.0039 0.0482 0.0517
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0321 0.0345
Brugia malayi Cathepsin L-like precursor 0.0108 0.1916 0.2059
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.054 0.054
Echinococcus multilocularis allatostatin A receptor 0.0042 0.054 0.054
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0321 0.0345
Schistosoma mansoni cathepsin S (C01 family) 0.0039 0.0482 0.0482
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.2895 0.8838
Echinococcus granulosus cathepsin l1 0.0154 0.2895 0.2895
Echinococcus granulosus cathepsin b 0.0461 0.931 0.931
Onchocerca volvulus Cathepsin L homolog 0.0154 0.2895 0.3687
Brugia malayi Tachykinin-like peptides receptor 99D 0.0042 0.054 0.058
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0042 0.054 0.054
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.2189 0.2189
Loa Loa (eye worm) glutathione reductase 0.0046 0.0619 0.0664
Echinococcus granulosus Protein patched homolog 1 0.0051 0.073 0.073
Trypanosoma brucei cysteine peptidase C (CPC) 0.017 0.3212 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Echinococcus multilocularis expressed conserved protein 0.0112 0.2 0.2
Plasmodium falciparum serine repeat antigen 7 0.0039 0.0482 0.1482
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0482 0.0517
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.03 0.0839
Brugia malayi Cathepsin L-like precursor 0.0154 0.2895 0.3109
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0482 0.0482
Echinococcus multilocularis somatostatin receptor 0.0042 0.054 0.054
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0039 0.0482 0.1482
Schistosoma mansoni neuropeptide receptor 0.0042 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Mycobacterium tuberculosis Probable reductase 0.0104 0.1843 0.8834
Brugia malayi cathepsin Z-like cysteine proteinase 0.0039 0.0482 0.0517
Entamoeba histolytica cysteine protease, putative 0.0086 0.146 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.0108 0.1916 0.1916
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0042 0.054 0.058
Onchocerca volvulus 0.0042 0.054 0.0314
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.146 0.1568
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.054 0.054
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0042 0.054 0.054
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.054 0.054
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0016 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.146 0.3583
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0482 0.0517
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Schistosoma mansoni amine GPCR 0.0042 0.054 0.054
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0011 0.0011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.054 0.054
Schistosoma mansoni growth hormone secretagogue receptor 0.0042 0.054 0.054
Schistosoma mansoni cathepsin s 0.0047 0.0641 0.0641
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.2151 0.231
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.2087 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0062 0.0062
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0016 0 0.5
Brugia malayi follicle stimulating hormone receptor 0.0042 0.054 0.058
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.054 0.054
Schistosoma mansoni cpg binding protein 0.0035 0.0388 0.0388
Brugia malayi Cathepsin L-like precursor 0.0108 0.1916 0.2059
Entamoeba histolytica cysteine protease, putative 0.0086 0.146 0.4054
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.054 0.054
Plasmodium vivax vivapain-2 0.0154 0.2895 1
Brugia malayi cathepsin L precursor 0.0039 0.0482 0.0517
Plasmodium falciparum serine repeat antigen 4 0.0039 0.0482 0.1482
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0042 0.054 0.054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0154 0.2895 0.3109
Loa Loa (eye worm) hypothetical protein 0.0082 0.1385 0.1488
Echinococcus multilocularis neuropeptide s receptor 0.0042 0.054 0.054
Brugia malayi G protein-coupled receptor 0.0042 0.054 0.058
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0086 0.146 0.146
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0321 0.0321
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0321 0.0321
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0321 0.0345
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0039 0.0482 0.1482
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0154 0.2895 0.8838
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.046 0.046
Leishmania major cathepsin L-like protease 0.0154 0.2895 0.9012
Brugia malayi Dopamine receptor protein 1 0.0042 0.054 0.058
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.054 0.054
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.054 0.054
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.146 0.4054
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0108 0.1916 0.2059
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0016 0 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.2182 0.2344
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.054 0.054
Plasmodium falciparum serine repeat antigen 1 0.0039 0.0482 0.1482
Echinococcus multilocularis sex peptide receptor 0.0042 0.054 0.054
Schistosoma mansoni opsin-like receptor 0.0042 0.054 0.054
Schistosoma mansoni hypothetical protein 0.0038 0.046 0.046
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0042 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0062 0.0297
Entamoeba histolytica cysteine protease, putative 0.0086 0.146 0.4054
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Schistosoma mansoni cathepsin F (C01 family) 0.0154 0.2895 0.2895
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.054 0.054
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0039 0.0482 0.0482
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0154 0.2895 0.2895
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.03 0.0933
Echinococcus granulosus g protein coupled receptor 0.0042 0.054 0.054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.146 0.4545
Schistosoma mansoni amine GPCR 0.0042 0.054 0.054
Onchocerca volvulus 0.0042 0.054 0.0314
Loa Loa (eye worm) hypothetical protein 0.0039 0.0482 0.0517
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0042 0.054 0.054
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.146 0.1568
Brugia malayi hypothetical protein 0.0017 0.0011 0.0011
Onchocerca volvulus 0.0154 0.2895 0.3687
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.2895 0.8838
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0321 0.0345
Plasmodium falciparum serine repeat antigen 5 0.0039 0.0482 0.1482
Plasmodium vivax glutathione reductase, putative 0.0046 0.0619 0.1965
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.054 0.054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.054 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.146 0.3583
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.017 0.3212 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0039 0.0482 0.0482
Onchocerca volvulus 0.0042 0.054 0.0314
Trypanosoma cruzi cruzipain precursor, putative 0.0154 0.2895 0.3109
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.054 0.054
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0042 0.054 0.058
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.073 0.073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0154 0.2895 0.9012
Echinococcus multilocularis dro:myosuppressin receptor 0.0042 0.054 0.054
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0631 0.0631
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.2895 0.8838
Loa Loa (eye worm) hypothetical protein 0.0047 0.0641 0.0688
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0011
Echinococcus granulosus neuropeptide receptor A26 0.0042 0.054 0.054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1202 0.1202
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.03 0.0322
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0154 0.2895 0.8838
Leishmania major cathepsin L-like protease 0.0154 0.2895 0.9012
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0016 0 0.5
Trypanosoma cruzi cysteine proteinase, putative 0.0086 0.146 0.1568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.2895 0.8838
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0482 0.0517
Echinococcus multilocularis cysteine protease 0.0154 0.2895 0.2895
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.046 0.046
Loa Loa (eye worm) cytochrome P450 family protein 0.0081 0.1351 0.1451
Schistosoma mansoni hypothetical protein 0.0205 0.3945 0.3945
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.054 0.054
Entamoeba histolytica cysteine protease, putative 0.0086 0.146 0.4054
Brugia malayi cathepsin F-like cysteine proteinase 0.0047 0.0641 0.0688
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0016 0 0.5
Echinococcus granulosus expressed conserved protein 0.0112 0.2 0.2
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0321 0.0345
Echinococcus multilocularis orexin receptor type 2 0.0042 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0011
Plasmodium falciparum serine repeat antigen 6 0.0039 0.0482 0.1482
Brugia malayi cathepsin F-like cysteine proteinase 0.0039 0.0482 0.0517
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0321 0.0345
Echinococcus granulosus cathepsin L cysteine protease 0.0086 0.146 0.146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.2895 0.8838
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0154 0.2895 0.8838
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.073 0.073
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0039 0.0482 0.0517
Loa Loa (eye worm) hypothetical protein 0.0039 0.0482 0.0517
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Onchocerca volvulus Cathepsin L homolog 0.0154 0.2895 0.3687
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0321 0.0345
Brugia malayi hypothetical protein 0.0042 0.054 0.058
Brugia malayi Melatonin receptor type 1A 0.0042 0.054 0.058
Brugia malayi hypothetical protein 0.0042 0.054 0.058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0154 0.2895 0.9012
Echinococcus multilocularis cathepsin L cysteine protease 0.0154 0.2895 0.2895
Trypanosoma cruzi major cysteine proteinase, putative 0.0039 0.0482 0.0517
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.054 0.054
Plasmodium falciparum thioredoxin reductase 0.0046 0.0619 0.1965
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0388 0.0417
Giardia lamblia Cathepsin B precursor 0.017 0.3212 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.054 0.054
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0641 0.0688
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0016 0 0.5
Entamoeba histolytica cysteine protease, putative 0.0086 0.146 0.4054
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0042 0.054 0.054
Brugia malayi steroid hormone receptor 0.0031 0.0321 0.0345
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0482 0.0482
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0016 0 0.5
Schistosoma mansoni cpg binding protein 0.0037 0.043 0.043
Toxoplasma gondii cathepsin CPL 0.0154 0.2895 0.9012
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0108 0.1916 0.2059
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.054 0.054
Echinococcus multilocularis neuropeptide receptor A26 0.0042 0.054 0.054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0154 0.2895 0.9012
Loa Loa (eye worm) hypothetical protein 0.0119 0.2151 0.231
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0042 0.054 0.054
Echinococcus granulosus cathepsin b 0.0461 0.931 0.931
Echinococcus granulosus cathepsin L 0.0039 0.0482 0.0482
Brugia malayi Thioredoxin reductase 0.0046 0.0619 0.0664
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0039 0.0482 0.1482
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Loa Loa (eye worm) hypothetical protein 0.0039 0.0482 0.0517
Loa Loa (eye worm) cysteine protease 0.0154 0.2895 0.3109
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0042 0.054 0.058
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1843 0.8834
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1038 0.3231
Loa Loa (eye worm) hypothetical protein 0.0365 0.7301 0.7842
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.054 0.054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.2182 0.2344
Brugia malayi Cathepsin L-like precursor 0.0154 0.2895 0.3109
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Echinococcus granulosus sex peptide receptor 0.0042 0.054 0.054
Brugia malayi cathepsin B-like cysteine proteinase 0.0461 0.931 1
Brugia malayi Serotonin receptor 0.0042 0.054 0.058
Schistosoma mansoni myosin xvIII 0.0042 0.054 0.054
Brugia malayi Cathepsin L-like precursor 0.0154 0.2895 0.3109
Onchocerca volvulus 0.0042 0.054 0.0314
Brugia malayi Cytochrome P450 family protein 0.0081 0.1351 0.1451
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.054 0.054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0154 0.2895 0.9012
Leishmania major cathepsin L-like protease 0.0154 0.2895 0.9012
Echinococcus multilocularis cathepsin L cysteine protease 0.0154 0.2895 0.2895
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0042 0.054 0.054
Onchocerca volvulus 0.0154 0.2895 0.3687
Echinococcus granulosus alpha 1A adrenergic receptor 0.0042 0.054 0.054
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0154 0.2895 0.3109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.146 0.4545
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0039 0.0482 0.1482
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.2895 0.8838
Echinococcus multilocularis protein dispatched 1 0.0058 0.0881 0.0881
Leishmania major cathepsin L-like protease 0.0154 0.2895 0.9012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0321 0.0321
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0461 0.931 0.931
Leishmania major cathepsin L-like protease 0.0154 0.2895 0.9012
Onchocerca volvulus 0.0042 0.054 0.0314
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0321 0.0345
Brugia malayi glutathione reductase 0.0046 0.0619 0.0664
Schistosoma mansoni hypothetical protein 0.0049 0.0692 0.0692
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.2895 0.8838
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0321 0.0345
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0321 0.0345
Brugia malayi Cathepsin L-like precursor 0.0154 0.2895 0.3109
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.03 0.0933
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Brugia malayi G protein-coupled receptor F59B2.13 0.0042 0.054 0.058
Brugia malayi isocitrate dehydrogenase 0.0019 0.0062 0.0066
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0011 0.0011
Brugia malayi G-protein coupled receptor 0.0042 0.054 0.058
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.2151 0.2151
Loa Loa (eye worm) hypothetical protein 0.0154 0.2895 0.3109
Schistosoma mansoni neuropeptide receptor 0.0042 0.054 0.054
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.146 0.4054
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.054 0.058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0321 0.0345
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Leishmania major cathepsin L-like protease 0.0154 0.2895 0.9012
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0321 0.0321
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0042 0.054 0.058
Entamoeba histolytica hypothetical protein 0.0043 0.0572 0.0374
Leishmania major cysteine peptidase A (CPA) 0.0154 0.2895 0.9012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0321 0.0345
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0154 0.2895 0.8838
Plasmodium falciparum serine repeat antigen 8 0.0039 0.0482 0.1482
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0042 0.054 0.054
Schistosoma mansoni adenoreceptor 0.0042 0.054 0.054
Onchocerca volvulus 0.0042 0.054 0.0314
Schistosoma mansoni amine GPCR 0.0042 0.054 0.054
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1843 0.8834
Entamoeba histolytica cysteine protease, putative 0.0086 0.146 0.4054
Toxoplasma gondii cathepsin CPC1 0.0039 0.0482 0.15
Onchocerca volvulus Cathepsin F homolog 0.0154 0.2895 0.3687
Schistosoma mansoni patched 1 0.0051 0.073 0.073
Onchocerca volvulus 0.0365 0.7301 1
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.3219 0.3219
Brugia malayi putative neuropeptide receptor NPR1 0.0042 0.054 0.058
Schistosoma mansoni coup transcription factor 0.0031 0.0321 0.0321
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.1385 0.1488
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.054 0.054
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.03 0.0322
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0461 0.931 1
Plasmodium vivax unspecified product 0.0039 0.0482 0.1482
Onchocerca volvulus Cathepsin L homolog 0.0039 0.0482 0.023
Brugia malayi hypothetical protein 0.0043 0.0572 0.0614
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.2087 1
Schistosoma mansoni neuropeptide receptor 0.0042 0.054 0.054
Echinococcus granulosus geminin 0.0205 0.3945 0.3945
Brugia malayi sulfakinin receptor protein 0.0042 0.054 0.058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.054 0.054
Echinococcus multilocularis G-protein coupled receptor, putative 0.0042 0.054 0.054
Entamoeba histolytica cysteine proteinase, putative 0.0154 0.2895 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0321 0.0321
Entamoeba histolytica cysteine proteinase 2 0.0086 0.146 0.4054
Brugia malayi Cathepsin L-like precursor 0.0154 0.2895 0.3109
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0321 0.0345
Plasmodium falciparum cysteine proteinase falcipain 3 0.0154 0.2895 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.073 0.0785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0154 0.2895 0.8838
Plasmodium vivax unspecified product 0.0086 0.146 0.4935
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0016 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0321 0.0345
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0062 0.0193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.054 0.054
Brugia malayi RE15519p 0.0042 0.054 0.058
Echinococcus granulosus g-protein coupled receptor 0.0042 0.054 0.054
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0321 0.0345
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Plasmodium falciparum glutathione reductase 0.0046 0.0619 0.1965
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.054 0.054
Loa Loa (eye worm) cathepsin B 0.017 0.3212 0.345
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0062 0.0066
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0016 0 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0154 0.2895 0.2895
Schistosoma mansoni biogenic amine receptor 0.0042 0.054 0.054
Leishmania major cathepsin L-like protease 0.0154 0.2895 0.9012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0321 0.0321
Brugia malayi neuropeptide F receptor 0.0042 0.054 0.058
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0042 0.054 0.058
Onchocerca volvulus 0.0042 0.054 0.0314
Plasmodium vivax vivapain-2 0.0154 0.2895 1
Brugia malayi nuclear receptor RXR 0.0017 0.0011 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0154 0.2895 0.3109
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.017 0.3212 0.3212
Trypanosoma cruzi cysteine protease, putative 0.0086 0.146 0.1568
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.054 0.054
Brugia malayi putative neuropeptide receptor 0.0042 0.054 0.058
Leishmania major trypanothione reductase 0.0046 0.0619 0.1926
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0321 0.0321
Toxoplasma gondii cathepsin B 0.017 0.3212 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1843 0.8834
Trypanosoma cruzi cysteine proteinase, putative 0.0086 0.146 0.1568
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.2182 0.2344
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.054 0.054
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0062 0.0193
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.2087 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0321 0.0345
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0154 0.2895 0.8838
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.146 0.1568
Brugia malayi hypothetical protein 0.0042 0.054 0.058
Echinococcus multilocularis cysteine protease 0.0154 0.2895 0.2895
Schistosoma mansoni opsin-like receptor 0.0042 0.054 0.054
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0321 0.0321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0154 0.2895 0.9012
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0042 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Brugia malayi hypothetical protein 0.0042 0.054 0.058
Echinococcus multilocularis g protein coupled receptor 0.0042 0.054 0.054
Echinococcus multilocularis cathepsin L 0.0086 0.146 0.146
Brugia malayi cathepsin Z-like cysteine proteinase 0.0039 0.0482 0.0517
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0042 0.054 0.054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0321 0.0321
Echinococcus multilocularis cathepsin L 0.0039 0.0482 0.0482
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0086 0.146 0.1568
Echinococcus granulosus neuropeptide receptor 0.0042 0.054 0.054
Toxoplasma gondii thioredoxin reductase 0.0046 0.0619 0.1926
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0016 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.0482 0.0517
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0039 0.0482 0.1482
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.054 0.054
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0321 0.0321
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0042 0.054 0.058
Echinococcus multilocularis cathepsin b 0.0461 0.931 0.931
Loa Loa (eye worm) hypothetical protein 0.0031 0.0321 0.0345
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0154 0.2895 0.9012
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.054 0.054
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0039 0.0482 0.1482
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.2895 0.8838
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.054 0.054
Brugia malayi hypothetical protein 0.0042 0.054 0.058
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0011
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.3219 0.3219
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0572 0.0572
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108 0.1916 0.5255
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0321 0.0321
Brugia malayi hypothetical protein 0.0042 0.054 0.058
Loa Loa (eye worm) melatonin receptor type 1A 0.0042 0.054 0.058
Onchocerca volvulus 0.0042 0.054 0.0314
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0042 0.054 0.054
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.054 0.054
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0011 0.0011
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Echinococcus granulosus GPCR family 2 0.0038 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.0108 0.1916 0.2059
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0039 0.0482 0.1482
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0016 0 0.5
Schistosoma mansoni hypothetical protein 0.0082 0.1385 0.1385
Schistosoma mansoni neuropeptide f receptor 76f 0.0042 0.054 0.054
Leishmania major cathepsin L-like protease 0.0154 0.2895 0.9012
Brugia malayi Cathepsin L-like precursor 0.0154 0.2895 0.3109
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.054 0.054
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.054 0.054
Entamoeba histolytica cysteine protease, putative 0.0086 0.146 0.4054
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0321 0.0321
Echinococcus granulosus cathepsin L 0.0086 0.146 0.146
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0016 0 0.5
Schistosoma mansoni hypothetical protein 0.0042 0.054 0.054
Brugia malayi larval opioid receptor 0.0042 0.054 0.058
Brugia malayi G-protein coupled receptor 0.0042 0.054 0.058
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0039 0.0482 0.1482
Echinococcus granulosus cathepsin l cysteine peptidase 0.0154 0.2895 0.2895
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.2895 0.8838
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0461 0.931 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.054 0.058

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.571 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1554, AID1674] ChEMBL. No reference
EC50 (functional) = 2.638 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 3.256 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 4.944 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
IC50 (functional) 38.89 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7308 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.4125 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 1.636 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.4974 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9093 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Beta-Lactamase Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9582 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1095 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.983 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.5911 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Fluorescein Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation in Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Texas Red Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6294 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23
Saccharomyces cerevisiae ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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