Detailed information for compound 1391694

Basic information

Technical information
  • TDR Targets ID: 1391694
  • Name: 1-[2-[(3-cyano-6-ethoxyquinolin-2-yl)amino]et hyl]-3-phenylurea
  • MW: 375.424 | Formula: C21H21N5O2
  • H donors: 3 H acceptors: 3 LogP: 3.82 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc2c(c1)cc(c(n2)NCCNC(=O)Nc1ccccc1)C#N
  • InChi: 1S/C21H21N5O2/c1-2-28-18-8-9-19-15(13-18)12-16(14-22)20(26-19)23-10-11-24-21(27)25-17-6-4-3-5-7-17/h3-9,12-13H,2,10-11H2,1H3,(H,23,26)(H2,24,25,27)
  • InChiKey: TTZVVXSANDEULP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-[(3-cyano-6-ethoxy-2-quinolyl)amino]ethyl]-3-phenyl-urea
  • 1-[2-[(3-cyano-6-ethoxy-2-quinolyl)amino]ethyl]-3-phenylurea
  • 1-[2-[(3-cyano-6-ethoxy-quinolin-2-yl)amino]ethyl]-3-phenyl-urea
  • 1-[2-(3-Cyano-6-ethoxy-quinolin-2-ylamino)-ethyl]-3-phenyl-urea
  • MLS000074890
  • ASN 05989291
  • SMR000006005

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens caspase 7, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens sphingomyelin phosphodiesterase 1, acid lysosomal Starlite/ChEMBL No references
Homo sapiens caspase 1, apoptosis-related cysteine peptidase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128629 All targets in OG5_128629
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Echinococcus granulosus caspase 8 caspase 1, apoptosis-related cysteine peptidase 383 aa 312 aa 26.6 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Brugia malayi Cell death protein 3 precursor caspase 7, apoptosis-related cysteine peptidase 303 aa 256 aa 37.1 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0433 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0325 0.7015
Schistosoma mansoni caspase-7 (C14 family) 0.0141 0.151 0.1502
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0433 1
Echinococcus granulosus geminin 0.0205 0.2288 0.228
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0073 0.0118
Onchocerca volvulus Cell death protein 3 homolog 0.0103 0.1043 1
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0356 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0433 0.7947
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0447 0.5266 1
Trypanosoma cruzi metacaspase, putative 0.0053 0.0433 0.0794
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0433 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0113
Trypanosoma brucei metacaspase 0.0053 0.0433 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0024 0.0073 0.1488
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0073 0.0138
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0113
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0073 0.0113
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0325 0.0316
Echinococcus granulosus apoptotic protease activating factor 1 0.005 0.0388 0.0378
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0542 0.0533
Schistosoma mansoni inositol monophosphatase 0.0045 0.0325 0.0315
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0073 0.0138
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0024 0.0073 0.0063
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0073 0.0138
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0433 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0095 0.2011
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0325 0.6996
Echinococcus multilocularis apoptotic protease activating factor 1 0.005 0.0388 0.0378
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0325 0.0459
Leishmania major fatty acid transporter protein-like protein 0.0447 0.5266 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0073 0.012
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0073 0.0113
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0325 0.0592
Echinococcus granulosus caspase 0.0141 0.151 0.1502
Trypanosoma brucei metacaspase MCA3 0.0053 0.0433 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0325 0.2714
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0024 0.0073 0.0138
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0542 0.0855
Trypanosoma cruzi metacaspase, putative 0.0053 0.0433 0.0794
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0325 0.0316
Echinococcus granulosus caspase 3 0.0088 0.0855 0.0846
Loa Loa (eye worm) hypothetical protein 0.005 0.0388 0.0681
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0325 0.7015
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0095 0.2011
Plasmodium falciparum metacaspase-like protein 0.0053 0.0433 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0356 0.3055
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0433 1
Brugia malayi jmjC domain containing protein 0.0071 0.0649 0.1151
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0073 0.0113
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.0073 0.0138
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0325 0.7459
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0447 0.5266 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0073 0.012
Schistosoma mansoni inositol monophosphatase 0.0045 0.0325 0.0315
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0542 0.1013
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0073 0.0138
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0453 0.5339 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0409 0.7498
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0409 0.9336
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0073 0.012
Schistosoma mansoni hypothetical protein 0.0205 0.2288 0.228
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0073 0.0113
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0113
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0649 0.064
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0542 0.0855
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0433 1
Brugia malayi hypothetical protein 0.005 0.0388 0.0681
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0325 0.7443
Trypanosoma brucei Metacaspase-4 0.0053 0.0433 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0267 0.0375
Schistosoma mansoni caspase-7 (C14 family) 0.0103 0.1043 0.1034
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0325 0.0315
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0649 0.064
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0113
Trypanosoma cruzi metacaspase, putative 0.0053 0.0433 0.0794
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0267 0.0507
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0433 0.0794
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0024 0.0073 0.0138
Trypanosoma brucei metacaspase MCA2 0.0053 0.0433 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0409 0.0399
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.1001 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0095 0.1598
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0024 0.0073 0.0138
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0433 1
Schistosoma mansoni hypothetical protein 0.005 0.0388 0.0378
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0073 0.012
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0325 0.0316
Loa Loa (eye worm) hypothetical protein 0.0053 0.0433 0.0762
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0325 0.0315
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0325 0.2721
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0433 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0433 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0024 0.0073 0.0113
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0325 0.5915
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0542 0.0533
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0113
Plasmodium vivax acetyl-CoA synthetase, putative 0.0024 0.0073 0.1488
Echinococcus multilocularis caspase 2 0.0103 0.1043 0.1034
Onchocerca volvulus 0.005 0.0388 0.3247
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0024 0.0073 0.1182
Echinococcus multilocularis geminin 0.0205 0.2288 0.228
Loa Loa (eye worm) hypothetical protein 0.0045 0.0325 0.0568
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0356 0.8191
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0542 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0325 0.0316
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0024 0.0073 0.1488
Brugia malayi hypothetical protein 0.0026 0.0095 0.0153
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0325 0.5
Plasmodium falciparum metacaspase 1 0.0053 0.0433 1
Leishmania major metacaspase, putative 0.0053 0.0433 0.0805
Echinococcus granulosus caspase 2 0.0103 0.1043 0.1034
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0325 0.7015
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0409 0.9336
Echinococcus multilocularis caspase 8 0.0053 0.0433 0.0423
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0073 0.0113
Brugia malayi Cell death protein 3 precursor 0.0103 0.1043 0.1861
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0325 0.0592
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0325 0.6996
Toxoplasma gondii propionate-CoA ligase 0.0024 0.0073 0.1182
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0073 0.0113
Trypanosoma cruzi metacaspase, putative 0.0053 0.0433 0.0794
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0433 1
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0649 0.064
Loa Loa (eye worm) hypothetical protein 0.0026 0.0095 0.0153
Loa Loa (eye worm) acetyltransferase 0.0175 0.1924 0.3449
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0024 0.0073 0.0063
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0649 0.064
Schistosoma mansoni caspase-3 (C14 family) 0.0141 0.151 0.1502
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0053 0.0433 0.0762
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0649 0.064
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0433 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1864 0.1856
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0325 0.0316
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1924 0.1917
Brugia malayi jmjC domain containing protein 0.0071 0.0649 0.1151
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0433 1
Echinococcus multilocularis caspase 3 0.0088 0.0855 0.0846
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0095 0.2011
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0542 0.0533
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0073 0.0113
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0325 0.0316
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0095 0.2011
Echinococcus granulosus long chain fatty acid transport protein 4 0.0453 0.5339 0.5334
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0325 0.0316
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0325 0.0599
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0542 0.0855
Echinococcus granulosus caspase 8 0.0053 0.0433 0.0423
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0053 0.0433 0.0423
Plasmodium vivax metacaspase 1, putative 0.0053 0.0433 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0325 0.0568
Schistosoma mansoni acetyl-CoA synthetase 0.0024 0.0073 0.0063
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0073 0.0118
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0433 0.0794
Echinococcus multilocularis caspase 0.0141 0.151 0.1502
Loa Loa (eye worm) oxidoreductase 0.0024 0.0073 0.0113
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0073 0.1488
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0073 0.0138
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0542 0.1029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0073 0.0138
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0325 0.0591
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0024 0.0073 0.0138
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0325 0.6996
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0024 0.0073 0.1182
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0325 0.06
Trypanosoma brucei metacaspase 5, putative 0.0053 0.0433 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0649 0.1151
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1924 0.3449
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0095 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0433 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1924 0.1917
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0073 0.0113
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0141 0.151 0.1502
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0453 0.5339 0.5334
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0073 0.012
Brugia malayi Inositol-1 0.0045 0.0325 0.0567
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0433 0.7947
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0409 0.7498
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0073 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0433 1
Loa Loa (eye worm) hypothetical protein 0.01 0.1001 0.1785
Brugia malayi AMP-binding enzyme family protein 0.0471 0.5561 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0649 0.064
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0649 0.064
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0141 0.151 0.1502
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.1001 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0433 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0471 0.5561 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0433 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.1043 0.1861
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0024 0.0073 0.0138
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0542 0.0533
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0095 0.016
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0325 0.0591
Leishmania major hypothetical protein, conserved 0.0026 0.0095 0.0162
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0073 0.0118
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0024 0.0073 0.0138
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0471 0.5561 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0433 0.7947
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0453 0.5339 1
Schistosoma mansoni hypothetical protein 0.0205 0.2288 0.228
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0073 0.0118
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0409 0.9435
Schistosoma mansoni FFA transport protein 0.0453 0.5339 0.5334
Loa Loa (eye worm) inositol-1 0.0045 0.0325 0.0567
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0325 0.0316

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1995 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0596 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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