Detailed information for compound 1395245

Basic information

Technical information
  • TDR Targets ID: 1395245
  • Name: 7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiaz epine
  • MW: 267.283 | Formula: C15H13N3O2
  • H donors: 1 H acceptors: 2 LogP: 2.85 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc2c(c1)C(=NCCN2)c1ccccc1
  • InChi: 1S/C15H13N3O2/c19-18(20)12-6-7-14-13(10-12)15(17-9-8-16-14)11-4-2-1-3-5-11/h1-7,10,16H,8-9H2
  • InChiKey: AOQMKLMZECLOEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • A3509/0148677
  • ZINC04623770

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0059 0.0058
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0204 0.1101 0.11
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.1613 0.8341
Echinococcus granulosus muscleblind protein 0.018 0.0965 0.0964
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0106 0.0541 0.1415
Brugia malayi hypothetical protein 0.0022 0.0059 0.0059
Echinococcus granulosus lamin dm0 0.003 0.0109 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Loa Loa (eye worm) fibroinase 0.0348 0.1922 0.1922
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0059 0.0058
Echinococcus granulosus geminin 0.0171 0.0908 0.0908
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0059 0.0058
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0059 0.0058
Plasmodium vivax vivapain-2 0.0348 0.1922 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0106 0.0541 0.054
Schistosoma mansoni cathepsin F (C01 family) 0.0348 0.1922 0.1922
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0059 0.0058
Schistosoma mansoni cpg binding protein 0.0034 0.0131 0.013
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0059 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0106 0.0541 0.1415
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0146 0.0145
Onchocerca volvulus 0.003 0.0109 0.0269
Plasmodium vivax vivapain-1 0.0204 0.1101 0.5378
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Onchocerca volvulus 0.0348 0.1922 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0106 0.0541 0.1415
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0229 0.0229
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0059 0.0058
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0619 0.3467 0.3126
Trypanosoma cruzi cysteine proteinase, putative 0.0204 0.1101 0.0637
Trypanosoma cruzi cysteine peptidase, putative 0.0348 0.1922 0.1501
Leishmania major cathepsin L-like protease 0.0402 0.2227 0.6054
Brugia malayi cathepsin L precursor 0.0106 0.0541 0.0541
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1765 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0229 0.0228
Brugia malayi nuclear receptor NHR-88 0.0022 0.0059 0.0059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1613 0.4561
Entamoeba histolytica cysteine protease, putative 0.0106 0.0541 0.2588
Schistosoma mansoni hypothetical protein 0.0171 0.0908 0.0908
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0059 0.0058
Echinococcus granulosus dnaJ subfamily B 0.046 0.2559 0.2559
Leishmania major cathepsin L-like protease 0.0348 0.1922 0.5084
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.0755 1
Giardia lamblia Cathepsin B precursor 0.0619 0.3467 1
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0326 0.0325
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0059 0.0058
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0106 0.0541 0.054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Brugia malayi Cathepsin L-like precursor 0.025 0.1362 0.1362
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Entamoeba histolytica cysteine protease, putative 0.0106 0.0541 0.2588
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0059 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0059 0.0059
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0326 0.0325
Schistosoma mansoni hypothetical protein 0.0051 0.0229 0.0228
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Loa Loa (eye worm) hypothetical protein 0.0348 0.1922 0.1922
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0059 0.0058
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0348 0.1922 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Brugia malayi Pre-SET motif family protein 0.0037 0.0146 0.0146
Giardia lamblia Cathepsin B precursor 0.0619 0.3467 1
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Echinococcus multilocularis lamin 0.003 0.0109 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0059 0.0059
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0059 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0059 0.0059
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0059 0.0058
Plasmodium vivax unspecified product 0.0204 0.1101 0.5378
Onchocerca volvulus Cathepsin L homolog 0.0348 0.1922 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0106 0.0541 0.2226
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0059 0.0058
Echinococcus multilocularis geminin 0.0171 0.0908 0.0908
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Echinococcus granulosus cathepsin l1 0.025 0.1362 0.1362
Echinococcus granulosus lamin 0.003 0.0109 0.0108
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0059 0.0058
Schistosoma mansoni cathepsin F (C01 family) 0.025 0.1362 0.1362
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0106 0.0541 0.2226
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0146 0.0145
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0059 0.0059
Schistosoma mansoni cathepsin s 0.0098 0.0496 0.0495
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0059 0.0058
Entamoeba histolytica hypothetical protein 0.0036 0.0143 0.0448
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Echinococcus granulosus expressed protein 0.042 0.233 0.2329
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Schistosoma mansoni cpg binding protein 0.0032 0.012 0.0119
Echinococcus multilocularis cathepsin L cysteine protease 0.0348 0.1922 0.1922
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0059 0.0059
Echinococcus granulosus sodium:glucose cotransporter 0.0043 0.0182 0.0181
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.002 0.0019
Entamoeba histolytica hypothetical protein 0.0036 0.0143 0.0448
Echinococcus granulosus cathepsin b 0.1765 1 1
Brugia malayi intermediate filament protein 0.003 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0106 0.0541 0.1415
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0001 0.0001
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0229 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0059 0.0059
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0204 0.1101 0.11
Brugia malayi nuclear receptor RXR 0.0011 0.0001 0.0001
Brugia malayi Muscleblind-like protein 0.018 0.0965 0.0965
Schistosoma mansoni cathepsin C 0.0106 0.0541 0.054
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0059 0.0058
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0098 0.0496 0.0495
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1613 0.4561
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0229 0.0228
Loa Loa (eye worm) hypothetical protein 0.0098 0.0496 0.0495
Loa Loa (eye worm) hypothetical protein 0.003 0.0109 0.0108
Echinococcus multilocularis cysteine protease 0.0348 0.1922 0.1922
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.018 0.0965 0.0964
Echinococcus multilocularis muscleblind protein 1 0.018 0.0965 0.0964
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Plasmodium vivax vivapain-2 0.0348 0.1922 1
Trypanosoma cruzi cruzipain precursor, putative 0.0402 0.2227 0.1821
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0162 0.0862 0.0861
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0106 0.0541 0.2226
Entamoeba histolytica hypothetical protein 0.0036 0.0143 0.0448
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0106 0.0541 0.2588
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0059 0.0058
Onchocerca volvulus Cathepsin L homolog 0.0348 0.1922 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0106 0.0541 0.0541
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Entamoeba histolytica cysteine protease, putative 0.0106 0.0541 0.2588
Onchocerca volvulus 0.0348 0.1922 1
Entamoeba histolytica hypothetical protein 0.0036 0.0143 0.0448
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0541 0.1415
Echinococcus multilocularis cathepsin L 0.0106 0.0541 0.0541
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma cruzi cysteine peptidase, putative 0.0402 0.2227 0.1821
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Loa Loa (eye worm) hypothetical protein 0.0098 0.0496 0.0495
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0059 0.0058
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0106 0.0541 0.054
Plasmodium falciparum cysteine proteinase falcipain 1 0.0204 0.1101 0.4054
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Plasmodium falciparum cysteine proteinase falcipain 3 0.0348 0.1922 1
Echinococcus multilocularis muscleblind protein 0.018 0.0965 0.0964
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0059 0.0058
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0348 0.1922 0.1922
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0043 0.0182 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0059 0.0058
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0143 0.0142
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0059 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0059 0.0058
Schistosoma mansoni lamin 0.003 0.0109 0.0108
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0204 0.1101 0.11
Brugia malayi Papain family cysteine protease containing protein 0.0106 0.0541 0.0541
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0106 0.0541 0.054
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0059 0.0059
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.1613 0.8341
Onchocerca volvulus 0.025 0.1362 0.6995
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0059 0.0058
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0109 0.0108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Entamoeba histolytica cysteine proteinase 2 0.0204 0.1101 0.5593
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0059 0.0058
Schistosoma mansoni hypothetical protein 0.0171 0.0908 0.0908
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0326 0.0542
Echinococcus multilocularis musashi 0.003 0.0109 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Brugia malayi Papain family cysteine protease containing protein 0.0204 0.1101 0.1101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.025 0.1362 0.3825
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0059 0.0058
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0059 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1613 0.4561
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0106 0.0541 0.1415
Trypanosoma cruzi major cysteine proteinase, putative 0.0106 0.0541 0.0048
Echinococcus granulosus GPCR family 2 0.0051 0.0229 0.0228
Echinococcus granulosus cathepsin L cysteine proteinase 0.0348 0.1922 0.1922
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0106 0.0541 0.0541
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.0755 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0348 0.1922 0.5468
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0619 0.3467 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Echinococcus granulosus high affinity choline transporter 1 0.0391 0.2165 0.2165
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0016
Onchocerca volvulus 0.0348 0.1922 1
Brugia malayi PXA domain containing protein 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0162 0.0862 0.0861
Brugia malayi Cathepsin L-like precursor 0.0348 0.1922 0.1922
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Echinococcus multilocularis cathepsin L cysteine protease 0.0348 0.1922 0.1922
Schistosoma mansoni cathepsin S (C01 family) 0.0106 0.0541 0.054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0059 0.0058
Schistosoma mansoni high-affinity choline transporter 0.0391 0.2165 0.2164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0059 0.0058
Echinococcus granulosus cathepsin b 0.1765 1 1
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0059 0.0058
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0029 0.0029
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0106 0.0541 0.2226
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Brugia malayi Calcitonin receptor-like protein seb-1 0.0162 0.0862 0.0862
Echinococcus multilocularis lamin dm0 0.003 0.0109 0.0108
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0304 0.1667 0.1232
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0348 0.1922 0.1922
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0619 0.3467 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.025 0.1362 0.3825
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0059 0.0058
Brugia malayi CXXC zinc finger family protein 0.0032 0.012 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0541 0.1415
Loa Loa (eye worm) hypothetical protein 0.1765 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Plasmodium vivax serine-repeat antigen (SERA) 0.0106 0.0541 0.2226
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.1613 0.5
Leishmania major cathepsin L-like protease 0.0348 0.1922 0.5084
Loa Loa (eye worm) hypothetical protein 0.0098 0.0496 0.0495
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0001 0.0001
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0029 0.0028
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Brugia malayi Cathepsin L-like precursor 0.025 0.1362 0.1362
Entamoeba histolytica cysteine proteinase, putative 0.0348 0.1922 1
Schistosoma mansoni hypothetical protein 0.046 0.2559 0.2558
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.002 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0106 0.0541 0.1415
Loa Loa (eye worm) hypothetical protein 0.0106 0.0541 0.0541
Leishmania major cathepsin L-like protease 0.0348 0.1922 0.5084
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0059 0.0058
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0059 0.0058
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0059 0.0058
Schistosoma mansoni hypothetical protein 0.0051 0.0229 0.0228
Echinococcus granulosus cathepsin l1 0.0348 0.1922 0.1922
Onchocerca volvulus 0.0348 0.1922 1
Schistosoma mansoni inositol transporter 0.0043 0.0182 0.0181
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.0755 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0204 0.1101 0.0637
Entamoeba histolytica cysteine protease, putative 0.0348 0.1922 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Loa Loa (eye worm) hypothetical protein 0.0106 0.0541 0.0541
Entamoeba histolytica cysteine proteinase, putative 0.0204 0.1101 0.5593
Brugia malayi PXA domain containing protein 0.0022 0.0059 0.0059
Loa Loa (eye worm) cathepsin B 0.0619 0.3467 0.3466
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0162 0.0862 0.0862
Plasmodium vivax unspecified product 0.0098 0.0496 0.1972
Onchocerca volvulus 0.0287 0.1571 0.8115
Loa Loa (eye worm) hypothetical protein 0.0043 0.0182 0.0181
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0059 0.0058
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0098 0.0496 0.0496
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0059 0.0059
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0059 0.0058
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0059 0.0058
Onchocerca volvulus 0.0348 0.1922 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0134 0.0133
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0059 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0059 0.0059
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0146 0.0145
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0106 0.0541 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0541 0.1415
Brugia malayi Sodium:solute symporter family protein 0.0043 0.0182 0.0182
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0059 0.0059
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0059 0.0058
Brugia malayi hypothetical protein 0.0036 0.0143 0.0143
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0326 0.0325
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0146 0.0145
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Entamoeba histolytica cysteine protease, putative 0.0106 0.0541 0.2588
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0059 0.0058
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0106 0.0541 0.2226
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0229 0.0228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0204 0.1101 0.3058
Echinococcus multilocularis cathepsin L 0.0204 0.1101 0.1101
Echinococcus granulosus cathepsin L 0.0204 0.1101 0.1101
Toxoplasma gondii cathepsin B 0.0619 0.3467 1
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0326 0.0325
Loa Loa (eye worm) intermediate filament protein 0.003 0.0109 0.0108
Echinococcus multilocularis cysteine protease 0.0348 0.1922 0.1922
Brugia malayi cathepsin F-like cysteine proteinase 0.0098 0.0496 0.0496
Brugia malayi Cathepsin L-like precursor 0.0348 0.1922 0.1922
Echinococcus multilocularis high affinity choline transporter 1 0.0391 0.2165 0.2165
Echinococcus multilocularis expressed protein 0.042 0.233 0.2329
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0059 0.0058
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1765 1 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0059 0.0058
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0106 0.0541 0.2226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0204 0.1101 0.3058
Brugia malayi Pre-SET motif family protein 0.0252 0.1373 0.1373
Loa Loa (eye worm) hypothetical protein 0.0106 0.0541 0.0541
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0059 0.0058
Onchocerca volvulus 0.0037 0.0146 0.0466
Brugia malayi Papain family cysteine protease containing protein 0.0204 0.1101 0.1101
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0146 0.0145
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0059 0.0058
Brugia malayi steroid hormone receptor 0.0022 0.0059 0.0059
Brugia malayi fibroinase precursor 0.0106 0.0541 0.0541
Onchocerca volvulus 0.0348 0.1922 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0059 0.0058
Brugia malayi Cathepsin L-like precursor 0.0348 0.1922 0.1922
Brugia malayi Cathepsin L-like cysteine proteinase 0.025 0.1362 0.1362
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0059 0.0058
Trypanosoma cruzi cysteine proteinase, putative 0.0204 0.1101 0.0637
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0391 0.2165 0.2165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Toxoplasma gondii preprocathepsin c precursor, putative 0.0106 0.0541 0.1191
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0229 0.0228
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.1613 0.3664
Loa Loa (eye worm) hypothetical protein 0.0106 0.0541 0.0541
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0059 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1613 0.4561
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0059 0.0058
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0293 0.0442
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0059 0.0058
Echinococcus granulosus cysteine protease 0.0204 0.1101 0.1101
Toxoplasma gondii cathepsin CPC2 0.0106 0.0541 0.1191
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0059 0.0059
Entamoeba histolytica cysteine proteinase, putative 0.0204 0.1101 0.5593
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0059 0.0059
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0059 0.0058
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.012 0.012
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Echinococcus multilocularis GPCR, family 2 0.0051 0.0229 0.0228
Entamoeba histolytica cysteine proteinase, putative 0.0204 0.1101 0.5593
Loa Loa (eye worm) hypothetical protein 0.025 0.1362 0.1362
Brugia malayi Papain family cysteine protease containing protein 0.0348 0.1922 0.1922
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0143 0.0142
Schistosoma mansoni sodium/solute symporter 0.0043 0.0182 0.0181
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0059 0.0058
Schistosoma mansoni hypothetical protein 0.0036 0.0143 0.0142
Onchocerca volvulus 0.003 0.0109 0.0269
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1613 0.4561
Schistosoma mansoni intermediate filament proteins 0.003 0.0109 0.0108
Schistosoma mansoni hypothetical protein 0.0111 0.0569 0.0568
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0043 0.0182 0.0109
Schistosoma mansoni hypothetical protein 0.0051 0.0229 0.0228
Echinococcus multilocularis dnaJ subfamily B 0.046 0.2559 0.2559
Onchocerca volvulus Cathepsin F homolog 0.0348 0.1922 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0541 0.1415
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0106 0.0541 0.054
Brugia malayi hypothetical protein 0.0322 0.1772 0.1772
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0059 0.0058
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1728 0.9789 0.9789
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0348 0.1922 0.5468
Echinococcus granulosus sodium:glucose cotransporter 2 0.0043 0.0182 0.0181
Onchocerca volvulus 0.0043 0.0182 0.066
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0059 0.0058
Brugia malayi cathepsin L-like precursor 0.025 0.1362 0.1362
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.0145
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0059 0.0058
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0059 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0059 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0059 0.0058
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0106 0.0541 0.2588
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0059 0.0058
Echinococcus multilocularis cpg binding protein 0.0034 0.0131 0.013
Loa Loa (eye worm) hypothetical protein 0.018 0.0965 0.0964
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0059 0.0058
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0334 0.0333
Toxoplasma gondii cathepsin CPC1 0.0106 0.0541 0.1191
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0106 0.0541 0.054
Schistosoma mansoni coup transcription factor 0.0022 0.0059 0.0058
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0106 0.0541 0.054
Brugia malayi GH02984p 0.0391 0.2165 0.2165
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0106 0.0541 0.2226
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0106 0.0541 0.1415
Brugia malayi Cathepsin L-like precursor 0.0348 0.1922 0.1922
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0106 0.0541 0.2226
Leishmania major cathepsin L-like protease 0.0402 0.2227 0.6054
Plasmodium vivax vivapain-3 0.0204 0.1101 0.5378
Schistosoma mansoni cathepsin F (C01 family) 0.0348 0.1922 0.1922
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0348 0.1922 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0348 0.1922 0.1922
Brugia malayi Cathepsin L-like precursor 0.0348 0.1922 0.1922
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0059 0.0059
Loa Loa (eye worm) ctsf protein 0.0348 0.1922 0.1922
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0059 0.0058
Echinococcus granulosus cathepsin L 0.0106 0.0541 0.0541
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0059 0.0058
Echinococcus granulosus cathepsin l cysteine peptidase 0.0348 0.1922 0.1922
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0146 0.0145
Plasmodium vivax serine-repeat antigen (SERA) 0.0106 0.0541 0.2226
Brugia malayi latrophilin 2 splice variant baaae 0.0111 0.0569 0.0569
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0146 0.0145
Brugia malayi cathepsin Z-like cysteine proteinase 0.0106 0.0541 0.0541
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1613 0.4561
Onchocerca volvulus 0.0322 0.1772 0.9194
Brugia malayi nuclear hormone receptor 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0111 0.0569 0.0568
Echinococcus granulosus cpg binding protein 0.0034 0.0131 0.013
Schistosoma mansoni cathepsin B (C01 family) 0.0106 0.0541 0.054
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0059 0.0058
Leishmania major cathepsin L-like protease 0.0348 0.1922 0.5084
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0059 0.0058
Giardia lamblia Cathepsin B precursor 0.0619 0.3467 1
Trypanosoma cruzi cysteine peptidase, putative 0.0402 0.2227 0.1821
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0059 0.0058
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Leishmania major cysteine peptidase A (CPA) 0.0348 0.1922 0.5084
Brugia malayi Papain family cysteine protease containing protein 0.0106 0.0541 0.0541
Onchocerca volvulus Cathepsin L homolog 0.0106 0.0541 0.2588
Loa Loa (eye worm) hypothetical protein 0.0106 0.0541 0.0541
Entamoeba histolytica cysteine proteinase, putative 0.025 0.1362 0.6995
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0106 0.0541 0.1415
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0059 0.0058
Brugia malayi hypothetical protein 0.0022 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0106 0.0541 0.1415
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1613 0.4561
Echinococcus granulosus solute carrier family 5 0.0043 0.0182 0.0181
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1765 1 1
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0043 0.0182 0.0181
Brugia malayi Papain family cysteine protease containing protein 0.0106 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Echinococcus multilocularis cathepsin b 0.1765 1 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0106 0.0541 0.0541
Entamoeba histolytica cysteine proteinase, putative 0.0204 0.1101 0.5593
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0059 0.0059
Onchocerca volvulus 0.0106 0.0541 0.2588
Echinococcus granulosus sodium:myo inositol cotransporter 0.0043 0.0182 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0059 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0106 0.0541 0.1415
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0619 0.3467 0.3466
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.1373 0.1373
Loa Loa (eye worm) hypothetical protein 0.0322 0.1772 0.1772
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0059 0.0058
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0059 0.0058
Trypanosoma cruzi major cysteine proteinase, putative 0.016 0.0846 0.0368
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Brugia malayi cathepsin L-like cysteine proteinase 0.0106 0.0541 0.0541
Onchocerca volvulus 0.0032 0.012 0.0329
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0106 0.0541 0.054
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0348 0.1922 0.1922
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Leishmania major cathepsin L-like protease 0.0348 0.1922 0.5084
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0109 0.0109
Entamoeba histolytica hypothetical protein 0.0106 0.0541 0.2588
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0059 0.0058
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0106 0.0541 0.2226
Trypanosoma brucei cysteine peptidase C (CPC) 0.0619 0.3467 1
Echinococcus granulosus cathepsin L cysteine protease 0.0204 0.1101 0.1101
Entamoeba histolytica cysteine protease, putative 0.0106 0.0541 0.2588
Entamoeba histolytica cysteine proteinase 1, putative 0.0204 0.1101 0.5593
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0059 0.0058
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0043 0.0182 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0541 0.1415
Plasmodium vivax unspecified product 0.0106 0.0541 0.2226
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0019
Leishmania major cathepsin L-like protease 0.0402 0.2227 0.6054
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.025 0.1362 0.1362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0541 0.1415
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0106 0.0541 0.2226
Brugia malayi Cathepsin L-like precursor 0.0348 0.1922 0.1922
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0059 0.0058
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0204 0.1101 0.0637
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Echinococcus multilocularis solute carrier family 5 0.0043 0.0182 0.0181
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0106 0.0541 0.0541
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0541 0.1415
Schistosoma mansoni inositol transporter 0.0043 0.0182 0.0181
Brugia malayi Cathepsin L-like precursor 0.0098 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0051 0.0229 0.0228
Trypanosoma cruzi cysteine protease, putative 0.0204 0.1101 0.0637
Echinococcus multilocularis cathepsin b 0.1765 1 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0106 0.0541 0.0541
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1765 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1613 0.4561
Trichomonas vaginalis set domain proteins, putative 0.0287 0.1571 0.4438
Echinococcus granulosus intermediate filament protein 0.003 0.0109 0.0108
Entamoeba histolytica cysteine proteinase, putative 0.0348 0.1922 1
Onchocerca volvulus 0.0348 0.1922 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0106 0.0541 0.0541
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0043 0.0182 0.0181
Schistosoma mansoni lamin 0.003 0.0109 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Schistosoma mansoni hypothetical protein 0.0051 0.0229 0.0228
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0143 0.0142
Brugia malayi cathepsin F-like cysteine proteinase 0.0106 0.0541 0.0541
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1765 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0229 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0059 0.0058
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.025 0.1362 0.1362
Trypanosoma cruzi cysteine peptidase, putative 0.0402 0.2227 0.1821
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.003 0.0106 0.0105
Toxoplasma gondii cathepsin CPL 0.0348 0.1922 0.535
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0541 0.1415
Brugia malayi ecdysteroid receptor 0.0022 0.0059 0.0059
Loa Loa (eye worm) cysteine protease 0.0348 0.1922 0.1922
Entamoeba histolytica cysteine protease, putative 0.0106 0.0541 0.2588
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0106 0.0541 0.1415
Schistosoma mansoni cpg binding protein 0.0034 0.0131 0.013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0066 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.1413 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.