Detailed information for compound 1396988

Basic information

Technical information
  • TDR Targets ID: 1396988
  • Name: N-(1-phenylethyl)-[1,2,4]triazolo[3,4-c]quino xalin-4-amine
  • MW: 289.335 | Formula: C17H15N5
  • H donors: 1 H acceptors: 3 LogP: 3.74 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1ccccc1)Nc1nc2ccccc2n2c1nnc2
  • InChi: 1S/C17H15N5/c1-12(13-7-3-2-4-8-13)19-16-17-21-18-11-22(17)15-10-6-5-9-14(15)20-16/h2-12H,1H3,(H,19,20)
  • InChiKey: OZIUWUZZYISAIK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-phenylethyl-([1,2,4]triazolo[3,4-c]quinoxalin-4-yl)amine
  • SMR000309848
  • MLS000731573
  • N-(1-phenylethyl)[1,2,4]triazolo[4,3-a]quinoxalin-4-amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0023 0.0023
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0094 0.0094
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0081 0.0553 0.029
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0075 0.0511 0.0498
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0315 0.2322 0.5103
Toxoplasma gondii preprocathepsin c precursor, putative 0.0081 0.0553 0.0959
Echinococcus multilocularis GPCR, family 2 0.0035 0.0211 0.0211
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0418 0.5
Schistosoma mansoni regulator of G protein signaling 0.002 0.0094 0.0094
Schistosoma mansoni inositol transporter 0.004 0.0243 0.0243
Entamoeba histolytica cysteine protease, putative 0.0266 0.1952 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0081 0.0553 0.0553
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0094 0.0094
Onchocerca volvulus Cathepsin L homolog 0.0266 0.1952 1
Schistosoma mansoni cathepsin B (C01 family) 0.0081 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.0266 0.1952 0.1518
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.054
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0023 0.0023
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0094 0.0094
Brugia malayi cathepsin L-like precursor 0.0191 0.1385 0.1374
Onchocerca volvulus 0.004 0.0243 0.1141
Brugia malayi Cathepsin L-like precursor 0.0191 0.1385 0.1374
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0094 0.0081
Brugia malayi Papain family cysteine protease containing protein 0.0081 0.0553 0.0541
Plasmodium vivax serine-repeat antigen (SERA) 0.0081 0.0553 0.029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.1952 0.5495
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0418 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.1952 0.5495
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0266 0.1952 0.5495
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.1952 0.5495
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0266 0.1952 0.1941
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0266 0.1952 0.1952
Brugia malayi Cathepsin L-like precursor 0.0266 0.1952 0.1941
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0315 0.2322 0.5103
Schistosoma mansoni cathepsin s 0.0075 0.0511 0.0511
Entamoeba histolytica cysteine protease, putative 0.0081 0.0553 0.2472
Plasmodium vivax vivapain-2 0.0266 0.1952 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0553 0.1358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.1952 0.5495
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0081 0.0553 0.0541
Onchocerca volvulus 0.0081 0.0553 0.2748
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0023 0.0023
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0418 0.5
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0094 0.0094
Echinococcus granulosus lamin 0.0028 0.0155 0.0155
Leishmania major cathepsin L-like protease 0.0266 0.1952 0.5017
Plasmodium vivax vivapain-3 0.0156 0.112 0.4226
Plasmodium vivax vivapain-1 0.0156 0.112 0.4226
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.1952 0.5495
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.3133 0.3133
Leishmania major cathepsin L-like protease 0.0315 0.2322 0.6228
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0023 0.0023
Schistosoma mansoni cathepsin F (C01 family) 0.0266 0.1952 0.1952
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0023 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.1952 0.5495
Loa Loa (eye worm) hypothetical protein 0.0075 0.0511 0.0498
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0553 0.1358
Loa Loa (eye worm) RGS-3 protein 0.002 0.0094 0.008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.1952 0.5495
Brugia malayi PXA domain containing protein 0.002 0.0094 0.0081
Onchocerca volvulus 0.0266 0.1952 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0081 0.0553 0.1358
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0081 0.0553 0.029
Loa Loa (eye worm) hypothetical protein 0.0191 0.1385 0.1373
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.112 0.3035
Entamoeba histolytica hypothetical protein 0.0043 0.0272 0.096
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0081 0.0553 0.0553
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0023 0.0023
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.0787 0.0775
Brugia malayi nuclear receptor NHR-88 0.001 0.0023 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0553 0.1358
Brugia malayi cathepsin F-like cysteine proteinase 0.0081 0.0553 0.0541
Onchocerca volvulus Cathepsin F homolog 0.0266 0.1952 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0838 0.6267 0.6267
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.1952 0.5495
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0094 0.0094
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0155 0.0142
Loa Loa (eye worm) cathepsin B 0.0468 0.3475 0.3466
Echinococcus multilocularis sodium:myo inositol cotransporter 0.004 0.0243 0.0243
Echinococcus multilocularis lamin 0.0028 0.0155 0.0155
Entamoeba histolytica cysteine protease, putative 0.0156 0.112 0.5524
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0023 0.0023
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0521 0.0508
Loa Loa (eye worm) hypothetical protein 0.0156 0.1123 0.111
Entamoeba histolytica cysteine protease, putative 0.0156 0.112 0.5524
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0057 0.0043
Schistosoma mansoni hypothetical protein 0.0043 0.0272 0.0272
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0023 0.0023
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0369 0.0388
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0081 0.0553 0.1358
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0094 0.0094
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.112 0.5524
Entamoeba histolytica cysteine protease, putative 0.0156 0.112 0.5524
Onchocerca volvulus 0.0191 0.1385 0.706
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0023 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0023 0.001
Entamoeba histolytica cysteine protease, putative 0.0156 0.112 0.5524
Entamoeba histolytica cysteine protease, putative 0.0156 0.112 0.5524
Entamoeba histolytica cysteine protease, putative 0.0081 0.0553 0.2472
Brugia malayi GH02984p 0.0359 0.2654 0.2645
Onchocerca volvulus 0.0266 0.1952 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0023 0.001
Echinococcus multilocularis cysteine protease 0.0266 0.1952 0.1952
Schistosoma mansoni regulator of G protein signaling 0.002 0.0094 0.0094
Brugia malayi Papain family cysteine protease containing protein 0.0081 0.0553 0.0541
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0211 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0315 0.2322 0.5103
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0081 0.0553 0.029
Schistosoma mansoni lamin 0.0028 0.0155 0.0155
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0081 0.0553 0.1358
Loa Loa (eye worm) fibroinase 0.0266 0.1952 0.1941
Schistosoma mansoni hypothetical protein 0.0076 0.0521 0.0521
Entamoeba histolytica cysteine protease, putative 0.0156 0.112 0.5524
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0266 0.1952 1
Echinococcus granulosus dnaJ subfamily B 0.0423 0.3133 0.3133
Schistosoma mansoni high-affinity choline transporter 0.0359 0.2654 0.2654
Brugia malayi Cathepsin L-like precursor 0.0266 0.1952 0.1941
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0081 0.0553 0.0553
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0023 0.001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0272 0.0272
Loa Loa (eye worm) cysteine protease 0.0266 0.1952 0.1941
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.054
Brugia malayi cathepsin L-like cysteine proteinase 0.0081 0.0553 0.0541
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.0787 0.0775
Entamoeba histolytica cysteine proteinase, putative 0.0266 0.1952 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.008
Schistosoma mansoni cpg binding protein 0.003 0.0168 0.0168
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.004 0.0243 0.0243
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0081 0.0553 0.0553
Onchocerca volvulus 0.0266 0.1952 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.001
Echinococcus granulosus axis inhibition protein axin 0.002 0.0094 0.0094
Brugia malayi hypothetical protein 0.0043 0.0272 0.026
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0156 0.112 0.112
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0094 0.0094
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0081 0.0553 0.054
Schistosoma mansoni thyroid hormone receptor 0.001 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.1952 0.5495
Echinococcus granulosus solute carrier family 5 0.004 0.0243 0.0243
Onchocerca volvulus 0.0266 0.1952 1
Echinococcus multilocularis solute carrier family 5 0.004 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.054
Entamoeba histolytica cysteine protease, putative 0.0156 0.112 0.5524
Echinococcus multilocularis expressed protein 0.0386 0.2855 0.2855
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.112 0.1109
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0094 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.1952 0.5495
Brugia malayi Cathepsin L-like precursor 0.0191 0.1385 0.1374
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0081 0.0553 0.029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0315 0.2322 0.5103
Entamoeba histolytica hypothetical protein 0.0043 0.0272 0.096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0315 0.2322 0.5103
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0023 0.0023
Trypanosoma brucei cysteine peptidase C (CPC) 0.0468 0.3475 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0023 0.0023
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0418 0.0418
Brugia malayi Cathepsin L-like precursor 0.0266 0.1952 0.1941
Leishmania major cysteine peptidase A (CPA) 0.0266 0.1952 0.5017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0081 0.0553 0.1358
Schistosoma mansoni axis inhibition protein axin 0.002 0.0094 0.0094
Brugia malayi Cathepsin L-like precursor 0.0075 0.0511 0.0499
Entamoeba histolytica cysteine proteinase 2 0.0156 0.112 0.5524
Entamoeba histolytica cysteine proteinase, putative 0.0266 0.1952 1
Brugia malayi Cathepsin L-like precursor 0.0266 0.1952 0.1941
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0023 0.0023
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0081 0.0553 0.029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.1952 0.5495
Toxoplasma gondii cathepsin CPC2 0.0081 0.0553 0.0959
Brugia malayi Sodium:solute symporter family protein 0.004 0.0243 0.0231
Echinococcus granulosus cathepsin l1 0.0191 0.1385 0.1385
Echinococcus granulosus lamin dm0 0.0028 0.0155 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0081 0.0553 0.1358
Entamoeba histolytica cysteine protease, putative 0.0156 0.112 0.5524
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0094 0.0094
Toxoplasma gondii cathepsin CPL 0.0266 0.1952 0.5286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0315 0.2322 0.5103
Loa Loa (eye worm) hypothetical protein 0.0266 0.1952 0.1941
Echinococcus granulosus cysteine protease 0.0156 0.112 0.112
Trypanosoma cruzi cysteine proteinase, putative 0.0156 0.112 0.0641
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.0787 0.0775
Brugia malayi cathepsin Z-like cysteine proteinase 0.0081 0.0553 0.0541
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0468 0.3475 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0211 0.0199
Plasmodium vivax unspecified product 0.0156 0.112 0.4226
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0468 0.3475 0.3123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.1952 0.5495
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0023 0.0023
Entamoeba histolytica hypothetical protein 0.0043 0.0272 0.096
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.112 0.5524
Schistosoma mansoni hypothetical protein 0.0035 0.0211 0.0211
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0155 0.0141
Brugia malayi intermediate filament protein 0.0028 0.0155 0.0142
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0081 0.0553 0.054
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.1952 0.1941
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0553 0.1358
Toxoplasma gondii cathepsin B 0.0468 0.3475 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0081 0.0553 0.0541
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0094 0.0081
Entamoeba histolytica hypothetical protein 0.0081 0.0553 0.2472
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0081 0.0553 0.1358
Entamoeba histolytica cysteine protease, putative 0.0156 0.112 0.5524
Schistosoma mansoni intermediate filament proteins 0.0028 0.0155 0.0155
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0081 0.0553 0.0553
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0094 0.0094
Onchocerca volvulus Cathepsin L homolog 0.0081 0.0553 0.2748
Entamoeba histolytica cysteine protease, putative 0.0156 0.112 0.5524
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0211 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.1952 0.5495
Loa Loa (eye worm) hypothetical protein 0.0359 0.2654 0.2644
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0081 0.0553 0.029
Brugia malayi Papain family cysteine protease containing protein 0.0081 0.0553 0.0541
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0081 0.0553 0.1358
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0094 0.008
Brugia malayi Cathepsin L-like precursor 0.0266 0.1952 0.1941
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0081 0.0553 0.1358
Plasmodium vivax vivapain-2 0.0266 0.1952 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.008
Echinococcus granulosus cathepsin L cysteine protease 0.0156 0.112 0.112
Echinococcus granulosus cathepsin l cysteine peptidase 0.0266 0.1952 0.1952
Entamoeba histolytica cysteine protease, putative 0.0156 0.112 0.5524
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0315 0.2322 0.5103
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0023 0.001
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0081 0.0553 0.0553
Leishmania major cathepsin L-like protease 0.0266 0.1952 0.5017
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0155 0.0141
Loa Loa (eye worm) hypothetical protein 0.0027 0.0151 0.0137
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0023 0.0023
Onchocerca volvulus 0.003 0.0168 0.0753
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.1952 0.5495
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0094 0.0081
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0468 0.3475 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0243 0.023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0023 0.0023
Schistosoma mansoni axis inhibition protein axin 0.002 0.0094 0.0094
Plasmodium falciparum cysteine proteinase falcipain 3 0.0266 0.1952 1
Onchocerca volvulus 0.0266 0.1952 1
Echinococcus granulosus cpg binding protein 0.0031 0.0181 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0023 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0023 0.001
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.001
Schistosoma mansoni hypothetical protein 0.0035 0.0211 0.0211
Plasmodium vivax serine-repeat antigen (SERA) 0.0081 0.0553 0.029
Leishmania major cathepsin L-like protease 0.0315 0.2322 0.6228
Brugia malayi Cathepsin L-like cysteine proteinase 0.0191 0.1385 0.1374
Echinococcus granulosus intermediate filament protein 0.0028 0.0155 0.0155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0315 0.2322 0.5103
Schistosoma mansoni cathepsin S (C01 family) 0.0081 0.0553 0.0553
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0023 0.0023
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.054
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0057 0.0044
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0081 0.0553 0.029
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0023 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.112 0.3035
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.112 0.5524
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.1952 0.5495
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0094 0.0094
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0023 0.001
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0023 0.001
Schistosoma mansoni hypothetical protein 0.0035 0.0211 0.0211
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0094 0.008
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0094 0.0094
Echinococcus granulosus GPCR family 2 0.0035 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0191 0.1385 0.1373
Brugia malayi fibroinase precursor 0.0081 0.0553 0.0541
Echinococcus granulosus high affinity choline transporter 1 0.0359 0.2654 0.2654
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0081 0.0553 0.2472
Echinococcus multilocularis cysteine protease 0.0266 0.1952 0.1952
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.054
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0094 0.0094
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0094 0.0094
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0156 0.112 0.112
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0094 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0553 0.1358
Brugia malayi steroid hormone receptor 0.001 0.0023 0.001
Entamoeba histolytica cysteine protease, putative 0.0081 0.0553 0.2472
Onchocerca volvulus 0.0028 0.0155 0.0682
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0075 0.0511 0.0499
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.1952 0.5495
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0023 0.0023
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0014 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0315 0.2322 0.5103
Brugia malayi Cathepsin L-like precursor 0.0266 0.1952 0.1941
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.0775
Schistosoma mansoni inositol transporter 0.004 0.0243 0.0243
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0081 0.0553 0.029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.1952 0.5495
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0028
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0094 0.008
Echinococcus granulosus expressed protein 0.0386 0.2855 0.2855
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.001
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0081 0.0553 0.0553
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.1385 0.3818
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0094 0.0081
Brugia malayi cathepsin L precursor 0.0081 0.0553 0.0541
Entamoeba histolytica hypothetical protein 0.0043 0.0272 0.096
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.112 0.1109
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0081 0.0553 0.1358
Trypanosoma cruzi cysteine peptidase, putative 0.0315 0.2322 0.1908
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0081 0.0553 0.029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.001
Echinococcus granulosus FTZ F1 alpha 0.001 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0553 0.1358
Echinococcus granulosus cathepsin L 0.0156 0.112 0.112
Giardia lamblia Cathepsin B precursor 0.0468 0.3475 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0023 0.0023
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0211 0.0211
Giardia lamblia Cathepsin B precursor 0.0468 0.3475 1
Leishmania major cathepsin L-like protease 0.0315 0.2322 0.6228
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0419 0.0419
Echinococcus granulosus cathepsin l1 0.0266 0.1952 0.1952
Leishmania major cathepsin L-like protease 0.0266 0.1952 0.5017
Trypanosoma cruzi cysteine peptidase, putative 0.0315 0.2322 0.1908
Echinococcus granulosus sodium:glucose cotransporter 2 0.004 0.0243 0.0243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0553 0.1358
Loa Loa (eye worm) hypothetical protein 0.0191 0.1385 0.1373
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.008
Onchocerca volvulus 0.0266 0.1952 1
Echinococcus multilocularis high affinity choline transporter 1 0.0359 0.2654 0.2654
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0023 0.001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0211 0.0211
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0418 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.1952 0.5495
Onchocerca volvulus 0.0028 0.0155 0.0682
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.1952 0.5495
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0081 0.0553 0.1358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0553 0.1358
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0023 0.0023
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0266 0.1952 0.1941
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0266 0.1952 1
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.112 0.5524
Schistosoma mansoni cpg binding protein 0.0031 0.0181 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.1385 0.3818
Schistosoma mansoni hypothetical protein 0.0035 0.0211 0.0211
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.1952 0.5495
Schistosoma mansoni sodium/solute symporter 0.004 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0023 0.001
Leishmania major cathepsin L-like protease 0.0266 0.1952 0.5017
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.054
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0023 0.0023
Onchocerca volvulus 0.0156 0.1123 0.5701
Brugia malayi hypothetical protein 0.0156 0.1123 0.1111
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0418 0.0418
Brugia malayi hypothetical protein 0.002 0.0094 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0315 0.2322 0.5103
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0211 0.0211
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0023 0.0023
Entamoeba histolytica cysteine protease, putative 0.0156 0.112 0.5524
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0272 0.0272
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.112 0.0641
Trypanosoma cruzi major cysteine proteinase, putative 0.013 0.0923 0.0434
Echinococcus multilocularis cpg binding protein 0.0031 0.0181 0.0181
Entamoeba histolytica cysteine protease, putative 0.0156 0.112 0.5524
Entamoeba histolytica cysteine proteinase, putative 0.0191 0.1385 0.6948
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0023 0.001
Echinococcus granulosus axis inhibition protein axin 0.002 0.0094 0.0094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0081 0.0553 0.1358
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0023 0.0023
Echinococcus granulosus cathepsin L 0.0081 0.0553 0.0553
Entamoeba histolytica cysteine protease, putative 0.0081 0.0553 0.2472
Loa Loa (eye worm) hypothetical protein 0.0075 0.0511 0.0498
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0023 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0023 0.001
Schistosoma mansoni regulator of G protein signaling 0.002 0.0094 0.0094
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0023 0.0023
Plasmodium vivax unspecified product 0.0081 0.0553 0.029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0211 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0023 0.001
Entamoeba histolytica cysteine proteinase 1, putative 0.0156 0.112 0.5524
Schistosoma mansoni hypothetical protein 0.0423 0.3133 0.3133
Schistosoma mansoni regulator of G protein signaling 0.002 0.0094 0.0094
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.024 0.1755 0.131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.1952 0.5495
Echinococcus multilocularis cathepsin L 0.0081 0.0553 0.0553
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0156 0.112 0.112
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0023 0.0023
Schistosoma mansoni nuclear hormone receptor 0.001 0.0023 0.0023
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0046 0.0046
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0468 0.3475 0.3475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.1952 0.5495
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0094 0.0094
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0081 0.0553 0.054
Trypanosoma cruzi cruzipain precursor, putative 0.0315 0.2322 0.1908
Schistosoma mansoni cathepsin F (C01 family) 0.0191 0.1385 0.1385
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0418 0.0418
Echinococcus multilocularis cathepsin L cysteine protease 0.0266 0.1952 0.1952
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0266 0.1952 0.5495
Onchocerca volvulus Cathepsin L homolog 0.0266 0.1952 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0094 0.0094
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0094 0.0094
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0168 0.0155
Trypanosoma cruzi cysteine peptidase, putative 0.0315 0.2322 0.1908
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0046 0.0046
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0094 0.008
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.004 0.0243 0.0243
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0156 0.112 0.0641
Brugia malayi hypothetical protein 0.002 0.0094 0.0081
Brugia malayi cathepsin F-like cysteine proteinase 0.0075 0.0511 0.0499
Toxoplasma gondii cathepsin CPC1 0.0081 0.0553 0.0959
Schistosoma mansoni thyroid hormone receptor 0.001 0.0023 0.0023
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0094 0.0094
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0094 0.0094
Echinococcus multilocularis cathepsin L 0.0156 0.112 0.112
Trypanosoma cruzi cysteine proteinase, putative 0.0156 0.112 0.0641
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.008
Brugia malayi ecdysteroid receptor 0.001 0.0023 0.001
Onchocerca volvulus 0.0266 0.1952 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0094 0.0094
Echinococcus multilocularis lamin dm0 0.0028 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.008
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0023 0.001
Echinococcus granulosus cathepsin L cysteine proteinase 0.0266 0.1952 0.1952
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0081 0.0553 0.029
Schistosoma mansoni cpg binding protein 0.0031 0.0181 0.0181
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0081 0.0553 0.0553
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0315 0.2322 0.5103
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.001
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0094 0.0094
Giardia lamblia Cathepsin B precursor 0.0468 0.3475 1
Brugia malayi PXA domain containing protein 0.002 0.0094 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0094 0.0094
Brugia malayi nuclear hormone receptor 0.001 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0155 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0028
Trypanosoma cruzi cysteine protease, putative 0.0156 0.112 0.0641
Schistosoma mansoni lamin 0.0028 0.0155 0.0155
Echinococcus multilocularis musashi 0.0028 0.0155 0.0155
Schistosoma mansoni cathepsin F (C01 family) 0.0266 0.1952 0.1952
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0023 0.0023
Loa Loa (eye worm) ctsf protein 0.0266 0.1952 0.1941
Schistosoma mansoni coup transcription factor 0.001 0.0023 0.0023
Echinococcus multilocularis cathepsin L cysteine protease 0.0266 0.1952 0.1952
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0081 0.0553 0.2472
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0094 0.0094
Echinococcus granulosus sodium:glucose cotransporter 0.004 0.0243 0.0243
Leishmania major cathepsin L-like protease 0.0266 0.1952 0.5017
Brugia malayi CXXC zinc finger family protein 0.003 0.0168 0.0156
Plasmodium falciparum cysteine proteinase falcipain 1 0.0156 0.112 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.1952 0.5495
Schistosoma mansoni cathepsin C 0.0081 0.0553 0.0553
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0418 0.5
Echinococcus granulosus sodium:myo inositol cotransporter 0.004 0.0243 0.0243
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0266 0.1952 0.1952
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0032
Echinococcus multilocularis sodium:glucose cotransporter 2 0.004 0.0243 0.0243
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0418 0.0418
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0023 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0023 0.001
Entamoeba histolytica cysteine protease, putative 0.0081 0.0553 0.2472
Loa Loa (eye worm) hypothetical protein 0.0076 0.0521 0.0508
Entamoeba histolytica cysteine protease, putative 0.0081 0.0553 0.2472
Loa Loa (eye worm) hypothetical protein 0.0075 0.0511 0.0498
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0211 0.0198
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0023 0.001
Trypanosoma cruzi major cysteine proteinase, putative 0.0081 0.0553 0.0044
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0081 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.001
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0094 0.0081

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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