Detailed information for compound 1397448

Basic information

Technical information
  • TDR Targets ID: 1397448
  • Name: [5-(methoxymethyl)thiophen-2-yl]-[3-(methyl-( phenylmethyl)amino)piperidin-1-yl]methanone
  • MW: 358.498 | Formula: C20H26N2O2S
  • H donors: 0 H acceptors: 1 LogP: 3.17 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCc1ccc(s1)C(=O)N1CCCC(C1)N(Cc1ccccc1)C
  • InChi: 1S/C20H26N2O2S/c1-21(13-16-7-4-3-5-8-16)17-9-6-12-22(14-17)20(23)19-11-10-18(25-19)15-24-2/h3-5,7-8,10-11,17H,6,9,12-15H2,1-2H3
  • InChiKey: DMNRBYJGHBMMFI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [5-(methoxymethyl)-2-thienyl]-[3-(methyl-(phenylmethyl)amino)-1-piperidyl]methanone
  • [5-(methoxymethyl)-2-thienyl]-[3-(methyl-(phenylmethyl)amino)-1-piperidinyl]methanone
  • [3-(benzyl-methyl-amino)-1-piperidyl]-[5-(methoxymethyl)-2-thienyl]methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH2 domain containing protein 0.0008 0.0098 0.0316
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0369 0.0365
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0369 0.0365
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0243 0.027
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0053 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0637 0.0708
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0161 0.2978
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0515
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0637 0.0664
Brugia malayi glycyl-tRNA synthetase 0.0006 0.0042 0.0108
Brugia malayi Cam kinase protein 1 0.0032 0.0637 0.2325
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0637 0.0925
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0006 0.0042 0.0262
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0856
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0152 0.0515
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0369 0.0365
Brugia malayi Sugar transporter family protein 0.0015 0.0243 0.0856
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0646 0.274
Plasmodium vivax hexose transporter 0.0103 0.2286 0.2253
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0243 0.0956
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2286 0.2509
Echinococcus granulosus solute carrier family 22 0.0015 0.0243 0.0224
Echinococcus multilocularis solute carrier family 22 0.0015 0.0243 0.0224
Schistosoma mansoni hypothetical protein 0.0015 0.0259 0.0288
Trypanosoma cruzi hexose transporter 0.0032 0.0646 0.868
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0637 0.0597
Plasmodium vivax sugar transporter, putative 0.0015 0.0243 0.0201
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.2694 1
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0622 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0515
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Entamoeba histolytica hypothetical protein 0.0035 0.0707 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0637 0.0597
Trichomonas vaginalis helicase, putative 0.0006 0.0053 0.0116
Echinococcus granulosus solute carrier family 22 0.0015 0.0243 0.0224
Brugia malayi hypothetical protein 0.0035 0.0707 0.2588
Brugia malayi MH2 domain containing protein 0.0121 0.2694 1
Brugia malayi nuclear hormone receptor 0.002 0.0369 0.1325
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0637 0.855
Onchocerca volvulus 0.0015 0.0243 0.279
Schistosoma mansoni cpg binding protein 0.0028 0.0546 0.0608
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0515
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1182 0.1274
Entamoeba histolytica hypothetical protein 0.0035 0.0707 1
Onchocerca volvulus 0.0015 0.0243 0.279
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2286 0.2509
Echinococcus multilocularis geminin 0.0163 0.3669 0.4055
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0126 0.0093
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0243 0.303
Giardia lamblia Hexose transporter 0.0015 0.0243 0.346
Loa Loa (eye worm) hypothetical protein 0.0009 0.0126 0.0418
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0126 0.014
Brugia malayi hypothetical protein 0.0015 0.0243 0.0856
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0369 0.0365
Toxoplasma gondii sugar transporter ST1 0.0015 0.0243 0.0327
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.2694 1
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0161 0.3243
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0312 0.3994
Loa Loa (eye worm) hypothetical protein 0.0009 0.0126 0.0418
Echinococcus granulosus General substrate transporter 0.0089 0.1952 0.2135
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0243 0.0956
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0369 0.1325
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Brugia malayi MH1 domain containing protein 0.0008 0.0098 0.0316
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0243 0.0956
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0369 0.0365
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0126 0.0093
Loa Loa (eye worm) hypothetical protein 0.0009 0.0126 0.0418
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0126 0.0093
Loa Loa (eye worm) hypothetical protein 0.002 0.0369 0.1325
Echinococcus granulosus cpg binding protein 0.0029 0.0582 0.0604
Schistosoma mansoni cpg binding protein 0.0029 0.0582 0.0648
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0369 0.1325
Onchocerca volvulus 0.0015 0.0243 0.279
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0646 0.274
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0369 0.1325
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0006 0.0042 0.0468
Trypanosoma brucei glucose transporter, putative 0.0032 0.0646 0.868
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1182 0.1274
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0152 0.0169
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0243 0.303
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0126 0.0418
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0067 0.0027
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0042 0.0218
Schistosoma mansoni zinc finger protein 0.0009 0.0126 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0116
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0259 0.0242
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0622 0.0692
Leishmania major glucose transporter, lmgt1 0.0032 0.0646 0.868
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0106 0.0071
Brugia malayi hypothetical protein 0.0011 0.0152 0.0515
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0126 0.0093
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0243 0.0224
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0637 0.0664
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0622 0.0692
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0053 0.0116
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0622 0.227
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0637 0.0664
Schistosoma mansoni glucose transporter 0.0015 0.0243 0.027
Trypanosoma brucei glucose transporter, putative 0.0032 0.0646 0.868
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0152 0.0169
Brugia malayi nuclear hormone receptor 0.0009 0.0126 0.0418
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0622 0.0648
Brugia malayi CXXC zinc finger family protein 0.0028 0.0546 0.1987
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0369 0.0365
Loa Loa (eye worm) hypothetical protein 0.002 0.0369 0.1325
Onchocerca volvulus 0.0015 0.0243 0.279
Leishmania major protein kinase, putative 0.0032 0.0637 0.855
Plasmodium falciparum proline--tRNA ligase 0.0036 0.074 0.0701
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1182 0.1274
Loa Loa (eye worm) hypothetical protein 0.0009 0.0126 0.0418
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0152 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0369 0.1325
Onchocerca volvulus 0.0015 0.0243 0.279
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0856
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0053 0.0116
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0856
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0856
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0637 0.2325
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0103 0.0335
Brugia malayi hypothetical protein 0.0015 0.0243 0.0856
Onchocerca volvulus Putative transporter 0.0015 0.0243 0.279
Schistosoma mansoni sugar transporter 0.0015 0.0243 0.027
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0856
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0369 0.041
Echinococcus granulosus smad 0.0008 0.0098 0.0063
Brugia malayi MH2 domain containing protein 0.0008 0.0098 0.0316
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0126 0.0093
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0646 0.868
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0369 0.0365
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0707 0.0787
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0369 0.1325
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0856
Brugia malayi Sugar transporter family protein 0.0103 0.2286 0.848
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0439 0.0399
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0243 0.0956
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0439 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0126 0.0418
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1182 0.1315
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0707 0.0743
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0116
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0126 0.0418
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0646 0.868
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0637 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0098 0.0063
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Brugia malayi tailless protein 0.0009 0.0126 0.0418
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0259 0.0242
Schistosoma mansoni hypothetical protein 0.0015 0.0259 0.0288
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.1015 0.3736
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0369 0.0365
Plasmodium falciparum protein kinase 7 0.0291 0.6626 0.6612
Schistosoma mansoni sugar transporter 0.0015 0.0243 0.027
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0637 0.0925
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0053 0.0116
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0439 0.0489
Loa Loa (eye worm) hypothetical protein 0.0031 0.0622 0.227
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0856
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0646 0.274
Loa Loa (eye worm) hypothetical protein 0.0009 0.0126 0.0418
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0243 0.0956
Leishmania major threonyl-tRNA synthetase, putative 0.0006 0.0042 0.0218
Schistosoma mansoni Smad4 0.0008 0.0098 0.0109
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0646 0.274
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Schistosoma mansoni smad 0.0008 0.0098 0.0109
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0592 0.0614
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0116
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0126 0.0418
Schistosoma mansoni hypothetical protein 0.0163 0.3669 0.4083
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0439 0.5783
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0369 0.1325
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0243 0.303
Toxoplasma gondii protein kinase, putative 0.0291 0.6626 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0637 0.0664
Leishmania major hypothetical protein, conserved 0.0015 0.0243 0.303
Schistosoma mansoni peptidase 0.0005 0.0024 0.0026
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0161 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0006 0.0042 0.0108
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0369 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0243 0.0956
Onchocerca volvulus 0.0015 0.0243 0.279
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0369 0.0365
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0201 0.0701
Trypanosoma brucei glucose transporter, putative 0.0032 0.0646 0.868
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0665 0.243
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0126 0.0093
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0369 0.1325
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0439 0.1589
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0243 0.5239
Schistosoma mansoni nuclear hormone receptor 0.002 0.0369 0.041
Schistosoma mansoni nuclear receptor 0.0009 0.0126 0.014
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0152 0.0515
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0622 0.2634
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.1015 0.3736
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0439 0.5783
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Echinococcus multilocularis cpg binding protein 0.0029 0.0582 0.0604
Loa Loa (eye worm) hypothetical protein 0.002 0.0369 0.1325
Loa Loa (eye worm) hypothetical protein 0.002 0.0369 0.1325
Loa Loa (eye worm) DR-78 0.0009 0.0126 0.0418
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0126 0.0093
Loa Loa (eye worm) hypothetical protein 0.0009 0.0126 0.0418
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0439 0.0399
Echinococcus granulosus FTZ F1 alpha 0.002 0.0369 0.0365
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Brugia malayi nuclear receptor NHR-88 0.002 0.0369 0.1325
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0243 0.0956
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0637 0.0597
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0359 1
Onchocerca volvulus 0.0015 0.0243 0.279
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0637 0.0664
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0374 0.1536
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0369 0.5782
Schistosoma mansoni glucose transport protein 0.0103 0.2286 0.2544
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0259 0.0242
Loa Loa (eye worm) hypothetical protein 0.0006 0.0042 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0369 0.1325
Trypanosoma brucei glucose transporter 1E 0.0032 0.0646 0.868
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0259 0.0915
Toxoplasma gondii sugar transporter ST2 0.0015 0.0243 0.0327
Brugia malayi ecdysone receptor 0.0009 0.0126 0.0418
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0622 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0126 0.0418
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0369 0.1325
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0369 0.041
Echinococcus multilocularis solute carrier family 22 0.0015 0.0243 0.0224
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0439 0.0489
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0126 0.0093
Leishmania major glucose transporter, lmgt2 0.0032 0.0646 0.868
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0106 0.0344
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0243 0.0224
Brugia malayi Sugar transporter family protein 0.0015 0.0243 0.0856
Schistosoma mansoni thyroid hormone receptor 0.002 0.0369 0.041
Brugia malayi conserved hypotetical protein 0.0009 0.0126 0.0418
Loa Loa (eye worm) sugar transporter 0.0015 0.0243 0.0856
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0369 0.041
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0369 0.0365
Schistosoma mansoni glucose transport protein 0.0103 0.2286 0.2544
Onchocerca volvulus 0.0015 0.0243 0.279
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0369 0.1325
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0126 0.0418
Schistosoma mansoni hypothetical protein 0.0163 0.3669 0.4083
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0515
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0439 0.0625
Brugia malayi MH1 domain containing protein 0.0008 0.0098 0.0316
Schistosoma mansoni hypothetical protein 0.0394 0.8986 1
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0126 0.014
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0622 0.227
Schistosoma mansoni hypothetical protein 0.0015 0.0259 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0369 0.1325
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.2286 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0646 0.274
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Loa Loa (eye worm) hypothetical protein 0.0015 0.0259 0.0915
Loa Loa (eye worm) hypothetical protein 0.0033 0.0665 0.243
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.2286 0.2509
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0637 0.0597
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0637 0.0597
Schistosoma mansoni sugar transporter 0.0015 0.0243 0.027
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0126 0.014
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0243 0.6499
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0126 0.0418
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0646 0.868
Entamoeba histolytica hypothetical protein 0.0035 0.0707 1
Schistosoma mansoni hypothetical protein 0.0103 0.2286 0.2544
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0369 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0116
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0167 0.3751 0.3724
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1182 0.1315
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0243 0.0856
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0067 0.0027
Giardia lamblia Sugar-proton symporter 0.0015 0.0243 0.346
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0259 0.0242
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0439 0.1826
Loa Loa (eye worm) hypothetical protein 0.0048 0.1015 0.3736
Trypanosoma brucei glucose transporter, putative 0.0032 0.0646 0.868
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0856
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0243 0.0201
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0243 0.303
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0856
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0369 0.5782
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0126 0.0418
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0369 0.041
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0646 0.868
Echinococcus multilocularis Smad4 0.0008 0.0098 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0369 0.1325
Schistosoma mansoni hypothetical protein 0.0033 0.0665 0.074
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0369 0.1325
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0053 0.0116
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0106 0.0071
Brugia malayi Smad1 0.0008 0.0098 0.0316
Entamoeba histolytica hypothetical protein 0.0023 0.0439 0.5972
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0126 0.0093
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0126 0.014
Brugia malayi hypothetical protein 0.0009 0.0126 0.0418
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0646 0.274
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0439 0.5783
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0369 0.041
Trypanosoma brucei glucose transporter, putative 0.0032 0.0646 0.868
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0053 0.0116
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0369 0.0365
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0053 0.0116
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0259 0.0915
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0369 0.1325
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1182 0.1315
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0856
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Echinococcus multilocularis dnaJ subfamily B 0.0394 0.8986 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0167 0.3751 0.5643
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.1015 0.3736
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.074 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0126 0.0418
Toxoplasma gondii histone lysine methyltransferase SET1 0.0052 0.1116 0.1651
Echinococcus multilocularis GPCR, family 2 0.0015 0.0259 0.0242
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0369 0.0365
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0707 0.0743
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0098 0.0063
Loa Loa (eye worm) hypothetical protein 0.0032 0.0637 0.2325
Loa Loa (eye worm) hypothetical protein 0.0031 0.0622 0.227
Loa Loa (eye worm) Smad1 0.0008 0.0098 0.0316
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0243 0.5239
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0098 0.0063
Loa Loa (eye worm) hypothetical protein 0.002 0.0369 0.1325
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0006 0.0042 0.0218
Brugia malayi nuclear receptor RXR 0.0011 0.0152 0.0515
Onchocerca volvulus 0.0015 0.0243 0.279
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0439 0.6932
Schistosoma mansoni smad1 5 8 and 0.0008 0.0098 0.0109
Schistosoma mansoni glucose transport protein 0.0103 0.2286 0.2544
Trypanosoma brucei glucose transporter, putative 0.0032 0.0646 0.868
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0243 0.0856
Loa Loa (eye worm) hypothetical protein 0.0023 0.0439 0.1589
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0856
Entamoeba histolytica hypothetical protein 0.0035 0.0707 1
Mycobacterium ulcerans sugar transporter 0.0015 0.0243 0.5239
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0546 0.1987
Schistosoma mansoni protein kinase 0.0032 0.0637 0.0708
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0006 0.0042 0.0069
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0006 0.0042 0.0108
Brugia malayi ecdysteroid receptor 0.002 0.0369 0.1325
Loa Loa (eye worm) hypothetical protein 0.002 0.0369 0.1325
Schistosoma mansoni glycyl-tRNA synthetase 0.0006 0.0042 0.0047
Echinococcus granulosus solute carrier family 22 0.0015 0.0243 0.0224
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0369 0.041
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0243 0.303
Brugia malayi nuclear receptor NHR-88 0.0009 0.0126 0.0418
Onchocerca volvulus 0.0015 0.0243 0.279
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0152 0.0515
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0067 0.0074
Onchocerca volvulus 0.0015 0.0243 0.279
Entamoeba histolytica protein kinase, putative 0.0032 0.0637 0.8941
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0126 0.0093
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0359 1
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0006 0.0042 0.0024
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0439 0.0444
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0439 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0243 0.0224
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Trypanosoma brucei glucose transporter, putative 0.0032 0.0646 0.868
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0369 0.1325
Brugia malayi nuclear receptor NHR-67 0.0009 0.0126 0.0418
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.074 0.1081
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2286 0.2509
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0067 0.0027
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.074 1
Onchocerca volvulus 0.002 0.0369 0.5782
Loa Loa (eye worm) hypothetical protein 0.0009 0.0126 0.0418
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0369 0.1325
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.074 0.0701
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0856
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0006 0.0042 0.0218
Trypanosoma brucei sugar transporter, putative 0.0015 0.0243 0.303
Echinococcus multilocularis smad 0.0008 0.0098 0.0063
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0369 0.5782
Brugia malayi major facilitator superfamily protein 0.0015 0.0243 0.0856
Leishmania major glucose transporter, lmgt3 0.0032 0.0646 0.868
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0243 0.6499
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0126 0.0093
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0646 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0116
Echinococcus multilocularis General substrate transporter 0.0089 0.1952 0.2135
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0369 0.1325
Echinococcus multilocularis solute carrier family 22 0.0015 0.0243 0.0224
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0369 0.041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1182 0.1274
Loa Loa (eye worm) hypothetical protein 0.002 0.0369 0.1325
Trypanosoma brucei glucose transporter 2A 0.0032 0.0646 0.868
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0637 0.2325
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0042 0.0218
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0856
Schistosoma mansoni protein kinase 0.0032 0.0637 0.0708
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0006 0.0042 0.0108
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0369 0.0365
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0053 0.0116
Onchocerca volvulus 0.0015 0.0243 0.279
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0622 0.0648
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1261 0.1403
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0098 0.0316
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0243 1
Toxoplasma gondii sugar transporter ST3 0.0015 0.0243 0.0327
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0646 0.868
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0369 0.1325
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0126 0.0418
Schistosoma mansoni smad1 5 8 and 0.0008 0.0098 0.0109
Brugia malayi major facilitator superfamily protein 0.0015 0.0243 0.0856
Schistosoma mansoni cpg binding protein 0.0029 0.0582 0.0648
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0856
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2286 0.2509
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1182 0.436
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0637 0.2325
Echinococcus multilocularis solute carrier family 22 0.0015 0.0243 0.0224
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0098 0.0316
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0243 0.0856
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0439 0.0444
Echinococcus granulosus solute carrier family 22 0.0015 0.0243 0.0224
Brugia malayi hypothetical protein 0.0015 0.0243 0.0856
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0006 0.0042 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0116
Echinococcus granulosus dnaJ subfamily B 0.0394 0.8986 1
Schistosoma mansoni coup transcription factor 0.002 0.0369 0.041
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0126 0.014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0369 0.1325
Brugia malayi nuclear receptor RXR 0.0009 0.0126 0.0418
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0006 0.0042 0.0377
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1182 0.436
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0359 0.5587
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0243 0.5239
Onchocerca volvulus 0.0028 0.0546 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0116
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2286 0.2509
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0243 0.0856
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0637 0.2699
Plasmodium falciparum hexose transporter 0.0103 0.2286 0.2253
Schistosoma mansoni hypothetical protein 0.0015 0.0259 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0369 0.1325
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0592 0.0614
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2286 0.2509
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0637 0.0597
Loa Loa (eye worm) hypothetical protein 0.0009 0.0126 0.0418
Loa Loa (eye worm) hypothetical protein 0.0009 0.0126 0.0418
Loa Loa (eye worm) hypothetical protein 0.0025 0.0488 0.1771
Schistosoma mansoni nuclear receptor 0.0009 0.0126 0.014
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0126 0.0093
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0637 0.0597
Toxoplasma gondii glycyl-tRNA synthetase 0.0006 0.0042 0.0024
Brugia malayi hypothetical protein 0.0009 0.0126 0.0418
Loa Loa (eye worm) hypothetical protein 0.002 0.0369 0.1325
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Onchocerca volvulus 0.0015 0.0243 0.279
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0646 0.868
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0637 0.0664
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0369 0.1325
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0637 0.0664
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0243 0.0327
Loa Loa (eye worm) hypothetical protein 0.0009 0.0126 0.0418
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0243 0.0224
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Onchocerca volvulus 0.0015 0.0243 0.279
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.074 1
Schistosoma mansoni hypothetical protein 0.0035 0.0707 0.0787
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2286 0.2509
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0622 0.8719
Loa Loa (eye worm) hypothetical protein 0.0009 0.0126 0.0418
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0646 0.274
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0369 0.1325
Loa Loa (eye worm) sugar transporter 0.0103 0.2286 0.848
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0637 0.0597
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0369 0.1325
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0637 0.0664
Schistosoma mansoni protein kinase 0.0032 0.0637 0.0708
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0152 0.0122
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0067 0.0027
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0243 0.0856
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0053 0.0116
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0439 0.6849
Onchocerca volvulus 0.0015 0.0243 0.279
Onchocerca volvulus 0.0015 0.0243 0.279
Entamoeba histolytica protein kinase, putative 0.0032 0.0637 0.8941
Trypanosoma brucei glucose transporter, putative 0.0032 0.0646 0.868
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0515
Schistosoma mansoni thyroid hormone receptor 0.002 0.0369 0.041
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.074 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0126 0.0418
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0243 0.0956
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0006 0.0042 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0369 0.1325
Plasmodium falciparum mitogen-activated protein kinase 2 0.0167 0.3751 0.3724
Brugia malayi hypothetical protein 0.0011 0.0152 0.0515
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0259 0.0915
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0439 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0369 0.0365
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0098 0.0109
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0243 0.0956
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0637 0.0925
Schistosoma mansoni smad1 5 8 and 0.0008 0.0098 0.0109
Echinococcus granulosus GPCR family 2 0.0015 0.0259 0.0242
Echinococcus granulosus geminin 0.0163 0.3669 0.4055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0369 0.0365
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0856
Echinococcus granulosus Smad4 0.0008 0.0098 0.0063
Schistosoma mansoni sugar transporter 0.0015 0.0243 0.027
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.074 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0098 0.0063
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0369 0.041
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.2286 0.3424
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0369 0.0365
Brugia malayi steroid hormone receptor 0.002 0.0369 0.1325

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6294 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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