Detailed information for compound 1397590

Basic information

Technical information
  • TDR Targets ID: 1397590
  • Name: 2-[2-(4-aminophenyl)sulfanylethyl]isoindole-1 ,3-dione
  • MW: 298.36 | Formula: C16H14N2O2S
  • H donors: 1 H acceptors: 2 LogP: 2.43 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(CCSc2ccc(cc2)N)C(=O)c2c1cccc2
  • InChi: 1S/C16H14N2O2S/c17-11-5-7-12(8-6-11)21-10-9-18-15(19)13-3-1-2-4-14(13)16(18)20/h1-8H,9-10,17H2
  • InChiKey: SYHPYRURUTWAPB-UHFFFAOYSA-N  


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Synonyms

  • 2-[2-(4-aminophenyl)sulfanylethyl]isoindoline-1,3-dione
  • 2-[2-[(4-aminophenyl)thio]ethyl]isoindoline-1,3-dione
  • 2-[2-[(4-aminophenyl)thio]ethyl]isoindoline-1,3-quinone
  • STOCK4S-11170
  • ZINC00254543
  • MLS000080870
  • SMR000043387
  • Oprea1_715846

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Histone deacetylase family protein 0.1008 0.2447 0.8186
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0045 0.0042 0.014
Onchocerca volvulus 0.0114 0.0213 0.175
Schistosoma mansoni carbonic anhydrase-related 0.0275 0.0614 0.2025
Trypanosoma brucei histone deacetylase 2 0.0515 0.1216 0.3992
Trichomonas vaginalis histone deacetylase, putative 0.1225 0.299 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.012 0.0364
Loa Loa (eye worm) carbonic anhydrase 3 0.0461 0.1079 0.3609
Echinococcus granulosus geminin 0.0205 0.044 0.1439
Trichomonas vaginalis histone deacetylase, putative 0.1225 0.299 1
Echinococcus granulosus histone deacetylase 6 0.1008 0.2447 0.818
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0052 0.0058 0.0159
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0045 0.0042 0.0014
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0052 0.0058 0.0071
Giardia lamblia Histone deacetylase 0.1225 0.299 1
Onchocerca volvulus 0.0033 0.0011 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0076 0.012 0.0364
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0038 0.0126
Schistosoma mansoni histone deacetylase 0.1225 0.299 1
Trypanosoma brucei histone deacetylase 1 0.1225 0.299 1
Schistosoma mansoni alpha-glucosidase 0.0169 0.0352 0.1143
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0038 0.0126
Onchocerca volvulus Histone deacetylase 10 homolog 0.0515 0.1216 1
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0038 0.0126
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2375 0.7935
Brugia malayi Histone deacetylase family protein 0.1008 0.2447 0.8186
Toxoplasma gondii histone deacetylase HDAC4 0.0515 0.1216 0.3992
Echinococcus multilocularis BRCA1 associated protein 0.0052 0.0058 0.0159
Leishmania major udp-glc 4-epimerase, putative 0.0049 0.0052 0.0172
Trypanosoma cruzi histone deacetylase, putative 0.1008 0.2447 0.8163
Echinococcus multilocularis histone deacetylase 0.1008 0.2447 0.818
Echinococcus granulosus histone deacetylase 7 0.1008 0.2447 0.818
Trypanosoma brucei histone deacetylase, putative 0.1008 0.2447 0.8163
Trichomonas vaginalis histone deacetylase, putative 0.1225 0.299 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0461 0.1079 0.3527
Loa Loa (eye worm) hypothetical protein 0.1225 0.299 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0052 0.0058 0.0071
Giardia lamblia UDP-glucose 4-epimerase 0.0049 0.0052 0.0033
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0052 0.0058 0.0159
Schistosoma mansoni histone deacetylase 4 5 0.1008 0.2447 0.818
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0052 0.0058 0.0056
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0052 0.0058 0.0071
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0045 0.0042 0.0103
Loa Loa (eye worm) histone deacetylase 11 0.0515 0.1216 0.4067
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0052 0.0058 0.0071
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0275 0.0614 0.2055
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.3987 0.9887 1
Schistosoma mansoni histone deacetylase 0.1225 0.299 1
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0052 0.0058 0.0056
Echinococcus granulosus histone deacetylase 6 0.106 0.2577 0.8616
Leishmania major carbonic anhydrase-like protein 0.0461 0.1079 0.3609
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0038 0.0126
Trypanosoma brucei histone deacetylase 3 0.1008 0.2447 0.8163
Trypanosoma cruzi histone deacetylase, putative 0.1008 0.2447 0.8163
Trypanosoma brucei histone deacetylase 4 0.1008 0.2447 0.8163
Loa Loa (eye worm) hypothetical protein 0.0038 0.0024 0.0079
Loa Loa (eye worm) hypothetical protein 0.0545 0.129 0.4314
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0042 0.0042
Leishmania major histone deacetylase, putative 0.1225 0.299 1
Echinococcus multilocularis carbonic anhydrase II 0.0461 0.1079 0.3585
Schistosoma mansoni carbonic anhydrase-related 0.0275 0.0614 0.2025
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0052 0.0058 0.0195
Echinococcus multilocularis disco interacting protein 2 0.0039 0.0026 0.0051
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0045 0.0042 0.0014
Echinococcus granulosus carbonic anhydrase II 0.0461 0.1079 0.3585
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0052 0.0058 0.0195
Echinococcus multilocularis histone deacetylase 6 0.1008 0.2447 0.818
Plasmodium falciparum carbonic anhydrase 0.0275 0.0614 0.1942
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0045 0.0042 0.014
Schistosoma mansoni histone deacetylase hda2 0.0515 0.1216 0.4045
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0052 0.0058 0.0195
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0045 0.0042 0.0103
Trypanosoma cruzi histone deacetylase 1, putative 0.1225 0.299 1
Loa Loa (eye worm) histone deacetylase 1 0.1225 0.299 1
Loa Loa (eye worm) hypothetical protein 0.0275 0.0614 0.2055
Plasmodium vivax histone deacetylase, putative 0.1008 0.2447 0.8161
Schistosoma mansoni brca1-associated protein (brap2) 0.0052 0.0058 0.0159
Schistosoma mansoni carbonic anhydrase-related 0.0275 0.0614 0.2025
Trichomonas vaginalis UDP-glucose 4-epimerase, putative 0.0051 0.0056 0.0063
Toxoplasma gondii hypothetical protein 0.0275 0.0614 0.1954
Trypanosoma brucei carbonic anhydrase-like protein 0.0461 0.1079 0.3527
Loa Loa (eye worm) histone deacetylase 0.1008 0.2447 0.8186
Brugia malayi CXXC zinc finger family protein 0.0033 0.0011 0.0037
Plasmodium vivax histone deacetylase 2, putative 0.1008 0.2447 0.8161
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0052 0.0058 0.0195
Echinococcus granulosus carbonic anhydrase 0.0275 0.0614 0.2025
Loa Loa (eye worm) histone deacetylase 7A 0.1008 0.2447 0.8186
Loa Loa (eye worm) RNA binding protein 0.0076 0.012 0.04
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.042 0.1372
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0052 0.0058 0.0056
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0275 0.0614 0.2055
Entamoeba histolytica histone deacetylase, putative 0.1225 0.299 1
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0052 0.0058 0.0071
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0052 0.0058 0.0159
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0045 0.0042 0.014
Schistosoma mansoni alpha glucosidase 0.0044 0.0038 0.0089
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0052 0.0058 0.0195
Leishmania major histone deacetylase, putative 0.1008 0.2447 0.8186
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.0045 0.0042 0.0042
Trypanosoma cruzi histone deacetylase 1, putative 0.1225 0.299 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0084 0.0137 0.0324
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0461 0.1079 0.3585
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0045 0.0042 0.014
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0052 0.0058 0.0195
Trypanosoma cruzi histone deacetylase, putative 0.1008 0.2447 0.8163
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.012 0.04
Schistosoma mansoni alpha-glucosidase 0.0169 0.0352 0.1143
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0038 0.0089
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.042 0.1372
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.042 0.1405
Leishmania major histone deacetylase, putative 0.1008 0.2447 0.8186
Loa Loa (eye worm) TAR-binding protein 0.0076 0.012 0.04
Echinococcus multilocularis histone deacetylase 6 0.106 0.2577 0.8616
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0052 0.0058 0.0159
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0052 0.0058 0.0056
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0275 0.0614 0.2055
Trypanosoma cruzi histone deacetylase, putative 0.0515 0.1216 0.3992
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.012 0.04
Schistosoma mansoni hypothetical protein 0.0205 0.044 0.1439
Loa Loa (eye worm) UDP galactose 4'-epimerase 0.0051 0.0056 0.0187
Giardia lamblia Hypothetical protein 0.0052 0.0058 0.0056
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0045 0.0042 0.0042
Trichomonas vaginalis histone deacetylase, putative 0.1225 0.299 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0275 0.0614 0.2055
Echinococcus multilocularis carbonic anhydrase 0.0275 0.0614 0.2025
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0052 0.0058 0.0071
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0039 0.0026 0.0051
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0052 0.0058 0.0071
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0052 0.0058 0.0195
Brugia malayi histone deacetylase 1 (HD1) 0.1225 0.299 1
Echinococcus multilocularis histone deacetylase 3 0.1225 0.299 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0011 0.0037
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0052 0.0058 0.0056
Trypanosoma cruzi histone deacetylase, putative 0.0515 0.1216 0.3992
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0045 0.0042 0.014
Plasmodium falciparum histone deacetylase 2 0.1008 0.2447 0.8161
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0052 0.0058 0.0195
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0045 0.0042 0.0014
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0051 0.0056 0.0063
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0052 0.0058 0.0071
Echinococcus granulosus BRCA1 associated protein 0.0052 0.0058 0.0159
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0052 0.0058 0.0159
Echinococcus multilocularis tar DNA binding protein 0.0076 0.012 0.0364
Trichomonas vaginalis histone deacetylase, putative 0.1225 0.299 1
Echinococcus granulosus carbonic anhydrase 0.0275 0.0614 0.2025
Brugia malayi BRCA1-associated protein 2 containing protein 0.0052 0.0058 0.0195
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.042 0.1405
Echinococcus granulosus histone deacetylase 3 0.1225 0.299 1
Leishmania major hypothetical protein, conserved 0.0052 0.0058 0.0195
Entamoeba histolytica UDP-glucose 4-epimerase, putative 0.0051 0.0056 0.0187
Echinococcus multilocularis histone deacetylase 8 0.0515 0.1216 0.4045
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0052 0.0058 0.0159
Brugia malayi Disco-interacting protein 2 homolog 0.0038 0.0024 0.0079
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0038 0.0126
Trypanosoma brucei UDP-galactose 4-epimerase 0.0049 0.0052 0.0047
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0052 0.0058 0.0071
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0461 0.1079 0.3609
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0052 0.0058 0.0195
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0051 0.0056 0.0063
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0461 0.1079 0.3585
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0052 0.0058 0.0195
Trichomonas vaginalis brca1-associated protein, putative 0.0052 0.0058 0.0071
Echinococcus granulosus histone deacetylase 8 0.0515 0.1216 0.4045
Toxoplasma gondii histone deacetylase HDAC1 0.1008 0.2447 0.8163
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0052 0.0058 0.0159
Schistosoma mansoni carbonic anhydrase 0.0275 0.0614 0.2025
Schistosoma mansoni tar DNA-binding protein 0.0076 0.012 0.0364
Onchocerca volvulus 0.0038 0.0024 0.0194
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0045 0.0042 0.0014
Brugia malayi RNA binding protein 0.0076 0.012 0.04
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.0045 0.0042 0.0042
Echinococcus multilocularis histone deacetylase 1 0.1225 0.299 1
Brugia malayi TAR-binding protein 0.0076 0.012 0.04
Schistosoma mansoni tar DNA-binding protein 0.0076 0.012 0.0364
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0058 0.0056
Plasmodium vivax histone deacetylase 1, putative 0.1225 0.299 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0461 0.1079 0.3527
Toxoplasma gondii histone deacetylase HDAC3 0.1225 0.299 1
Loa Loa (eye worm) hypothetical protein 0.0493 0.116 0.388
Schistosoma mansoni tar DNA-binding protein 0.0076 0.012 0.0364
Brugia malayi histone deacetylase 3 (HD3) 0.1225 0.299 1
Schistosoma mansoni UDP-glucose 4-epimerase 0.0051 0.0056 0.0151
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0052 0.0058 0.048
Schistosoma mansoni brca1-associated protein (brap2) 0.0052 0.0058 0.0159
Schistosoma mansoni histone deacetylase 4 5 0.1008 0.2447 0.818
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0052 0.0058 0.0071
Echinococcus granulosus histone deacetylase 6 0.1008 0.2447 0.818
Echinococcus granulosus carbonic anhydrase 0.0275 0.0614 0.2025
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0052 0.0058 0.0071
Echinococcus granulosus histone deacetylase 0.1008 0.2447 0.818
Toxoplasma gondii histone deacetylase HDAC2 0.1225 0.299 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.1225 0.299 1
Brugia malayi UDP galactose 4'-epimerase 0.0051 0.0056 0.0187
Loa Loa (eye worm) histone deacetylase 3 0.1225 0.299 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0052 0.0058 0.0071
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.1225 0.299 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0275 0.0614 0.2055
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0045 0.0042 0.0014
Echinococcus multilocularis UDP glucose 4 epimerase 0.0051 0.0056 0.0151
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0038 0.0089
Trichomonas vaginalis BRCA1-associated protein, putative 0.0052 0.0058 0.0071
Plasmodium falciparum histone deacetylase, putative 0.1008 0.2447 0.8161
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0052 0.0058 0.0071
Toxoplasma gondii histone deacetylase HDAC5 0.0515 0.1216 0.3992
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0052 0.0058 0.0056
Echinococcus granulosus histone deacetylase 1 0.1225 0.299 1
Brugia malayi Histone deacetylase 1 0.1225 0.299 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0275 0.0614 0.2055
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0052 0.0058 0.0195
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0052 0.0058 0.0071
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.1225 0.299 1
Plasmodium falciparum histone deacetylase 1 0.1225 0.299 1
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0052 0.0058 0.0195
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0461 0.1079 0.3609
Schistosoma mansoni hypothetical protein 0.0205 0.044 0.1439
Leishmania major hypothetical protein, conserved 0.0052 0.0058 0.0195
Schistosoma mansoni histone deacetylase 1 2 3 0.0515 0.1216 0.4045
Brugia malayi histone deacetylase 11 0.0515 0.1216 0.4067
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0052 0.0058 0.0159
Toxoplasma gondii hypothetical protein 0.0084 0.0137 0.0338
Leishmania major histone deacetylase, putative 0.1225 0.299 1
Echinococcus granulosus UDP glucose 4 epimerase 0.0051 0.0056 0.0151
Echinococcus multilocularis histone deacetylase 6 0.1008 0.2447 0.818
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0461 0.1079 0.3609
Loa Loa (eye worm) hypothetical protein 0.0515 0.1216 0.4067
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0052 0.0058 0.0071
Trypanosoma cruzi UDP-galactose 4-epimerase 0.0051 0.0056 0.0063
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0045 0.0042 0.0103
Trypanosoma cruzi UDP-galactose 4-epimerase, putative 0.0051 0.0056 0.0063
Echinococcus granulosus tar DNA binding protein 0.0076 0.012 0.0364
Schistosoma mansoni hypothetical protein 0.0275 0.0614 0.2025
Echinococcus multilocularis carbonic anhydrase 0.0275 0.0614 0.2025
Echinococcus multilocularis histone deacetylase 7 0.1008 0.2447 0.818
Loa Loa (eye worm) hypothetical protein 0.0859 0.2074 0.6938
Echinococcus multilocularis geminin 0.0205 0.044 0.1439
Loa Loa (eye worm) hypothetical protein 0.0275 0.0614 0.2055
Plasmodium vivax histone deacetylase, putative 0.0515 0.1216 0.3983
Trichomonas vaginalis histone deacetylase, putative 0.1225 0.299 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.042 0.1372
Echinococcus granulosus disco interacting protein 2 0.0039 0.0026 0.0051
Schistosoma mansoni histone deacetylase hda2 0.106 0.2577 0.8616
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0052 0.0058 0.0071
Toxoplasma gondii UDP-glucose 4-epimerase 0.0051 0.0056 0.0063
Echinococcus multilocularis carbonic anhydrase 0.0275 0.0614 0.2025

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0041 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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