Detailed information for compound 1400134

Basic information

Technical information
  • TDR Targets ID: 1400134
  • Name: N'-[2-(3-methoxyphenyl)-5,6,7,8-tetrahydropyr azolo[5,1-b]quinazolin-9-yl]-N,N,2,2-tetramet hylpropane-1,3-diamine
  • MW: 407.552 | Formula: C24H33N5O
  • H donors: 1 H acceptors: 2 LogP: 4.73 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)c1nn2c(c1)nc1c(c2NCC(CN(C)C)(C)C)CCCC1
  • InChi: 1S/C24H33N5O/c1-24(2,16-28(3)4)15-25-23-19-11-6-7-12-20(19)26-22-14-21(27-29(22)23)17-9-8-10-18(13-17)30-5/h8-10,13-14,25H,6-7,11-12,15-16H2,1-5H3
  • InChiKey: GHONBSJAWLVFJJ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N'-[2-(3-methoxyphenyl)-5,6,7,8-tetrahydropyrazolo[5,1-b]quinazolin-9-yl]-N,N,2,2-tetramethyl-propane-1,3-diamine
  • (3-dimethylamino-2,2-dimethyl-propyl)-[2-(3-methoxyphenyl)-5,6,7,8-tetrahydropyrazolo[5,1-b]quinazolin-9-yl]amine
  • ASN 08737574
  • MLS000856853
  • SMR000278798

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Mus musculus heat shock factor 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica heat shock transcription factor, putative Get druggable targets OG5_129203 All targets in OG5_129203
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock transcription factor, putative Get druggable targets OG5_129203 All targets in OG5_129203
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129203 All targets in OG5_129203
Candida albicans similar to S. cerevisiae Heat Shock Factor HSF1 (YGL073W) RNA Pol II transcriptional activator Get druggable targets OG5_129203 All targets in OG5_129203
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Heat shock factor protein 2 homolog Get druggable targets OG5_129203 All targets in OG5_129203
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae Heat Shock Factor HSF1 (YGL073W) RNA Pol II transcriptional activator Get druggable targets OG5_129203 All targets in OG5_129203
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi HSF-type DNA-binding domain containing protein Get druggable targets OG5_129203 All targets in OG5_129203
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica heat shock transcription factor, putative Get druggable targets OG5_129203 All targets in OG5_129203
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum histone deacetylase, putative 0.0592 0.6776 0.6762
Loa Loa (eye worm) histone deacetylase 0.0592 0.6776 0.6776
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0043 0.0043
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0046 0.0315 0.0273
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0046 0.0315 0.0273
Trypanosoma brucei heat shock protein, putative 0.0039 0.0239 0.0196
Brugia malayi TAR-binding protein 0.0076 0.0679 0.0679
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0046 0.0315 0.0315
Brugia malayi heat shock protein 90 0.0039 0.0239 0.0239
Echinococcus multilocularis heat shock protein 90 0.0031 0.0144 0.0144
Toxoplasma gondii histone deacetylase HDAC5 0.0338 0.3777 0.375
Echinococcus granulosus histone deacetylase 6 0.0592 0.6776 0.6776
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0679 0.0679
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0487 0.0487
Trypanosoma cruzi histone deacetylase, putative 0.0338 0.3777 0.375
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.0315 0.0273
Echinococcus multilocularis endoplasmin 0.0031 0.0144 0.0144
Leishmania major histone deacetylase, putative 0.0592 0.6776 0.6762
Trypanosoma brucei heat shock protein, putative 0.0039 0.0239 0.0196
Trypanosoma brucei heat shock protein, putative 0.0039 0.0239 0.0196
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0289 0.0289
Trypanosoma brucei heat shock protein, putative 0.0039 0.0239 0.0196
Trypanosoma cruzi histone deacetylase, putative 0.0592 0.6776 0.6762
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0289 0.0289
Echinococcus granulosus BRCA1 associated protein 0.0046 0.0315 0.0315
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0046 0.0315 0.0273
Leishmania major hypothetical protein, conserved 0.0046 0.0315 0.0273
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0046 0.0315 0.0315
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0239 0.0196
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Trichomonas vaginalis BRCA1-associated protein, putative 0.0046 0.0315 0.0273
Loa Loa (eye worm) hypothetical protein 0.0041 0.0261 0.0261
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0239 0.0196
Schistosoma mansoni ap endonuclease 0.0023 0.0043 0.0043
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0046 0.0315 0.0273
Toxoplasma gondii heat shock protein HSP90 0.0039 0.0239 0.0196
Entamoeba histolytica hypothetical protein 0.0043 0.0289 0.0246
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0046 0.0315 0.0315
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.0144 0.0144
Echinococcus multilocularis histone deacetylase 7 0.0592 0.6776 0.6776
Loa Loa (eye worm) intermediate filament protein 0.0033 0.016 0.016
Echinococcus granulosus histone deacetylase 0.0592 0.6776 0.6776
Entamoeba histolytica hypothetical protein 0.0043 0.0289 0.0246
Entamoeba histolytica heat shock transcription factor, putative 0.012 0.1191 0.1152
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0679 0.0679
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0289 0.0289
Leishmania major hypothetical protein, conserved 0.0046 0.0315 0.0273
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0043 0.0043
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0046 0.0315 0.0273
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0144 0.0102
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0046 0.0315 0.0273
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0679 0.0679
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0315 0.0273
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0239 0.0196
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Schistosoma mansoni histone deacetylase hda2 0.0638 0.7317 0.7317
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0679 0.0679
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0239 0.0196
Echinococcus multilocularis BRCA1 associated protein 0.0046 0.0315 0.0315
Echinococcus multilocularis heat shock protein 0.0039 0.0239 0.0239
Brugia malayi Endoplasmin precursor 0.0039 0.0239 0.0239
Echinococcus multilocularis histone deacetylase 0.0592 0.6776 0.6776
Loa Loa (eye worm) endoplasmin 0.0039 0.0239 0.0239
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0.0144 0.5
Echinococcus multilocularis musashi 0.0033 0.016 0.016
Trypanosoma cruzi histone deacetylase, putative 0.0592 0.6776 0.6762
Loa Loa (eye worm) hypothetical protein 0.012 0.1191 0.1191
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0046 0.0315 0.0273
Schistosoma mansoni histone deacetylase hda2 0.0338 0.3777 0.3777
Schistosoma mansoni histone deacetylase 4 5 0.0592 0.6776 0.6776
Giardia lamblia Hypothetical protein 0.0046 0.0315 0.0273
Echinococcus granulosus heat shock protein 0.0039 0.0239 0.0239
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0046 0.0315 0.0315
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0046 0.0315 0.0273
Echinococcus multilocularis histone deacetylase 8 0.0338 0.3777 0.3777
Schistosoma mansoni heat shock protein 0.0039 0.0239 0.0239
Schistosoma mansoni lamin 0.0033 0.016 0.016
Trichomonas vaginalis endoplasmin, putative 0.0024 0.0059 0.0016
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0046 0.0315 0.0273
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.0144 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0679 0.0679
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.0315 0.0273
Leishmania major histone deacetylase, putative 0.0592 0.6776 0.6762
Loa Loa (eye worm) hypothetical protein 0.0254 0.2774 0.2774
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.0315 0.0273
Brugia malayi intermediate filament protein 0.0033 0.016 0.016
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0046 0.0315 0.0315
Schistosoma mansoni histone deacetylase 4 5 0.0592 0.6776 0.6776
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0239 0.0196
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0059 0.0016
Echinococcus multilocularis histone deacetylase 6 0.0592 0.6776 0.6776
Loa Loa (eye worm) histone deacetylase 7A 0.0592 0.6776 0.6776
Echinococcus granulosus histone deacetylase 8 0.0338 0.3777 0.3777
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.0315 0.0273
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0046 0.0315 0.0273
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0046 0.0315 0.0273
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0261 0.0261
Brugia malayi BRCA1-associated protein 2 containing protein 0.0046 0.0315 0.0315
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0679 0.0679
Schistosoma mansoni hypothetical protein 0.0043 0.0289 0.0289
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0144 0.0102
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.016 0.016
Plasmodium falciparum endoplasmin, putative 0.0024 0.0059 0.0016
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Echinococcus granulosus tar DNA binding protein 0.0076 0.0679 0.0679
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0032 0.0153 0.0153
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0239 0.0196
Schistosoma mansoni histone deacetylase 1 2 3 0.0338 0.3777 0.3777
Echinococcus granulosus endoplasmin 0.0031 0.0144 0.0144
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.0239 0.0196
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0046 0.0315 0.0273
Loa Loa (eye worm) histone deacetylase 11 0.0338 0.3777 0.3777
Mycobacterium ulcerans heat shock protein 90 0.0031 0.0144 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0239 0.0196
Schistosoma mansoni ap endonuclease 0.0023 0.0043 0.0043
Trypanosoma brucei heat shock protein, putative 0.0039 0.0239 0.0196
Echinococcus multilocularis histone deacetylase 6 0.0638 0.7317 0.7317
Toxoplasma gondii histone deacetylase HDAC4 0.0338 0.3777 0.375
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0046 0.0315 0.0315
Echinococcus granulosus heat shock protein 90 0.0031 0.0144 0.0144
Brugia malayi Histone deacetylase family protein 0.0592 0.6776 0.6776
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.0315 0.0273
Trypanosoma brucei histone deacetylase, putative 0.0592 0.6776 0.6762
Toxoplasma gondii histone deacetylase HDAC1 0.0592 0.6776 0.6762
Entamoeba histolytica heat shock transcription factor, putative 0.012 0.1191 0.1152
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Echinococcus granulosus histone deacetylase 6 0.0638 0.7317 0.7317
Schistosoma mansoni endoplasmin 0.0039 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0338 0.3777 0.3777
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0046 0.0315 0.0273
Entamoeba histolytica heat shock transcription factor, putative 0.012 0.1191 0.1152
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.0315 0.0273
Schistosoma mansoni lamin 0.0033 0.016 0.016
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0046 0.0315 0.0315
Plasmodium vivax endoplasmin, putative 0.0039 0.0239 0.0196
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0679 0.0679
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0046 0.0315 0.0315
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0046 0.0315 0.0315
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0239 0.0196
Schistosoma mansoni intermediate filament proteins 0.0033 0.016 0.016
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.016 0.016
Echinococcus multilocularis histone deacetylase 6 0.0592 0.6776 0.6776
Plasmodium vivax histone deacetylase 2, putative 0.0592 0.6776 0.6762
Loa Loa (eye worm) RNA binding protein 0.0076 0.0679 0.0679
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.0144 1
Loa Loa (eye worm) heat shock protein 90 0.0039 0.0239 0.0239
Brugia malayi hypothetical protein 0.0043 0.0289 0.0289
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0046 0.0315 0.0315
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0144 0.0102
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Echinococcus multilocularis lamin 0.0033 0.016 0.016
Plasmodium vivax histone deacetylase, putative 0.0338 0.3777 0.375
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0144 0.0102
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0046 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.006 0.0487 0.0487
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0239 0.0196
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0049 0.0005
Echinococcus granulosus lamin 0.0033 0.016 0.016
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0144 0.0102
Entamoeba histolytica hypothetical protein 0.0043 0.0289 0.0246
Brugia malayi HSF-type DNA-binding domain containing protein 0.012 0.1191 0.1191
Brugia malayi histone deacetylase 11 0.0338 0.3777 0.3777
Echinococcus granulosus histone deacetylase 7 0.0592 0.6776 0.6776
Echinococcus granulosus lamin dm0 0.0033 0.016 0.016
Echinococcus multilocularis lamin dm0 0.0033 0.016 0.016
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0046 0.0315 0.0273
Schistosoma mansoni hypothetical protein 0.0041 0.0261 0.0261
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Echinococcus granulosus heat shock protein 90 0.0039 0.0239 0.0239
Trypanosoma cruzi histone deacetylase, putative 0.0338 0.3777 0.375
Trypanosoma cruzi histone deacetylase, putative 0.0592 0.6776 0.6762
Brugia malayi RNA binding protein 0.0076 0.0679 0.0679
Trypanosoma brucei heat shock protein, putative 0.0039 0.0239 0.0196
Giardia lamblia Grp94/Hsp90 0.0031 0.0144 0.0102
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0046 0.0315 0.0429
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0046 0.0315 0.0315
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0046 0.0315 0.0273
Schistosoma mansoni endoplasmin 0.0039 0.0239 0.0239
Trypanosoma brucei histone deacetylase 4 0.0592 0.6776 0.6762
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0043 0.0043
Schistosoma mansoni brca1-associated protein (brap2) 0.0046 0.0315 0.0315
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.0239 0.0196
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0046 0.0315 0.0273
Echinococcus multilocularis heat shock protein 90 0.0039 0.0239 0.0239
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.0315 0.0273
Plasmodium vivax histone deacetylase, putative 0.0592 0.6776 0.6762
Trypanosoma brucei heat shock protein, putative 0.0039 0.0239 0.0196
Leishmania major heat shock protein 83-1 0.0039 0.0239 0.0196
Loa Loa (eye worm) hypothetical protein 0.0299 0.3315 0.3315
Plasmodium vivax heat shock protein 86, putative 0.0039 0.0239 0.0196
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.016
Brugia malayi Histone deacetylase family protein 0.0592 0.6776 0.6776
Trypanosoma brucei heat shock protein, putative 0.0039 0.0239 0.0196
Plasmodium falciparum heat shock protein 90 0.0039 0.0239 0.0196
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0046 0.0315 0.0315
Treponema pallidum heat shock protein 90 0.0031 0.0144 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0487 0.0487
Trypanosoma brucei histone deacetylase 3 0.0592 0.6776 0.6762
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0239 0.0196
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0144 0.0102
Schistosoma mansoni heat shock protein 0.0039 0.0239 0.0239
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0487 0.0487
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0679 0.0679
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0679 0.0679
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0239 0.0196
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0046 0.0315 0.0315
Schistosoma mansoni brca1-associated protein (brap2) 0.0046 0.0315 0.0315
Trichomonas vaginalis brca1-associated protein, putative 0.0046 0.0315 0.0273
Echinococcus granulosus histone deacetylase 6 0.0592 0.6776 0.6776
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0031 0.0144 0.0102
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.0315 0.0273
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0046 0.0315 0.0315
Onchocerca volvulus Heat shock factor protein 2 homolog 0.012 0.1191 0.285
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0046 0.0315 0.0273
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0046 0.0315 0.0315
Plasmodium falciparum histone deacetylase 2 0.0592 0.6776 0.6762
Entamoeba histolytica hypothetical protein 0.0043 0.0289 0.0246
Onchocerca volvulus Histone deacetylase 10 homolog 0.0338 0.3777 1
Echinococcus granulosus intermediate filament protein 0.0033 0.016 0.016
Trypanosoma brucei histone deacetylase 2 0.0338 0.3777 0.375
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.0315 0.0273

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 56.028 uM PUBCHEM_BIOASSAY: HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Based System Using Plate Reader - 2038-03_Inhibitor_DoseNoFile_CherryPick_Internal-Standard_Set3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2118] ChEMBL. No reference
EC50 (functional) = 0.775 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] ChEMBL. No reference
IC50 (binding) = 2.388 um PUBCHEM_BIOASSAY: Luminescence-based dose response biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90). (Class of assay: confirmatory) [Related pubchem assays: 1831 (Summary AID.), 1846 (Confirmation screen.), 1789 (Primary screen.)] ChEMBL. No reference
Potency (functional) = 0.0398 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2931 uM PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] ChEMBL. No reference
Potency (functional) 0.5791 uM PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Giardia lamblia

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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