Detailed information for compound 1404286

Basic information

Technical information
  • TDR Targets ID: 1404286
  • Name: (3'aS,6'aR)-5-chloro-5'-cyclopentyl-7-methyl- 3'-(2-methylsulfanylethyl)spiro[1H-indole-3,1 '-2,3,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole]- 2,4',6'-trione
  • MW: 447.978 | Formula: C22H26ClN3O3S
  • H donors: 2 H acceptors: 3 LogP: 2.39 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCCC1NC2([C@H]3[C@@H]1C(=O)N(C3=O)C1CCCC1)C(=O)Nc1c2cc(Cl)cc1C
  • InChi: 1S/C22H26ClN3O3S/c1-11-9-12(23)10-14-18(11)24-21(29)22(14)17-16(15(25-22)7-8-30-2)19(27)26(20(17)28)13-5-3-4-6-13/h9-10,13,15-17,25H,3-8H2,1-2H3,(H,24,29)/t15?,16-,17+,22?/m1/s1
  • InChiKey: BFMZDHYCAYZMNW-IZCOPSDLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3aS,6aR)-5'-chloro-5-cyclopentyl-7'-methyl-3-(2-methylsulfanylethyl)spiro[2,3,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-1,3'-indoline]-2',4,6-trione
  • (3aS,6aR)-5'-chloro-5-cyclopentyl-7'-methyl-3-[2-(methylthio)ethyl]spiro[2,3,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-1,3'-indoline]-2',4,6-trione
  • MLS000083531
  • SMR000048288

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Candida albicans hypothetical protein Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0252 0.2041
Brugia malayi hypothetical protein 0.0023 0.0051 0.0182
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0154 0.3858
Echinococcus granulosus o acyltransferase membrane bound domain 0.0043 0.0298 0.0294
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0154 0.1034
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0319 0.165
Trichomonas vaginalis transmembrane protein nessy, putative 0.0043 0.0298 0.9246
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0252 0.2055
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0057 0.0043
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0043 0.0298 0.0294
Echinococcus granulosus dna polymerase eta 0.0054 0.0434 0.043
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0101 0.1016 0.593
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Giardia lamblia Grp94/Hsp90 0.0031 0.0154 0.3724
Leishmania major chitinase 0.0155 0.1674 1
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Entamoeba histolytica hypothetical protein 0.0101 0.1016 0.5945
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0319 0.0314
Trypanosoma cruzi glycerol uptake protein, putative 0.0043 0.0298 0.2535
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0057 0.0052
Loa Loa (eye worm) hhat protein 0.0043 0.0298 0.0577
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.0154 0.015
Entamoeba histolytica hypothetical protein 0.0043 0.0298 0.1526
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.154 0.2976
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0043 0.0298 0.0294
Echinococcus granulosus o acyltransferase membrane bound domain 0.0043 0.0298 0.0294
Trypanosoma brucei heat shock protein, putative 0.0039 0.0252 0.2041
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0298 0.9246
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.0154 0.073
Loa Loa (eye worm) hypothetical protein 0.0132 0.1393 0.2692
Mycobacterium ulcerans chitinase/cellulase 0.0132 0.1393 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.0252 0.2041
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0043 0.0298 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0319 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0319 0.0616
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0043 0.0298 0.0294
Loa Loa (eye worm) heat shock protein 90 0.0039 0.0252 0.0487
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0154 0.1034
Loa Loa (eye worm) hypothetical protein 0.0246 0.2792 0.5394
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0057 0.0043
Brugia malayi Endochitinase 0.0023 0.0051 0.0182
Trypanosoma brucei heat shock protein, putative 0.0039 0.0252 0.2041
Leishmania major glycerol uptake protein, putative 0.0043 0.0298 0.1496
Echinococcus granulosus heat shock protein 0.0039 0.0252 0.0248
Schistosoma mansoni chitinase 0.0023 0.0051 0.0047
Leishmania major glycerol uptake protein, putative 0.0043 0.0298 0.1496
Plasmodium falciparum endoplasmin, putative 0.0024 0.0066 0.0055
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0319 0.0314
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0246 0.2792 0.2789
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0004 0.0008
Trypanosoma brucei heat shock protein, putative 0.0039 0.0252 0.2041
Brugia malayi MH2 domain containing protein 0.0144 0.154 0.5516
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.154 0.2976
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Trypanosoma cruzi GUP1, putative 0.0043 0.0298 0.2535
Trypanosoma brucei glycerol uptake protein, putative 0.0043 0.0298 0.2522
Echinococcus multilocularis heat shock protein 0.0039 0.0252 0.0248
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0252 0.2055
Onchocerca volvulus Putative endochitinase 0.0155 0.1674 0.5995
Brugia malayi heat shock protein 90 0.0039 0.0252 0.0903
Onchocerca volvulus Putative endochitinase 0.0155 0.1674 0.5995
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0319 0.0314
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0057 0.0052
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0043 0.0298 0.0577
Echinococcus granulosus dna polymerase kappa 0.0023 0.0057 0.0052
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0509 0.1825
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0043 0.0298 0.0241
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0509 0.1825
Leishmania major glycerol uptake protein, putative 0.0043 0.0298 0.1496
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0057 0.0214
Schistosoma mansoni endoplasmin 0.0039 0.0252 0.0248
Echinococcus granulosus sterol O acyltransferase 1 0.044 0.5176 0.5174
Loa Loa (eye worm) hypothetical protein 0.0101 0.1009 0.195
Loa Loa (eye worm) hypothetical protein 0.006 0.0509 0.0984
Leishmania major DNA polymerase eta, putative 0.0038 0.0237 0.1115
Loa Loa (eye worm) MBOAT family protein 0.0043 0.0298 0.0577
Onchocerca volvulus 0.0246 0.2792 1
Loa Loa (eye worm) MBOAT family protein 0.0043 0.0298 0.0577
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0154 0.3858
Schistosoma mansoni heat shock protein 0.0039 0.0252 0.0248
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0098
Schistosoma mansoni zinc finger protein 0.0043 0.0298 0.0294
Brugia malayi endochitinase 0.0174 0.1903 0.6817
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0043 0.0298 0.0294
Entamoeba histolytica chitinase, putative 0.0155 0.1674 1
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0043 0.0298 0.1526
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0252 0.7522
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0008
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0043 0.0298 0.0294
Echinococcus multilocularis heat shock protein 90 0.0031 0.0154 0.015
Leishmania major hypothetical protein, conserved 0.0043 0.0298 0.1496
Brugia malayi Endoplasmin precursor 0.0039 0.0252 0.0903
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0319 0.2746
Plasmodium vivax heat shock protein 86, putative 0.0039 0.0252 0.0735
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0043 0.0298 0.0294
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Loa Loa (eye worm) hypothetical protein 0.0397 0.4648 0.898
Trypanosoma cruzi glycerol uptake protein, putative 0.0043 0.0298 0.2535
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0319 0.0314
Schistosoma mansoni heat shock protein 0.0039 0.0252 0.0248
Leishmania major DNA polymerase eta, putative 0.0054 0.0434 0.2335
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0101 0.1016 1
Loa Loa (eye worm) hhat protein 0.0043 0.0298 0.0577
Loa Loa (eye worm) chitinase I 0.0155 0.1674 0.3234
Leishmania major glycerol uptake protein, putative 0.0043 0.0298 0.1496
Entamoeba histolytica protein kinase domain containing protein 0.0101 0.1016 0.5945
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0057 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0298 0.9246
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0057 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0098
Brugia malayi Hhat protein 0.0043 0.0298 0.1069
Echinococcus multilocularis dna polymerase eta 0.0054 0.0434 0.043
Loa Loa (eye worm) hypothetical protein 0.0246 0.2792 0.5394
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0057 0.0018
Schistosoma mansoni sterol O-acyltransferase 1 0.044 0.5176 0.5174
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0252 0.7468
Loa Loa (eye worm) hypothetical protein 0.0043 0.0298 0.0577
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0252 0.2055
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0237 0.1894
Leishmania major glycerol uptake protein, putative 0.0043 0.0298 0.1496
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0057 0.0109
Mycobacterium ulcerans chitinase/cellulase 0.0132 0.1393 1
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0434 0.3937
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0043 0.0298 0.0294
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0043 0.0298 0.0241
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0057 0.0052
Loa Loa (eye worm) hypothetical protein 0.0054 0.0434 0.0839
Plasmodium falciparum conserved protein, unknown function 0.0246 0.2792 1
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.0252 0.006
Loa Loa (eye worm) glycosyl hydrolase family 18 protein 0.0023 0.0051 0.0098
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0101 0.1016 1
Plasmodium vivax endoplasmin, putative 0.0039 0.0252 0.0735
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0057 0.0035
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0434 0.3948
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0043 0.0298 0.0903
Brugia malayi MBOAT family protein 0.0043 0.0298 0.1069
Trypanosoma cruzi GUP1, putative 0.0043 0.0298 0.2535
Echinococcus multilocularis sterol O acyltransferase 1 0.044 0.5176 0.5174
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0319 0.1621
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0319 0.0314
Trypanosoma brucei heat shock protein, putative 0.0039 0.0252 0.2041
Echinococcus multilocularis heat shock protein 90 0.0039 0.0252 0.0248
Plasmodium falciparum heat shock protein 90 0.0039 0.0252 0.0735
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0246 0.2792 0.2789
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0043 0.0298 0.0294
Trypanosoma brucei heat shock protein, putative 0.0039 0.0252 0.2041
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0043 0.0298 0.1526
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0252 0.1241
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0031 0.0154 0.0604
Loa Loa (eye worm) hypothetical protein 0.0043 0.0298 0.0577
Echinococcus granulosus heat shock protein 90 0.0031 0.0154 0.015
Brugia malayi endochitinase 0.0155 0.1674 0.5995
Trypanosoma brucei heat shock protein, putative 0.0039 0.0252 0.2041
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Echinococcus multilocularis endoplasmin 0.0031 0.0154 0.015
Onchocerca volvulus Putative endochitinase 0.0174 0.1903 0.6817
Brugia malayi Glycosyl hydrolases family 18 protein 0.0023 0.0051 0.0182
Brugia malayi Glycosyl hydrolases family 18 protein 0.0023 0.0051 0.0182
Trichomonas vaginalis porcupine, putative 0.0043 0.0298 0.9246
Echinococcus granulosus endoplasmin 0.0031 0.0154 0.015
Toxoplasma gondii hypothetical protein 0.0246 0.2792 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0276 0.0987
Brugia malayi MBOAT family protein 0.0043 0.0298 0.1069
Brugia malayi diacylglycerol acyltransferase 0.0043 0.0298 0.1069
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0057 0.0214
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Plasmodium vivax hypothetical protein, conserved 0.0246 0.2792 1
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Echinococcus granulosus o acyltransferase membrane bound domain 0.0043 0.0298 0.0294
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0319 1
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0154 0.3858
Onchocerca volvulus Putative endochitinase 0.0023 0.0051 0.0182
Onchocerca volvulus Putative endochitinase 0.0174 0.1903 0.6817
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.1016 0.1012
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0252 0.2055
Mycobacterium tuberculosis Possible chitinase 0.0132 0.1393 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0043 0.0298 0.0294
Entamoeba histolytica protein kinase, putative 0.0101 0.1016 0.5945
Brugia malayi MBOAT family protein 0.0043 0.0298 0.1069
Onchocerca volvulus 0.0246 0.2792 1
Toxoplasma gondii hypothetical protein 0.0043 0.0298 0.0241
Loa Loa (eye worm) endoplasmin 0.0039 0.0252 0.0487
Echinococcus multilocularis Glycoside hydrolase, chitinase domain containing protein 1 0.0023 0.0051 0.0047
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0319 0.2746
Loa Loa (eye worm) hypothetical protein 0.044 0.5176 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0319 0.1141
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0509 0.0984
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.0252 0.2041
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0043 0.0298 0.0294
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0043 0.0298 0.0577
Mycobacterium ulcerans heat shock protein 90 0.0031 0.0154 0.077
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0252 0.2055
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0057 0.0202
Echinococcus granulosus Glycoside hydrolase chitinase domain containing protein 1 0.0023 0.0051 0.0047
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0319 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0004 0.0015
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0434 0.1555
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0066 0.0568
Echinococcus granulosus dual specificity 0.0101 0.1016 0.1012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0057 0.0018
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0319 0.2733
Brugia malayi Protein kinase domain containing protein 0.0101 0.1016 0.3637
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.0154 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0298 0.0577
Treponema pallidum alginate O-acetylation protein (algI) 0.0043 0.0298 1
Entamoeba histolytica vacuolar protein sorting 26 0.0043 0.0298 0.1526
Trichomonas vaginalis endoplasmin, putative 0.0024 0.0066 0.0568
Entamoeba histolytica protein kinase, putative 0.0101 0.1016 0.5945
Echinococcus granulosus heat shock protein 90 0.0039 0.0252 0.0248
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0043 0.0298 0.0294
Loa Loa (eye worm) hypothetical protein 0.0041 0.0276 0.0533
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0298 0.9246
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0101 0.1016 0.1962
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0043 0.0298 0.0294
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0004 0.0015
Schistosoma mansoni endoplasmin 0.0039 0.0252 0.0248
Brugia malayi hypothetical protein 0.0023 0.0051 0.0182
Brugia malayi MBOAT family protein 0.0043 0.0298 0.1069
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0057 0.0018
Onchocerca volvulus 0.0043 0.0298 0.1069
Trypanosoma brucei glycerol uptake protein, putative 0.0043 0.0298 0.2522
Echinococcus multilocularis dual specificity 0.0101 0.1016 0.1012
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0043 0.0298 0.0294
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0252 0.2041
Loa Loa (eye worm) microfilarial chitinase 0.0151 0.1623 0.3136
Onchocerca volvulus Putative chitinase 0.0023 0.0051 0.0182
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0246 0.2792 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0319 0.0314
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0043 0.0298 0.0294
Loa Loa (eye worm) cuticular endochitinase 0.0155 0.1674 0.3234
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0101 0.1016 1
Entamoeba histolytica hypothetical protein, conserved 0.0043 0.0298 0.1526
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0043 0.0298 0.0294
Onchocerca volvulus Putative endochitinase 0.0174 0.1903 0.6817
Trypanosoma brucei heat shock protein, putative 0.0039 0.0252 0.2041
Schistosoma mansoni DNA polymerase eta 0.0054 0.0434 0.043
Trypanosoma cruzi glycerol uptake protein, putative 0.0043 0.0298 0.2535
Schistosoma mansoni hypothetical protein 0.0246 0.2792 0.2789
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0043 0.0298 0.1526
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0.0154 0.5
Leishmania major heat shock protein 83-1 0.0039 0.0252 0.121
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0043 0.0298 0.0294
Loa Loa (eye worm) MBOAT family protein 0.0043 0.0298 0.0577
Brugia malayi Endochitinase 0.0174 0.1903 0.6817
Schistosoma mansoni hypothetical protein 0.0041 0.0276 0.0271
Toxoplasma gondii heat shock protein HSP90 0.0039 0.0252 0.006
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0043 0.0298 0.0294
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0319 0.0314
Brugia malayi MBOAT family protein 0.0043 0.0298 0.1069
Loa Loa (eye worm) hypothetical protein 0.0101 0.1009 0.195
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0319 0.0314
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0154 0.3724
Schistosoma mansoni hypothetical protein 0.0043 0.0298 0.0294
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0057 0.0018
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0319 1
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0043 0.0298 0.0903
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0043 0.0298 0.0294
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0252 0.1241

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 10.112 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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