Detailed information for compound 1417624

Basic information

Technical information
  • TDR Targets ID: 1417624
  • Name: 2-(1-amino-4-phenylimidazol-2-yl)sulfanyl-1-( 4-phenylsulfonylpiperazin-1-yl)ethanone
  • MW: 457.569 | Formula: C21H23N5O3S2
  • H donors: 1 H acceptors: 4 LogP: 2.42 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)S(=O)(=O)c1ccccc1)CSc1nc(cn1N)c1ccccc1
  • InChi: 1S/C21H23N5O3S2/c22-26-15-19(17-7-3-1-4-8-17)23-21(26)30-16-20(27)24-11-13-25(14-12-24)31(28,29)18-9-5-2-6-10-18/h1-10,15H,11-14,16,22H2
  • InChiKey: JUKUWDSVUMLFLK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(1-amino-4-phenyl-imidazol-2-yl)sulfanyl-1-(4-phenylsulfonylpiperazin-1-yl)ethanone
  • 2-[(1-amino-4-phenyl-2-imidazolyl)thio]-1-(4-phenylsulfonyl-1-piperazinyl)ethanone
  • 2-[(1-amino-4-phenyl-imidazol-2-yl)thio]-1-(4-phenylsulfonylpiperazin-1-yl)ethanone
  • MLS000879980
  • MLS001066210
  • T5341001
  • MLS000055971
  • SMR000068377

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0026
Echinococcus multilocularis GPCR, family 2 0.0207 0.1152 0.4434
Giardia lamblia Cathepsin B precursor 0.0026 0.0037 0.0445
Plasmodium falciparum thioredoxin reductase 0.0057 0.0229 0.1667
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0179 0.4304
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0245 0.0943
Plasmodium falciparum serine repeat antigen 4 0.0026 0.0037 0.0269
Giardia lamblia DINP protein human, muc B family 0.0023 0.0022 0.0261
Echinococcus granulosus peptidase Clp S14 family 0.016 0.0859 0.3306
Loa Loa (eye worm) MH2 domain-containing protein 0.0709 0.4229 0.4223
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0026 0.0037 0.0269
Plasmodium vivax unspecified product 0.0049 0.0179 0.1301
Toxoplasma gondii cathepsin B 0.0155 0.0829 0.6033
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0037 0.0159
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.01 0.0727
Onchocerca volvulus 0.0036 0.01 0.0547
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0026 0.0037 0.042
Schistosoma mansoni cathepsin F (C01 family) 0.0083 0.0387 0.0387
Brugia malayi Pre-SET motif family protein 0.0251 0.1421 0.1421
Giardia lamblia Cathepsin B precursor 0.0026 0.0037 0.0445
Onchocerca volvulus 0.006 0.0245 0.1441
Loa Loa (eye worm) transcription factor SMAD2 0.0709 0.4229 0.4223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0387 0.0387
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0387 0.0387
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0037 0.0037
Brugia malayi Latrophilin receptor protein 2 0.0207 0.1152 0.1152
Loa Loa (eye worm) MH1 domain-containing protein 0.0048 0.0175 0.0164
Echinococcus granulosus cathepsin l cysteine peptidase 0.0083 0.0387 0.1489
Loa Loa (eye worm) hypothetical protein 0.0027 0.0042 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0387 0.4668
Loa Loa (eye worm) hypothetical protein 0.006 0.0245 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0387 0.4668
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0092 0.0353
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.0387 0.1489
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0026 0.0037 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0245 0.0245
Leishmania major cathepsin L-like protease 0.0083 0.0387 0.4668
Schistosoma mansoni smad1 5 8 and 0.0048 0.0175 0.0175
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.01 0.0384
Brugia malayi MH2 domain containing protein 0.0709 0.4229 0.4229
Giardia lamblia Hypothetical protein 0.0026 0.0037 0.0445
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0022 0.0251
Onchocerca volvulus 0.0083 0.0387 0.2315
Echinococcus granulosus cysteine protease 0.0049 0.0179 0.0688
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0229 0.1667
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0022 0.0261
Entamoeba histolytica cysteine protease, putative 0.0083 0.0387 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0022 0.0261
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0037 0.0026
Echinococcus granulosus cathepsin l1 0.006 0.0245 0.0943
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0022 0.0083
Entamoeba histolytica cysteine protease, putative 0.0049 0.0179 0.4304
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0244 0.1374 1
Echinococcus multilocularis cathepsin b 0.0443 0.2597 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.003 0.0216
Trypanosoma cruzi cysteine proteinase, putative 0.0049 0.0179 0.0688
Plasmodium falciparum cysteine proteinase falcipain 3 0.0083 0.0387 0.2816
Onchocerca volvulus Cathepsin L homolog 0.0083 0.0387 0.2315
Entamoeba histolytica cysteine protease, putative 0.0049 0.0179 0.4304
Plasmodium falciparum serine repeat antigen 5 0.0026 0.0037 0.0269
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0079 0.0364 0.2653
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0037 0.0037
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0022 0.0083
Trypanosoma cruzi cysteine proteinase, putative 0.0049 0.0179 0.0688
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0394 0.2866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0179 0.2157
Brugia malayi Cathepsin L-like precursor 0.006 0.0245 0.0245
Onchocerca volvulus 0.0083 0.0387 0.2315
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0037 0.0037
Toxoplasma gondii hypothetical protein 0.0084 0.0394 0.2866
Echinococcus granulosus cathepsin b 0.0443 0.2597 1
Schistosoma mansoni cathepsin F (C01 family) 0.0083 0.0387 0.0387
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0387 0.0387
Brugia malayi Cathepsin L-like precursor 0.0023 0.002 0.002
Trypanosoma brucei unspecified product 0.0023 0.0022 0.0261
Plasmodium vivax serine-repeat antigen (SERA) 0.0026 0.0037 0.0269
Onchocerca volvulus 0.0286 0.1634 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0364 0.1403
Echinococcus granulosus dna polymerase eta 0.0023 0.0022 0.0083
Schistosoma mansoni glutaminase 0.1649 1 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0026 0.0037 0.0269
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0049 0.0179 0.0179
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0079 0.0364 0.4244
Loa Loa (eye worm) glutaminase 0.1649 1 1
Leishmania major cathepsin L-like protease 0.0083 0.0387 0.4668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0037 0.0037
Toxoplasma gondii thioredoxin reductase 0.0057 0.0229 0.1667
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0229 0.0882
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0083 0.0387 0.0387
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0026 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0083 0.0387 0.0387
Entamoeba histolytica cysteine protease, putative 0.0049 0.0179 0.4304
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0026 0.0037 0.0269
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.0428 0.0428
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0083 0.0387 0.1489
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0179 0.4304
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0364 0.4397
Brugia malayi Isocitrate dehydrogenase 0.0079 0.0364 0.0364
Toxoplasma gondii isocitrate dehydrogenase 0.0079 0.0364 0.2653
Giardia lamblia Cathepsin L precursor 0.0026 0.0037 0.0445
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0083 0.0387 0.0376
Echinococcus granulosus cathepsin L cysteine proteinase 0.0083 0.0387 0.1489
Entamoeba histolytica cysteine protease, putative 0.0049 0.0179 0.4304
Plasmodium falciparum serine repeat antigen 3 0.0026 0.0037 0.0269
Schistosoma mansoni tyrosinase precursor 0.009 0.0428 0.0428
Entamoeba histolytica cysteine protease, putative 0.0026 0.0037 0.042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0022 0.0083
Leishmania major DNA polymerase eta, putative 0.0023 0.0022 0.0261
Schistosoma mansoni hypothetical protein 0.0448 0.2629 0.2629
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0244 0.1374 1
Entamoeba histolytica cysteine proteinase, putative 0.0083 0.0387 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0026 0.0037 0.0269
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0261
Plasmodium vivax serine-repeat antigen (SERA) 0.0026 0.0037 0.0269
Echinococcus multilocularis Smad4 0.0048 0.0175 0.0674
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.016 0.0859 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0009
Entamoeba histolytica cysteine proteinase 1, putative 0.0049 0.0179 0.4304
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0079 0.0364 0.1403
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0026 0.0037 0.0269
Echinococcus multilocularis cathepsin L 0.0049 0.0179 0.0688
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0179 0.4304
Schistosoma mansoni peptidase Clp (S14 family) 0.0244 0.1374 0.1374
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0387 0.4668
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.0829 0.0829
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0244 0.1374 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0428 0.0418
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.016 0.0859 1
Schistosoma mansoni tyrosinase precursor 0.009 0.0428 0.0428
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0261
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0229 0.0882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0179 0.0179
Brugia malayi N-terminal motif family protein 0.0218 0.1217 0.1217
Plasmodium vivax vivapain-1 0.0049 0.0179 0.1301
Giardia lamblia Cathepsin L precursor 0.0026 0.0037 0.0445
Echinococcus granulosus cathepsin l1 0.0083 0.0387 0.1489
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.003 0.0114
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0229 0.0882
Plasmodium falciparum serine repeat antigen 2 0.0026 0.0037 0.0269
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0026 0.0037 0.0445
Brugia malayi Cathepsin L-like precursor 0.0083 0.0387 0.0387
Entamoeba histolytica cysteine protease, putative 0.0049 0.0179 0.4304
Schistosoma mansoni smad1 5 8 and 0.0048 0.0175 0.0175
Entamoeba histolytica cysteine protease, putative 0.0049 0.0179 0.4304
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0037 0.0037
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0244 0.1374 0.1374
Plasmodium vivax unspecified product 0.0023 0.002 0.0149
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.002 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0037 0.0037
Entamoeba histolytica hypothetical protein 0.0026 0.0037 0.042
Leishmania major cysteine peptidase A (CPA) 0.0083 0.0387 0.4668
Brugia malayi MH1 domain containing protein 0.0027 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0026
Giardia lamblia Encystation-specific protease 0.0026 0.0037 0.0445
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0079 0.0364 0.4397
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0026 0.0037 0.0037
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.01 0.0384
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0443 0.2597 0.2597
Brugia malayi Probable ClpP-like protease 0.0244 0.1374 0.1374
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0387 0.0387
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0026 0.0037 0.0037
Mycobacterium tuberculosis Probable reductase 0.013 0.0678 0.7897
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0656 0.3902 0.3895
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0229 0.2667
Entamoeba histolytica cysteine protease, putative 0.0049 0.0179 0.4304
Brugia malayi Cathepsin L-like precursor 0.0083 0.0387 0.0387
Echinococcus multilocularis peptidase Clp (S14 family) 0.016 0.0859 0.3306
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0026 0.0037 0.0445
Echinococcus multilocularis cathepsin L 0.0026 0.0037 0.0142
Onchocerca volvulus 0.0026 0.0037 0.0159
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0026 0.0037 0.0269
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0387 0.0387
Toxoplasma gondii cathepsin CPC1 0.0026 0.0037 0.0269
Brugia malayi cathepsin L-like cysteine proteinase 0.0026 0.0037 0.0037
Entamoeba histolytica cysteine protease, putative 0.0026 0.0037 0.042
Brugia malayi Cathepsin L-like precursor 0.0083 0.0387 0.0387
Echinococcus granulosus cathepsin L cysteine protease 0.0049 0.0179 0.0688
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0022 0.0022
Giardia lamblia Cathepsin L-like protease 0.0026 0.0037 0.0445
Brugia malayi cathepsin F-like cysteine proteinase 0.0026 0.0037 0.0037
Schistosoma mansoni smad 0.0022 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0387 0.4668
Echinococcus multilocularis cysteine protease 0.0083 0.0387 0.1489
Leishmania major cathepsin L-like protease 0.0083 0.0387 0.4668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0387 0.0387
Brugia malayi Pre-SET motif family protein 0.0036 0.01 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0387 0.0387
Leishmania major hypothetical protein, conserved 0.0025 0.003 0.0358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0387 0.0387
Brugia malayi Smad1 0.0048 0.0175 0.0175
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0022 0.0251
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.003 0.0114
Entamoeba histolytica cysteine proteinase, putative 0.0083 0.0387 1
Leishmania major cathepsin L-like protease 0.0083 0.0387 0.4668
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0387 0.4668
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0009
Brugia malayi Common central domain of tyrosinase family protein 0.009 0.0428 0.0428
Entamoeba histolytica cysteine protease, putative 0.0049 0.0179 0.4304
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.01 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0261
Brugia malayi cathepsin F-like cysteine proteinase 0.0023 0.002 0.002
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0244 0.1374 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0026 0.0037 0.0269
Leishmania major cathepsin L-like protease 0.0083 0.0387 0.4668
Plasmodium vivax vivapain-3 0.0049 0.0179 0.1301
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0022 0.0022
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0026 0.0037 0.0445
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0022 0.0022
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0394 0.2866
Schistosoma mansoni cathepsin F (C01 family) 0.006 0.0245 0.0245
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.0387 0.1489
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0387 0.0387
Brugia malayi Papain family cysteine protease containing protein 0.0049 0.0179 0.0179
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0026 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0026 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0026 0.0037 0.0037
Onchocerca volvulus 0.009 0.0428 0.257
Loa Loa (eye worm) hypothetical protein 0.0443 0.2597 0.2589
Brugia malayi ShTK domain containing protein 0.009 0.0428 0.0428
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0244 0.1374 0.5289
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0048 0.0175 0.0674
Giardia lamblia Cathepsin L precursor 0.0026 0.0037 0.0445
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0026 0.0037 0.0037
Brugia malayi glutaminase DH11.1 0.1649 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0387 0.4668
Loa Loa (eye worm) fibroinase 0.0083 0.0387 0.0376
Echinococcus multilocularis cathepsin L cysteine protease 0.0083 0.0387 0.1489
Schistosoma mansoni smad1 5 8 and 0.0048 0.0175 0.0175
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0443 0.2597 0.2597
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0026 0.0037 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0387 0.4668
Loa Loa (eye worm) hypothetical protein 0.006 0.0245 0.0234
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.01 0.01
Entamoeba histolytica cysteine proteinase 2 0.0049 0.0179 0.4304
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0026 0.0037 0.0037
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0049 0.0179 0.0688
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0037 0.0037
Loa Loa (eye worm) nuclear factor I 0.0027 0.0042 0.0031
Trypanosoma brucei trypanothione reductase 0.0057 0.0229 0.2763
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0022 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0261
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0026 0.0037 0.0269
Brugia malayi MH1 domain containing protein 0.0048 0.0175 0.0175
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0026 0.0037 0.0037
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0022 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0261
Giardia lamblia Cathepsin L precursor 0.0026 0.0037 0.0445
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0026 0.0037 0.0037
Schistosoma mansoni smad 0.0048 0.0175 0.0175
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.0428 0.0428
Plasmodium falciparum serine repeat antigen 9 0.0026 0.0037 0.0269
Brugia malayi hypothetical protein 0.0025 0.003 0.003
Leishmania major cathepsin L-like protease 0.0083 0.0387 0.4668
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0767 0.8936
Loa Loa (eye worm) cathepsin B 0.0155 0.0829 0.0819
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0443 0.2597 0.2597
Loa Loa (eye worm) isocitrate dehydrogenase 0.0079 0.0364 0.0354
Loa Loa (eye worm) hypothetical protein 0.006 0.0245 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0037 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0387 0.4668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0387 0.0387
Brugia malayi MH2 domain containing protein 0.0048 0.0175 0.0175
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.003 0.0216
Onchocerca volvulus 0.009 0.0428 0.257
Giardia lamblia Hypothetical protein 0.0026 0.0037 0.0445
Schistosoma mansoni cathepsin B (C01 family) 0.0026 0.0037 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.01 0.01
Schistosoma mansoni hypothetical protein 0.0207 0.1152 0.1152
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0079 0.0364 0.1403
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.009 0.0428 0.0428
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0026 0.0037 0.0269
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.002 0.0079
Onchocerca volvulus Cathepsin L homolog 0.0083 0.0387 0.2315
Echinococcus granulosus mothers against decapentaplegic 2 0.0022 0.0011 0.0042
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0207 0.1152 0.4434
Toxoplasma gondii cathepsin CPL 0.0083 0.0387 0.2816
Plasmodium vivax glutathione reductase, putative 0.0057 0.0229 0.1667
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0443 0.2597 0.2597
Trypanosoma cruzi cruzipain precursor, putative 0.0023 0.002 0.0079
Entamoeba histolytica cysteine proteinase, putative 0.006 0.0245 0.6116
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0656 0.3902 0.3902
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0022 0.0083
Brugia malayi fibroinase precursor 0.0026 0.0037 0.0037
Brugia malayi glutathione reductase 0.0057 0.0229 0.0229
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0207 0.1152 0.4434
Trypanosoma cruzi cysteine protease, putative 0.0049 0.0179 0.0688
Echinococcus granulosus Smad4 0.0048 0.0175 0.0674
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.009 0.0428 0.0418
Brugia malayi isocitrate dehydrogenase 0.0079 0.0364 0.0364
Echinococcus granulosus cathepsin b 0.0443 0.2597 1
Echinococcus granulosus dna polymerase kappa 0.0023 0.0022 0.0083
Brugia malayi cathepsin Z-like cysteine proteinase 0.0026 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0387 0.0387
Echinococcus granulosus GPCR family 2 0.0207 0.1152 0.4434
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0022 0.0083
Leishmania major cathepsin L-like protease 0.0083 0.0387 0.4668
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0022 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0364 0.1403
Onchocerca volvulus 0.009 0.0428 0.257
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0678 0.7897
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.0428 0.0418
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0207 0.1152 0.4434
Trypanosoma cruzi cruzipain precursor, putative 0.0083 0.0387 0.1489
Plasmodium falciparum cysteine proteinase falcipain 1 0.0049 0.0179 0.1301
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0026 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0218 0.1217 0.1207
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0026 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0656 0.3902 0.3895
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0022 0.0083
Giardia lamblia Cysteine protease 0.0026 0.0037 0.0445
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0244 0.1374 1
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0179 0.4304
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0767 0.3812
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0364 0.1403
Brugia malayi Calcitonin receptor-like protein seb-1 0.0656 0.3902 0.3902
Loa Loa (eye worm) tyrosinase 1 0.009 0.0428 0.0418
Schistosoma mansoni Smad4 0.0022 0.0011 0.0011
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.1217 0.7427
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.0829 0.0829
Entamoeba histolytica cysteine protease, putative 0.0026 0.0037 0.042
Giardia lamblia Cysteine protease 0.0026 0.0037 0.0445
Plasmodium vivax vivapain-2 0.0083 0.0387 0.2816
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0011
Echinococcus multilocularis smad 0.0048 0.0175 0.0674
Brugia malayi Thioredoxin reductase 0.0057 0.0229 0.0229
Trypanosoma brucei cysteine peptidase C (CPC) 0.0155 0.0829 1
Brugia malayi cathepsin L-like precursor 0.006 0.0245 0.0245
Plasmodium vivax SET domain protein, putative 0.0036 0.01 0.0727
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0387 0.0387
Brugia malayi Cathepsin L-like precursor 0.0083 0.0387 0.0387
Giardia lamblia Cathepsin B precursor 0.0026 0.0037 0.0445
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0261
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0079 0.0364 0.1403
Echinococcus granulosus TGF beta signal transducer SmadC 0.0048 0.0175 0.0674
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0037 0.0026
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0767 0.8936
Loa Loa (eye worm) latrophilin receptor protein 2 0.0207 0.1152 0.1142
Entamoeba histolytica cysteine protease, putative 0.0026 0.0037 0.042
Plasmodium falciparum serine repeat antigen 7 0.0026 0.0037 0.0269
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0678 0.2901
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0155 0.0829 0.3191
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0387 0.4668
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0179 0.2157
Brugia malayi cathepsin Z-like cysteine proteinase 0.0026 0.0037 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0261
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0083 0.0387 0.2816
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0387 0.0387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0387 0.0387
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0049 0.0179 0.0179
Giardia lamblia Cathepsin B precursor 0.0026 0.0037 0.0445
Schistosoma mansoni cathepsin S (C01 family) 0.0026 0.0037 0.0037
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0023 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0026
Schistosoma mansoni cathepsin s 0.0023 0.002 0.002
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.0387 0.1489
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0037 0.0037
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.003 0.0216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0387 0.4668
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0022 0.0022
Echinococcus multilocularis mothers against decapentaplegic 2 0.0022 0.0011 0.0042
Entamoeba histolytica cysteine protease, putative 0.0049 0.0179 0.4304
Onchocerca volvulus 0.0083 0.0387 0.2315
Plasmodium falciparum serine repeat antigen 8 0.0026 0.0037 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0244 0.1374 0.1364
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0022 0.0022
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.016 0.0859 0.4744
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0207 0.1152 0.1152
Echinococcus granulosus cathepsin L 0.0026 0.0037 0.0142
Loa Loa (eye worm) hypothetical protein 0.0083 0.0387 0.0376
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0049 0.0179 0.0179
Trypanosoma cruzi major cysteine proteinase, putative 0.0026 0.0037 0.0142
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0079 0.0364 0.0364
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0026 0.0037 0.0269
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0229 0.0218
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.0428 0.0418
Brugia malayi Cathepsin L-like cysteine proteinase 0.006 0.0245 0.0245
Giardia lamblia Cathepsin B precursor 0.0155 0.0829 1
Brugia malayi MH2 domain containing protein 0.0022 0.0011 0.0011
Plasmodium falciparum glutathione reductase 0.0057 0.0229 0.1667
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.003 0.0216
Onchocerca volvulus Cathepsin F homolog 0.0083 0.0387 0.2315
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1421 0.1412
Brugia malayi MH1 domain containing protein 0.0048 0.0175 0.0175
Loa Loa (eye worm) ctsf protein 0.0083 0.0387 0.0376
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.0428 0.0428
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0244 0.1374 1
Schistosoma mansoni hypothetical protein 0.0207 0.1152 0.1152
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0364 0.1403
Brugia malayi Papain family cysteine protease containing protein 0.0049 0.0179 0.0179
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0155 0.0829 1
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0179 0.0688
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0022 0.0261
Echinococcus multilocularis cathepsin L cysteine protease 0.0083 0.0387 0.1489
Loa Loa (eye worm) MH2 domain-containing protein 0.0048 0.0175 0.0164
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.01 0.0384
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0244 0.1374 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0387 0.0387
Giardia lamblia Cathepsin B precursor 0.0155 0.0829 1
Giardia lamblia Cysteine protease 0.0026 0.0037 0.0445
Giardia lamblia Cathepsin B precursor 0.0026 0.0037 0.0445
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0083 0.0387 0.1489
Echinococcus granulosus smad 0.0048 0.0175 0.0674
Brugia malayi cathepsin L precursor 0.0026 0.0037 0.0037
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0394 0.2866
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0022 0.0022
Echinococcus multilocularis mothers against decapentaplegic 6 0.0022 0.0011 0.0042
Echinococcus multilocularis cysteine protease 0.0083 0.0387 0.1489
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0026
Leishmania major trypanothione reductase 0.0057 0.0229 0.2763
Brugia malayi mothers against decapentaplegic homolog 3 0.0022 0.0011 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.01 0.01
Echinococcus granulosus mothers against decapentaplegic 6 0.0022 0.0011 0.0042
Onchocerca volvulus 0.009 0.0428 0.257
Toxoplasma gondii preprocathepsin c precursor, putative 0.0026 0.0037 0.0269
Schistosoma mansoni Smad4 0.0022 0.0011 0.0011
Brugia malayi MH1 domain containing protein 0.0027 0.0042 0.0042
Trichomonas vaginalis glutaminase, putative 0.1649 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0026 0.0037 0.0142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0387 0.0387
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0026 0.0037 0.0269
Entamoeba histolytica cysteine protease, putative 0.0049 0.0179 0.4304
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0026 0.0037 0.0037
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0026 0.0037 0.0269
Giardia lamblia Cysteine protease 0.0026 0.0037 0.0445
Giardia lamblia Cathepsin L precursor 0.0026 0.0037 0.0445
Echinococcus multilocularis mothers against decapentaplegic 5 0.0048 0.0175 0.0674
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0207 0.1152 0.4434
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0037 0.0037
Plasmodium falciparum serine repeat antigen 6 0.0026 0.0037 0.0269
Echinococcus multilocularis cathepsin b 0.0443 0.2597 1
Giardia lamblia Cathepsin L precursor 0.0026 0.0037 0.0445
Echinococcus multilocularis isocitrate dehydrogenase 0.0079 0.0364 0.1403
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0678 0.7897
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0387 0.0387
Schistosoma mansoni DNA polymerase eta 0.0023 0.0022 0.0022
Onchocerca volvulus 0.0083 0.0387 0.2315
Loa Loa (eye worm) cysteine protease 0.0083 0.0387 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0179 0.0179
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0767 0.8936
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0387 0.0387
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0026 0.0037 0.0037
Brugia malayi latrophilin 2 splice variant baaae 0.0448 0.2629 0.2629
Onchocerca volvulus 0.0083 0.0387 0.2315
Plasmodium vivax unspecified product 0.0026 0.0037 0.0269
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0022 0.0083
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0026 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0026
Loa Loa (eye worm) hypothetical protein 0.0036 0.01 0.0089
Brugia malayi MH2 domain containing protein 0.0048 0.0175 0.0175
Echinococcus multilocularis dna polymerase eta 0.0023 0.0022 0.0083
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0678 0.7897
Onchocerca volvulus 0.0083 0.0387 0.2315
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.003 0.0358
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0207 0.1152 0.1152
Entamoeba histolytica cysteine protease, putative 0.0049 0.0179 0.4304
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0244 0.1374 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0048 0.0175 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0261
Schistosoma mansoni cathepsin C 0.0026 0.0037 0.0037
Leishmania major cathepsin L-like protease 0.0083 0.0387 0.4668
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0083 0.0387 0.2816
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0037 0.0037
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0678 0.7897
Entamoeba histolytica cysteine protease, putative 0.0049 0.0179 0.4304
Brugia malayi cathepsin B-like cysteine proteinase 0.0443 0.2597 0.2597
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0079 0.0364 0.2653
Entamoeba histolytica cysteine protease, putative 0.0026 0.0037 0.042
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0083 0.0387 0.0376
Toxoplasma gondii isocitrate dehydrogenase 0.0079 0.0364 0.2653
Loa Loa (eye worm) hypothetical protein 0.0448 0.2629 0.2621
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0443 0.2597 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0026 0.0037 0.0037
Echinococcus granulosus mothers against decapentaplegic 5 0.0048 0.0175 0.0674
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0244 0.1374 0.1374
Echinococcus granulosus cathepsin L 0.0049 0.0179 0.0688
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0387 0.4668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0387 0.0387
Schistosoma mansoni Smad4 0.0048 0.0175 0.0175
Mycobacterium ulcerans glutaminase 0.1649 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0026 0.0037 0.0445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0387 0.0387
Entamoeba histolytica cysteine protease, putative 0.0049 0.0179 0.4304
Plasmodium falciparum serine repeat antigen 1 0.0026 0.0037 0.0269
Leishmania major DNA polymerase kappa, putative 0.0023 0.0022 0.0261
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0019
Loa Loa (eye worm) glutathione reductase 0.0057 0.0229 0.0218
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0026 0.0037 0.0037
Toxoplasma gondii cathepsin CPC2 0.0026 0.0037 0.0269
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0022 0.0083
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0364 0.4397
Brugia malayi Papain family cysteine protease containing protein 0.0083 0.0387 0.0387
Brugia malayi Cathepsin L-like precursor 0.0083 0.0387 0.0387
Schistosoma mansoni hypothetical protein 0.0207 0.1152 0.1152
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0026 0.0037 0.042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0037 0.0037
Loa Loa (eye worm) Smad1 0.0048 0.0175 0.0164
Loa Loa (eye worm) hypothetical protein 0.0207 0.1152 0.1142
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0244 0.1374 0.5289
Giardia lamblia Cathepsin B precursor 0.0155 0.0829 1
Entamoeba histolytica cysteine protease, putative 0.0026 0.0037 0.042
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0678 0.7897
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0037 0.0037
Brugia malayi Cathepsin L-like precursor 0.006 0.0245 0.0245
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0244 0.1374 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0026 0.0037 0.0037
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1634 0.1634
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0387 0.0387
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0261
Brugia malayi Cathepsin L-like precursor 0.0083 0.0387 0.0387
Giardia lamblia Cathepsin L-like protease 0.0026 0.0037 0.0445
Onchocerca volvulus 0.0083 0.0387 0.2315
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.0387 0.1489
Plasmodium vivax vivapain-2 0.0083 0.0387 0.2816

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0147 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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