Detailed information for compound 1421761

Basic information

Technical information
  • TDR Targets ID: 1421761
  • Name: ethyl 2-[[2-[3-[3-[(2-methoxyphenyl)methylami no]-3-oxopropyl]-2,4-dioxoquinazolin-1-yl]ace tyl]amino]benzoate
  • MW: 558.582 | Formula: C30H30N4O7
  • H donors: 2 H acceptors: 5 LogP: 3.2 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)c1ccccc1NC(=O)Cn1c2ccccc2c(=O)n(c1=O)CCC(=O)NCc1ccccc1OC
  • InChi: 1S/C30H30N4O7/c1-3-41-29(38)21-11-5-7-13-23(21)32-27(36)19-34-24-14-8-6-12-22(24)28(37)33(30(34)39)17-16-26(35)31-18-20-10-4-9-15-25(20)40-2/h4-15H,3,16-19H2,1-2H3,(H,31,35)(H,32,36)
  • InChiKey: JNBPCDYXXPGZFO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[[2-[3-[3-[(2-methoxyphenyl)methylamino]-3-oxo-propyl]-2,4-dioxo-quinazolin-1-yl]acetyl]amino]benzoate
  • 2-[[2-[3-[3-[(2-methoxyphenyl)methylamino]-3-oxopropyl]-2,4-dioxo-1-quinazolinyl]-1-oxoethyl]amino]benzoic acid ethyl ester
  • 2-[[2-[2,4-diketo-3-[3-keto-3-[(2-methoxybenzyl)amino]propyl]quinazolin-1-yl]acetyl]amino]benzoic acid ethyl ester
  • ethyl 2-[2-[3-[3-[(2-methoxyphenyl)methylamino]-3-oxo-propyl]-2,4-dioxo-quinazolin-1-yl]ethanoylamino]benzoate
  • C260-1219
  • NCGC00106523-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0118 0.0592
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0777 0.4815 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0118 0.0104
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0118 0.0542
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0055 0.0056
Echinococcus multilocularis dna polymerase eta 0.0038 0.0118 0.0104
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0055 0.0264
Echinococcus granulosus importin subunit beta 1 0.0029 0.0063 0.0102
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0585 0.3264
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0144 0.0795 0.1366
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0118 0.0181
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0186 0.0358
Schistosoma mansoni protein kinase 0.0264 0.1555 0.7159
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0055 0.0233
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.0409 0.6687
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0111 0.0631
Loa Loa (eye worm) hypothetical protein 0.0071 0.0328 0.0549
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0108 0.0567 0.0967
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0186 0.03
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0303 0.0626
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0105 0.0544 0.0926
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0055 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0118 0.0592
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0028 0.009
Loa Loa (eye worm) hypothetical protein 0.0084 0.0409 0.0691
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0111 0.0631
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0226 0.3234
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0144 0.0795 0.1627
Trichomonas vaginalis STE family protein kinase 0.0249 0.1461 0.9391
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0055 0.0056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0055 0.0056
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0144 0.0795 0.3661
Plasmodium falciparum carbonic anhydrase 0.0108 0.0567 0.359
Trypanosoma cruzi aurora B kinase, putative 0.0264 0.1555 0.881
Brugia malayi beta-lactamase family protein 0.0111 0.0585 0.0998
Brugia malayi Cytochrome P450 family protein 0.0046 0.0168 0.0269
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0295 0.1357
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0226 0.0212
Entamoeba histolytica protein kinase , putative 0.0264 0.1555 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0281 0.1527
Toxoplasma gondii hypothetical protein 0.0029 0.0061 0.0305
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.0409 0.0823
Schistosoma mansoni carbonic anhydrase-related 0.0108 0.0567 0.2612
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0295 0.0491
Leishmania major importin beta-1 subunit, putative 0.0024 0.0028 0.0079
Schistosoma mansoni inositol monophosphatase 0.0037 0.0111 0.0513
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0055 0.0041
Loa Loa (eye worm) hypothetical protein 0.0028 0.0055 0.0071
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0186 0.0172
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.0585 0.3721
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.1852 0.3214
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0118 0.0542
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.0585 0.1271
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.0585 0.1271
Onchocerca volvulus 0.0095 0.048 0.8024
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0028 0.0079
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.02 0.1151 0.5299
Echinococcus multilocularis PAK box P21 Rho binding 0.0144 0.0795 0.0782
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0186 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0281 0.1527
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0585 0.3705
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.0585 0.3721
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0585 0.3264
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.077 0.4323
Schistosoma mansoni carbonic anhydrase 0.0108 0.0567 0.2612
Brugia malayi Inositol-1 0.0037 0.0111 0.017
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0055 0.0056
Loa Loa (eye worm) hypothetical protein 0.0108 0.0567 0.0967
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0108 0.0567 0.0967
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0303 0.0626
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0055 0.0071
Schistosoma mansoni inositol monophosphatase 0.0037 0.0111 0.0513
Trichomonas vaginalis esterase, putative 0.0111 0.0585 0.3705
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0111 0.0556
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0111 0.0631
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.0585 0.0998
Schistosoma mansoni DNA polymerase eta 0.0038 0.0118 0.0542
Leishmania major DNA polymerase eta, putative 0.0038 0.0118 0.0592
Leishmania major carbonic anhydrase-like protein 0.02 0.1151 0.65
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0055 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0118 0.0592
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0055 0.0233
Trichomonas vaginalis STE family protein kinase 0.0249 0.1461 0.9391
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0543 0.0925
Giardia lamblia Aurora kinase 0.0264 0.1555 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0409 0.2565
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0751 0.1535
Echinococcus granulosus tar DNA binding protein 0.0066 0.0295 0.0584
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0055 0.0233
Schistosoma mansoni importin beta-1 0.0029 0.0063 0.029
Mycobacterium ulcerans hypothetical protein 0.0156 0.0871 0.5728
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0118 0.0592
Echinococcus multilocularis snurportin 1 0.0311 0.1852 0.1841
Mycobacterium ulcerans aldehyde dehydrogenase 0.0252 0.148 1
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0144 0.0795 0.0782
Leishmania major protein kinase, putative 0.0264 0.1555 0.881
Plasmodium vivax importin-beta 2, putative 0.0029 0.0063 0.0317
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0063 0.0279
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0246 0.1327
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0118 0.0592
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0118 0.0672
Echinococcus multilocularis aurora kinase A 0.0264 0.1555 0.1543
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0186 0.03
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0055 0.0071
Mycobacterium ulcerans hypothetical protein 0.0095 0.048 0.2986
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.0585 0.1271
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0118 0.0592
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0328 0.1917
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0055 0.0056
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0777 0.4815 0.4808
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0585 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0328 0.0549
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0055 0.0071
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0711 0.4394 1
Echinococcus granulosus GPCR family 2 0.0048 0.0186 0.0358
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0055 0.0233
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0226 0.0449
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0144 0.0795 0.1627
Schistosoma mansoni carbonic anhydrase-related 0.0108 0.0567 0.2612
Loa Loa (eye worm) AUR protein kinase 0.0264 0.1555 0.2694
Loa Loa (eye worm) RNA binding protein 0.0066 0.0295 0.0491
Entamoeba histolytica protein kinase, putative 0.0149 0.0827 0.5275
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0264 0.1555 1
Echinococcus granulosus aurora kinase A 0.0264 0.1555 0.3209
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0043 0.0167
Echinococcus multilocularis GPCR, family 2 0.0048 0.0186 0.0172
Echinococcus granulosus PAK box P21 Rho binding 0.0144 0.0795 0.1627
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0087 0.0606
Trichomonas vaginalis AGC family protein kinase 0.0264 0.1555 1
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.1763 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0055 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0751 0.3459
Loa Loa (eye worm) hypothetical protein 0.0095 0.048 0.0815
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0118 0.0592
Toxoplasma gondii hypothetical protein 0.0108 0.0567 0.359
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0295 0.1357
Loa Loa (eye worm) beta-lactamase 0.0111 0.0585 0.0998
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.048 0.2986
Trypanosoma cruzi p21-activated kinase 3, putative 0.0105 0.0544 0.3029
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0055 0.0071
Entamoeba histolytica protein kinase, putative 0.0264 0.1555 1
Brugia malayi WH1 domain containing protein 0.0144 0.0795 0.1366
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0055 0.0071
Echinococcus multilocularis carbonic anhydrase II 0.02 0.1151 0.1138
Brugia malayi RNA, U transporter 1 0.0083 0.0404 0.0682
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0055 0.0264
Leishmania major cathepsin L-like protease 0.0063 0.0281 0.1527
Mycobacterium tuberculosis Conserved protein 0.0111 0.0585 0.1271
Loa Loa (eye worm) oxidoreductase 0.0028 0.0055 0.0071
Mycobacterium ulcerans beta-lactamase 0.0111 0.0585 0.3721
Schistosoma mansoni hypothetical protein 0.0048 0.0186 0.0856
Brugia malayi beta-lactamase family protein 0.0111 0.0585 0.0998
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0295 0.1357
Echinococcus granulosus dna polymerase eta 0.0038 0.0118 0.0216
Loa Loa (eye worm) AUR protein kinase 0.0264 0.1555 0.2694
Brugia malayi serine/threonine-protein kinase 6 0.0264 0.1555 0.2694
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.0851 0.1464
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0295 0.1357
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0143 0.0737
Echinococcus granulosus carbonic anhydrase 0.0108 0.0567 0.1152
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0028 0.009
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0249 0.1461 0.3014
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0108 0.0567 0.0967
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0585 0.2693
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.02 0.1151 0.1988
Toxoplasma gondii hypothetical protein 0.0048 0.0182 0.109
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0751 0.0738
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0186 0.0358
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0028 0.009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0751 0.3459
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0105 0.0544 0.0926
Leishmania major DNA polymerase kappa, putative 0.0038 0.0118 0.0592
Entamoeba histolytica protein kinase, putative 0.0149 0.0827 0.5275
Leishmania major hypothetical protein, conserved 0.0111 0.0585 0.3264
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0055 0.0233
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0195 0.1033
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0055 0.0264
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0118 0.0592
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0061 0.0305
Trypanosoma brucei unspecified product 0.0038 0.0118 0.0592
Schistosoma mansoni hypothetical protein 0.0048 0.0186 0.0856
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0105 0.0544 0.0926
Plasmodium falciparum serine/threonine protein kinase, putative 0.0264 0.1555 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0751 0.3459
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0409 1
Loa Loa (eye worm) inositol-1 0.0037 0.0111 0.017
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0118 0.0441
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0264 0.1555 1
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0061 0.0118
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0409 0.2488
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0118 0.0592
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0063 0.0279
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0281 0.1527
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0871 0.1926
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0055 0.0085
Loa Loa (eye worm) hypothetical protein 0.0071 0.0328 0.0549
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0143 0.0737
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0249 0.1461 0.1449
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0264 0.1555 0.1543
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0252 0.148 0.3321
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0585 0.3705
Leishmania major cathepsin L-like protease 0.0063 0.0281 0.1527
Loa Loa (eye worm) hypothetical protein 0.0095 0.048 0.0815
Echinococcus granulosus dna polymerase kappa 0.0038 0.0118 0.0216
Trypanosoma brucei unspecified product 0.0026 0.0043 0.0167
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0063 0.0317
Echinococcus multilocularis carbonic anhydrase 0.0108 0.0567 0.0554
Entamoeba histolytica protein kinase domain containing protein 0.0264 0.1555 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0252 0.148 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.077 0.4323
Entamoeba histolytica acyl-CoA synthetase, putative 0.0095 0.048 0.3025
Schistosoma mansoni hypothetical protein 0.0048 0.0186 0.0856
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.0585 0.1189
Brugia malayi Probable ClpP-like protease 0.0084 0.0409 0.0691
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0118 0.0592
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0111 0.0097
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0108 0.0567 0.0967
Echinococcus multilocularis carbonic anhydrase 0.0108 0.0567 0.0554
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0118 0.0216
Mycobacterium leprae Probable lipase LipE 0.0111 0.0585 1
Echinococcus multilocularis geminin 0.0361 0.2172 0.2161
Entamoeba histolytica protein kinase, putative 0.0149 0.0827 0.5275
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0055 0.0264
Schistosoma mansoni hypothetical protein 0.0048 0.0186 0.0856
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0118 0.0181
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0226 0.0442
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0281 0.1527
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.0585 0.0998
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.048 0.2986
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0249 0.1461 0.3014
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0118 0.0592
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0118 0.02
Echinococcus granulosus carbonic anhydrase 0.0108 0.0567 0.1152
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.0409 0.0396
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0118 0.0104
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0585 0.3705
Schistosoma mansoni hypothetical protein 0.0311 0.1852 0.8527
Loa Loa (eye worm) hypothetical protein 0.0108 0.0567 0.0967
Entamoeba histolytica acyl-CoA synthetase, putative 0.0095 0.048 0.3025
Schistosoma mansoni hypothetical protein 0.0144 0.0795 0.3661
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0281 0.1527
Loa Loa (eye worm) hypothetical protein 0.0038 0.0118 0.0181
Brugia malayi AMP-binding enzyme family protein 0.0095 0.048 0.0815
Trichomonas vaginalis AGC family protein kinase 0.0264 0.1555 1
Onchocerca volvulus 0.0111 0.0585 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0409 0.2565
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0111 0.0556
Entamoeba histolytica p21-activated kinase 0.0249 0.1461 0.9391
Onchocerca volvulus 0.0111 0.0585 1
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0249 0.1461 0.3014
Loa Loa (eye worm) hypothetical protein 0.0111 0.0585 0.0998
Echinococcus granulosus geminin 0.0361 0.2172 0.4495
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0095 0.048 0.8024
Brugia malayi beta-lactamase 0.0111 0.0585 0.0998
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0055 0.0056
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0585 0.2693
Trichomonas vaginalis AGC family protein kinase 0.0264 0.1555 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0143 0.0737
Echinococcus multilocularis PAK box P21 Rho binding 0.0149 0.0827 0.0814
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0055 0.0233
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0118 0.0181
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0095 0.048 0.1031
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0143 0.0737
Toxoplasma gondii aldehyde dehydrogenase 0.0252 0.148 0.9511
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0795 0.3661
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0111 0.0203
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.02 0.1151 0.5299
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0055 0.0253
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0055 0.0071
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0186 0.03
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0281 0.1527
Schistosoma mansoni hypothetical protein 0.0361 0.2172 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0118 0.0592
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0226 0.0449
Giardia lamblia Kinase, STE STE20 0.0249 0.1461 0.9391
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.0585 0.1271
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0071 0.0328 0.0682
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0118 0.0592
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0095 0.048 0.2986
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0095 0.048 0.8024
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0055 0.0056
Loa Loa (eye worm) hypothetical protein 0.0108 0.0567 0.0967
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.1763 1
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0544 0.2504
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0409 0.2565
Schistosoma mansoni protein kinase 0.0249 0.1461 0.6727
Loa Loa (eye worm) carbonic anhydrase 3 0.02 0.1151 0.1988
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0063 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0043 0.0167
Loa Loa (eye worm) hypothetical protein 0.0111 0.0585 0.0998
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0111 0.0397
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0252 0.148 0.3052
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.0585 0.0572
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0168 0.0269
Brugia malayi P21-Rho-binding domain containing protein 0.0144 0.0795 0.1366
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0111 0.0556
Schistosoma mansoni protein kinase 0.0249 0.1461 0.6727
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0095 0.048 0.2986
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0095 0.048 0.2986
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0409 0.2565
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0281 0.1527
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.0585 0.1271
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0295 0.0281
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0043 0.0167
Schistosoma mansoni tyrosine kinase 0.0144 0.0795 0.3661
Plasmodium falciparum importin beta, putative 0.0029 0.0063 0.0317
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0055 0.0264
Echinococcus granulosus serine:threonine protein kinase PAK 1 0.01 0.0512 0.1037
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.1429 0.9186
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0281 0.1527
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0118 0.0592
Schistosoma mansoni aldehyde dehydrogenase 0.0252 0.148 0.6812
Plasmodium vivax acyl-CoA synthetase, putative 0.0071 0.0328 0.2037
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0585 0.3705
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.0851 0.1464
Echinococcus granulosus snurportin 1 0.0311 0.1852 0.3828
Loa Loa (eye worm) hypothetical protein 0.0111 0.0585 0.0998
Entamoeba histolytica hypothetical protein 0.0024 0.0028 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0281 0.1527
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0264 0.1555 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.02 0.1151 0.65
Brugia malayi AMP-binding enzyme family protein 0.0095 0.048 0.0815
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0281 0.1527
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0264 0.1555 1
Trichomonas vaginalis AGC family protein kinase 0.0264 0.1555 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0055 0.0056
Brugia malayi TAR-binding protein 0.0066 0.0295 0.0491
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0055 0.0264
Schistosoma mansoni hypothetical protein 0.0361 0.2172 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0585 0.0998
Trichomonas vaginalis STE family protein kinase 0.0149 0.0827 0.5275
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0249 0.1461 0.1449
Plasmodium falciparum acyl-CoA synthetase 0.0071 0.0328 0.2037
Giardia lamblia DINP protein human, muc B family 0.0038 0.0118 0.0672
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0095 0.048 0.1031
Schistosoma mansoni aldehyde dehydrogenase 0.0252 0.148 0.6812
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0055 0.0071
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.02 0.1151 0.1988
Schistosoma mansoni hypothetical protein 0.0144 0.0795 0.3661
Loa Loa (eye worm) hypothetical protein 0.0105 0.0543 0.0925
Entamoeba histolytica hypothetical protein 0.0144 0.0795 0.507
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0409 0.2488
Mycobacterium ulcerans hypothetical protein 0.0111 0.0585 0.3721
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0281 0.1527
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0111 0.0631
Trichomonas vaginalis STE family protein kinase 0.0249 0.1461 0.9391
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.0751 0.1289
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.1763 1
Mycobacterium tuberculosis Conserved protein 0.0111 0.0585 0.1271
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0544 0.2504
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0118 0.0592
Loa Loa (eye worm) hypothetical protein 0.0071 0.0328 0.0549
Mycobacterium tuberculosis Conserved protein 0.0111 0.0585 0.1271
Trypanosoma brucei unspecified product 0.0026 0.0043 0.0167
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0061 0.0305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0281 0.1527
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0055 0.0233
Mycobacterium ulcerans lipase LipD 0.0111 0.0585 0.3721
Onchocerca volvulus 0.0111 0.0585 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0111 0.0556
Toxoplasma gondii ABC1 family protein 0.0111 0.0585 0.3705
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0585 0.3264
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0295 0.0491
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.0409 0.1885
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.0409 1
Schistosoma mansoni hypothetical protein 0.0108 0.0567 0.2612
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0585 0.3705
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0055 0.0264
Trypanosoma brucei carbonic anhydrase-like protein 0.02 0.1151 0.65
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0921 0.5732 1
Brugia malayi Putative carbonic anhydrase 5 precursor 0.02 0.1151 0.1988
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.048 0.2665
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0118 0.02
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0087 0.013
Brugia malayi serine/threonine-protein kinase PAK 7 0.0921 0.5732 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0281 0.1527
Loa Loa (eye worm) hypothetical protein 0.0028 0.0055 0.0071
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0252 0.148 0.8379
Echinococcus granulosus carbonic anhydrase II 0.02 0.1151 0.2368
Entamoeba histolytica acyl-coA synthetase, putative 0.0095 0.048 0.3025
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0111 0.0631
Brugia malayi serine/threonine protein kinase 6 0.0264 0.1555 0.2694
Loa Loa (eye worm) hypothetical protein 0.0048 0.0186 0.03
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0118 0.0672
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0105 0.0544 0.3438
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.0751 0.1289
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0055 0.0233
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0108 0.0567 0.0967
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0585 0.3705
Loa Loa (eye worm) hypothetical protein 0.0111 0.0585 0.0998
Entamoeba histolytica protein kinase, putative 0.0264 0.1555 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.1429 0.2475
Schistosoma mansoni protein kinase 0.0144 0.0795 0.3661
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0105 0.0544 0.3029
Brugia malayi RNA binding protein 0.0066 0.0295 0.0491
Entamoeba histolytica protein kinase, putative 0.0249 0.1461 0.9391
Schistosoma mansoni serine/threonine protein kinase 0.0264 0.1555 0.7159
Schistosoma mansoni protein kinase 0.0149 0.0827 0.3807
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0249 0.1461 0.1449
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0108 0.0567 0.0967
Toxoplasma gondii aurora kinase 0.0264 0.1555 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0328 0.0549
Mycobacterium ulcerans aldehyde dehydrogenase 0.0252 0.148 1
Loa Loa (eye worm) AUR protein kinase 0.0264 0.1555 0.2694
Schistosoma mansoni hypothetical protein 0.0105 0.0543 0.2501
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.0851 0.1464
Echinococcus granulosus carbonic anhydrase 0.0108 0.0567 0.1152
Brugia malayi serine/threonine kinase 12 0.0264 0.1555 0.2694
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0201 0.1069
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0295 0.1357
Schistosoma mansoni ran 0.0021 0.0014 0.0065
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.048 0.2986
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0303 0.0626
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0118 0.0592
Leishmania major cathepsin L-like protease 0.0063 0.0281 0.1527
Trichomonas vaginalis STE family protein kinase 0.0249 0.1461 0.9391
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0409 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0118 0.0592
Brugia malayi AMP-binding enzyme family protein 0.0095 0.048 0.0815
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.02 0.1151 0.65
Schistosoma mansoni hypothetical protein 0.0144 0.0795 0.3661
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0409 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0118 0.0592
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.048 0.2665
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0118 0.0592
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0055 0.0056
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.077 0.4323
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0751 0.0738
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0281 0.1527
Loa Loa (eye worm) hypothetical protein 0.0029 0.0063 0.0085
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.1763 1
Trypanosoma brucei aurora B kinase 0.0264 0.1555 0.881
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0252 0.148 0.1467
Brugia malayi P21-Rho-binding domain containing protein 0.0144 0.0795 0.1366
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0055 0.0233
Brugia malayi Protein kinase domain 0.0249 0.1461 0.253
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0118 0.0672
Entamoeba histolytica hypothetical protein 0.0144 0.0795 0.507
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0264 0.1555 0.3209
Echinococcus multilocularis carbonic anhydrase 0.0108 0.0567 0.0554
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0303 0.0626
Brugia malayi Importin beta-1 subunit 0.0029 0.0063 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0751 0.1535
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.0585 0.1271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0281 0.1527
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0055 0.0264
Loa Loa (eye worm) hypothetical protein 0.0095 0.048 0.0815
Schistosoma mansoni carbonic anhydrase-related 0.0108 0.0567 0.2612
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0095 0.048 0.2986
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.048 0.2665
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0295 0.0491
Schistosoma mansoni ran 0.0021 0.0014 0.0065
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0118 0.0592
Loa Loa (eye worm) hypothetical protein 0.0111 0.0585 0.0998
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.0585 0.1271
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0118 0.0441
Loa Loa (eye worm) hypothetical protein 0.0153 0.0851 0.1464

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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