Detailed information for compound 1436165

Basic information

Technical information
  • TDR Targets ID: 1436165
  • Name: 2-[bis[di(phenyl)phosphoryl]methyl]pyridine
  • MW: 493.473 | Formula: C30H25NO2P2
  • H donors: 0 H acceptors: 3 LogP: 5.36 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=P(C(P(=O)(c1ccccc1)c1ccccc1)c1ccccn1)(c1ccccc1)c1ccccc1
  • InChi: 1S/C30H25NO2P2/c32-34(25-15-5-1-6-16-25,26-17-7-2-8-18-26)30(29-23-13-14-24-31-29)35(33,27-19-9-3-10-20-27)28-21-11-4-12-22-28/h1-24,30H
  • InChiKey: FHYIILFIEINZOX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_006012
  • STOCK1S-64016
  • 2-[Bis-(diphenyl-phosphinoyl)-methyl]-pyridine
  • MLS001012360
  • SMR000426891

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.1093 0.1093
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.1093 0.2145
Mycobacterium leprae conserved hypothetical protein 0.007 0.1093 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0061 0.0927 0.0934
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0979 0.8946
Loa Loa (eye worm) hypothetical protein 0.0077 0.1206 0.2227
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0359 0.0705
Loa Loa (eye worm) hypothetical protein 0.0014 0.0071 0.0131
Loa Loa (eye worm) hypothetical protein 0.0077 0.1206 0.2227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Entamoeba histolytica hypothetical protein, conserved 0.029 0.5094 1
Schistosoma mansoni zinc finger protein 0.0014 0.0071 0.0139
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.1206 0.2227
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0111 0.0218
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0102 0.0188
Loa Loa (eye worm) hypothetical protein 0.0016 0.0102 0.0188
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.1093 0.1147
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0359 0.0705
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0021 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Schistosoma mansoni hypothetical protein 0.0016 0.0102 0.02
Onchocerca volvulus Chorion peroxidase homolog 0.0077 0.1206 0.226
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0021 0.0195
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.007 0.1093 0.2018
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0144 0.1321
Brugia malayi steroid hormone receptor 0.003 0.0359 0.0705
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0359 0.0705
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0199 0.1711
Brugia malayi beta-lactamase family protein 0.007 0.1093 0.2145
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0359 0.0359
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0071 0.0071
Brugia malayi Animal haem peroxidase family protein 0.0077 0.1206 0.2368
Loa Loa (eye worm) hypothetical protein 0.0016 0.0102 0.0188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0199 0.1822
Loa Loa (eye worm) blistered cuticle protein 3 0.0077 0.1206 0.2227
Plasmodium falciparum thioredoxin reductase 0.0021 0.0199 0.07
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0016 0.0102 0.0188
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0359 0.0705
Echinococcus multilocularis neuropeptide receptor A26 0.056 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0359 0.0705
Loa Loa (eye worm) hypothetical protein 0.0077 0.1206 0.2227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0199 0.1711
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0144 0.1203
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0102 0.02
Onchocerca volvulus Peroxidase homolog 0.0077 0.1206 0.226
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0021 0.0199 0.1279
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0021 0.0199 0.1711
Echinococcus multilocularis geminin 0.0165 0.2806 0.2806
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1093 1
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.1093 0.1147
Loa Loa (eye worm) hypothetical protein 0.0077 0.1206 0.2227
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.1206 0.2227
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0359 0.0359
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0102 0.0102
Loa Loa (eye worm) RecQ helicase 0.0021 0.019 0.0351
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0957 0.1767
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0145 0.1327
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0074 0.0145
Echinococcus granulosus geminin 0.0165 0.2806 0.2806
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0268 0.2453
Loa Loa (eye worm) hypothetical protein 0.0077 0.1206 0.2227
Onchocerca volvulus 0.007 0.1093 0.2035
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0979 0.8946
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0957 0.1879
Trypanosoma brucei hypothetical protein, conserved 0.007 0.1093 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0071 0.0131
Onchocerca volvulus Dual oxidase homolog 0.0077 0.1206 0.226
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0199 0.5
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0144 0.1203
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0359 0.0705
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0097 0.019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0268 0.2302
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0199 0.1822
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0021 0.0199 0.1279
Loa Loa (eye worm) beta-lactamase 0.007 0.1093 0.2018
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0014 0.0071 0.0131
Loa Loa (eye worm) hypothetical protein 0.003 0.0359 0.0663
Trichomonas vaginalis esterase, putative 0.007 0.1093 1
Echinococcus multilocularis neuropeptide s receptor 0.056 1 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1206 0.2227
Loa Loa (eye worm) hypothetical protein 0.0016 0.0102 0.0188
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0144 0.1203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Onchocerca volvulus Protein cereblon homolog 0.029 0.5094 1
Schistosoma mansoni nuclear receptor 0.0014 0.0071 0.0139
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1093 0.2145
Brugia malayi nuclear hormone receptor 0.003 0.0359 0.0705
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0071 0.0131
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0199 0.5
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0071 0.0139
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0359 0.0705
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.3956 0.7304
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0144 0.0267
Loa Loa (eye worm) hypothetical protein 0.003 0.0359 0.0663
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0359 0.0705
Treponema pallidum NADH oxidase 0.0021 0.0199 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0359 0.0705
Toxoplasma gondii ABC1 family protein 0.007 0.1093 1
Schistosoma mansoni hypothetical protein 0.0165 0.2806 0.5509
Echinococcus granulosus protein cereblon 0.029 0.5094 0.5094
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1093 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0071 0.0139
Brugia malayi beta-lactamase family protein 0.007 0.1093 0.2145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0359 0.0663
Brugia malayi hypothetical protein 0.0014 0.0071 0.0139
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0359 0.0359
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0359 0.0663
Echinococcus multilocularis GPCR, family 2 0.0016 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0016 0.0102 0.02
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1093 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Loa Loa (eye worm) hypothetical protein 0.003 0.0359 0.0663
Toxoplasma gondii NADPH-glutathione reductase 0.0021 0.0199 0.1659
Brugia malayi hypothetical protein 0.0077 0.1206 0.2368
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.019 0.0373
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0027 0.03 0.0554
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0359 0.0359
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0979 0.0979
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0359 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Schistosoma mansoni nuclear receptor 0.0014 0.0071 0.0139
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0102 0.0102
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0102 0.0102
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0102 0.02
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0957 0.1879
Brugia malayi Animal haem peroxidase family protein 0.0077 0.1206 0.2368
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0073
Mycobacterium tuberculosis Conserved protein 0.007 0.1093 0.1147
Schistosoma mansoni thyroid hormone receptor 0.0152 0.2583 0.507
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0359 0.0359
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0015 0.0134
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0144 0.1203
Echinococcus multilocularis musashi 0.0027 0.03 0.03
Schistosoma mansoni coup transcription factor 0.003 0.0359 0.0705
Onchocerca volvulus 0.0027 0.03 0.0457
Loa Loa (eye worm) hypothetical protein 0.0014 0.0071 0.0131
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0359 0.0574
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.1093 0.1147
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1093 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.03 0.0589
Leishmania major trypanothione reductase 0.0061 0.0927 0.846
Mycobacterium ulcerans hypothetical protein 0.007 0.1093 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1206 0.2227
Loa Loa (eye worm) hypothetical protein 0.003 0.0359 0.0663
Loa Loa (eye worm) hypothetical protein 0.0014 0.0071 0.0131
Echinococcus multilocularis lamin dm0 0.0027 0.03 0.03
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0359 0.0359
Schistosoma mansoni thyroid hormone receptor 0.0152 0.2583 0.507
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0359 0.0574
Onchocerca volvulus 0.0077 0.1206 0.226
Toxoplasma gondii thioredoxin reductase 0.0061 0.0927 0.845
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0144 0.0283
Loa Loa (eye worm) hypothetical protein 0.007 0.1093 0.2018
Echinococcus granulosus intermediate filament protein 0.0027 0.03 0.03
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0359 0.0705
Echinococcus granulosus lamin dm0 0.0027 0.03 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0359 0.0663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0957 0.1879
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0048 0.0048
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0021 0.0199 0.1711
Onchocerca volvulus 0.007 0.1093 0.2035
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0359 0.0705
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0144 0.1321
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0359 0.0705
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.03 0.0554
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0204 0.187
Giardia lamblia NADH oxidase lateral transfer candidate 0.0021 0.0199 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0021 0.0199 0.5
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0065 0.0408
Loa Loa (eye worm) hypothetical protein 0.007 0.1093 0.2018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0359 0.0359
Brugia malayi hypothetical protein 0.029 0.5094 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1206 0.2227
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0144 0.0283
Brugia malayi RNA binding protein 0.0063 0.0957 0.1879
Brugia malayi hypothetical protein 0.0118 0.1963 0.3854
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0199 0.1822
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0071 0.0139
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0957 0.1879
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0359 0.0574
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0979 0.1922
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0359 0.0359
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0102 0.0102
Mycobacterium ulcerans beta-lactamase 0.007 0.1093 1
Echinococcus granulosus neuropeptide receptor A26 0.056 1 1
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0488 0.0488
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0359 0.0705
Onchocerca volvulus Peroxidase homolog 0.0077 0.1206 0.226
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0102 0.02
Schistosoma mansoni nuclear hormone receptor 0.003 0.0359 0.0705
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0071 0.0071
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0144 0.1203
Onchocerca volvulus 0.0077 0.1206 0.226
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.205 0.3786
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0021 0.0199 0.0199
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0957 0.1879
Brugia malayi beta-lactamase 0.007 0.1093 0.2145
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0268 0.0268
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1093 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0021 0.0199 0.1711
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0144 0.1148
Loa Loa (eye worm) hypothetical protein 0.003 0.0359 0.0663
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0359 0.0705
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0268 0.0526
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0957 0.1879
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0102 0.0102
Trypanosoma brucei trypanothione reductase 0.0061 0.0927 0.846
Brugia malayi hypothetical protein 0.0016 0.0102 0.02
Echinococcus multilocularis lamin 0.0027 0.03 0.03
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0144 0.1203
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0102 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Loa Loa (eye worm) hypothetical protein 0.0016 0.0102 0.0188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0359 0.0663
Echinococcus granulosus GPCR family 2 0.0016 0.0102 0.0102
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0071 0.0071
Schistosoma mansoni peroxidasin 0.0077 0.1206 0.2368
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1093 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1206 0.2227
Trypanosoma cruzi trypanothione reductase, putative 0.0061 0.0927 0.8481
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0071 0.0131
Loa Loa (eye worm) hypothetical protein 0.0014 0.0071 0.0131
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0726 0.1425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0074 0.0137
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0979 0.1922
Mycobacterium tuberculosis Conserved protein 0.007 0.1093 0.1147
Loa Loa (eye worm) hypothetical protein 0.003 0.0359 0.0663
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0144 0.1321
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0071 0.0139
Loa Loa (eye worm) hypothetical protein 0.0077 0.1206 0.2227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Loa Loa (eye worm) hypothetical protein 0.003 0.0359 0.0663
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0359 0.0705
Brugia malayi Thioredoxin reductase 0.0061 0.0927 0.1819
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0199 0.1822
Loa Loa (eye worm) DR-78 0.0014 0.0071 0.0131
Schistosoma mansoni hypothetical protein 0.0016 0.0102 0.02
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0437 0.0858
Loa Loa (eye worm) hypothetical protein 0.0034 0.0437 0.0807
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0071 0.0071
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0359 0.0705
Loa Loa (eye worm) hypothetical protein 0.0014 0.0071 0.0131
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0071 0.0071
Schistosoma mansoni peroxidasin 0.0077 0.1206 0.2368
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0102 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0359 0.0705
Loa Loa (eye worm) hypothetical protein 0.0021 0.0204 0.0377
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0268 0.0526
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0979 0.1922
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0071 0.0139
Loa Loa (eye worm) hypothetical protein 0.0308 0.5416 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0071 0.0139
Loa Loa (eye worm) hypothetical protein 0.007 0.1093 0.2018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0359 0.0705
Schistosoma mansoni lamin 0.0027 0.03 0.0589
Loa Loa (eye worm) hypothetical protein 0.0014 0.0071 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0359 0.0705
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Brugia malayi follicle stimulating hormone receptor 0.0228 0.3956 0.7766
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0144 0.0144
Plasmodium vivax glutathione reductase, putative 0.0061 0.0927 0.838
Echinococcus granulosus FTZ F1 alpha 0.003 0.0359 0.0359
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0199 0.1822
Loa Loa (eye worm) hypothetical protein 0.005 0.0726 0.134
Loa Loa (eye worm) hypothetical protein 0.003 0.0359 0.0663
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0021 0.0199 0.0391
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0359 0.0359
Brugia malayi hypothetical protein 0.0016 0.0102 0.02
Loa Loa (eye worm) intermediate filament protein 0.0027 0.03 0.0554
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0144 0.0283
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0071 0.0139
Echinococcus granulosus tar DNA binding protein 0.0063 0.0957 0.0957
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.1093 0.1147
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0144 0.1321
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.019 0.174
Brugia malayi nuclear receptor NHR-88 0.0014 0.0071 0.0139
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.007 0.1093 0.2018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0359 0.0663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Brugia malayi ecdysone receptor 0.0014 0.0071 0.0139
Schistosoma mansoni lamin 0.0027 0.03 0.0589
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0359 0.0359
Echinococcus multilocularis bloom syndrome protein 0.0021 0.019 0.019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Onchocerca volvulus 0.0027 0.03 0.0457
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0071 0.0071
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0359 0.0705
Schistosoma mansoni hypothetical protein 0.0034 0.0437 0.0858
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.1093 0.1147
Loa Loa (eye worm) hypothetical protein 0.0016 0.0102 0.0188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0199 0.1822
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0979 0.0979
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Brugia malayi Animal haem peroxidase family protein 0.0077 0.1206 0.2368
Onchocerca volvulus Peroxidasin homolog 0.0077 0.1206 0.226
Schistosoma mansoni hypothetical protein 0.029 0.5094 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0021 0.0199 0.1711
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1093 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.1093 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0144 0.1203
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0979 0.896
Brugia malayi nuclear receptor NHR-88 0.003 0.0359 0.0705
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0021 0.0199 0.07
Onchocerca volvulus 0.007 0.1093 0.2035
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.1093 1
Brugia malayi Blistered cuticle protein 3 0.0077 0.1206 0.2368
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.205 0.3786
Brugia malayi TAR-binding protein 0.0063 0.0957 0.1879
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.1093 0.1093
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0199 0.1822
Brugia malayi intermediate filament protein 0.0027 0.03 0.0589
Trypanosoma cruzi trypanothione reductase, putative 0.0021 0.0199 0.1822
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1093 0.2145
Brugia malayi Animal haem peroxidase family protein 0.0077 0.1206 0.2368
Plasmodium vivax hypothetical protein, conserved 0.007 0.1093 1
Trichomonas vaginalis glutathione reductase, putative 0.0021 0.0199 0.1822
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0016 0.0102 0.02
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0144 0.0283
Loa Loa (eye worm) hypothetical protein 0.0017 0.0114 0.021
Brugia malayi ecdysteroid receptor 0.003 0.0359 0.0705
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0979 0.896
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.1206 0.2227
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.019 0.174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0268 0.2453
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0144 0.0267
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0015 0.0134
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0979 0.1808
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0359 0.0663
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0071 0.0131
Echinococcus multilocularis thioredoxin glutathione reductase 0.0061 0.0927 0.0927
Loa Loa (eye worm) hypothetical protein 0.007 0.1093 0.2018
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.03 0.0589
Loa Loa (eye worm) hypothetical protein 0.0077 0.1206 0.2227
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0097 0.019
Loa Loa (eye worm) hypothetical protein 0.0077 0.1206 0.2227
Plasmodium falciparum thioredoxin reductase 0.0061 0.0927 1
Echinococcus granulosus bloom syndrome protein 0.0021 0.019 0.019
Onchocerca volvulus Peroxidasin homolog 0.0077 0.1206 0.226
Loa Loa (eye worm) thioredoxin reductase 0.0061 0.0927 0.1711
Loa Loa (eye worm) hypothetical protein 0.0013 0.0048 0.0089
Brugia malayi Animal haem peroxidase family protein 0.0077 0.1206 0.2368
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0268 0.235
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0144 0.1321
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0071 0.0139
Brugia malayi nuclear receptor NHR-67 0.0014 0.0071 0.0139
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0048 0.0048
Trichomonas vaginalis mercuric reductase, putative 0.0021 0.0199 0.1822
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0359 0.0705
Loa Loa (eye worm) glutathione reductase 0.0061 0.0927 0.1711
Plasmodium falciparum glutathione reductase 0.0021 0.0199 0.07
Loa Loa (eye worm) hypothetical protein 0.0077 0.1206 0.2227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0144 0.1203
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0359 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0359 0.0705
Brugia malayi nuclear hormone receptor 0.0014 0.0071 0.0139
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0488 0.0488
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0102 0.02
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0359 0.0705
Mycobacterium leprae Probable lipase LipE 0.007 0.1093 1
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0071 0.0139
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0011 0.0021 0.0062
Echinococcus granulosus thioredoxin glutathione reductase 0.0061 0.0927 0.0927
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.1093 0.2018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0726 0.134
Schistosoma mansoni hypothetical protein 0.0165 0.2806 0.5509
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0268 0.0268
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0359 0.0705
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0199 0.1711
Schistosoma mansoni hypothetical protein 0.0122 0.2037 0.3998
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0021 0.0199 0.0199
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.2037 0.2037
Echinococcus granulosus lamin 0.0027 0.03 0.03
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0199 0.1822
Mycobacterium ulcerans lipase LipD 0.007 0.1093 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0071 0.0139
Loa Loa (eye worm) hypothetical protein 0.0014 0.0071 0.0131
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0957 0.0957
Brugia malayi glutathione reductase 0.0061 0.0927 0.1819
Echinococcus multilocularis peroxidasin 0.0077 0.1206 0.1206
Brugia malayi hypothetical protein 0.0014 0.0071 0.0139
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.2583 0.2583
Mycobacterium tuberculosis Conserved protein 0.007 0.1093 0.1147
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0021 0.0199 0.07
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0144 0.0283
Echinococcus granulosus peroxidasin 0.0077 0.1206 0.1206
Brugia malayi nuclear receptor RXR 0.0016 0.0102 0.02
Loa Loa (eye worm) hypothetical protein 0.0026 0.0291 0.0538
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.2037 0.2037
Plasmodium vivax thioredoxin reductase, putative 0.0061 0.0927 0.838
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0359 0.0663
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0359 0.0663
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0015 0.0029
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0359 0.0359
Brugia malayi MH2 domain containing protein 0.0123 0.205 0.4025
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.1093 0.1147
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0199 0.1711
Leishmania major hypothetical protein, conserved 0.007 0.1093 1
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.1206 0.2227
Loa Loa (eye worm) hypothetical protein 0.0014 0.0071 0.0131
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0102 0.02
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0145 0.1209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0144 0.0283
Entamoeba histolytica hypothetical protein 0.0025 0.0268 0.0526
Onchocerca volvulus 0.003 0.0359 0.0574
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0726 0.1425
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0144 0.0144
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0144 0.0144
Brugia malayi conserved hypotetical protein 0.0014 0.0071 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Brugia malayi Peroxidasin 0.0077 0.1206 0.2368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0957 0.1767
Echinococcus multilocularis protein cereblon 0.029 0.5094 0.5094
Loa Loa (eye worm) RNA binding protein 0.0063 0.0957 0.1767
Brugia malayi nuclear receptor RXR 0.0014 0.0071 0.0139
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0014 0.0071 0.0131
Loa Loa (eye worm) hypothetical protein 0.0014 0.0071 0.0131
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0449 0.7988 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0359 0.0359
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0144 0.1203
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0102 0.0102
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0021 0.0199 0.1659
Loa Loa (eye worm) hypothetical protein 0.029 0.5094 0.9405
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0359 0.0705
Loa Loa (eye worm) hypothetical protein 0.0014 0.0071 0.0131
Loa Loa (eye worm) hypothetical protein 0.0077 0.1206 0.2227
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0071 0.0139
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0071 0.0071
Plasmodium falciparum glutathione reductase 0.0061 0.0927 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0021 0.0199 0.0391
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0144 0.1203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0144 0.1321
Mycobacterium tuberculosis Probable hydrolase 0.007 0.1093 0.1147
Onchocerca volvulus 0.0077 0.1206 0.226
Brugia malayi tailless protein 0.0014 0.0071 0.0139

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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