Detailed information for compound 1436356

Basic information

Technical information
  • TDR Targets ID: 1436356
  • Name: methyl (2S)-4-methyl-2-[(4-methylpiperidine-1 -carbonyl)amino]pentanoate
  • MW: 270.368 | Formula: C14H26N2O3
  • H donors: 1 H acceptors: 2 LogP: 2.48 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)[C@@H](NC(=O)N1CCC(CC1)C)CC(C)C
  • InChi: 1S/C14H26N2O3/c1-10(2)9-12(13(17)19-4)15-14(18)16-7-5-11(3)6-8-16/h10-12H,5-9H2,1-4H3,(H,15,18)/t12-/m0/s1
  • InChiKey: KSKDMRCVMVAMNI-LBPRGKRZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-4-methyl-2-[[(4-methyl-1-piperidinyl)-oxomethyl]amino]pentanoic acid methyl ester
  • (2S)-4-methyl-2-[(4-methylpiperidine-1-carbonyl)amino]valeric acid methyl ester
  • methyl (2S)-4-methyl-2-[(4-methylpiperidin-1-yl)carbonylamino]pentanoate
  • SMR000440088
  • STOCK1N-65292
  • ZINC00542197
  • (S)-4-Methyl-2-[(4-methyl-piperidine-1-carbonyl)-amino]-pentanoic acid methyl ester
  • MLS000758797

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0724 0.4335
Brugia malayi nuclear receptor NHR-88 0.001 0.0036 0.0045
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0359 0.5
Plasmodium falciparum importin beta, putative 0.0035 0.0717 0.4794
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0359 0.1913
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0717 0.0717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0794 0.8147
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.0359 0.2404
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.1577 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.1577 1
Brugia malayi hypothetical protein 0.0156 0.4061 0.5078
Loa Loa (eye worm) hypothetical protein 0.0036 0.075 0.075
Schistosoma mansoni hypothetical protein 0.0033 0.0678 0.0678
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0359 0.1913
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0463 0.31
Brugia malayi Animal haem peroxidase family protein 0.0156 0.4061 0.5078
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0036 0.0045
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0724 0.4335
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.3227 0.3227
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1104 0.138
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0164 0.0164
Mycobacterium ulcerans lipase LipD 0.0036 0.075 1
Leishmania major GTP-binding protein, putative 0.0026 0.0463 0.2604
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0359 0.1913
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0036 0.0036
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0359 0.5
Onchocerca volvulus Protein cereblon homolog 0.0299 0.7998 1
Schistosoma mansoni hypothetical protein 0.0169 0.4427 0.4427
Toxoplasma gondii thioredoxin reductase 0.0063 0.1495 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1104 0.138
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0535 0.5449
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0971 0.0971
Schistosoma mansoni importin beta-1 0.0035 0.0717 0.0717
Echinococcus granulosus importin subunit beta 1 0.0035 0.0717 0.0717
Brugia malayi Thioredoxin reductase 0.0063 0.1495 0.1869
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0033 0.0678 0.0678
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0036 0.0036
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0463 0.2604
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.0359 0.2404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0164 0.1579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.066 0.6753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0723 0.7408
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.075 0.068
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.075 0.7686
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0036 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0009 0.0013 0.0013
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0971 0.5979
Onchocerca volvulus Peroxidasin homolog 0.0156 0.4061 0.5056
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.4061 0.4061
Trichomonas vaginalis esterase, putative 0.0036 0.075 0.7686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.066 0.6753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.066 0.6753
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.075 0.068
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.1577 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.075 0.4505
Entamoeba histolytica Ran family GTPase 0.0026 0.0463 0.0495
Schistosoma mansoni hypothetical protein 0.0372 1 1
Onchocerca volvulus Chorion peroxidase homolog 0.0156 0.4061 0.5056
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0463 0.31
Onchocerca volvulus 0.0156 0.4061 0.5056
Brugia malayi nuclear hormone receptor 0.001 0.0036 0.0045
Mycobacterium tuberculosis Conserved protein 0.0036 0.075 0.068
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Treponema pallidum NADH oxidase 0.0022 0.0359 0.5
Giardia lamblia GTOR 0.0044 0.0971 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.02 0.0249
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0971 0.0971
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0022 0.0359 0.5
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0463 0.0463
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0071 0.0609
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.075 0.7686
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0413 0.4171
Giardia lamblia NADH oxidase lateral transfer candidate 0.0022 0.0359 0.37
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.0359 0.0359
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0009 0.0013 0.0088
Brugia malayi beta-lactamase family protein 0.0036 0.075 0.0937
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0036 0.0036
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0463 0.0463
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.075 0.075
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0572 0.5829
Loa Loa (eye worm) hypothetical protein 0.0015 0.0183 0.0183
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0971 0.5979
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0359 0.1913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0545 0.5555
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0036 0.0036
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0274 0.1832
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0345 0.3467
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.0359 0.0359
Schistosoma mansoni ran 0.0026 0.0463 0.0463
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Plasmodium vivax glutathione reductase, putative 0.0063 0.1495 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0156 0.4061 0.4061
Loa Loa (eye worm) hypothetical protein 0.0299 0.7998 0.7998
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.4061 0.4061
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.075 0.7686
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0164 0.0618
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1104 0.1104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0483 0.4901
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0036 0.0036
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0036 0.0036
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0463 0.2604
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0164 0.0206
Leishmania major trypanothione reductase 0.0063 0.1495 0.9457
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0463 0.2302
Onchocerca volvulus Peroxidase homolog 0.0156 0.4061 0.5056
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Echinococcus granulosus bloom syndrome protein 0.0021 0.0345 0.0345
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0164 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0412 0.4161
Brugia malayi Animal haem peroxidase family protein 0.0156 0.4061 0.5078
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0475 0.4826
Echinococcus multilocularis snurportin 1 0.0372 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0226 0.0226
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0036 0.0045
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.00000000011056 0.00000000073963
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0261 0.1263
Echinococcus granulosus GPCR family 2 0.0015 0.0183 0.0183
Schistosoma mansoni thyroid hormone receptor 0.0136 0.3505 0.3505
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0971 0.5979
Plasmodium vivax thioredoxin reductase, putative 0.0063 0.1495 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.075 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0063 0.1495 0.1495
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.075 0.7686
Trichomonas vaginalis ran, putative 0.0026 0.0463 0.4699
Brugia malayi hypothetical protein 0.0122 0.3112 0.3891
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0036 0.0036
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Schistosoma mansoni hypothetical protein 0.0299 0.7998 0.7998
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0463 0.0463
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0971 0.0971
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0036 0.0036
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0036 0.0036
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.3227 0.3227
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0183 0.0229
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.0359 0.1913
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.1577 0.1899
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0222 0.0222
Entamoeba histolytica hypothetical protein 0.0028 0.0535 0.0585
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.066 0.4416
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.1577 0.1577
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Onchocerca volvulus Peroxidasin homolog 0.0156 0.4061 0.5056
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0036 0.0045
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0036 0.0036
Brugia malayi hypothetical protein 0.0299 0.7998 1
Schistosoma mansoni coup transcription factor 0.001 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0049 0.1104 0.1104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0413 0.4171
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0164 0.0618
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.6097 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0359 0.1913
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0183 0.0229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0723 0.7408
Schistosoma mansoni ran 0.0026 0.0463 0.0463
Plasmodium vivax importin-beta 2, putative 0.0035 0.0717 0.4193
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0971 0.5979
Echinococcus granulosus geminin 0.0169 0.4427 0.4427
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.081 0.081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.066 0.6753
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Echinococcus granulosus peroxidasin 0.0156 0.4061 0.4061
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.0359 0.1913
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0036 0.0036
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.075 0.075
Echinococcus multilocularis geminin 0.0169 0.4427 0.4427
Echinococcus multilocularis GPCR, family 2 0.0015 0.0183 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0971 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0359 0.1913
Onchocerca volvulus Peroxidase homolog 0.0156 0.4061 0.5056
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.075 0.068
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.075 0.4505
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0971 0.1135
Echinococcus multilocularis thyroid hormone receptor alpha 0.0136 0.3505 0.3505
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0036 0.0036
Brugia malayi Importin beta-1 subunit 0.0035 0.0717 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0164 0.1579
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0036 0.0045
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0036 0.0036
Loa Loa (eye worm) glutathione reductase 0.0063 0.1495 0.1495
Schistosoma mansoni hypothetical protein 0.0169 0.4427 0.4427
Plasmodium vivax hypothetical protein, conserved 0.0036 0.075 0.4438
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0359 0.1913
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0463 0.4771
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0164 0.0164
Schistosoma mansoni peroxidasin 0.0156 0.4061 0.4061
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0164 0.0164
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0359 0.1913
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0331 0.1727
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.1577 0.1577
Brugia malayi beta-lactamase 0.0036 0.075 0.0937
Onchocerca volvulus 0.0036 0.075 0.0896
Brugia malayi RNA, U transporter 1 0.0099 0.2486 0.3108
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0036 0.0045
Onchocerca volvulus 0.0156 0.4061 0.5056
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0345 0.0432
Mycobacterium ulcerans beta-lactamase 0.0036 0.075 1
Onchocerca volvulus 0.0156 0.4061 0.5056
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Loa Loa (eye worm) hypothetical protein 0.0036 0.075 0.075
Echinococcus multilocularis peroxidasin 0.0156 0.4061 0.4061
Brugia malayi ecdysteroid receptor 0.001 0.0036 0.0045
Plasmodium falciparum thioredoxin reductase 0.0022 0.0359 0.2404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0413 0.4171
Plasmodium falciparum glutathione reductase 0.0022 0.0359 0.2404
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.075 0.075
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0345 0.0345
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0463 0.2604
Leishmania major importin beta-1 subunit, putative 0.0028 0.0535 0.3082
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.1577 0.1577
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0036 0.0036
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0463 0.0579
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0036 0.0045
Mycobacterium leprae Probable lipase LipE 0.0036 0.075 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0063 0.1495 0.1495
Brugia malayi beta-lactamase family protein 0.0036 0.075 0.0937
Echinococcus multilocularis protein cereblon 0.0299 0.7998 0.7998
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Onchocerca volvulus 0.0036 0.075 0.0896
Mycobacterium tuberculosis Conserved protein 0.0036 0.075 0.068
Loa Loa (eye worm) hypothetical protein 0.0317 0.8501 0.8501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0412 0.4161
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0036 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0036 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0412 0.4161
Entamoeba histolytica hypothetical protein, conserved 0.0299 0.7998 1
Schistosoma mansoni hypothetical protein 0.0015 0.0183 0.0183
Brugia malayi Blistered cuticle protein 3 0.0156 0.4061 0.5078
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.075 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.02 0.0249
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0036 0.0036
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.075 0.075
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0036 0.0045
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Schistosoma mansoni hypothetical protein 0.0015 0.0183 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0971 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0036 0.0045
Schistosoma mansoni thyroid hormone receptor 0.0136 0.3505 0.3505
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0005
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.0359 0.1526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0723 0.7408
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.075 1
Brugia malayi Animal haem peroxidase family protein 0.0156 0.4061 0.5078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0475 0.4826
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0971 0.5979
Brugia malayi Peroxidasin 0.0156 0.4061 0.5078
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0971 0.5979
Schistosoma mansoni hypothetical protein 0.0015 0.0183 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0483 0.4901
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.1577 0.1971
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0036 0.0036
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.015 0.1005
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.0359 0.3614
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0036 0.0045
Echinococcus granulosus FTZ F1 alpha 0.001 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.075 0.075
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0717 0.4794
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0164 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0164 0.1579
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0036 0.0036
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.4061 0.4061
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.075 0.4505
Loa Loa (eye worm) hypothetical protein 0.0036 0.075 0.075
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0359 0.1913
Brugia malayi Animal haem peroxidase family protein 0.0156 0.4061 0.5078
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0036 0.0045
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.0359 0.0359
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.0359 0.2404
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.075 0.7686
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0036 0.0036
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0724 0.4335
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0063 0.1495 0.1979
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Echinococcus granulosus protein cereblon 0.0299 0.7998 0.7998
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0678 0.0848
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.0359 0.2404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0483 0.4901
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0036 0.0036
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0183 0.0183
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.6141 0.6141
Onchocerca volvulus 0.0036 0.075 0.0896
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0036 0.0045
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0723 0.7408
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0971 0.1135
Schistosoma mansoni hypothetical protein 0.0126 0.3227 0.3227
Brugia malayi Animal haem peroxidase family protein 0.0156 0.4061 0.5078
Toxoplasma gondii ABC1 family protein 0.0036 0.075 0.5014
Schistosoma mansoni nuclear hormone receptor 0.001 0.0036 0.0036
Loa Loa (eye worm) beta-lactamase 0.0036 0.075 0.075
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.075 0.068
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0036 0.0045
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0535 0.5449
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0971 0.1214
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.4061 0.4061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0036 0.0036
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0183 0.0183
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.075 0.0937
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0717 0.4287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0723 0.7408
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Schistosoma mansoni peroxidasin 0.0156 0.4061 0.4061
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0036 0.0036
Brugia malayi follicle stimulating hormone receptor 0.0232 0.6141 0.7678
Mycobacterium tuberculosis Conserved protein 0.0036 0.075 0.068
Loa Loa (eye worm) RecQ helicase 0.0021 0.0345 0.0345
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0345 0.3467
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.1577 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0036 0.0036
Brugia malayi glutathione reductase 0.0063 0.1495 0.1869
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0183 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0413 0.4171
Leishmania major hypothetical protein, conserved 0.0036 0.075 0.4505
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.1577 0.1577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0971 1
Trypanosoma cruzi trypanothione reductase, putative 0.0063 0.1495 0.9457
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.075 0.068
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0164 0.1579
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.0359 0.1913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0164 0.1579
Plasmodium falciparum glutathione reductase 0.0063 0.1495 1
Schistosoma mansoni hypothetical protein 0.0015 0.0183 0.0183
Plasmodium falciparum thioredoxin reductase 0.0063 0.1495 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0535 0.3082
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0036 0.0045
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0036 0.0036
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.075 0.068
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0164 0.0618
Onchocerca volvulus Dual oxidase homolog 0.0156 0.4061 0.5056
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.075 0.075
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.0359 0.1913
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0036 0.0036
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0717 0.4287
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.0359 0.1526
Trypanosoma brucei trypanothione reductase 0.0063 0.1495 0.9457
Mycobacterium leprae conserved hypothetical protein 0.0036 0.075 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0164 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.066 0.6753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.066 0.6753
Loa Loa (eye worm) hypothetical protein 0.0036 0.075 0.075
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0164 0.0618
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0359 0.1913
Brugia malayi steroid hormone receptor 0.001 0.0036 0.0045
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.0359 0.0449
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.075 0.068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0083 0.0729
Echinococcus granulosus transcription factor Dp 1 0.0038 0.081 0.081
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.0359 0.3614
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0036 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0036 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0359 0.1913
Loa Loa (eye worm) hypothetical protein 0.0035 0.0717 0.0717
Loa Loa (eye worm) thioredoxin reductase 0.0063 0.1495 0.1495
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.066 0.6753
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0971 0.0971
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0359 0.1913
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0036 0.0045
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0535 0.5449
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0359 0.1913
Loa Loa (eye worm) hypothetical protein 0.0036 0.075 0.075

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4147 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.1735 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.